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A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

David L Masica, Marco Dal Molin, Christopher L Wolfgang, Tyler Tomita, Mohammad R Ostovaneh, Amanda Blackford, Robert A Moran, Joanna K Law, Thomas Barkley, Michael Goggins, Marcia Irene Canto, Meredith Pittman (+24 others)
2016 JAMIA Journal of the American Medical Informatics Association  
Objective: Our objective was to develop an approach for selecting combinatorial markers of pathology from diverse clinical data types.  ...  To derive optimal markers for cyst classification from the preoperative clinical and radiological data, we developed a statistical approach for combining any number of categorical, dichotomous, or continuous-valued  ...  of clinical data, and select composite markers of cyst type and grade from a large cohort of patients with surgically resected pancreatic cysts.  ... 
doi:10.1093/jamia/ocw069 pmid:27330075 pmcid:PMC5201184 fatcat:zkgav5xf3zch7oxsrc7nsr6pey

Radiomics for the Diagnosis and Differentiation of Pancreatic Cystic Lesions

Jorge D. Machicado, Eugene J. Koay, Somashekar G. Krishna
2020 Diagnostics  
Although these studies are limited by the use of retrospective design, single center data, and small sample sizes, radiomic features in combination with clinical data appear to be superior to the current  ...  There is a need for multicenter prospective studies to elucidate the role of radiomics in the management of PCLs.  ...  As evidenced in large surgical databases, 17-25% of patients who undergo surgical resection for a presumed mucinous lesion ultimately have a benign cyst [10, 11] .  ... 
doi:10.3390/diagnostics10070505 pmid:32708348 pmcid:PMC7399814 fatcat:kjirioji5fblph33pv4f2eicaa

Natural language processing for the development of a clinical registry: a validation study in intraductal papillary mucinous neoplasms

Mohammad A. Al-Haddad, Jeff Friedlin, Joe Kesterson, Joshua A. Waters, Juan R. Aguilar-Saavedra, C. Max Schmidt
2010 HPB  
We seek to develop a novel NLP system that could be applied in our clinical network to develop a functional registry of IPMN patients.  ...  Conclusions: Natural language processing is a reliable and accurate method for identifying selected patient cohorts and may facilitate the identification and follow-up of patients with IPMN.  ...  Conflicts of interest None declared.  ... 
doi:10.1111/j.1477-2574.2010.00235.x pmid:21083794 pmcid:PMC3003479 fatcat:ziuwwul4ubb75lpypwfoj7i3qq

Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer

Randa G. Hanna-Sawires, Jorinde H. Schiphuis, Manfred Wuhrer, Hans F. A. Vasen, Monique E. van Leerdam, Bert A. Bonsing, Wilma E. Mesker, Yuri E. M. van der Burgt, Rob A. E. M. Tollenaar
2021 International Journal of Molecular Sciences  
However, for reasons discussed in this review, the validation and clinical translation of these candidate markers has not been successful.  ...  Consequently, there has been a change of mindset from initial efforts to identify new unimarkers into the current hypothesis that a combination of biomarkers better suits a diagnostic or prognostic panel  ...  Acknowledgments: The authors wish to thank J.W.  ... 
doi:10.3390/ijms22052655 pmid:33800786 fatcat:mdo4cjrrkfdvzgyatgfdjpnkgu

Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms

Jennifer B. Permuth, Jung Choi, Yoganand Balarunathan, Jongphil Kim, Dung-Tsa Chen, Lu Chen, Sonia Orcutt, Matthew P. Doepker, Kenneth Gage, Geoffrey Zhang, Kujtim Latifi, Sarah Hoffe (+10 others)
2016 OncoTarget  
Using a retrospective cohort of 38 surgically-resected, pathologically-confirmed IPMNs (20 benign; 18 malignant) with preoperative computed tomography (CT) images and matched plasma-based 'miRNA genomic  ...  Consensus guidelines for IPMN management rely on standard radiologic features to predict pathology, but they lack accuracy.  ...  ACKNOWLEDGMENTS The authors wish to thank the following individuals for their contributions: Christina Georgeades, Rebecca Bohinc, Kimberly Quinn, Michelle Fournier, Sean Yoder, Danny Yakoub, Alberto Garcia  ... 
doi:10.18632/oncotarget.11768 pmid:27589689 pmcid:PMC5349874 fatcat:dln6zqpfxvgzreotf6kie6vtxu

Biomarkers and Strategy to Detect Pre-Invasive and Early Pancreatic Cancer: State of the Field and the Impact of the EDRN

Ying Liu, Sukhwinder Kaur, Ying Huang, Johannes F. Fahrmann, Jo Ann Rinaudo, Samir M Hanash, Surinder K. Batra, Aatur D. Singhi, Randall E. Brand, Anirban Maitra, Brian B. Haab
2020 Cancer Epidemiology, Biomarkers and Prevention  
A compelling strategy to broaden the use of surveillance for PDAC is to incorporate molecular biomarkers in combination with clinical analysis and imaging tools.  ...  Patients afflicted with pancreatic ductal adenocarcinoma (PDAC) face a dismal prognosis, but headway could be made if physicians could identify the disease earlier.  ...  Haab); Alliance of Glycobiologists for Cancer Detection, U01 CA226158 (to B.B. Haab and R.E. Brand); U01 CA200468, U01 CA196403, R01 CA218004, and P50 CA221707 (to A. Maitra); U01 CA200466 (to R.E.  ... 
doi:10.1158/1055-9965.epi-20-0161 pmid:32532830 pmcid:PMC7710622 fatcat:jnncvcr4zrgp5b7vhoqo3n6qsa

Multi-Omic Biomarkers as Potential Tools for the Characterisation of Pancreatic Cystic Lesions and Cancer: Innovative Patient Data Integration

Laura E Kane, Gregory S Mellotte, Kevin C Conlon, Barbara M Ryan, Stephen G Maher
2021 Cancers  
Successful integration of different 'omics' data could aid in the identification of a novel integrated biomarker profile for the risk stratification of patients with PCLs and PC.  ...  This review highlights the importance of biological markers in the context of PCLs and PC, with a focus on 'omics'-related work.  ...  Acknowledgments: We are deeply grateful to the Meath Foundation for supporting our research. Figure 2 was created with  ... 
doi:10.3390/cancers13040769 pmid:33673153 pmcid:PMC7918773 fatcat:qwvv5qnixrgtrd2enmuwbcv66a

Endoscopic Ultrasound and Related Technologies for the Diagnosis and Treatment of Pancreatic Disease - Research Gaps and Opportunities

Linda S. Lee, Dana K. Andersen, Reiko Ashida, William R. Brugge, Mimi I. Canto, Kenneth J. Chang, Suresh T. Chari, John DeWitt, Joo Ha Hwang, Mouen A. Khashab, Kang Kim, Michael J. Levy (+11 others)
2017 Pancreas  
Although some advocate for surgical resection without biopsy, sampling these masses to determine the exact diagnosis remains important because a significant minority of these patients do not have pancreatic  ...  Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders  ...  We thank Ms Joy Merusi of the University of Pittsburgh and Ms Mary Allen of Scientific Consulting Group, Inc, for logistic and organizational assistance.  ... 
doi:10.1097/mpa.0000000000000936 pmid:28926412 pmcid:PMC5645254 fatcat:oqz7dna3mbabniq33qzzte3tuy


2013 HPB  
Here we deliver novel drugs selectively to pancreatic cancers using sigma-2 ligands and targeting a survival/apoptosis pathway.  ...  for complex pancreatic resections and reconstructions to be performed through a minimally invasive approach.  ...  A stepwise approach to achieve resectability avoids the long-term sequelae of OLT.  ... 
doi:10.1111/hpb.12048 pmid:23383868 pmcid:PMC3575878 fatcat:d33jq2zluvfypjexhqqchspzcq


2009 HPB  
Methods: A retrospective review of all patients undergoing hepatic resection for HCC from 1/1990 to 1/2008 was conducted.  ...  The purpose of this study was to determine the outcome of patients undergoing a second hepatic resection for recurrent HCC at a Western center and to identify prognostic variables.  ...  Tq as a novel inhibitor of proinflammatory pathways provides a promising strategy that combines anti-inflammatory and proapoptotic modes of action. 21 A proteomic based platform for marker discovery  ... 
doi:10.1111/j.1477-2574.2008.00035.x fatcat:3xvrc3duzjfzbiartcgkmyvxga

New Era of Endoscopic Ultrasound-Guided Tissue Acquisition: Next-Generation Sequencing by Endoscopic Ultrasound-Guided Sampling for Pancreatic Cancer

Imaoka, Sasaki, Hashimoto, Watanabe, Ikeda
2019 Journal of Clinical Medicine  
Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses.  ...  Due to advancements in next-generation sequencing (NGS) technologies, multiple parallel sequencing can be applied to EUS-TA samples.  ...  Consequently, EUS-TA is expected to play a complementary role in the clinical management of pancreatic cysts.  ... 
doi:10.3390/jcm8081173 pmid:31387310 pmcid:PMC6723875 fatcat:xerdfs3jfjav5fd6ztnprhrchy

Management of pancreatic ductal adenocarcinoma (PDAC): Progress in the past decade and challenges for the future

Roger Clementine, Mas Leo, Granier Sandra, Colle Elise, Neuzillet C, Hammel Pascal
2019 Cancer Reports and Reviews  
Large cohorts of patients with pancreatic cysts are being followed to improve knowledge of the natural history and risks of progression in these pre-cancerous lesions.  ...  Although there is a large window for surgical resection before progression from preneoplastic lesions to invasive cancer, the rate of advanced PDAC (stage III or IV) at diagnosis is more than 80%.  ... 
doi:10.15761/crr.1000184 fatcat:caxwd3eqovbb7isoo4tst3xuky


2012 HPB  
of neoadjuvant therapy without systemic progression. 3D-CASP was particularly helpful in patient with borderline resectable pancreatic cancer to reduce risk for a margin-positive resection.  ...  We investigated the impact of lean body mass among patients who underwent neoadjuvant therapy and surgical resection for pancreatic cancer (PC).  ...  We conducted a retrospective chart review of 40 RADP performed by a single surgeon (A. Y.) between 2006 and 2010.  ... 
doi:10.1111/j.1477-2574.2012.00437.x pmid:22356212 pmcid:PMC4503268 fatcat:bkprfwgc7zakpcrwfnkj26v6tm

Concurrent Sessions Orals

2013 HPB  
Conclusion: MELD has a better performance over the CTP score in determination of priorities for organ allocation.  ...  Aim of the study to compare the CTP scores and MELD score for 3, 6 months survival in cirrhotic patients waiting for liver transplant.  ...  Acknowledgements: The work was supported by the National Natural Science Foundation of China (81070354).  ... 
doi:10.1111/hpb.12092 fatcat:qhlbq4pqqzhj3kvpcmbvnztd6u

Summary of the 44th Annual Pancreas Club Meeting Proceedings

Nicholas J. Zyromski, William R. Schiller
2011 Journal of Gastrointestinal Surgery  
Ten posters each day were chosen for presentation as part of the professor rounds portion of the formal poster viewing program. Summaries of the oral presentations are provided.  ...  Discussion The program consisted of 42 oral presentations (Table 1 ) and 61 abstracts chosen for poster presentation.  ...  They concluded that evaluation of both EGFR and EGF may select patients who best respond to targeted therapies with EGFR inhibitors. ( 18 ) "HuR Status Is a Powerful Clinical Marker for Resected Pancreatic  ... 
doi:10.1007/s11605-011-1449-2 pmid:21336498 fatcat:jpo2wvc3afhsfcqbh6xjngjtxa
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