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A modular computational framework for medical digital twins

J. Masison, J. Beezley, Y. Mei, HAL Ribeiro, A. C. Knapp, L. Sordo Vieira, B. Adhikari, Y. Scindia, M. Grauer, B. Helba, W. Schroeder, B. Mehrad (+1 others)
2021 Proceedings of the National Academy of Sciences of the United States of America  
In analogy to a common industrial strategy used for preventive maintenance of engineered products, medical digital twins are computational models of disease processes calibrated to individual patients  ...  This paper presents a modular software design for the construction of computational modeling technology that will help implement precision medicine.  ...  /10.1073/pnas.2024287118 A modular computational framework for medical digital twins Downloaded by guest on May 11, 2021  ... 
doi:10.1073/pnas.2024287118 pmid:33972437 pmcid:PMC8157963 fatcat:oosv3yaoyra3tdvgcph2xvqdx4

The Digital Twin: Modular Model-Based Approach to Personalized Medicine

Jan Gaebel, Johannes Keller, Daniel Schneider, Adrian Lindenmeyer, Thomas Neumuth, Stefan Franke
2021 Current Directions in Biomedical Engineering  
Describing medical patterns and contexts with Resource Description Framework (RDF) allows for standardised way of connecting medical knowledge and processing modules.  ...  Transition of the Digital Twin to clinical practice promises effective assistance and safer clinical decisions.  ...  Second, we present techniques to use the capabilities of the Digital Twin with a modular and dynamic system that, for instance, provides data preparation, data processing, calculations of medical scores  ... 
doi:10.1515/cdbme-2021-2057 fatcat:4fa6fywgqna5hd244rypxsuhcu

Cognitive Ledger Project: Towards Building Personal Digital Twins Through Cognitive Blockchain [article]

Amir Reza Asadi
2022 arXiv   pre-print
In this work-in-progress paper, we propose a cognitive architecture for cognitive digital twins. The suggested design embraces a cognitive blockchain (Cognitive ledger) at its core.  ...  digital twin of users.  ...  Nardini et al. [18] Fig 4: Different levels of Cognitive Digital Twins in Cognitive Ledger proposed a framework for building a decentralized electronic Project  ... 
arXiv:2201.08163v1 fatcat:x2kq3bl3ivexzoxb5ybm4w2pre

A Modular Digital Twinning Framework for Safety Assurance of Collaborative Robotics

J.A. Douthwaite, B. Lesage, M. Gleirscher, R. Calinescu, J. M. Aitken, R. Alexander, J. Law
2021 Frontiers in Robotics and AI  
In this paper we present a novel, modular digital twinning framework developed for the investigation of safety within collaborative robotic manufacturing processes.  ...  We describe the creation of a digital twin scenario, consisting of individual digital twins of entities in the manufacturing case study, and the application of a synthesised safety controller from our  ...  situation-based testing at the University of York with the digital twinning research at the University of Sheffield.  ... 
doi:10.3389/frobt.2021.758099 pmid:34977162 pmcid:PMC8719333 fatcat:2mynwch3evhsneupyh54dtetsi

Conceptual framework of Digital Health Public Emergency System: digital twins and multiparadigm simulation

Román Rodríguez-Aguilar, Jose-Antonio Marmolejo-Saucedo
2018 EAI Endorsed Transactions on Pervasive Health and Technology  
RESULTS: The proposal establishes the conceptual framework for the integration of a digital public health emergency system, incorporating multi-paradigm simulation in the construction of a digital twin  ...  OBJECTIVES: This study aims to develop the conceptual framework for the development of a Digital Public Health Emergency System.  ...  To the International Conference on Computer Science and Engineering and Health Services (COMPSE) for the space for the dissemination of knowledge and ideas.  ... 
doi:10.4108/eai.13-7-2018.164261 fatcat:rvh7i33eu5e6hksf3sv6zsul6a

Graph Representation Forecasting of Patient's Medical Conditions: Toward a Digital Twin

Pietro Barbiero, Ramon Viñas Torné, Pietro Lió
2021 Frontiers in Genetics  
To this purpose, we propose a "digital twin" of patients modeling the human body as a whole and providing a panoramic view over individuals' conditions.Methods: We propose a general framework that composes  ...  of transcriptomic integrability.Results: We tested our digital twin model on two simulated clinical case studies combining information at organ, tissue, and cellular level.  ...  Finally, by relying upon flexible and modular architectures, our "digital twin" model can be conveniently deployed in dedicated hardware modules paving the way for a next-generation of medical devices.  ... 
doi:10.3389/fgene.2021.652907 pmid:34603366 pmcid:PMC8481902 fatcat:p7ckxmcgpbh3lmlaylsboof5vu

Graph representation forecasting of patient's medical conditions: towards a digital twin [article]

Pietro Barbiero, Ramon Viñas Torné, Pietro Lió
2020 arXiv   pre-print
We believe that this work represents a step forward towards a healthcare digital twin.  ...  Methods: We propose a general framework that composes advanced AI approaches and integrates mathematical modelling in order to provide a panoramic view over current and future physiological conditions.  ...  The personal medical digital twin could also represent a pragmatic way for the cyber-physical fusion, as a new approach to support biomedical engineering design.  ... 
arXiv:2009.08299v1 fatcat:b6h54uc4ojf4phnvywiwq3phcy

Digital twin-based sustainable intelligent manufacturing: a review

Bin He, Kai-Jian Bai
2020 Advances in Manufacturing  
Subsequently, a digital twin and its application are introduced along with the development of intelligent manufacturing based on the digital twin technology.  ...  Sustainable intelligent manufacturing based on a digital twin has advantages in practical applications.  ...  A modular approach was studied to build a digital twin and make the corresponding changes [42] .  ... 
doi:10.1007/s40436-020-00302-5 fatcat:ckbvw5si5jffxcdbvaixlrud3e

Flexible Work Cell Simulator Using Digital Twin Methodology for Highly Complex Systems in Industry 4.0 [chapter]

Pedro Tavares, Joao André Silva, Pedro Costa, Germano Veiga, António Paulo Moreira
2017 Advances in Intelligent Systems and Computing  
Recently the concept of digital twin methodology has been introduced to mimic the real world through a virtual substitute, such as, a simulator.  ...  Despite the fact that streamline manufacturing relies on automation systems, most production lines within the industrial environment lack a exible framework that allows for evaluation and optimisation  ...  Within this industrial trend, notion of Digital Twins, virtual substitutes of real world objects, has gained considerable importance.  ... 
doi:10.1007/978-3-319-70833-1_44 fatcat:2dmetmlb2nhirctfc6ddo6kpfq

Parallel Healthcare: Robotic Medical and Health Process Automation for Secured and Smart Social Healthcares

Fei-Yue Wang
2020 IEEE Transactions on Computational Social Systems  
Parallel Hospitals and Digital Personal Doctors The current phase of my medical and healthcare research is on parallel hospitals and digital personal doctors, this is a new form of computational social  ...  A parallel hospital is a real physical hospital combined with one or many virtual digital hospitals, you might want to call them digital twins of hospitals, but I still prefer to call them artificial hospitals  ... 
doi:10.1109/tcss.2020.2995282 fatcat:agvge5pytffo5ge4phc6am3r3y

Graph representation forecasting of patient's medical conditions: towards a digital twin [article]

Pietro Barbiero, Ramon Viñas Torné, Pietro Lió
2020 medRxiv   pre-print
We believe that this work represents a step forward towards a healthcare digital twin.  ...  Methods: We propose a general framework that composes advanced AI approaches and integrates mathematical modelling in order to provide a panoramic view over current and future physiological conditions.  ...  The personal medical digital twin could also represent a pragmatic way for the cyber-physical fusion, as a new approach to support biomedical engineering design.  ... 
doi:10.1101/2020.09.19.20197764 fatcat:c4oginzfcvfcvn7mn5dpe7a5aa

Complexity Problems Handled by Advanced Computer Simulation Technology in Smart Cities 2021

Zhihan Lv, Kaoru Ota, Jaime Lloret, Wei Xiang, Paolo Bellavista
2022 Complexity  
Meta et al. proposed a modular framework for urban digital twins, combined with the concept of urban physiology, to better solve the theoretical problems of smart city construction. Y.  ...  Urban digital twins are virtual representations of urban physical assets and are an important development direction of digital twin technology.  ... 
doi:10.1155/2022/9847249 fatcat:zyrfohu4vraxrcfkpzt5dulepm

The Digital Mouse: why computational modelling of mouse models of disease can improve translation [article]

Natal A. van Riel, Ralph Mueller, Enrico Dall'Ara
2020 bioRxiv   pre-print
The Digital Mouse is proposed as framework to support the development of evidence-based medicine, for example to develop geroprotectors, which are drugs that target fundamental mechanisms of ageing.  ...  Computational models can be used to study the mechanistic phenomena of disease. Current mechanistic computer simulation models mainly focus on (patho)physiology in humans.  ...  The development of digital twinning for the life sciences and 230 health and medical care is gaining momentum 1 .  ... 
doi:10.1101/2020.05.04.075812 fatcat:xaznq4zoavbclcjexxmfzzdj3e

Digital Twin: Values, Challenges and Enablers [article]

Adil Rasheed, Omer San, Trond Kvamsdal
2019 arXiv   pre-print
Also referred to as a computational megamodel, device shadow, mirrored system, avatar or a synchronized virtual prototype, there can be no doubt that a digital twin plays a transformative role not only  ...  A digital twin can be defined as an adaptive model of a complex physical system.  ...  ACKNOWLEDGMENT The authors would like to thank Professor Harald Martens for his helpful comments and suggestions on an earlier draft of this manuscript.  ... 
arXiv:1910.01719v1 fatcat:3r2bbivffbeizelake7oo3xgbm

Digital Twin Conceptual Model within the Context of Internet of Things

A. R. Al-Ali, Ragini Gupta, Tasneem Zaman Batool, Taha Landolsi, Fadi Aloul, Ahmad Al Nabulsi
2020 Future Internet  
A virtual replica of such object (digital twin) is based in the cloud computing platform and hosts the real-time physical object data, 2D and 3D models, historical data, and bill of materials (BOM) for  ...  While an object is on the move, its operational and surrounding environmental parameters are collected by an edge computing device for local decision.  ...  Limited work has been done focusing on a complete modular architecture of a digital twin in the context of Industry 4.0 that leverages the data from the physical layer followed by lightweight protocols  ... 
doi:10.3390/fi12100163 fatcat:nnamk2axcfcgleqe6wpq7ysqrm
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