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A new method for assessing PET-MRI coregistration

Christine DeLorenzo, Arno Klein, Arthur Mikhno, Neil Gray, Francesca Zanderigo, J. John Mann, Ramin V. Parsey, Josien P. W. Pluim, Benoit M. Dawant
2009 Medical Imaging 2009: Image Processing  
This reference will only be accurate if the PET image is properly coregistered to the MRI; yet currently, a method to evaluate PET-MRI coregistration accuracy does not exist.  ...  Positron emission tomography (PET) images are acquired for many purposes, from diagnostic assessment to aiding in the development of novel therapies.  ...  METHODS In this work, we developed an automated system for evaluating PET-MRI coregistration.  ... 
doi:10.1117/12.812170 dblp:conf/miip/DeLorenzoKMGZMP09 fatcat:6ocedmnxy5cxthze7swzg7qprm

MRI and PET in Mouse Models of Myocardial Infarction

Guido Buonincontri, Carmen Methner, T. Adrian Carpenter, Robert C. Hawkes, Stephen J. Sawiak, Thomas Krieg
2013 Journal of Visualized Experiments  
Positron emission tomography (PET) is a complementary technique that is highly specific for molecular imaging, but lacks the anatomical detail of MRI.  ...  We used MRI to measure systolic function and infarct size with late gadolinium enhancement, and PET with fluorodeoxyglucose (FDG) to assess metabolic function in the infarcted region.  ...  Acknowledgements We are grateful for funding from the British Heart Foundation to TK and to the UK Medical Research Council for a postgraduate research studentship to GB.  ... 
doi:10.3791/50806 pmid:24378323 pmcid:PMC4110968 fatcat:hh3drvcndjflhktozyczixlawi

Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit

Jagan A. Pillai, Mykol Larvie, Jacqueline Chen, Anna Crawford, Jeffery L. Cummings, Stephen E. Jones
2020 Scientific Reports  
We therefore developed a robust MRI analysis method to identify brain regions that correlate linearly with regional amyloid burden in congruent PET images.  ...  This method could be used with amyloid and tau PET to assess corresponding cortical thickness changes.  ...  Acknowledgements We thank Frank DiFilippo, PhD, for his review of physics aspects regarding nuclear medicine imaging, and Megan Griffiths for editorial support.  ... 
doi:10.1038/s41598-020-77503-2 pmid:33244036 fatcat:w27x3j6mjvf4bnzua6xmmlunci

Hybrid PET/MR Imaging in Neurology: Present Applications and Prospects for the Future

W.-D. Heiss
2016 Journal of Nuclear Medicine  
for numerous indications and that a great number of specific PET tracers are available today to assess functional and molecular processes in the brain.  ...  The feasibility of simultaneous PET and MRI data acquisition for human studies was first demonstrated in 2007, and proof-of-principle brain data were collected using a prototype MRI-compatible PET insert-called  ...  Another interesting field is angiogenesis, which can be investigated by PET of 18 F-galacto-RGD and dynamic contrastenhanced MRI, and might be a new target for selective tumor therapy (38, 39) .  ... 
doi:10.2967/jnumed.116.175208 pmid:27056615 fatcat:rtxedxa5zncmtduwzfyxspzy2m

An Evaluation of the Benefits of Simultaneous Acquisition on PET/MR Coregistration in Head/Neck Imaging

Serena Monti, Carlo Cavaliere, Mario Covello, Emanuele Nicolai, Marco Salvatore, Marco Aiello
2017 Journal of Healthcare Engineering  
Aim of this study is to assess the performance of state-of-the-art coregistration methods applied to PET and MR acquired as single modalities, comparing the results with the implicitly coregistration of  ...  Registration accuracy was qualitatively assessed in terms of visual alignment of anatomical structures and qualitatively measured by the Dice scores computed on segmented tumors in PET and MRI.  ...  Acknowledgments This work was partially supported by the RRC-2015-2360454 of the Italian Minister of Health and by the Italian project PON03PE_00128_1 "eHealthNet: Software ecosystem for Electronic Health  ... 
doi:10.1155/2017/2634389 pmid:29076331 fatcat:lwantfjiifajzgimbyelwuceiq

Comparison of Coregistration Accuracy of Pelvic Structures Between Sequential and Simultaneous Imaging During Hybrid PET/MRI in Patients with Bladder Cancer

Andrew B. Rosenkrantz, Arjun V. Balar, William C. Huang, Kimberly Jackson, Kent P. Friedman
2015 Clinical Nuclear Medicine  
18 F-FDG PET/MRI performed using a diuresis protocol in bladder cancer patients.  ...  Methods-Six bladder cancer patients underwent 18 F-FDG hybrid PET/MRI, including IV Lasix administration and oral hydration, before imaging to achieve bladder clearance.  ...  Keywords bladder cancer; PET/MRI; coregistration; staging; hybrid imaging Bladder cancer is a common malignancy, with an estimate of nearly 75,000 new diagnoses in the United States in 2014. 1 Although  ... 
doi:10.1097/rlu.0000000000000772 pmid:25783514 pmcid:PMC4494885 fatcat:anrxyjg4izgsjjz77yglazszye

Increased Fluorine-18 2-Fluoro-2-Deoxy-D-Glucose (FDG) Uptake in Childhood CNS Tumors Is Correlated With Malignancy Grade: A Study With FDG Positron Emission Tomography/Magnetic Resonance Imaging Coregistration and Image Fusion

Lise Borgwardt, Liselotte Højgaard, Henrik Carstensen, Henning Laursen, Markus Nowak, Carsten Thomsen, Kjeld Schmiegelow
2005 Journal of Clinical Oncology  
There is a need for new PET tracers that more specifi- cally identify the benign tumors.  ...  In conclusion, MRI is the method of choice for diagno- sis of brain tumors in children.  ... 
doi:10.1200/jco.2005.02.074 pmid:15860860 fatcat:bzwx6dsibrdpbeij4vhh6vds7e

PET/MRI assessment of the infarcted mouse heart

Guido Buonincontri, Carmen Methner, Thomas Krieg, Robert C. Hawkes, T. Adrian Carpenter, Stephen J. Sawiak
2014 Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment  
These measures are followed by positron emission tomography (PET) with 18-F-fluorodeoxyglucose to assess cellular metabolism.  ...  We use in vivo magnetic resonance imaging (MRI) to assess heart function with cine-MRI, hindered perfusion with late gadolinium enhancement imaging and muscular function with displacement encoded with  ...  PET images were binned into 8 heart phases and reconstructed with a 3D filtered back projection algorithm. For PET/MRI coregistration, a fixed matrix was used to adjust scaling and rotations 12 .  ... 
doi:10.1016/j.nima.2013.08.066 pmid:26005235 pmcid:PMC4441008 fatcat:q7dlemcrknaibno3x3fyaepmoe

The potential of PET/MR for brain imaging

Wolf-Dieter Heiss
2008 European Journal of Nuclear Medicine and Molecular Imaging  
Objective This new technology will make fusion of morphological and biological information much easier, yield real-time assessment of complementary variables and will provide dynamic information for kinetic  ...  Discussion A new field may open up for molecular and cellular imaging, where new targetse.g. angiogenesis, gene transfer, function and migration of transplanted cellscan be imaged in the morphological  ...  ] , and 17 O as a new MRI tracer for oxygen utilization [39] can be compared to cerebral metabolic rate of O 2 as determined by PET.  ... 
doi:10.1007/s00259-008-0962-3 pmid:19104801 fatcat:2uixvyim4reirdshhdbr2f6c5q

Coregistration of Magnetic Resonance and Single Photon Emission Computed Tomography Images for Noninvasive Localization of Stem Cells Grafted in the Infarcted Rat Myocardium

Dinggang Shen, Dengfeng Liu, Zixiong Cao, Paul D. Acton, Rong Zhou
2006 Molecular Imaging and Biology  
The same animals were subjected to cardiac MRI. A mutual-information-based coregistration method was then applied to the SPECT and MRIs.  ...  Thus, coregistration of PET or SPECT images with MRI will map the location and distribution of stem cells on detailed myocardium structures.  ...  Daniel Thomas and Hui Qiao for their help with generation of the experimental data.  ... 
doi:10.1007/s11307-006-0062-3 pmid:17053860 pmcid:PMC2579787 fatcat:dtd5jgtus5abrfmatc6gpc25em

MRI and PET Coregistration—A Cross Validation of Statistical Parametric Mapping and Automated Image Registration

Stefan J. Kiebel, John Ashburner, Jean-Baptiste Poline, Karl J. Friston
1997 NeuroImage  
Coregistration of functional PET and T1-weighted MR images is a necessary step for combining functional information from PET images with anatomical information in MR images.  ...  Under the assumption that the simulated PET images embody the salient features of real PET images with respect to coregistration, this study shows that the routines examined reliably solve the MRI to PET  ...  We thank Cornelius Weiller and Richard Frackowiak for their help and support. We also thank Michael Krams for contributing the MR images used above.  ... 
doi:10.1006/nimg.1997.0265 pmid:9345556 fatcat:b3tvgqzq5feyzcwzndchtlk7qm

PET and MRI in gliomas: progress and perspectives

Karl Herholz
2018 Clinical and translational imaging  
A recent series of articles in this journal addressed the current status of brain tumour imaging with PET and advanced MRI methods [1] [2] [3] [4] [5] [6] .  ...  Up-to-date provision of brain tumour PET scanning includes 3D coregistration with structural scans, usually contrast-enhanced and ideally even multimodal MRI.  ... 
doi:10.1007/s40336-017-0258-3 fatcat:wp3i4hyhxzh27j2mzfc6o5ipze

The Utility of Positron Emission Tomography in Epilepsy

Jorge G. Burneo, Raymond Poon, Sarah Kellett, O. Carter Snead
2015 Canadian Journal of Neurological Sciences  
The purpose of this study was to systematically review the literature to assess the diagnostic accuracy and utility of PET in this setting.  ...  In adult patients, PET hypometabolism showed a 56 to 90% agreement with seizure onset localized by intracranial electroencephalogram (pediatric: 21 to 86%).  ...  (68%) was the same for both FDG-PET/MRI coregistration and FDG-PET alone PET/MRI coregistration detected a partially hypometabolic gyrus in 4 additional cases.  ... 
doi:10.1017/cjn.2015.279 pmid:26437611 fatcat:775rfvrjlbffhcgjojydzvb4qm

Software-based PET-MR image coregistration: combined PET-MRI for the rest of us!

Matthew S. Robertson, Xinyang Liu, William Plishker, George F. Zaki, Pranav K. Vyas, Nabile M. Safdar, Raj Shekhar
2016 Pediatric Radiology  
Objective-To provide a viable alternative to the hybrid PET/MRI hardware by validating a software-based solution for PET/MR image coregistration.  ...  Background-With the introduction of hybrid positron emission tomography (PET)/MRI, a new imaging option to acquire multimodality images with complementary anatomical and functional information has become  ...  The capital investment required for initial purchase and infrastructure upgrade, coupled with the lower volume of PET imaging performed in pediatric centers, puts procurement of a new PET/MRI scanner outside  ... 
doi:10.1007/s00247-016-3641-8 pmid:27380195 pmcid:PMC5039099 fatcat:zqo2xkve75fbjlej62h7o42hye

Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques

Matthias Hofmann, Bernd Pichler, Bernhard Schölkopf, Thomas Beyer
2008 European Journal of Nuclear Medicine and Molecular Imaging  
Current concepts of PET/MRI do not include CT-like transmission sources and, therefore, alternative methods of PET attenuation correction must be found.  ...  Introduction Combined PET/CT has emerged as a powerful imaging modality for the diagnosis, staging and restaging of a variety of cancers [1] .  ...  Future: integrate MR information into a unified statistical PET reconstruction method 12 Head Four subjects; 1.5-T MRI with T1-W; linear coregistration of MRI to TX and four-class segmentation/mu-assignment  ... 
doi:10.1007/s00259-008-1007-7 pmid:19104810 fatcat:llgt6pmcabhglbr2mbibcfrmou
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