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A generic Deep Convolutional Neural Network framework for prediction of Receptor-ligand Interactions. NetPhosPan; Application to Kinase Phosphorylation prediction

Emilio Fenoy, Jose M G Izarzugaza, Vanessa Jurtz, Søren Brunak, Morten Nielsen, John Hancock
2018 Bioinformatics  
The framework is based on deep artificial neural networks and integrates information from individual receptors into a single pan-receptor model, leveraging information across multiple receptor-specific  ...  Motivation: Understanding the specificity of protein receptor-ligand interactions is pivotal for our comprehension of biological mechanisms and systems.  ...  , and finally, MusiteDeep is a kinase-specific predictor based on deep convolutional neural networks trained on data spanning 5 kinase families, covering 61 kinases.  ... 
doi:10.1093/bioinformatics/bty715 pmid:30169744 fatcat:7mqjjpoh2nfbvolb2evrperbie