Filters








13,066 Hits in 9.9 sec

A novel approach for exposing and sharing clinical data: the Translator Integrated Clinical and Environmental Exposures Service

2019 JAMIA Journal of the American Medical Informatics Association  
This study aimed to develop a novel, regulatory-compliant approach for openly exposing integrated clinical and environmental exposures data: the Integrated Clinical and Environmental Exposures Service  ...  The results validated our overall approach for openly exposing and sharing integrated clinical and environmental exposures data.  ...  ACKNOWLEDGEMENTS The authors acknowledge that this work was inspired by the work of other members of the Biomedical Data Translator Consortium.  ... 
doi:10.1093/jamia/ocz042 pmid:31077269 pmcid:PMC6748811 fatcat:lidagjfs7fbupk23iu3zrjgrmu

Clinical Data: Sources and Types, Regulatory Constraints, Applications

Stanley C. Ahalt, Christopher G. Chute, Karamarie Fecho, Gustavo Glusman, Jennifer Hadlock, Casey Overby Taylor, Emily R. Pfaff, Peter N. Robinson, Harold Solbrig, Casey Ta, Nicholas Tatonetti, Chunhua Weng
2019 Clinical and Translational Science  
Support for this project was provided by the National Center for Advancing Translational Sciences, National Institutes of Health through the Biomedical Data Translator program (awards 1OT3TR002019, 1OT3TR002020  ...  , 1OT3TR002025, 1OT3TR002026, 1OT3TR002027, 1OT2TR002514, 1OT2TR002515, 1OT2TR002517, 1OT2TR002520, 1OT2TR002584) and the Clinical and Translational Sciences Award program (award UL1TR002489).  ...  , Columbia Open Health Data (COHD), and the Integrated Clinical and Environmental Exposures Service (ICEES).  ... 
doi:10.1111/cts.12638 pmid:31074176 pmcid:PMC6617834 fatcat:snayt3p3ljb2ram43ls5ppn5he

Secondary Use and Analysis of Big Data Collected for Patient Care

F. J. Martin-Sanchez, V. Aguiar-Pulido, G. H. Lopez-Campos, N. Peek, L. Sacchi
2017 IMIA Yearbook of Medical Informatics  
Through the use of several examples, this article aims to provide a glimpse into the different areas of application, namely clinical research, genomic research, study of environmental factors, and population  ...  Results and Conclusions: Although most of the examples of secondary use of patient data lie in the arena of clinical and health services research, we have started to witness other important applications  ...  of Cancer -G-DOC - [19] , integrated clinical omics database -iCOD - [20] , integrating data for analysis, anonymization and sharing -iDASH - [21] and tranSMART [22] ) in their review [23] .  ... 
doi:10.1055/s-0037-1606529 fatcat:xaytctv24ffqpcfz4fsa5phtou

Secondary Use and Analysis of Big Data Collected for Patient Care

F. J. Martin-Sanchez, V. Aguiar-Pulido, G. H. Lopez-Campos, N. Peek, L. Sacchi
2017 IMIA Yearbook of Medical Informatics  
Through the use of several examples, this article aims to provide a glimpse into the different areas of application, namely clinical research, genomic research, study of environmental factors, and population  ...  Results and Conclusions: Although most of the examples of secondary use of patient data lie in the arena of clinical and health services research, we have started to witness other important applications  ...  of Cancer -G-DOC - [19] , integrated clinical omics database -iCOD - [20] , integrating data for analysis, anonymization and sharing -iDASH - [21] and tranSMART [22] ) in their review [23] .  ... 
doi:10.15265/iy-2017-008 pmid:28480474 pmcid:PMC6239231 fatcat:kj4p5tf72zbzza6nady6ug4wcy

The PULSE Project: A Case of Use of Big Data Uses Toward a Cohomprensive Health Vision of City Well Being [chapter]

Domenico Vito, Manuel Ottaviano, Riccardo Bellazzi, Cristiana Larizza, Vittorio Casella, Daniele Pala, Marica Franzini
2020 Lecture Notes in Computer Science  
PULSE aims to design and build a large-scale data management system enabling real time analytics of health, behaviour and environmental data on air quality.  ...  The objective is to reduce the environmental and behavioral risk of chronic disease incidence to allow timely and evidence-driven management of epidemiological episodes linked in particular to two pathologies  ...  This research was funded by the European Union's research and innovation program H2020 and is documented in grant No 727816.  ... 
doi:10.1007/978-3-030-51517-1_39 fatcat:dnmvm75x6vfrne7gjiaq4ggs6y

Grappling with the Future Use of Big Data for Translational Medicine and Clinical Care

S. Murphy, V. Castro, K. Mandl
2017 IMIA Yearbook of Medical Informatics  
Objectives: Although patients may have a wealth of imaging, genomic, monitoring, and personal device data, it has yet to be fully integrated into clinical care.  ...  Methods: We identify three reasons for the lack of integration. The first is that "Big Data" is poorly managed by most Electronic Medical Record Systems (EMRS).  ...  Acknowledgments Thanks to Christopher Herrick for development of figure 1. Funding from NIH awards U54 HG007963 and RO1 HG009174 contributed to these concepts.  ... 
doi:10.1055/s-0037-1606487 fatcat:zb3jkz6njnh6zpszglmxbtpuge

Grappling with the Future Use of Big Data for Translational Medicine and Clinical Care

S. Murphy, V. Castro, K. Mandl
2017 IMIA Yearbook of Medical Informatics  
Objectives: Although patients may have a wealth of imaging, genomic, monitoring, and personal device data, it has yet to be fully integrated into clinical care.  ...  Methods: We identify three reasons for the lack of integration. The first is that "Big Data" is poorly managed by most Electronic Medical Record Systems (EMRS).  ...  Acknowledgments Thanks to Christopher Herrick for development of figure 1. Funding from NIH awards U54 HG007963 and RO1 HG009174 contributed to these concepts.  ... 
doi:10.15265/iy-2017-020 pmid:29063545 pmcid:PMC6239222 fatcat:ljpbzrh2brd7nflk5rwlqyb4vm

Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data

Thomas C. Neylan, Eric E. Schadt, Rachel Yehuda
2014 European Journal of Psychotraumatology  
By integrating large-scale, highdimensional molecular, physiological, clinical, and behavioral data, the molecular networks that directly respond to perturbations that can lead to PTSD can be identified  ...  Posttraumatic stress disorder (PTSD) and other deployment-related outcomes originate from a complex interplay between constellations of changes in DNA, environmental traumatic exposures, and other biological  ...  Army Conflict of interest and funding There is no conflict of interest in the present study for any of the authors.  ... 
doi:10.3402/ejpt.v5.23938 pmid:25206954 pmcid:PMC4138711 fatcat:2tq466cdwvg5dcoih72pa5rpaa

Breast Imaging in the Era of Big Data: Structured Reporting and Data Mining

Laurie R. Margolies, Gaurav Pandey, Eliot R. Horowitz, David S. Mendelson
2016 American Journal of Roentgenology  
Data currently stored in silos can be exposed and integrated to show a 360° view of a patient that will ultimately benefit that individual.  ...  National Institutes of Health Clinical and Translational Science Award program is asking for broad collaborative efforts among researchers.  ... 
doi:10.2214/ajr.15.15396 pmid:26587797 pmcid:PMC4876713 fatcat:zlityyz5rvernjc4el2246m2cq

Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams

Khader Shameer, Marcus A. Badgeley, Riccardo Miotto, Benjamin S. Glicksberg, Joseph W. Morgan, Joel T. Dudley
2016 Briefings in Bioinformatics  
Dudley laboratory is involved in various projects for identification and development of novel therapeutic and diagnostic approaches for human disease through integration and analysis of health care, biomedical  ...  We also discuss examples of translational bioinformatics approaches to integrating patient-generated data with existing EMRs, personal health records, patient portals and clinical data repositories.  ...  (NCI, U54-CA189201-02) to JTD and National Center for Advancing Translational Sciences (NCATS, UL1TR000067) Clinical and Translational Science Awards (CTSA) grant to JTD and KS.  ... 
doi:10.1093/bib/bbv118 pmid:26876889 pmcid:PMC5221424 fatcat:aqurlfusq5hslpabllsfmygk6m

Human Cell-Based in vitro Phenotypic Profiling for Drug Safety-Related Attrition

Ellen L. Berg
2019 Frontiers in Big Data  
, and organs-on-a-chip.  ...  Even so, unexpected toxicities still account for 20-30% of clinical trial failures, in part due to the persistence of animal testing as the primary approach for de-risking new drugs.  ...  ADVERSE OUTCOME PATHWAY FRAMEWORKS FOR INTEGRATING ASSAY PLATFORM RESULTS The Adverse Outcome Pathway (AOP) approach provides a particularly useful framework as it aligns platforms and data types to key  ... 
doi:10.3389/fdata.2019.00047 pmid:33693370 pmcid:PMC7931891 fatcat:ddti7ta3bfetljj64ea3hm4piq

Unlocking Big Data for better health

Steven Munevar
2017 Nature Biotechnology  
, medical, translational and clinical domains.  ...  opened in 2013), which houses ELIXIR and an Innovation and Translation Suite, and for the on-going use of Tier III data centres and the equipment to enable data service provision.  ... 
doi:10.1038/nbt.3918 pmid:28700551 fatcat:oqiurm5cgzec7lfenvjvlemxoy

The GA4GH Phenopacket schema: A computable representation of clinical data for precision medicine [article]

Julius OB Jacobsen, Michael Baudis, Gareth S Baynam, Jacques S Beckmann, Sergi Beltran, Tiffany J Callahan, Christopher G Chute, Melanie Courtot, Daniel Danis, Olivier Elemento, Robert R Freimuth, Michael A Gargano (+35 others)
2021 medRxiv   pre-print
, and this has impeded the sharing of phenotypic information for computational analysis.  ...  Despite great strides in the development and wide acceptance of standards for exchanging structured information about genomic variants, there is no corresponding standard for exchanging phenotypic data  ...  Acknowledgements The authors gratefully acknowledge insight and feedback from Marian H. Adly, Orion J. Buske, Pier Luigi Buttigieg, Nour Gazzaz, Janine Lewis, Manuel Posada de la Paz and Maria Taboada  ... 
doi:10.1101/2021.11.27.21266944 fatcat:rv7ksvht45dn5idczjwxdgjy5y

In Search of Big Medical Data Integration Solutions -A Comprehensive Survey

Houssein Dhayne, Rafiqul Haque, Rima Kilany, Yehia Taher
2019 IEEE Access  
Data integration is critically important within the healthcare sector because it enriches data, enhances its value, and more importantly paves a solid foundation for highly efficient and effective healthcare  ...  However, it is not only the volume of the data but also the speed, variety, and uncertainty, which are promoting a massive challenge for traditional technologies such as data warehouse.  ...  Also, integrating historical patient data about lifestyle and environmental exposure has the potential to determine the causes triggering the onset of a disease state. • Infectious diseases early detection  ... 
doi:10.1109/access.2019.2927491 fatcat:6ooixehrznfdnbwghzfeds3mky

4088 Longitudinal Assessment of Metabolic Syndrome as a Modifiable Risk factor of World Trade Center Particulate Matter Exposure Associated Lung Disease

Sophia Kwon, Myeonggyun Lee, Theresa Schwartz, Rachel Zeig-Owens, David Prezant, Mengling Liu, Anna Nolan
2020 Journal of Clinical and Translational Science  
METHODS/STUDY POPULATION: WTC-particulate exposed firefighters, consented, with pre-9/11 FEV1 LLN (N = 5,746). Data assessed from last pre-9/11 till August 1, 2017.  ...  of MetSyn to time of onset of WTC-LI; iii. a novel, partially linear single index regression model with repeatedly measured MetSyn to assess their joint effects and delineate their relative contribution  ...  Variables were screened for inclusion in the model based on clinical relevance, availability in the EHR as structured data, and likelihood of timely documentation during routine clinical care, in the hopes  ... 
doi:10.1017/cts.2020.180 fatcat:wm7owbdq3fg6zmom4n73z7ueby
« Previous Showing results 1 — 15 out of 13,066 results