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Cortical reorganisation in patients with MS

M Filippi
2004 Journal of Neurology, Neurosurgery and Psychiatry  
This is demonstrated in patients with SPMS 18 and in patients with clinically definite MS and non-specific (less than three lesions) conventional MRI findings. 19 Is the extent of functional cortical  ...  patients with relapsing 16 27 31 and PP 32 MS. and DW MRI, has been found to modulate the activity of some cortical areas.  ...  proteins. 3 4 Thus, detection of antineuronal autoantibodies in a patient with a progressive neurological disorder may allow the diagnosis of a paraneoplastic syndrome and also provide information about  ... 
doi:10.1136/jnnp.2004.036020 pmid:15258204 pmcid:PMC1739161 fatcat:vecowp5lofci5b7bfs7mfxnogu

Recommended diagnostic criteria for paraneoplastic neurological syndromes

J E Greenlee
2004 Journal of Neurology, Neurosurgery and Psychiatry  
This is demonstrated in patients with SPMS 18 and in patients with clinically definite MS and non-specific (less than three lesions) conventional MRI findings. 19 Is the extent of functional cortical  ...  patients with relapsing 16 27 31 and PP 32 MS. and DW MRI, has been found to modulate the activity of some cortical areas.  ...  proteins. 3 4 Thus, detection of antineuronal autoantibodies in a patient with a progressive neurological disorder may allow the diagnosis of a paraneoplastic syndrome and also provide information about  ... 
doi:10.1136/jnnp.2004.038489 pmid:15258205 pmcid:PMC1739162 fatcat:5z2h5itf55emromqop7hp67jh4

The Role of fMRI to Assess Plasticity of the Motor System in MS

Patrizia Pantano, Nikolaos Petsas, Francesca Tona, Emilia Sbardella
2015 Frontiers in Neurology  
Increased cortical activity during the performance of the same simple motor task was also observed in patients with primary progressive MS (3).  ...  CONCLUSION Functional MRI studies exploring the motor system in MS have demonstrated the ability of the brain to reorganize itself as a response to the disease.  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fneur.2015.00055 pmid:25852634 pmcid:PMC4360702 fatcat:d6l4ztsevjc7floxe6honxobaa

Gray Matter Density of Auditory Association Cortex Relates to Knowledge of Sound Concepts in Primary Progressive Aphasia

M. F. Bonner, M. Grossman
2012 Journal of Neuroscience  
Structural MRI analysis in lvPPA revealed gray matter atrophy in auditory association cortex, as defined functionally in a separate BOLD fMRI study of healthy adults.  ...  Human participants with the logopenic variant of primary progressive aphasia (lvPPA) performed a recognition task on words with strong associations in three modalities: Sound, Sight, and Manipulation.  ...  However, these studies have not examined the convergence of fMRI findings in healthy adults with structural MRI of cortical atrophy, and we are unaware of studies assessing sound-related words in individuals  ... 
doi:10.1523/jneurosci.6241-11.2012 pmid:22674273 pmcid:PMC3392081 fatcat:txdmibmrejgqha3hge3sge32z4

Sound naming in neurodegenerative disease

Maggie L. Chow, Simona M. Brambati, Maria Luisa Gorno-Tempini, Bruce L. Miller, Julene K. Johnson
2010 Brain and Cognition  
In particular, the CBD/PSP patients scored the lowest when naming sounds of manipulable objects (p<0.05), but did not show deficits in naming sounds of non-manipulable objects.  ...  To test this hypothesis, we examined the naming of environmental sounds in patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), two neurodegenerative diseases associated  ...  lobule, intraparietal sulcus, and posterior middle temporal gyrus were activated in a functional MRI paradigm.  ... 
doi:10.1016/j.bandc.2009.12.003 pmid:20089342 pmcid:PMC2832081 fatcat:q3lnghujwzcc5jfy3m27ofts7u

Representation of Manipulable Man-Made Objects in the Dorsal Stream

Linda L. Chao, Alex Martin
2000 NeuroImage  
In humans and monkeys, there appears to be a close link between manipulable objects and information about the actions associated with their use.  ...  We used fMRI to examine the neural response in frontal and parietal cortices associated with viewing and naming pictures of different categories of objects.  ...  In the current studies, we used functional magnetic resonance imaging (fMRI) to examine the neural responses in frontal and parietal cortices associated with viewing and naming pictures of tools relative  ... 
doi:10.1006/nimg.2000.0635 pmid:10988041 fatcat:p4scmbuq5zgdparfidvi4x5qii

Functional, anatomical and diffusion tensor MRI study of radiology expertise

David J. Ouellette, Eric Van Staalduinen, Syed H. Hussaini, Sindhuja T. Govindarajan, Patricia Stefancin, Dan-Ling Hsu, Timothy Q. Duong, Kai Yuan
2020 PLoS ONE  
Some brain circuits appear to be uniquely associated with differential-diagnosis paradigm expertise that are not involved in simpler object-recognition cases.  ...  The goal of this study is to use task fMRI to study the brain of expert radiologists performing a diagnosis task where a series of medical images were presented during fMRI acquisition for 12s and participants  ...  The main goal of this study is to use task fMRI to study the brain of expert radiologists while performing a difficult diagnosis task in which a series of medical images with a brief patient history are  ... 
doi:10.1371/journal.pone.0231900 pmid:32339188 fatcat:3xm4d4wtjjh4nm7yrde6nhjffu

Investigation of the neural correlates underlying action observation in multiple sclerosis patients

Andrea C. Pierno, Luca Turella, Paola Grossi, Federico Tubaldi, Massimiliano Calabrese, Paola Perini, Luigi Barachino, Aldo Morra, Paolo Gallo, Umberto Castiello
2009 Experimental Neurology  
Our findings are in line with previous fMRI evidence demonstrating cortical reorganization in MS patients during action observation.  ...  Recent fMRI evidence indicates that both the execution and the observation of hand actions in multiple sclerosis (MS) patients increase recruitment of a portion of the so-called mirror neuron system.  ...  Rather it seems to be the expression of an adaptive but unspecific functional cortical change needs to be put in place by MS patients as to maintain a suitable level of function whatever the task at hand  ... 
doi:10.1016/j.expneurol.2009.02.016 pmid:19285072 fatcat:gaghpmpsurbfdeqr3nauuvmcfm

Functional Magnetic Resonance Imaging [chapter]

M. Filippi, M. A. Rocca
2002 Primary Progressive Multiple Sclerosis  
Cortex 2008 Own child versus other child Healthy subjects: object manipulation MS patients: simple motor task Filippi et al., NeuroImage 2004 Object manipulation MNS task fMRI Clinical applications  ...  p = 0.02) and MD (In fMRI data acquired at rest (i.e., in absence of external stimulation), several studies have shown the presence of spontaneous low-frequency (0.01-0.1 Hz) fluctuations with high temporal  ...  Heterogeneity in frequency of fMRI activity between cord levels: p<0. 001 (highest frequencies at C6 and C7)  ... 
doi:10.1007/978-88-470-2234-8_11 fatcat:kgi7neqiebfbxaiufpovk6fnaa

Test-Retest Reliability of fMRI During Nonverbal Semantic Decisions in Moderate-Severe Nonfluent Aphasia Patients

Jacquie Kurland, Margaret A. Naeser, Errol H. Baker, Karl Doron, Paula I. Martin, Heidi E. Seekins, Andrew Bogdan, Perry Renshaw, Deborah Yurgelun-Todd
2004 Behavioural Neurology  
Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted  ...  Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery.  ...  Recently, Fridriksson and Morrow [9] examined changes in cortical activation as a result of manipulating task difficulty on a picture-word verification task.  ... 
doi:10.1155/2004/974094 pmid:15706052 pmcid:PMC1434895 fatcat:b3juthkgnbgttiwch4o7m7lzwm

Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing–remitting MS

Katrin Morgen, Gebhard Sammer, Susan M. Courtney, Tobias Wolters, Hanne Melchior, Carlo R. Blecker, Patrick Oschmann, Manfred Kaps, Dieter Vaitl
2006 NeuroImage  
These findings indicate that MS-related deficits in cognition are closely associated with cortical atrophy. D  ...  Here, we examined the association between neuropsychological test performance and brain atrophy in a group of mildly disabled patients with relapsing -remitting MS.  ...  Acknowledgments We wish to thank Sabine Vogel, Britta Thomé, Petra Mü tze and the entire MS clinic team for their valuable support.  ... 
doi:10.1016/j.neuroimage.2005.10.032 pmid:16360321 fatcat:3ea5qtssvjcrbe644ajwwvucae

Neuropsychiatric Manifestations of Multiple Sclerosis

Laura C. Politte, Jeff C. Huffman, Theodore A. Stern
2008 The Primary Care Companion to the Journal Clinical Psychiatry  
The authors report no sources of financial or material support for this article. This information has not been previously presented.  ...  tasks mirrors findings from studies of motor deficits in MS patients.  ...  Rates of suicide are also significantly higher in those with MS, and in 1 study, depression superceded physical disability and cognitive function as a significant determinant of quality of life. 13 Several  ... 
doi:10.4088/pcc.v10n0408 pmid:18787677 pmcid:PMC2528238 fatcat:6qvbkplyvfd6hi7mk7ty7weuuq

Functional neuroanatomy of speech signal decoding in primary progressive aphasias

Chris J.D. Hardy, Jennifer L. Agustus, Charles R. Marshall, Camilla N. Clark, Lucy L. Russell, Emilie V. Brotherhood, Rebecca L. Bond, Cassidy M. Fiford, Sasha Ondobaka, David L. Thomas, Sebastian J. Crutch, Jonathan D. Rohrer (+1 others)
2017 Neurobiology of Aging  
Here, we addressed this issue using activation fMRI in a cohort of 27 patients with primary progressive aphasia (nonfluent, semantic, and logopenic variants) versus 15 healthy controls.  ...  Semantic variant patients had relatively reduced activation of caudate and anterior cingulate in response to increased entropy.  ...  They thank Helen Mackenzie and her fellow radiographers at the National Hospital for Neurology and Neurosurgery for assistance with MRI scanning and Dr Doris-Eva Bamiou for providing the audiometer.  ... 
doi:10.1016/j.neurobiolaging.2017.04.026 pmid:28571652 pmcid:PMC5476347 fatcat:jp73t4c2lzaklfazhfrhqle7iu

Thematic knowledge, artifact concepts, and the left posterior temporal lobe: Where action and object semantics converge

Solène Kalénine, Laurel J. Buxbaum
2016 Cortex  
of 48 stroke patients with a range of lesion foci in the left hemisphere.  ...  LTO and visual motion area hMT+, were associated both with relatively slower response times in identifying thematic relations for artifacts and poorer artifact action knowledge in patients.  ...  Acknowledgments We appreciate the help of H. Branch Coslett with lesion identification and Alexis Kington with testing patients. This research was funded by NIH grant R01-NS065049 to Laurel Buxbaum.  ... 
doi:10.1016/j.cortex.2016.06.008 pmid:27389801 pmcid:PMC4969110 fatcat:f54hi5rjqjhu7j6xadd5bncfjy

Impaired motor control due to proprioceptive sensory loss in a patient with cerebral infarction localized to the postcentral gyrus

H Kato, M Izumiyama
2015 Journal of Rehabilitation Medicine  
Conclusion: Loss of motor control may occur even with a normal corticospinal tract when proprioception is severely impaired by dysfunction of the sensorimotor network in the brain.  ...  Objective: Most rehabilitative interventions following stroke emphasize the improvement of motor deficits but rarely address sensory function and sensorimotor control.  ...  ACKNOWLEDGEMENTS The authors would like to thank Mr Katsuhiro Aki at the MRI section of Sendai Nakae Hospital for his help in performing the fMRI studies, and Ms Saika Kanno (occupational therapist) and  ... 
doi:10.2340/16501977-1900 pmid:25268114 fatcat:bg3rzlyl3ff7pfkiwtv4fu3gp4
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