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Drosophila Melanogaster as a Model to Study Human Neurodegenerative Diseases

Mohammad Haddadi
2018 International Journal of Basic Science in Medicine  
Here I summarize few points on the contribution of Drosophila melanogaster in neurobiology of learning and memory as well as human NDDs.  ...  Neurobehavioral functions of CNS play a vital role in making appropriate responses to the environmental stimuli.  ...  Acknowledgments I would like to thank Chairperson of Biology Department, the University of Zabol for all help and supports.  ... 
doi:10.15171/ijbsm.2018.02 fatcat:7l5w7tqe7vbvjf2bw2uudu4vue

Comparative chemosensory cognition

Alan Gelperin
2014 Frontiers in Behavioral Neuroscience  
The maintenance of a range of cognitive tasks in male Drosophila, including but not limited to olfactory learning ability, was significantly reduced after 100 generations of enforced monogamy (Anderson  ...  Extension of these methods to olfactory conditioning will allow assessment of olfactory learning in a quantitative and unbiased fashion and facilitate the search for higher order learning about odors.  ...  Conflict of Interest Statement: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fnbeh.2014.00190 pmid:24904341 pmcid:PMC4033254 fatcat:pzi2fre6qfc65hegmzoi2ebeam

Associative Learning: The Instructive Function of Biogenic Amines

Martin Giurfa
2006 Current Biology  
[6] have addressed this question in Drosophila larvae, an insect model that has become popular for the study of associative olfactory learning.  ...  Thus, these monoamines do not up-regulate or down-regulate these behaviours in a non-specific way, rather they act specifically as an instructive element in associative learning phenomena.  ... 
doi:10.1016/j.cub.2006.09.021 pmid:17055975 fatcat:nvefy5u2nbenfbpt7ahy7h3e74

Fruit flies and intellectual disability

Francois V. Bolduc, Tim Tully
2009 Fly  
Several animal models have been used in the study of memory and cognition.  ...  As a result of the analysis of familial cases and recent advances in clinical genetic testing, great strides have been made in our understanding of the genetic etiologies of mental retardation.  ...  Seymour Benzer (1921Benzer ( -2007 for his pioneering work in the field. We would like to thank Mr. Michel Bolduc, Mme. Susan Van Nispen, Mr. Cory Rosenfelt and Mr.  ... 
doi:10.4161/fly.3.1.7812 pmid:19182539 pmcid:PMC3045854 fatcat:xhyivaho75cmdk5ong4zlcf35e

Olfactory learning without the mushroom bodies: Spiking neural network models of the honeybee lateral antennal lobe tract reveal its capacities in odour memory tasks of varied complexities

HaDi MaBouDi, Hideaki Shimazaki, Martin Giurfa, Lars Chittka, Gabriel Kreiman
2017 PLoS Computational Biology  
The honeybee olfactory system is a well-established model for understanding functional mechanisms of learning and memory.  ...  Thus, our model explains several-but not alltypes of associative olfactory learning and generalization by a few neural layers of odour processing in the l-ALT.  ...  and non-elemental olfactory learning is still unknown.  ... 
doi:10.1371/journal.pcbi.1005551 pmid:28640825 pmcid:PMC5480824 fatcat:2sj6urpocrf2jkravdb6rfunja

The vomeronasal system and pheromones

Heather L. Eisthen, Tristram D. Wyatt
2006 Current Biology  
It was argued whether a model is really a model or a description of the data, and if it was just a description then it could not be tested.  ...  For example, a piece of limb was removed and the reoccurrence of the missing part was described. On the basis of the final product of regeneration, models were developed.  ...  It was argued whether a model is really a model or a description of the data, and if it was just a description then it could not be tested.  ... 
doi:10.1016/j.cub.2006.01.038 pmid:16461264 fatcat:5mlpme7aq5eozlr32jqhncajde

Thirty years of olfactory learning and memory research in Drosophila melanogaster

Sean E. McGuire, Mitch Deshazer, Ronald L. Davis
2005 Progress in Neurobiology  
The last 30 years have witnessed tremendous progress in elucidating the basic mechanisms underlying a simple form of olfactory learning and memory in Drosophila.  ...  The application of the mutagenic approach to the study of olfactory learning and memory in Drosophila has yielded insights into the participation of a large number of genes in both the development of critical  ...  Olfactory learning in Drosophila. (A) A schematic diagram of the apparatus used for olfactory operant conditioning.  ... 
doi:10.1016/j.pneurobio.2005.09.003 pmid:16266778 fatcat:klajgh6rqrca5gpjzgvrjhrrre

Disorder and the Neural Representation of Complex Odors

Kamesh Krishnamurthy, Ann M. Hermundstad, Thierry Mora, Aleksandra M. Walczak, Vijay Balasubramanian
2022 Frontiers in Computational Neuroscience  
Animals smelling in the real world use a small number of receptors to sense a vast number of natural molecular mixtures, and proceed to learn arbitrary associations between odors and valences.  ...  Moreover, introducing any order in the expansive projections degrades the ability to recall the learned associations in the presence of noise.  ...  To construct each mixture composition vector x, we set a small number K of its elements to be non-zero (where K specifies the complexity of the mixture).  ... 
doi:10.3389/fncom.2022.917786 pmid:36003684 pmcid:PMC9393645 fatcat:bv5rsfyoqjb2zjfgryk3qf6x2u

Pre- and Postsynaptic Role of Dopamine D2 Receptor DD2R in Drosophila Olfactory Associative Learning

Cheng Qi, Daewoo Lee
2014 Biology  
Using a DD2R-RNAi transgenic line, we have examined the role of DD2R, expressed in dopamine neurons (i.e., the presynaptic DD2R autoreceptor), in larval olfactory learning.  ...  The function of postsynaptic DD2R expressed in mushroom body (MB) was also studied as MB is the center for Drosophila learning, with a function analogous to that of the mammalian hippocampus.  ...  Varga for his contributions on the initial stage of this work, and R. A. Colvin for valuable inputs on previous versions of this manuscript.  ... 
doi:10.3390/biology3040831 pmid:25422852 pmcid:PMC4280513 fatcat:npwqljw36fbz5bbbk2b6z5aida

Modelling learning and memory in Drosophila to understand Intellectual Disabilities

Vittoria Mariano, Tilmann Achsel, Claudia Bagni, Alexandros K. Kanellopoulos
2020 Neuroscience  
We discuss how technologies in the fly model, combined with a high degree of molecular and physiological conservation between flies and mammals, highlight the Drosophila system as an ideal model to study  ...  Here, we review studies where the use of well-established assays to study mechanisms of learning and memory in Drosophila has permitted insights into molecular mechanisms underlying IDs.  ...  Drosophila is one of the most widely studied invertebrates and is a highly tractable genetic model organism.  ... 
doi:10.1016/j.neuroscience.2020.07.034 pmid:32730949 fatcat:ymkgowwt7bb7rfvankwuj3fzy4

Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning

Archan Ganguly, Cheng Qi, Jeevisha Bajaj, Daewoo Lee
2020 Scientific Reports  
While the role of dopamine in olfactory learning in Drosophila is well described, the function of serotonin and its downstream receptors on Drosophila olfactory learning remain largely unexplored.  ...  In summary, our results establish a critical, and previously unknown, role of d5-HT7 in olfactory learning.  ...  Dolan for their help with the larval learning experiments and Dr. R.A. Colvin for his valuable inputs on this manuscript.  ... 
doi:10.1038/s41598-020-77910-5 pmid:33277559 fatcat:luitxi2bnfewji6e4lhqpv4ch4

Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae

Annekathrin Widmann, Marc Artinger, Lukas Biesinger, Kathrin Boepple, Christina Peters, Jana Schlechter, Mareike Selcho, Andreas S. Thum, Serge Birman
2016 PLoS Genetics  
In adult Drosophila it was shown that memory formation after aversive Pavlovian conditioning includes-besides other forms-a labile short-term component that consolidates within hours to a longer-lasting  ...  Compared to adult Drosophila, memory formation was only sporadically analyzed at its larval stage. Here we deconstruct the larval mnemonic organization after aversive olfactory conditioning.  ...  The anatomical analyses were supported by the Bioimaging Facility of the University of Konstanz.  ... 
doi:10.1371/journal.pgen.1006378 pmid:27768692 pmcid:PMC5074598 fatcat:2umc6sawf5eujpdiigkbxlbdwa

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

Mauro Agostino Zordan, Federica Sandrelli
2015 Frontiers in Neurology  
Here, we examine the features which we believe make Drosophila melanogaster a model apt to study the role of the circadian clock in psychiatric disease.  ...  In addition, Drosophila has a rather complex nervous system, which shares much at the cell and neurobiological level with humans, i.e., a tripartite brain, the main neurotransmitter systems, and behavioral  ...  We would also like to acknowledge the use of the following open-source software packages: Zotero (; a bibliographical database and citation manager), Blender (http: //  ... 
doi:10.3389/fneur.2015.00080 pmid:25941512 pmcid:PMC4403521 fatcat:um4jfroibjcxnaylkvbm4j4aj4

Page 14 of Cellular and Molecular Life Sciences Vol. 63, Issue 9 [page]

2006 Cellular and Molecular Life Sciences  
Drosophila models of human learning and memory disorders One of the outcomes of sequencing the genomes of hu- mans and model organisms was the high degree of simi- larity in the proteins they encode, and  ...  However, it is un- clear whether such a mechanism, or misregulation of Raf activity and MAPK signaling is responsible for compro- mised MB-dependent olfactory learning and memory.  ... 

Page 2684 of Psychological Abstracts Vol. 92, Issue 8 [page]

2005 Psychological Abstracts  
—Associative plasticity is a basic characteristic of behav- iour. We analysed associative olfactory learning in larval Drosophila, using a reciprocal conditioning assay.  ...  These experiments provide a basis for future investigations into the cellular and molecular underpinnings of appetitive olfactory learning in lar- val Drosophila. —Journal abstract. 22183.  ... 
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