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A method for quantification of calponin expression in myoepithelial cells in immunohistochemical images of ductal carcinoma in situ

Elliot Gray, Elizabeth Mitchell, Sonali Jindal, Pepper Schedin, Young Hwan Chang
<span title="">2018</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qcepwfkflvg5toaa6fh2alj3b4" style="color: black;">2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018)</a> </i> &nbsp;
Keywords DCIS; calponin; invasive breast cancer; feature engineering; myoepithelial cell DCIS AND INVASIVE BREAST CANCER Incidence of ductal carcinoma in situ (DCIS) increased from 3% in the early 1970  ...  Ductal carcinoma in situ (DCIS) is breast cancer confined within mammary ducts, surrounded by an intact myoepithelial cell layer that prevents local invasion.  ...  Acknowledgements: This research was supported by a grant from Susan G. Komen® PDF17480342 (E.M), and the Oregon Health and Science University (OHSU) Center for Spatial Systems Biomedicine.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/isbi.2018.8363692">doi:10.1109/isbi.2018.8363692</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30364524">pmid:30364524</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6196724/">pmcid:PMC6196724</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/isbi/GrayMJSC18.html">dblp:conf/isbi/GrayMJSC18</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kysvs2hipndsrewll3mdsa5nbq">fatcat:kysvs2hipndsrewll3mdsa5nbq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210110946/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6196724&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c2/a7/c2a733f1bb2d2b91ec5a84ed1c5f4e11f97cb568.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/isbi.2018.8363692"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196724" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Myoepithelial Cell Differentiation Markers in Ductal Carcinoma in Situ Progression

Tanya D. Russell, Sonali Jindal, Samiat Agunbiade, Dexiang Gao, Megan Troxell, Virginia F. Borges, Pepper Schedin
<span title="2015-09-04">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yzldvkrryjcwzk5k74akntsgke" style="color: black;">American Journal of Pathology</a> </i> &nbsp;
We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive  ...  Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 in adjacent tumor cells.  ...  Supplemental Data Supplemental material for this article can be found at http://dx.doi.org/10.1016/j.ajpath.2015.07.004.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ajpath.2015.07.004">doi:10.1016/j.ajpath.2015.07.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26343330">pmid:26343330</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4630168/">pmcid:PMC4630168</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/654g27r7pfalriac7ofsb3svde">fatcat:654g27r7pfalriac7ofsb3svde</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208161427/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4630168&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/99/84/9984edac16b8e8d6ca0fe5e1064e81d5626a60a9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ajpath.2015.07.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630168" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Loss of myoepithelial calponin‐1 characterizes high‐risk ductal carcinoma in situ cases, which are further stratified by T cell composition

Elizabeth Mitchell, Sonali Jindal, Tiffany Chan, Jayasri Narasimhan, Shamilene Sivagnanam, Elliot Gray, Young Hwan Chang, Sheila Weinmann, Pepper Schedin
<span title="2020-03-05">2020</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2y65k2ddgjfqtb2ysbu5f4bwo4" style="color: black;">Molecular Carcinogenesis</a> </i> &nbsp;
A hallmark of ductal carcinoma in situ (DCIS) progression is a loss of the surrounding ductal myoepithelium.  ...  Notably, the majority of pure (low-risk) DCIS lesions clustered in a high calponin-1, T cell low group, whereas the majority of mixed (high-risk) DCIS lesions clustered in a low calponin-1, T cell high  ...  ACKNOWLEDGMENTS The authors wish to acknowledge the contributions of Weston Anderson for the excellent support in drafting, review, and editing of the manuscript; Nathan Pennock for critical review of  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/mc.23171">doi:10.1002/mc.23171</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32134153">pmid:32134153</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kgg22vy36bhnbjj7bkd2vrd2ji">fatcat:kgg22vy36bhnbjj7bkd2vrd2ji</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200307145551/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mc.23171" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/51/4b/514bf2090cade3016076d09ed7eef62de979bc0b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/mc.23171"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a>

FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures

Martinez
<span title="2010-05-27">2010</span> <i title="Spandidos Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bn3oiyuxabf5la53plxz5mrcfa" style="color: black;">Oncology Reports</a> </i> &nbsp;
Specific FGF-2 receptors were found in the malignant epithelial but not in the benign myoepithelial cells of CXPA, indicating a paracrine role for benign myoepithelial cell-derived FGF-2.  ...  Increasing emphasis has been placed on the role of myoepithelial cells, the contractile components of secretory glands, in the in situ to invasive carcinoma transition.  ...  Acknowledgements The authors wish to thank Audrey Jordão Basso, Jerusa Pinheiro and Pollyanna Tombini Montaldi for their excellent technical expertise and assistance.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3892/or_00000840">doi:10.3892/or_00000840</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20514456">pmid:20514456</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/etypb44zuzd2le3ld5yywzoigm">fatcat:etypb44zuzd2le3ld5yywzoigm</a> </span>
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Cytokeratin 5 determines maturation of the mammary myoepithelium

Vivi Deckwirth, Eeva Kaisa Rajakylä, Sandhanakrishnan Cattavarayane, Anna Acheva, Niccole Schaible, Ramaswamy Krishnan, Juan José Valle-Delgado, Monika Österberg, Pia Björkenheim, Antti Sukura, Sari Tojkander
<span title="2021-04-15">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5u6jlpnlzndwrequnssxehzurq" style="color: black;">iScience</a> </i> &nbsp;
At invasion, transformed mammary epithelial cells expand into the stroma through a disrupted myoepithelial (ME) cell layer and basement membrane (BM).  ...  Consequently, a differentiation bias toward luminal epithelial cell type was detected with loss of mature, α-SMA-expressing ME cells and reduced deposition of basement membrane protein laminin-5.  ...  Basal cytokeratin phenotypes of myoepithelial cells indicates the origin of ductal carcinomas in situ of the breast. Appl. Immunohistochem. Mol. Morphol. 23, 558-564.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2021.102413">doi:10.1016/j.isci.2021.102413</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34007958">pmid:34007958</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8111680/">pmcid:PMC8111680</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rupcpveeqbbe3i4hslxln7g55e">fatcat:rupcpveeqbbe3i4hslxln7g55e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716223716/https://acris.aalto.fi/ws/portalfiles/portal/62650987/CHEM_Deckwirth_et_al_Cytokeratin_5_determines_maturation_2021_iScience.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/00/1a004037add04aa50d5178bb9d8ef1f11e7d4a89.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2021.102413"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111680" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Intraductal administration of N-methyl-N-nitrosourea as a novel rodent mammary tumor model

Dongcheng Gao, Jianhua Liu, Jingping Yuan, Juan Wu, Xinwen Kuang, Deguang Kong, Weijie Zheng, Guannan Wang, Saraswati Sukumar, Yi Tu, Chuang Chen, Shengrong Sun
<span title="">2021</span> <i title="AME Publishing Company"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u5ioqxxruvelzolwnumjlphsfe" style="color: black;">Annals of Translational Medicine</a> </i> &nbsp;
Histopathology revealed atypical hyperplasia in the mammary gland 4 weeks after carcinogen injection, developing into carcinoma in situ 5-6 weeks after treatment, with loss of α-SMA and calponin expressions  ...  An i.duc injection of 20 µL (1 mg/per duct) MNU in the fourth rat mammary gland induced stable carcinomas in situ.  ...  arrows: sieve-like structure), (iii) ductal carcinoma, (iv) tubular carcinoma (arrow: tubule-like structure), (v) ductal carcinoma in situ (arrow: lack of myoepithelial cells), (vi) atypical hyperplasia  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21037/atm-21-1540">doi:10.21037/atm-21-1540</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33987274">pmid:33987274</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8105867/">pmcid:PMC8105867</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hamaj5yv4nepbav7ql7vvgilpi">fatcat:hamaj5yv4nepbav7ql7vvgilpi</a> </span>
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Breast

<span title="">2005</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d3f6n54x25ho7bxaem7itvedxi" style="color: black;">Laboratory Investigation</a> </i> &nbsp;
Design: Archival tissue specimens from 20 patients having lobular carcinoma of which 12 had a lobular carcinoma in-situ breast cancers were analyzed for the expression of Occludin (Zymed, pre-diluted)  ...  More recently, immunohistochemical quantification of Ki67 has been applied in routine study of proliferative activity in breast cancer.  ...  Results: While p63 and SMA marked both the myoepithelial-like cells of ACC and the myoepithelial cells of CS, calponin was negative in the myoepithelial-like cells of ACC and positive in the myoepithelial  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.labinvest.3700633">doi:10.1038/sj.labinvest.3700633</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/r3s5mw62vrhrhcbymmntqqzdja">fatcat:r3s5mw62vrhrhcbymmntqqzdja</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510193331/https://www.nature.com/articles/3700633.pdf?error=cookies_not_supported&amp;code=d34bb425-3574-411a-b111-81f3b97b6e25" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e1/bd/e1bdaed5399d8df698e6118b07bccb849ad019ad.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.labinvest.3700633"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Breast

<span title="">2005</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/l7jwciowjvhanbf3cedbhw5g2a" style="color: black;">Modern Pathology</a> </i> &nbsp;
Design: Archival tissue specimens from 20 patients having lobular carcinoma of which 12 had a lobular carcinoma in-situ breast cancers were analyzed for the expression of Occludin (Zymed, pre-diluted)  ...  More recently, immunohistochemical quantification of Ki67 has been applied in routine study of proliferative activity in breast cancer.  ...  Results: While p63 and SMA marked both the myoepithelial-like cells of ACC and the myoepithelial cells of CS, calponin was negative in the myoepithelial-like cells of ACC and positive in the myoepithelial  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.modpathol.3800906">doi:10.1038/sj.modpathol.3800906</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/r6o56hmgtbct7ksvvbne2hsjeq">fatcat:r6o56hmgtbct7ksvvbne2hsjeq</a> </span>
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Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

Lina Ding, Ying Su, Anne Fassl, Kunihiko Hinohara, Xintao Qiu, Nicholas W. Harper, Sung Jin Huh, Noga Bloushtain-Qimron, Bojana Jovanović, Muhammad Ekram, Xiaoyuan Zi, William C. Hines (+36 others)
<span title="2019-09-13">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a4wan6l5o5dfzn767kyz7jqevi" style="color: black;">Nature Communications</a> </i> &nbsp;
Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma  ...  These myoepithelial perturbations in normal breast tissues of BRCA1 germline mutation carriers may play a role in their higher risk of breast cancer.  ...  Acknowledgements We thank members of our laboratories for their critical reading of this manuscript and useful discussions. Author contributions  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-12125-5">doi:10.1038/s41467-019-12125-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31519911">pmid:31519911</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6744561/">pmcid:PMC6744561</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/e5eof2smgfhm5aynsiaw53dy2m">fatcat:e5eof2smgfhm5aynsiaw53dy2m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200312210932/https://escholarship.org/content/qt9tr503q5/qt9tr503q5.pdf?t=pzkthk" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/82/61/8261d34caa103af5d3c0deadb256ad487575d87d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-12125-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744561" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mechanobiology of tumor invasion: Engineering meets oncology

Shawn P. Carey, Timothy M. D'Alfonso, Sandra J. Shin, Cynthia A. Reinhart-King
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6xdzy3eadredziurebhmqin2mq" style="color: black;">Critical reviews in oncology/hematology</a> </i> &nbsp;
strategies that have contributed to a more robust mechanistic understanding of tumor cell invasion.  ...  Highlights • Tumor invasion, the process by which cells physically dissociate from primary tumors, is a rate-limiting step in metastasis. • Invasion depends on coordination of intracellular molecular machinery  ...  Acknowledgments This work was supported in part by the Cornell Center on the Microenvironment & Metastasis through Award Number U54CA143876 from the National Cancer Institute to CAR and SJS and by a National  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.critrevonc.2011.11.005">doi:10.1016/j.critrevonc.2011.11.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22178415">pmid:22178415</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3322250/">pmcid:PMC3322250</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uswxcahh7zd3jjt5lkfbjgk7di">fatcat:uswxcahh7zd3jjt5lkfbjgk7di</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505173345/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3322250&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/cd/c9cdf5a18b855dc4de3c99d652c65639055eb8a9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.critrevonc.2011.11.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322250" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Breast

<span title="">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/l7jwciowjvhanbf3cedbhw5g2a" style="color: black;">Modern Pathology</a> </i> &nbsp;
Background: High-grade ductal carcinoma in-situ (DCIS) is a major risk factor in the development of invasive ductal carcinoma.  ...  non--micropapillary ductal carcinoma in situ.  ...  Background: Demographic data associated with invasive ductal carcinoma (IDC) have been extensively studied; however, data is relatively limited for ductal carcinoma in situ (DCIS).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/modpathol.2010.8">doi:10.1038/modpathol.2010.8</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y46qj2kmfffmjke2zmpxxpqixa">fatcat:y46qj2kmfffmjke2zmpxxpqixa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510224341/https://www.nature.com/articles/modpathol20108.pdf?error=cookies_not_supported&amp;code=57243291-30e7-4096-b809-99ede52af8e9" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cf/bc/cfbcd54f2569dcec70bc863a4c42b1ee7dd6413a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/modpathol.2010.8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Breast

<span title="">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d3f6n54x25ho7bxaem7itvedxi" style="color: black;">Laboratory Investigation</a> </i> &nbsp;
Background: High-grade ductal carcinoma in-situ (DCIS) is a major risk factor in the development of invasive ductal carcinoma.  ...  non--micropapillary ductal carcinoma in situ.  ...  Background: Demographic data associated with invasive ductal carcinoma (IDC) have been extensively studied; however, data is relatively limited for ductal carcinoma in situ (DCIS).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/labinvest.2010.11">doi:10.1038/labinvest.2010.11</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6av6qcrh7zfivalsdlzcyomkki">fatcat:6av6qcrh7zfivalsdlzcyomkki</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718170555/https://www.nature.com/articles/labinvest201011.pdf?error=cookies_not_supported&amp;code=fccbbb8b-1722-4aed-a396-ca95b64870e1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ce/45/ce45b36cbb3f7536a838b9deffaa3ed1ed9d795c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/labinvest.2010.11"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Breast

<span title="">2008</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d3f6n54x25ho7bxaem7itvedxi" style="color: black;">Laboratory Investigation</a> </i> &nbsp;
Conclusions: A CHOP rearrangement in PLS should be recognized as only a representative part of complex karyotypic feature, because the number of cells with split signals was surely minute compared with  ...  tissue sections of representative areas in all cases.  ...  Results: Calponin, p63, D2-40 and CD10 highlighted the myoepithelial cells in all cases. The stromal cells in both FA and PT were uniformly positive for calponin and negative for p63.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.labinvest.3700724">doi:10.1038/sj.labinvest.3700724</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5gvygglkinhvhcr7qaaz23qmru">fatcat:5gvygglkinhvhcr7qaaz23qmru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200315125723/https://www.nature.com/articles/3700724.pdf?error=cookies_not_supported&amp;code=b273fdf5-d327-4695-8dc8-9353df684b9f" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/19/bf/19bfea8c0a4f618ffd34584beab909bec9fa99aa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.labinvest.3700724"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB

Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z. Wu, Laura A. Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N. Skhinas, Thomas R. Cox, Bhupinder Pal, Nicholas D. Huntington (+5 others)
<span title="2021-01-20">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5u6jlpnlzndwrequnssxehzurq" style="color: black;">iScience</a> </i> &nbsp;
Here, we show that ID4 has a cell autonomous role in preventing myoepithelial differentiation of basal cells in mammary organoids and in vivo.  ...  We conclude that high ID4 expression in mammary basal stem cells antagonizes HEB transcriptional activity, preventing myoepithelial differentiation and allowing for appropriate tissue morphogenesis.  ...  Quantification of fluorescence demonstrated that ID4 was more highly expressed in cap cells of TEBs than in basal cells of ducts, whereas the opposite was true for a-SMA expression ( Figures 2E and 2F  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2021.102072">doi:10.1016/j.isci.2021.102072</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33554073">pmid:33554073</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7851187/">pmcid:PMC7851187</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xkda2m4d7bbcrd2vxlcpguluwa">fatcat:xkda2m4d7bbcrd2vxlcpguluwa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718000000/https://minerva-access.unimelb.edu.au/bitstream/handle/11343/272914/PMC7851187.pdf;jsessionid=15062B7AE52603CC2EAE1F03D21633C3?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/15/62/1562ee3c3d31d417f58cad42fb770bbd87acc739.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2021.102072"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851187" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Recent advances in molecular genetics of breast cancer

Krešimir Pavelić, Koraljka Gall-Trošelj
<span title="2001-07-26">2001</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sxg7t24bwnd7lk7suovmj5tgla" style="color: black;">Journal of Molecular Medicine</a> </i> &nbsp;
The rate of in situ carcinomas was only 3.24%, with a predominance of high and intermediate grade of ductal in situ carcinomas.  ...  Moreover, we observed that p63 helps identify myoepithelial cells overlying malignant cell clusters that we found consistently in cases of ductal carcinoma in situ.  ...  MUCINOUS COLORECTAL CARCINOMAS IN EFFECT OF MORPHOLOGIC CELL TYPES ON THE EXPRESSION OF BCL-2, KI-67 AND P-53 IN UVEAL MELANOMAS A. Krvavica 1 , J. Talan-HraniloviÊ 2 , M.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s001090100256">doi:10.1007/s001090100256</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11692153">pmid:11692153</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lskqd5dn6ffwzggjvyzuykkd64">fatcat:lskqd5dn6ffwzggjvyzuykkd64</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501180349/https://hrcak.srce.hr/file/23039" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dd/2f/dd2fcb711d927dbb99e2ed1cd61c77725e0fe6fd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s001090100256"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>
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