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Gene–gene effects on central processing of aversive stimuli

M N Smolka, M Bühler, G Schumann, S Klein, X-Z Hu, M Moayer, A Zimmer, J Wrase, H Flor, K Mann, D F Braus, D Goldman (+1 others)
2007 Molecular Psychiatry  
Effects of 5-HTT and COMT genotypes did not affect brain processing of pleasant stimuli.  ...  Using functional magnetic resonance imaging, we assessed the effects of COMT Val 158 Met and both 5-HTT genotypes on brain activation by standardized affective visual stimuli (unpleasant, pleasant, and  ...  However, both the COMT and 5-HTT gene loci exert substantially stronger effects on central processing of unpleasant stimuli: in paradigms that assess the central processing of affective visual stimuli  ... 
doi:10.1038/sj.mp.4001946 pmid:17211439 fatcat:rbh2yp2ggndbdbyue3sdquqdum

Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex

M. N. Smolka
2005 Journal of Neuroscience  
Using functional magnetic resonance imaging, we assessed the effects of COMT genotype on brain activation by standardized affective visual stimuli (unpleasant, pleasant, and neutral) in 35 healthy subjects  ...  A functional polymorphism in the COMT gene (val 158 met) accounts for a fourfold variation in enzyme activity.  ...  If genotype effects on brain activation are stronger than on overt behavior, functional brain imaging should be an excellent tool to assess genotype effects on central processing of emotional stimuli  ... 
doi:10.1523/jneurosci.1792-04.2005 pmid:15673663 fatcat:ylfcvhdpk5e65fwbnoanxxwrcy

Imaging oxytocin × dopamine interactions: an epistasis effect of CD38 and COMT gene variants influences the impact of oxytocin on amygdala activation to social stimuli

Carina Sauer, Christian Montag, Martin Reuter, Peter Kirsch
2013 Frontiers in Neuroscience  
While under PLA the effect of CD38 on bilateral amygdala activation to social stimuli was modulated by the COMT genotype, no such epistasis effect was found under OT.  ...  We postulate that the effect of central OT secretion on amygdala response is modulated by the availability of DA.  ...  Taking it the other way around, the effect of COMT val158met genotype on amygdala activation is strongly depending on central OT secretion.  ... 
doi:10.3389/fnins.2013.00045 pmid:23554586 pmcid:PMC3612689 fatcat:z5yxb4yjfnfjln3yliylutfeq4

COMT genotype influences prefrontal response to emotional distraction

S. J. BISHOP, J. D. COHEN, J. FOSSELLA, B. J. CASEY, M. J. FARAH
2006 Cognitive, Affective, & Behavioral Neuroscience  
(COMT) gene, on prefrontal cognitive processes such as working memory, or that of polymorphisms in the serotonin transporter gene on the amygdala response to threatening stimuli.  ...  Specifically, we assess the effect of the COMT val 158 met polymorphism on frontal regulation of attention under emotional distraction.  ...  DISCUSSION Here, we report an effect of COMT val 158 met genotype on activation in neural regions associated with controlled processing (VLPFC and OFC) and the processing of taskrelated stimuli (bilateral  ... 
doi:10.3758/cabn.6.1.62 pmid:16869230 fatcat:ji2i7njnsjghfbycf7ol2qh3qq

Influence ofCOMTgenotype and affective distractors on the processing of self-generated thought

Emma J. Kilford, Iroise Dumontheil, Nicholas W. Wood, Sarah-Jayne Blakemore
2014 Social Cognitive and Affective Neuroscience  
The results also suggest sexually dimorphic effects of COMT genotype on the influence of affective distractors on executive function.  ...  This study investigated the effect of COMT genotype on the flexible modulation of the balance between processing self-generated and processing stimulus-oriented information, in the presence or absence  ...  Effects of COMT genotype were explored using a Val dominant model (Met/Met vs Val carriers).  ... 
doi:10.1093/scan/nsu118 pmid:25190703 pmcid:PMC4305337 fatcat:kysr4npgffdg7frxotw4jkwyta

Separability and Commonality of Auditory and Visual Bistable Perception

H. M. Kondo, N. Kitagawa, M. S. Kitamura, A. Koizumi, M. Nomura, M. Kashino
2011 Cerebral Cortex  
We performed factor analyses on the number of perceptual switches in the tasks. A 3-factor model provided a better fit to the data than the other possible models.  ...  We compared the number of perceptual switches among genotype groups to identify the effects of neurotransmitter functions on the factors.  ...  The 3-factor model is endorsed in terms of fit indices (see Figure 4 . 4 Number of perceptual switches for genotype groups. (A) COMT genotype group comparison.  ... 
doi:10.1093/cercor/bhr266 pmid:21965442 fatcat:sn475sz7mndfpfghjyrnevlpee

Neurotransmitters and Novelty: A Systematic Review

Mauricio Rangel-Gomez, Martijn Meeter
2015 Journal of Psychopharmacology  
Dopamine was found to affect electrophysiological responses to novelty early in time after stimulus presentation, but evidence on its effects on later processing was found to be contradictory: While neuropharmacological  ...  While theoretical models and studies on nonhuman animals have pointed to a role of the dopaminergic, cholinergic, noradrenergic and serotonergic systems, the human literature has focused almost exclusively  ...  A stronger repetition effect indicates that novel stimuli are processed differently than familiar ones.  ... 
doi:10.1177/0269881115612238 pmid:26601905 fatcat:3bdaepmjanfnzhj7wkg73bsmly

Catechol- O -Methyltransferase Valine 158 Methionine Genotype and Resting Regional Cerebral Blood Flow in Medication-Free Patients with Schizophrenia

Daniel Paul Eisenberg, Deepak Sarpal, Philip D. Kohn, Andreas Meyer-Lindenberg, Dylan Wint, Bhaskar Kolachana, José Apud, Daniel R. Weinberger, Karen Faith Berman
2010 Biological Psychiatry  
Data were analyzed with a random-effects general linear model using COMT genotype as a covariate.  ...  In schizophrenia, brain structures important for executive and affective processing show activity that is differentially predicted by COMT allelic variation in an opposing manner even at rest, providing  ...  Acknowledgments We would like to thank the staff of the NIH PET Center and the NIMH GCAP Inpatient Program for their assistance in data acquisition.  ... 
doi:10.1016/j.biopsych.2009.08.039 pmid:19892319 pmcid:PMC2812618 fatcat:rtzqjaf25nanzaps2mgr47mbgm

Pain modality- and sex-specific effects of COMT genetic functional variants

Inna Belfer, Samantha K. Segall, William R. Lariviere, Shad B. Smith, Feng Dai, Gary D. Slade, Naim U. Rashid, Jeffrey S. Mogil, Claudia M. Campbell, Robert R. Edwards, Qian Liu, Eric Bair (+2 others)
2013 Pain  
In this study, we found that the effects of Comt functional variation in mice are modality specific.  ...  These findings reemphasize the fundamental contribution of COMT to pain processes, and provide a fine-grained resolution of this contribution at the genetic level that can be used to guide future studies  ...  In general, there are three major scenarios of sex-specific differences in the effect on of a gene on a trait or behavior: sex-specific effects (COMT affects only one sex), sex-biased effects (COMT affects  ... 
doi:10.1016/j.pain.2013.04.028 pmid:23701723 pmcid:PMC3700530 fatcat:zzcrrt2sz5bwzgdfc7xwg63hie

Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele

Jacob A S Vorstman, Bruce I Turetsky, Monique E J Sijmens-Morcus, Monique G de Sain, Bert Dorland, Mirjam Sprong, Eric F Rappaport, Frits A Beemer, Beverly S Emanuel, René S Kahn, Herman van Engeland, Chantal Kemner
2008 Neuropsychopharmacology  
We hypothesized an interaction between the COMT 158 genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the  ...  These findings are consistent with a model in which elevated proline negatively affects brain function by an increase in dopamine in the prefrontal cortex. 22q11DS patients with low dopamine catabolic  ...  SPEM Data Acquisition and Processing Stimuli were displayed on a 21-inch computer screen (42 Â 32 cm) positioned 1 m in front of the subject. Display resolution was 800 Â 600 pixels.  ... 
doi:10.1038/npp.2008.132 pmid:18769474 pmcid:PMC2817942 fatcat:nuoa326amzeplmdaur3j6uv76e

Time-Resolved Influences of Functional DAT1 and COMT Variants on Visual Perception and Post-Processing

Stephan Bender, Thomas Rellum, Christine Freitag, Franz Resch, Marcella Rietschel, Jens Treutlein, Christine Jennen-Steinmetz, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht, Katharina Domschke
2012 PLoS ONE  
Conclusions: Late visual potentials allow the genomic imaging of dopamine inactivation effects on visual post-processing.  ...  Results: Significant additive main effects of DAT1 and COMT on the occipito-temporal early CNV were observed. In addition, there was a trend towards an interaction between the two polymorphisms.  ...  There was no hint that the effects of DAT1 and COMT on increased post-processing could have been a consequence of increased initial visual processing.  ... 
doi:10.1371/journal.pone.0041552 pmid:22844499 pmcid:PMC3402385 fatcat:fhbtkehgcrartllgmg47lbzkue

Divergent backward masking performance in schizophrenia and bipolar disorder: Association with COMT

Vina M. Goghari, Scott R. Sponheim
2008 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
This study provides novel evidence for differential effects of the COMT gene on neural systems underlying visual perception in schizophrenia and bipolar disorder.  ...  A locationbased backward masking task, which equated participants on the perceptual intensity of stimuli, was completed by 41 schizophrenia outpatients, 28 bipolar outpatients, and 43 nonpsychiatric controls  ...  Goghari was supported by a PGS Doctoral Award from the Natural Sciences and Engineering Research Council of Canada. We gratefully acknowledge Drs.  ... 
doi:10.1002/ajmg.b.30583 pmid:17948281 fatcat:o5eeftjeevak3fxesob6vrjr6m

Dissociative Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention

Nir Shalev, Signe Vangkilde, Matt J. Neville, Elizabeth M. Tunbridge, Anna C. Nobre, Magdalena Chechlacz
2019 Neuroscience  
The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes - COMT (Val158Met) and DBH (444 G/A) - on individual differences in attention functions.  ...  Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance.  ...  Namely, our secondary analyses indicate that the effect on Val allele dosage on the perceptual threshold (i.e., threshold below which no effective processing of visual stimuli takes place) might be a result  ... 
doi:10.1016/j.neuroscience.2019.05.068 pmid:31195057 pmcid:PMC6645579 fatcat:z7fghgc5o5deflrsdr5fvnmvse

Contributions of COMT Val158Met to cognitive stability and flexibility in infancy

Julie Markant, Dante Cicchetti, Susan Hetzel, Kathleen M. Thomas
2014 Developmental Science  
Cognitive stability and flexibility were assessed using (1) a motor approach task, (2) a habituation task, and (3) a parental-report measure of temperament.  ...  From this perspective, the present study examined whether COMT genotype was related to 7-month-old infants' reactivity to novel stimuli and behavioral regulation.  ...  Acknowledgments The authors gratefully acknowledge support from the Institute of Child Development and the Graduate School at the University of Minnesota, as well as an NICHD Predoctoral Traineeship (#  ... 
doi:10.1111/desc.12128 pmid:24410746 pmcid:PMC4034686 fatcat:r5wtkgvbzveitc4mbznspze5s4

Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both β2- and β3-adrenergic receptors

Andrea Gail Nackley, Kai Soo Tan, Karamarie Fecho, Patrick Flood, Luda Diatchenko, William Maixner
2007 Pain  
responsiveness to mechanical and thermal stimuli.  ...  These data provide the first direct evidence that low COMT activity leads to increased pain sensitivity via a β 2/3 -adrenergic mechanism.  ...  Acknowledgements We thank Ollie Monbureau for the development of the behavioral testing hardware and software. We thank B. Lambeth and J.M.  ... 
doi:10.1016/j.pain.2006.09.022 pmid:17084978 pmcid:PMC1905861 fatcat:einm54x7xzcm7danlalcvhpzm4
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