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A modality-adaptive method for segmenting brain tumors and organs-at-risk in radiation therapy planning

Mikael Agn, Per Munck af Rosenschöld, Oula Puonti, Michael J. Lundemann, Laura Mancini, Anastasia Papadaki, Steffi Thust, John Ashburner, Ian Law, Koen Van Leemput
2019 Medical Image Analysis  
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas.  ...  The proposed method may be a valuable step towards automating the delineation of brain tumors and organs-at-risk in glioblastoma patients undergoing radiation therapy.  ...  The Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome Trust (203147/Z/16/Z).  ... 
doi:10.1016/j.media.2019.03.005 pmid:30952038 pmcid:PMC6554451 fatcat:hmxhuvy5rfcrzopsw5r3rv4jmy

A Modality-Adaptive Method for Segmenting Brain Tumors and Organs-at-Risk in Radiation Therapy Planning [article]

Mikael Agn , Michael J. Lundemann, Anastasia Papadaki (5 and 6), Steffi Thust, Koen Van Leemput Department of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark, Radiation Physics, Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden, Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre (+25 others)
2018 arXiv   pre-print
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas.  ...  The proposed method may be a valuable step towards automating the delineation of brain tumors and organs-at-risk in glioblastoma patients undergoing radiation therapy.  ...  (B.1) is a so-called quadratic programming problem, for which an implementation is directly available in MAT-LAB.  ... 
arXiv:1807.10588v2 fatcat:7lxbgom24vby3k24t5jkgfcmxq

Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients [chapter]

Habib Zaidi, Srinivasan Senthamizhchelvan
2011 Tumors of the Central Nervous System, Volume 2  
In this chapter, the applicability of PET in assessing the biologically active tumor volumes in high-grade glioma patients for radiation therapy treatment planning and therapy monitoring will be reviewed  ...  It allows a better understanding of pathology at the molecular level. This ability is especially useful in brain tumors where tissue sampling in vivo is associated with significant risks.  ...  the normal organs, and in the assessment of tumor burden, blood flow, tissue inflammation, and hypoxia.  ... 
doi:10.1007/978-94-007-0618-7_15 fatcat:t7lwahjovrbnph54m5ic4hyvwu

Radiation Oncology in the Era of Big Data and Machine Learning for Precision Medicine [chapter]

Alexander F.I. Osman
2019 Machine Learning in Medicine and Biology [Working Title]  
(i.e., potentials for decision-making support toward a practical application of precision medicine in radiation therapy) of patient care.  ...  , treatment planning, treatment delivery, quality assurance, and treatment response and outcome predictions.  ...  Acknowledgements The author is grateful to the attending physicians, physicists, residents, and staff at the radiation oncology department, at American University of Beirut Medical Center (AUBMC), Lebanon  ... 
doi:10.5772/intechopen.84629 fatcat:tobl67e5qvgf5mat43ex5lounq

The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective

Robert H. Press, Hui-Kuo G. Shu, Hyunsuk Shim, James M. Mountz, Brenda F. Kurland, Richard L. Wahl, Ella F. Jones, Nola M. Hylton, Elizabeth R. Gerstner, Robert J. Nordstrom, Lori Henderson, Karen A. Kurdziel (+14 others)
2018 International Journal of Radiation Oncology, Biology, Physics  
Modern radiation therapy is delivered with great precision, in part by relying on high-resolution multidimensional anatomic imaging to define targets in space and time.  ...  In particular, the QIN has significant interest in the application of QI to widen the therapeutic window of radiation therapy.  ...  The importance of MRI in radiation oncology continues to grow as treatment planning becomes more dependent on reliable delineation of targets and organs at risk.  ... 
doi:10.1016/j.ijrobp.2018.06.023 pmid:29966725 pmcid:PMC6348006 fatcat:6s7f3b74wbbjxg64wwethckqn4

Modern radiotherapy techniques
Moderne metode radioterapije

Franjo Cmrečak, Iva Andrašek, Meliha Solak-Mekić, Mirna Ravlić, Lidija Beketić-Orešković
2020 Libri Oncologici Croatian Journal of Oncology  
Image-guided radiotherapy (IGRT) and adaptive radiotherapy enable the delivery of high precision radiation to the target volume and spares organs at risk by correcting interfractional and intrafractional  ...  The transition from two-dimensional to three-dimensional radiotherapy has allowed contouring of target volume and organs at risk and accurate information on radiation dosage delivered.  ...  This development was initially started by a need for higher radiation dose on target volume and at the same time conservation of the organs at risk, which resulted in better tolerance of the radiation  ... 
doi:10.20471/lo.2019.47.02-03.17 fatcat:pcitx7tjb5dwplnv7a4pztdrly

Radiotherapy for brain tumors – New techniques and treatment strategies

Anca-Ligia Grosu, Franziska Fels
2012 Journal of Solid Tumors  
Other radiation treatment modalities Hadron therapy Radiotherapy with hadrons is a special section in radio oncology.  ...  Multileaf-collimators also permit a dynamic adaption of the irradiated area during radiation treatment. By the static IMRT-method, each segment is successively irradiated ("step and shoot").  ... 
doi:10.5430/jst.v2n1p1 fatcat:wgquojhs2zd5rj23o7vnxu5guy

Modern Radiation Oncology: From IMRT to Particle Therapy—Present Status and the Days to Come

Sarbani Ghosh Laskar, Sangeeta Kakoti
2022 Indian Journal of Medical and Paediatric Oncology  
Present-day radiation therapy is aimed at precision, in terms of physical accuracy of both its planning and delivery.  ...  This has been made possible by improvements in defining the target (use of various radiological and functional imaging modalities), advanced radiotherapy planning methods (intensity-modulated radiation  ...  There has also been implementation of various image segmentation techniques, based on atlas or deep learning models to define organs at risk (OARs) or targets.  ... 
doi:10.1055/s-0042-1742446 fatcat:uxykmdbisnh4xbmskuwfci2c5y

Molecular Imaging to Plan Radiotherapy and Evaluate Its Efficacy

R. Jeraj, T. Bradshaw, U. Simon i
2015 Journal of Nuclear Medicine  
and various MRI techniques which are particularly applicable for assessment of brain tumors.  ...  Fortunately, a number of alternative PET radiotracers and different modalities for molecular imaging exist, most notably 3ʹ-( 18 F)fluoro-3ʹ-deoxy-L-thymidine (FLT), a surrogate of tumor proliferation,  ...  Radiation therapy is a localized cancer treatment modality, and as such requires accurate spatial localization of the tumor.  ... 
doi:10.2967/jnumed.114.141424 pmid:26383148 fatcat:m43wmxd4rrhm5p4pgs7qu3p54i

A concise review of irradiation sequelae on the cardiovascular system in pulmonary malignancies

Sager Omer, Beyzadeoglu Murat, Dincoglan Ferrat, Demiral Selcuk, Uysal Bora, Gamsiz Hakan, Ozcan Fatih, Colak Onurhan, Dirican Bahar
2020 Journal of Surgery and Surgical Research  
automatic segmentation procedures, Image Guided Radiation Therapy (IGRT), Breathing Adapted Radiation Therapy (BART), Adaptive Radiation Therapy (ART), Intensity Modulated Radiation Therapy (IMRT).  ...  Nevertheless, main modalities for management of pulmonary malignancies include surgery, Radiation Therapy (RT), and systemic therapies.  ... 
doi:10.17352/2455-2968.000102 fatcat:sluhtjlrjngiznsiihmkcwmfuq

Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review

Pierre Decazes, Pauline Hinault, Ovidiu Veresezan, Sébastien Thureau, Pierrick Gouel, Pierre Vera
2021 Frontiers in Oncology  
Computed tomography (CT) has revolutionized external radiotherapy by making it possible to visualize and segment the tumors and the organs at risk in a three-dimensional way.  ...  Trimodality is already possible in clinical routine and can have a high clinical impact and good inter-observer agreement, notably for head and neck cancers, brain tumor, prostate cancer, cervical cancer  ...  TECHNICAL PARTS CT, MRI, and PET CT is the reference imaging used by radiation oncologists for target volumes and organs at risk delineation for radiotherapy treatment planning.  ... 
doi:10.3389/fonc.2020.614008 pmid:33614497 pmcid:PMC7890017 fatcat:oyv73uw44zcntfaqsbqge36c6u

Multiparametric Quantitative MRI as a Metric for Radiation Treatment Planning

Ali Fatemi
2017 Novel Approaches in Cancer Study  
MRI images, either used directly or fused with CT, play an increasingly important role in contouring gross tumor volume (GTV) and organs at risk (OAR) in radiation treatment planning (RTP) systems.  ...  We discuss the potential of these functional MRI techniques in different sites for tumor response evaluation and possible adaptive radiotherapy.  ...  Acknowledgement I would like to thank all of my colleagues in radiation oncology and radiology for their support.  ... 
doi:10.31031/nacs.2017.01.000503 fatcat:b7ol2tnd5fdftjln5etvcdkaoa

A generative model for segmentation of tumor and organs-at-risk for radiation therapy planning of glioblastoma patients

Mikael Agn, Ian Law, Per Munck af Rosenschöld, Koen Van Leemput, Martin A. Styner, Elsa D. Angelini
2016 Medical Imaging 2016: Image Processing  
We present a fully automated generative method for simultaneous brain tumor and organs-at-risk segmentation in multi-modal magnetic resonance images.  ...  The method is not tuned to any specific imaging protocol and can simultaneously segment the gross tumor volume, peritumoral edema and healthy tissue structures relevant for radiotherapy planning.  ...  ACKNOWLEDGMENTS This research was supported by NIH NCRR (P41-RR14075), NIBIB (R01EB013565) and the Lundbeck Foundation (R141-2013-13117).  ... 
doi:10.1117/12.2216814 dblp:conf/miip/AgnLRL16 fatcat:6hzsj5mu7ja4dmy3zkfdupczkm

Advances and future of Radiation Oncology

Carlos A. Perez, Sasa Mutic
2013 Reports of Practical Oncology & Radiotherapy  
planning, optimal delivery of radiation therapy to the target and lower doses to surrounding Organs at Risk.  ...  Materials and methods: The relevant literature was reviewed and the authors offer their perspective on future opportunities for advancement in Radiation Oncology.  ...  The knowledge of D A will enable further optimization of tradeoffs between doses delivered to tumor volumes and those delivered to Organs at Risk.  ... 
doi:10.1016/j.rpor.2013.10.010 pmid:24416573 pmcid:PMC3863316 fatcat:27n5nufrunak7e7qsj6gvcps3y

Current Targets of Immune Suppression in Tumor Microenvironment

Shih-Hsien Hsu
2017 Novel Approaches in Cancer Study  
MRI images, either used directly or fused with CT, play an increasingly important role in contouring gross tumor volume (GTV) and organs at risk (OAR) in radiation treatment planning (RTP) systems.  ...  We discuss the potential of these functional MRI techniques in different sites for tumor response evaluation and possible adaptive radiotherapy.  ...  Acknowledgement I would like to thank all of my colleagues in radiation oncology and radiology for their support.  ... 
doi:10.31031/nacs.2017.01.000505 fatcat:dqn6qa2unjbpbglv6ehltdztou
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