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Neuroradiological evaluation of demyelinating disease

Jan-Mendelt Tillema, Istvan Pirko
2013 Therapeutic Advances in Neurological Disorders  
Neuroimaging plays a central role in the accurate diagnosis, prognosis, disease monitoring and research efforts that are being undertaken in this disease.  ...  Central nervous system inflammatory demyelinating disease can affect patients across the life span.  ...  Conflict of interest statement The authors declare no conflicts of interest in preparing this article.  ... 
doi:10.1177/1756285613478870 pmid:23858328 pmcid:PMC3707351 fatcat:46hkt7vdv5hjnk35r6kvjixuhy

Quantifying disease progression in amyotrophic lateral sclerosis

Neil G. Simon, Martin R. Turner, Steve Vucic, Ammar Al-Chalabi, Jeremy Shefner, Catherine Lomen-Hoerth, Matthew C. Kiernan
2014 Annals of Neurology  
(A) The corticospinal tracts (CST) can be reconstructed using diffusion tensor tractography.  ...  of patients with clinical and progression data (for example via the PRO-ACT database 18 ) may provide a mechanism to predict disease progression prospectively.  ... 
doi:10.1002/ana.24273 pmid:25223628 pmcid:PMC4305209 fatcat:wdhstxlt55eanb7j5ihyoeivpi

MRI Prognostic Factors in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Antibody Disease

Rosa Cortese, Antonio Giorgio, Gianmarco Severa, Nicola De Stefano
2021 Frontiers in Neurology  
Several MRI measures have been developed in the last couple of decades, providing a number of imaging biomarkers that can capture the complexity of the pathological processes occurring in multiple sclerosis  ...  Moreover, the process of identifying new effective therapies for MS patients has been supported by the use of serial MRI examinations in order to sensitively detect the sub-clinical effects of disease-modifying  ...  Temporal dynamics of diffusion metrics in early multiple sclerosis and clinically isolated syndrome: a 2-year follow-up tract-based spatial statistics study. Front Neurol.  ... 
doi:10.3389/fneur.2021.679881 pmid:34867701 pmcid:PMC8636325 fatcat:hktdfscaevfz3pppabwiba7nla

Multimodal MRI of Cerebral Small Vessel Disease [chapter]

Bence Gunda, Gyrgy Vrallyay, Dniel Bereczki
2012 Neuroimaging - Clinical Applications  
By measuring diffusion from several directions the net orientation of axons in a voxel of white matter can be determined as a 3 dimensional vector -a "tensor".  ...  This method has been used to specifically localize small infarcts with regard to the functional pathway of the CST with good topographical accuracy [38] [39] [40] .  ...  The scope of this book is not to provide a comprehensive overview of methods and their clinical applications but to provide a "snapshot" of current approaches using well established and newly emerging  ... 
doi:10.5772/25045 fatcat:gcsqo2wjabe6zodltzj7anad6q

Picturing Multiple Sclerosis: Conventional and Diffusion Tensor Imaging

Robert Fox
2008 Seminars in neurology  
Several advanced imaging methodologies such as diffusion tensor imaging (DTI) provide a greater dynamic range for evaluating tissue integrity.  ...  A greater appreciation of the classic imaging characteristics of MS and their relevance to the disease process can help the clinician in both the accurate diagnosis and successful management of patients  ...  Figure 10 10 Diffusion tensor images from a patient with multiple sclerosis.  ... 
doi:10.1055/s-0028-1083689 pmid:18843574 fatcat:qfz4uhjqqfcxbnoc7gu3xhczdy

Cerebellum and neurodegenerative diseases: Beyond conventional magnetic resonance imaging

Enricomaria Mormina, Maria Petracca, Giulia Bommarito, Niccolò Piaggio, Sirio Cocozza, Matilde Inglese
2017 World Journal of Radiology  
and by a discussion of the clinical relevance of MRI measures of cerebellar damage in terms of both clinical status and cognitive performance.  ...  In the present review, after providing a brief description of each technique's advantages and limitations, we focus on their application to the study of cerebellar injury in major neurodegenerative diseases  ...  MRI AND CLINICAL APPLICATIONS ON NEURODEGENERATIVE DISEASES Multiple sclerosis Multiple Sclerosis (MS) is an inflammatory/demyelinating disease of the central nervous system (CNS) chara cterized by  ... 
doi:10.4329/wjr.v9.i10.371 pmid:29104740 pmcid:PMC5661166 fatcat:m5c4cnc2bzagpdipk57mssmo6e

DTI Measurements in Multiple Sclerosis: Evaluation of Brain Damage and Clinical Implications

Emilia Sbardella, Francesca Tona, Nikolaos Petsas, Patrizia Pantano
2013 Multiple Sclerosis International  
Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results.  ...  In this paper, we examine the DTI analysis methods, the results obtained in the various tissues of the central nervous system, and correlations with clinical features and other MRI parameters.  ...  ., "Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study, " Radiology, vol. 260, no. 2, pp. 541-  ... 
doi:10.1155/2013/671730 pmid:23606965 pmcid:PMC3628664 fatcat:dphi7chb6zdwnb7lwsofxfoopy

Biomarkers and surrogate outcomes in neurodegenerative disease: Lessons from multiple sclerosis

David H. Miller
2004 Neurotherapeutics  
Multiple sclerosis (MS) is a chronic disease of the CNS that most commonly affects young adults.  ...  Because of the protracted and unpredictable clinical course, biological surrogate markers are much needed to make clinical trials of potential disease-modifying treatments more efficient.  ...  THE CLINICAL COURSE AND PATHOLOGICAL BASIS OF MULTIPLE SCLEROSIS Multiple sclerosis (MS) is a chronic disorder of the CNS.  ... 
doi:10.1007/bf03206612 fatcat:oz5bbfl37bb5bfwwk52rkfrkjm

Biomarkers and surrogate outcomes in neurodegenerative disease: Lessons from multiple sclerosis

David H. Miller
2004 NeuroRx  
Multiple sclerosis (MS) is a chronic disease of the CNS that most commonly affects young adults.  ...  Because of the protracted and unpredictable clinical course, biological surrogate markers are much needed to make clinical trials of potential disease-modifying treatments more efficient.  ...  THE CLINICAL COURSE AND PATHOLOGICAL BASIS OF MULTIPLE SCLEROSIS Multiple sclerosis (MS) is a chronic disorder of the CNS.  ... 
doi:10.1602/neurorx.1.2.284 pmid:15717029 pmcid:PMC534945 fatcat:uwst5dap2zespnovpwo7ticicq

Neuroimaging in Multiple Sclerosis [chapter]

Elisabeth Andreadou
2012 Neuroimaging - Clinical Applications  
made in patients with clinically isolated syndrome (CIS) (McDonald et al., 2001) .  ...  Apparently MRI started to play a prominent role in establishing a firm and clear diagnosis of multiple sclerosis and predicting conversion to clinically definite MS in patients who present with a first  ...  The scope of this book is not to provide a comprehensive overview of methods and their clinical applications but to provide a "snapshot" of current approaches using well established and newly emerging  ... 
doi:10.5772/24069 fatcat:dk3zwfkz6jhctdrgmrhj2hwhaq

Just pretty pictures? What diffusion tractography can add in clinical neuroscience

Heidi Johansen-Berg, Timothy EJ Behrens
2006 Current Opinion in Neurology  
comparisons of specific white matter pathways in disease; second, evidence from tractography for the presence of qualitatively different pathways in congenital disorders or following recovery; third,  ...  This raises immediate possibilities for clinical application but responsible use of this approach requires careful consideration of the scope and limitations of the technique.  ...  Acknowledgments We are grateful to The Wellcome Trust (HJB) and Medical Research Council (TEJB) for funding and to Derek Jones for useful discussion.  ... 
doi:10.1097/01.wco.0000236618.82086.01 pmid:16914977 pmcid:PMC3119814 fatcat:snvopu55bfgilfb3wg5yiypu5u

Dilated Virchow-Robin space and Parkinson's disease: A case report of combined MRI and diffusion tensor imaging

Renata Conforti, Angela Sardaro, Alberto Negro, Giuseppina Caiazzo, Antonella Paccone, Rosita De Micco, Sossio Cirillo, Alessandro Tessitore
2018 Radiology Case Reports  
Parkinson's disease Magnetic resonance imaging (MRI) Diffusion tensor imaging (DTI) a b s t r a c t In this manuscript we report the case of a 69-year-old female patient, who suffers from Parkinson's disease  ...  In the text a review of the recent literature on the presence of dVRSs, located in mono and bilateral seat, in patients with PD is reported, explaining its possible implications on disease progression,  ...  Diffusion tensor is a neuroimaging modality in the diagnosis and evaluation of numerous diseases of the nervous system.  ... 
doi:10.1016/j.radcr.2018.05.011 pmid:29988793 pmcid:PMC6031236 fatcat:r4pm4qcv5vevvmbjwk3zdzhaym

Quantifying Disease Pathology and Predicting Diseaffse Progression in Multiple Sclerosis with only Clinical Routine T2-FLAIR MRI

Tom A Fuchs, Michael Dwyer, Dejan Jakimovski, Niels Bergsland, Deepa Ramasamy, Bianca Weinstock-Guttman, Ralph HB Benedict, Robert Zivadinov
2021 NeuroImage: Clinical  
Although quantitative measures from research-quality MRI provide a means to study multiple sclerosis (MS) pathology in vivo, these metrics are often unavailable in legacy clinical datasets.  ...  The combination of the five T2-FLAIR measures explained most of the variance in standard research-quality MRI.  ...  ACKNOWLEDGMENTS The method for medulla oblongata volume measurement was developed with partial funding support by Mark Diamond Research Fund, Grant ID# FA-10-12.  ... 
doi:10.1016/j.nicl.2021.102705 pmid:34091352 fatcat:cxh56kcd5jd23azw7u73g5agru

The contribution of MRI in assessing cognitive impairment in multiple sclerosis

M. Filippi, M. A. Rocca, R. H. B. Benedict, J. DeLuca, J. J. G. Geurts, S. A. R. B. Rombouts, M. Ron, G. Comi
2010 Neurology  
Following an updated overview of the assessment methods and profile of cognitive impairment in patients with MS, this review provides a state-of-the-art summary of the main results obtained from the application  ...  Cognitive impairment affects a large proportion of patients with multiple sclerosis (MS) and has a profound impact on their daily-life activities.  ...  a clinically isolated syndrome (CIS) has been found to predict poor executive function when patients were cognitively examined years later, suggesting that early and widespread inflammatory damage to  ... 
doi:10.1212/wnl.0b013e318200d768 pmid:21135387 pmcid:PMC3385423 fatcat:jz72dhpfnncvjdtin2gefldfw4

Profiling morphologic MRI features of motor neuron disease caused by TARDBP mutations

Edoardo Gioele Spinelli, Edoardo Gioele Spinelli, Alma Ghirelli, Alma Ghirelli, Alma Ghirelli, Nilo Riva, Nilo Riva, Elisa Canu, Veronica Castelnovo, Teuta Domi, Laura Pozzi, Paola Carrera (+11 others)
2022 Frontiers in Neurology  
Patients underwent clinical and cognitive evaluations, as well as 3D T1-weighted and diffusion tensor (DT) MRI on a 3 Tesla scanner.  ...  ObjectiveMutations in the TARDBP gene are a rare cause of genetic motor neuron disease (MND). Morphologic MRI characteristics of MND patients carrying this mutation have been poorly described.  ...  In the present cohort, all patients carrying mutations in the TARDBP gene presented with a pure MND phenotype, as no patient fulfilled established clinical criteria for a defined FTD syndrome (61, 62)  ... 
doi:10.3389/fneur.2022.931006 pmid:35911889 pmcid:PMC9334911 doaj:6047c59f82b24d8bb3680aaeef13b7bb fatcat:42lkhex4rrbdtnzffdoqsm267y
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