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A New Module for On-Line Manipulation and Display of Molecular Information in the Brain Architecture Management System

Mihail Bota, Larry W. Swanson
2006 Neuroinformatics  
A new "Molecules" module of the Brain Architecture Management System (BAMS; is described.  ...  With this module, BAMS becomes the first online knowledge management system to handle central nervous system (CNS) region and celltype chemoarchitectonic data in the context of axonal connections between  ...  Acknowledgments This work was supported by NIH Grants MH61223, NS16668, and NS050792-01. We especially thank Drs. Alan Watts and Arshad Khan for their suggestions and feedback.  ... 
doi:10.1385/ni:4:4:275 pmid:17142838 fatcat:5kpen3oalvhphmdrn2lzhuhsiu

Novel theory of the human brain: information-commutation basis of architecture and principles of operation

Andrey Bryukhovetskiy
2015 Journal of Neurorestoratology  
modules, forming a vertical architecture of nervous tissue in the brain as information lines and information channels, and a horizontal architecture as central, intermediate, and peripheral information-commutation  ...  proposes a new theory of information-commutation organization and architecture of the human brain which is an alternative to the conventional systemic connective morphofunctional paradigm of the brain  ...  In system vertical commutation of information, NT in the brain functions as a telephone switchboard, dispatcher, and router of information through NT modules for information input and output channels and  ... 
doi:10.2147/jn.s75126 fatcat:5mc35mg625dj3jqvwq6w7qdbwy

Design of an anatomy information system

J.F. Brinkley, B.A. Wong, K.P. Hinshaw, C. Rosse
1999 IEEE Computer Graphics and Applications  
The Digital Anatomist Project aims to "put anatomy on a computer." Both the content and the structure-based information system should have wide applicability outside the initial implementation.  ...  We've begun to test this hypothesis in the context of the Human Brain Project, a national effort to build information systems that can manage the massive amounts of data accumulating about the human brain  ...  Clicking "Label All" in (a) generates a new image with structure names placed in the margins and lines drawn to the regions' centers.  ... 
doi:10.1109/38.761548 fatcat:afboeyhbwrbylkxq3h2ib6t6ti

The Fruit Fly Brain Observatory: From Structure to Function [article]

Nikul H. Ukani, Chung-Heng Yeh, Adam Tomkins, Yiyin Zhou, Dorian Florescu, Carlos Luna Ortiz, Yu-Chi Huang, Cheng-Te Wang, Mehmet K. Turkcan, Tingkai Liu, Paul Richmond, Chung-Chuan Lo (+3 others)
2019 bioRxiv   pre-print
of experimental and modeling data that has yet to be distilled into new knowledge and understanding of the functional logic of the brain.  ...  AbstractThe fruit fly is a key model organism for studying the activity of interconnected brain circuits.  ...  Acknowledgements The "Fruit Fly Observatory" was selected as a Phase I winner of the 2016 Open Science Prize Challenge and was initially supported in part by the NIH, Wellcome Trust and HHMI.  ... 
doi:10.1101/580290 fatcat:udubxzazlfct3beks2onuaduje

ACQ4: an open-source software platform for data acquisition and analysis in neurophysiology research

Luke Campagnola, Megan B. Kratz, Paul B. Manis
2014 Frontiers in Neuroinformatics  
The system is highly modular, which facilitates the addition of new devices and functionality.  ...  The modules included with ACQ4 provide for rapid construction of acquisition protocols, live video display, and customizable analysis tools.  ...  ACKNOWLEDGMENTS This work was supported by NIH (NIDCD) grants R01DC004551, R01DC000425, and R01DC009809 to Paul B. Manis and NIH (NIDCD) National Research Service Award F31DC10320 to Luke Campagnola.  ... 
doi:10.3389/fninf.2014.00003 pmid:24523692 pmcid:PMC3906568 fatcat:axx2m5zqovamlph5drmrvdi2ki

Rewards, perils and pitfalls of untangling spinal pain circuits

Brett A Graham, David I Hughes
2019 Current Opinion in Physiology  
Acknowledgements Support from the BBSRC (grants BB/J000620/1 and BB/P007996/1 to DIH) and the National Health and Medical Research Council (NHMRC) of Australia (grants 631000 and 1043933 to BAG) is gratefully  ...  a key role in the gating, modulation and relay of nociceptive sensory input to brain higher centres [3,4 ,5 ] .  ...  In doing so, the detailed understanding that will follow is likely form the basis for new spinally-based analgesic approaches and help develop better pain management treatments.  ... 
doi:10.1016/j.cophys.2019.04.015 fatcat:he5f354rhncqniqkfab35r26p4

Systems Genetics: a Powerful Approach for Gene-Environment Interactions

Brynn H. Voy
2011 Journal of Nutrition  
Genetic variation in a population creates an impressive spectrum of phenotypic diversity, particularly when changes in diet or the environment are imposed on the population.  ...  When applied to nutrition, systems genetics enables the identification of pathways through which nutrients influence health and the determination of the mechanisms that cause individuals to differ in their  ...  Acknowledgment The sole author had responsibility for all parts of the manuscript. Literature Cited  ... 
doi:10.3945/jn.110.130401 pmid:21270362 fatcat:gjv6ogkzbbg2ldl5cd4ncp2ife

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

Mauro Agostino Zordan, Federica Sandrelli
2015 Frontiers in Neurology  
Despite differences in the organization of the clock system, the molecular architecture of the Drosophila and mammalian circadian oscillators are comparable and many components are evolutionarily related  ...  We discuss Drosophila in comparison to mammals with reference to the: organization of the brain and neurotransmitter systems; architecture of the circadian clock; clock-controlled behaviors.  ...  We would also like to acknowledge the use of the following open-source software packages: Zotero (; a bibliographical database and citation manager), Blender (http: //  ... 
doi:10.3389/fneur.2015.00080 pmid:25941512 pmcid:PMC4403521 fatcat:um4jfroibjcxnaylkvbm4j4aj4

Automated Segmentation and Morphometry of Cell and Tissue Structures. Selected Algorithms in ImageJ [chapter]

Dimiter Prodanov, Kris Verstreke
2012 Molecular Imaging  
Dynamic reports can be generated for arbitrary periods. The Manipulation management module manages the records for performed manipulations.  ...  The Subject management module manages the records for experimental animals.  ... 
doi:10.5772/36729 fatcat:qbskbb3g5bhyzgkltynfxntbzm

Frontiers of research and future directions in information and communication technology

Angel G. Jordan
2008 Technology in society  
Information and communication technology (ICT), characterized by continual innovation and rapid technological change, is having a tremendous impact on society.  ...  This paper deals with frontiers of research and trends in selected areas of ICT, including computer hardware, microelectronics, and semiconductor devices and materials-areas that are leading the innovations  ...  of software-intensive systems; product-line systems to enable widespread product-line practice through architecture-based development; and software engineering process management to allow software-dependent  ... 
doi:10.1016/j.techsoc.2008.05.002 fatcat:lmemejqecrfuhc7sxpex37eyoe

Organoids Models for the Study of Cell-Cell Interactions [chapter]

Margarita Jimenez-Palomares, Alba Cristobal, Mª Carmen Duran Ruiz
2021 Cell Interaction - Molecular and Immunological Basis for Disease Management  
This chapter will address the basis of organoids origin, their importance on immune system cell–cell interactions and the benefits of using them in biomedicine, specifically their potential applications  ...  Organoids have arisen as promising model systems in biomedical research and regenerative medicine due to their potential to reproduce the original tissue architecture and function.  ...  Acknowledgements This study was supported by the Institute of Health Carlos III, ISCIII (PI16-00784), and the Programa Operativo de Andalucia-FEDER, Iniciativa Territorial Cell Interaction -Molecular and  ... 
doi:10.5772/intechopen.94562 fatcat:qcyzldgu7vfmjn6qxxmw7combe

HelioScan: A software framework for controlling in vivo microscopy setups with high hardware flexibility, functional diversity and extendibility

Dominik Langer, Marcel van 't Hoff, Andreas J. Keller, Chetan Nagaraja, Oliver A. Pfäffli, Maurice Göldi, Hansjörg Kasper, Fritjof Helmchen
2013 Journal of Neuroscience Methods  
We recommend HelioScan as a convenient software framework for the in vivo imaging community.  ...  h i g h l i g h t s HelioScan, a software framework for vivo microscopy control applications, written in the LabVIEW environment, is introduced.  ...  We thank Klas Kullander from Uppsala University for support of CN. We are also grateful to Roland Krüppel, Yves Kremer and Carl Petersen for their valuable feedback on the manuscript.  ... 
doi:10.1016/j.jneumeth.2013.02.006 pmid:23416135 fatcat:fvq3qorrdncnhnuofwgkatp2ca

Exploring the Computational Explanatory Gap

James Reggia, Di-Wei Huang, Garrett Katz
2017 Philosophies  
for a conscious machine, and to a better understanding of the mind-brain problem in general.  ...  We suggest that bridging this gap is not only critical to further progress in the area of machine consciousness, but would also inform the search for neurobiological correlates of consciousness and would  ...  The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.  ... 
doi:10.3390/philosophies2010005 fatcat:uarphrh2rrfkjnjfneqdlnlyxm

Highlights from the Era of Open Source Web-Based Tools

Kristin R. Anderson, Julie A. Harris, Lydia Ng, Pjotr Prins, Sara Memar, Bengt Ljungquist, Daniel Fürth, Robert W. Williams, Giorgio A. Ascoli, Dani Dumitriu
2021 Journal of Neuroscience  
Repositories and platforms have emerged across the whole spectrum of subdisciplines, paving the way for a paradigm shift in the way we share, analyze, and reuse vast amounts of data collected across many  ...  High digital connectivity and a focus on reproducibility are contributing to an open science revolution in neuroscience.  ...  This includes information on the most studied brain regions, the types of manipulations and behaviors used, manipulated cell types, and the sexes of rodents studied.  ... 
doi:10.1523/jneurosci.1657-20.2020 pmid:33472826 pmcid:PMC7880282 fatcat:gsdfjetgafboflmnr23txfywuy

Nanorobotics : A Newer Platform for Molecular Diagnose

Vijayakumar R, Jagannathan S, Rahul Gandhi P, Chaansha S
2011 Nano Biomedicine and Engineering  
This study of nanorobot serves as a lead to the field of nanomedicine. There are many applications for nanorobotic systems and its biggest impact would be in the area of medicine.  ...  This article deals with the nanorobotic design and their applications in molecular diagnosis.  ...  The problem under study concentrates its main focus on nanorobot control design for molecular manipulation and the use of evolutionary agents as a suitable way to enable the robustness on the proposed  ... 
doi:10.5101/nbe.v3i3.p192-201 fatcat:hyboiyqb2fgxvkasroiq7op4li
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