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A modular computational framework for medical digital twins
2021
Proceedings of the National Academy of Sciences of the United States of America
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In analogy to a common industrial strategy used for preventive maintenance of engineered products, medical digital twins are computational models of disease processes calibrated to individual patients ...
This paper presents a modular software design for the construction of computational modeling technology that will help implement precision medicine. ...
/10.1073/pnas.2024287118 A modular computational framework for medical digital twins Downloaded by guest on May 11, 2021 ...
doi:10.1073/pnas.2024287118
pmid:33972437
pmcid:PMC8157963
fatcat:oosv3yaoyra3tdvgcph2xvqdx4
The Digital Twin: Modular Model-Based Approach to Personalized Medicine
2021
Current Directions in Biomedical Engineering
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Describing medical patterns and contexts with Resource Description Framework (RDF) allows for standardised way of connecting medical knowledge and processing modules. ...
Transition of the Digital Twin to clinical practice promises effective assistance and safer clinical decisions. ...
Second, we present techniques to use the capabilities of the Digital Twin with a modular and dynamic system that, for instance, provides data preparation, data processing, calculations of medical scores ...
doi:10.1515/cdbme-2021-2057
fatcat:4fa6fywgqna5hd244rypxsuhcu
Cognitive Ledger Project: Towards Building Personal Digital Twins Through Cognitive Blockchain
[article]
2022
arXiv
pre-print
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Other Versions
2021
2021 2nd International Informatics and Software Engineering Conference (IISEC)
unpublished
doi:10.1109/iisec54230.2021.9672433 fatcat:rnc5hzjn35gphjgqjchhauu6la
doi:10.1109/iisec54230.2021.9672433 fatcat:rnc5hzjn35gphjgqjchhauu6la
In this work-in-progress paper, we propose a cognitive architecture for cognitive digital twins. The suggested design embraces a cognitive blockchain (Cognitive ledger) at its core. ...
digital twin of users. ...
Nardini et al. [18] Fig 4: Different levels of Cognitive Digital Twins in Cognitive Ledger
proposed a framework for building a decentralized electronic Project ...
arXiv:2201.08163v1
fatcat:x2kq3bl3ivexzoxb5ybm4w2pre
A Modular Digital Twinning Framework for Safety Assurance of Collaborative Robotics
2021
Frontiers in Robotics and AI
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In this paper we present a novel, modular digital twinning framework developed for the investigation of safety within collaborative robotic manufacturing processes. ...
We describe the creation of a digital twin scenario, consisting of individual digital twins of entities in the manufacturing case study, and the application of a synthesised safety controller from our ...
situation-based testing at the University of York with the digital twinning research at the University of Sheffield. ...
doi:10.3389/frobt.2021.758099
pmid:34977162
pmcid:PMC8719333
fatcat:2mynwch3evhsneupyh54dtetsi
Conceptual framework of Digital Health Public Emergency System: digital twins and multiparadigm simulation
2018
EAI Endorsed Transactions on Pervasive Health and Technology
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RESULTS: The proposal establishes the conceptual framework for the integration of a digital public health emergency system, incorporating multi-paradigm simulation in the construction of a digital twin ...
OBJECTIVES: This study aims to develop the conceptual framework for the development of a Digital Public Health Emergency System. ...
To the International Conference on Computer Science and Engineering and Health Services (COMPSE) for the space for the dissemination of knowledge and ideas. ...
doi:10.4108/eai.13-7-2018.164261
fatcat:rvh7i33eu5e6hksf3sv6zsul6a
Graph Representation Forecasting of Patient's Medical Conditions: Toward a Digital Twin
2021
Frontiers in Genetics
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To this purpose, we propose a "digital twin" of patients modeling the human body as a whole and providing a panoramic view over individuals' conditions.Methods: We propose a general framework that composes ...
of transcriptomic integrability.Results: We tested our digital twin model on two simulated clinical case studies combining information at organ, tissue, and cellular level. ...
Finally, by relying upon flexible and modular architectures, our "digital twin" model can be conveniently deployed in dedicated hardware modules paving the way for a next-generation of medical devices. ...
doi:10.3389/fgene.2021.652907
pmid:34603366
pmcid:PMC8481902
fatcat:p7ckxmcgpbh3lmlaylsboof5vu
Graph representation forecasting of patient's medical conditions: towards a digital twin
[article]
2020
arXiv
pre-print
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We believe that this work represents a step forward towards a healthcare digital twin. ...
Methods: We propose a general framework that composes advanced AI approaches and integrates mathematical modelling in order to provide a panoramic view over current and future physiological conditions. ...
The personal medical digital twin could also represent a pragmatic way for the cyber-physical fusion, as a new approach to support biomedical engineering design. ...
arXiv:2009.08299v1
fatcat:b6h54uc4ojf4phnvywiwq3phcy
Digital twin-based sustainable intelligent manufacturing: a review
2020
Advances in Manufacturing
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Subsequently, a digital twin and its application are introduced along with the development of intelligent manufacturing based on the digital twin technology. ...
Sustainable intelligent manufacturing based on a digital twin has advantages in practical applications. ...
A modular approach was studied to build a digital twin and make the corresponding changes [42] . ...
doi:10.1007/s40436-020-00302-5
fatcat:ckbvw5si5jffxcdbvaixlrud3e
Flexible Work Cell Simulator Using Digital Twin Methodology for Highly Complex Systems in Industry 4.0
[chapter]
2017
Advances in Intelligent Systems and Computing
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Recently the concept of digital twin methodology has been introduced to mimic the real world through a virtual substitute, such as, a simulator. ...
Despite the fact that streamline manufacturing relies on automation systems, most production lines within the industrial environment lack a exible framework that allows for evaluation and optimisation ...
Within this industrial trend, notion of Digital Twins, virtual substitutes of real world objects, has gained considerable importance. ...
doi:10.1007/978-3-319-70833-1_44
fatcat:2dmetmlb2nhirctfc6ddo6kpfq
Parallel Healthcare: Robotic Medical and Health Process Automation for Secured and Smart Social Healthcares
2020
IEEE Transactions on Computational Social Systems
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Parallel Hospitals and Digital Personal Doctors The current phase of my medical and healthcare research is on parallel hospitals and digital personal doctors, this is a new form of computational social ...
A parallel hospital is a real physical hospital combined with one or many virtual digital hospitals, you might want to call them digital twins of hospitals, but I still prefer to call them artificial hospitals ...
doi:10.1109/tcss.2020.2995282
fatcat:agvge5pytffo5ge4phc6am3r3y
Graph representation forecasting of patient's medical conditions: towards a digital twin
[article]
2020
medRxiv
pre-print
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We believe that this work represents a step forward towards a healthcare digital twin. ...
Methods: We propose a general framework that composes advanced AI approaches and integrates mathematical modelling in order to provide a panoramic view over current and future physiological conditions. ...
The personal medical digital twin could also represent a pragmatic way for the cyber-physical fusion, as a new approach to support biomedical engineering design. ...
doi:10.1101/2020.09.19.20197764
fatcat:c4oginzfcvfcvn7mn5dpe7a5aa
Complexity Problems Handled by Advanced Computer Simulation Technology in Smart Cities 2021
2022
Complexity
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Meta et al. proposed a modular framework for urban digital twins, combined with the concept of urban physiology, to better solve the theoretical problems of smart city construction. Y. ...
Urban digital twins are virtual representations of urban physical assets and are an important development direction of digital twin technology. ...
doi:10.1155/2022/9847249
fatcat:zyrfohu4vraxrcfkpzt5dulepm
The Digital Mouse: why computational modelling of mouse models of disease can improve translation
[article]
2020
bioRxiv
pre-print
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The Digital Mouse is proposed as framework to support the development of evidence-based medicine, for example to develop geroprotectors, which are drugs that target fundamental mechanisms of ageing. ...
Computational models can be used to study the mechanistic phenomena of disease. Current mechanistic computer simulation models mainly focus on (patho)physiology in humans. ...
The development of digital twinning for the life sciences and 230 health and medical care is gaining momentum 1 . ...
doi:10.1101/2020.05.04.075812
fatcat:xaznq4zoavbclcjexxmfzzdj3e
Digital Twin: Values, Challenges and Enablers
[article]
2019
arXiv
pre-print
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Also referred to as a computational megamodel, device shadow, mirrored system, avatar or a synchronized virtual prototype, there can be no doubt that a digital twin plays a transformative role not only ...
A digital twin can be defined as an adaptive model of a complex physical system. ...
ACKNOWLEDGMENT The authors would like to thank Professor Harald Martens for his helpful comments and suggestions on an earlier draft of this manuscript. ...
arXiv:1910.01719v1
fatcat:3r2bbivffbeizelake7oo3xgbm
Digital Twin Conceptual Model within the Context of Internet of Things
2020
Future Internet
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A virtual replica of such object (digital twin) is based in the cloud computing platform and hosts the real-time physical object data, 2D and 3D models, historical data, and bill of materials (BOM) for ...
While an object is on the move, its operational and surrounding environmental parameters are collected by an edge computing device for local decision. ...
Limited work has been done focusing on a complete modular architecture of a digital twin in the context of Industry 4.0 that leverages the data from the physical layer followed by lightweight protocols ...
doi:10.3390/fi12100163
fatcat:nnamk2axcfcgleqe6wpq7ysqrm
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