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A Deep Learning Model for Automated Sub-Basal Corneal Nerve Segmentation and Evaluation Using In Vivo Confocal Microscopy

Shanshan Wei, Faqiang Shi, Yuexin Wang, Yilin Chou, Xuemin Li
2020 Translational Vision Science & Technology  
We established a deep learning model, CNS-Net, which demonstrated a high accuracy and fast speed in sub-basal corneal nerve segmentation with IVCM.  ...  The purpose of this study was to establish a deep learning model for automated sub-basal corneal nerve fiber (CNF) segmentation and evaluation with in vivo confocal microscopy (IVCM).  ...  Acknowledgments The research was supported by the National Science and Technology Major Project 2018ZX10101004003003. Disclosure: S. Wei, None; F. Shi, None; Y. Wang, None; Y. Chou, None; X.  ... 
doi:10.1167/tvst.9.2.32 pmid:32832205 pmcid:PMC7414615 fatcat:ig2rr42czvaxropcpgzz5h4bju

An Automatic Corneal Subbasal Nerve Registration System Using FFT and Phase Correlation Techniques for an Accurate DPN Diagnosis

Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S. Al-Waisy, Stan Ipsopn
2015 2015 IEEE International Conference on Computer and Information Technology; Ubiquitous Computing and Communications; Dependable, Autonomic and Secure Computing; Pervasive Intelligence and Computing  
Confocal microscopy is employed as a fast and non-invasive way to capture a sequence of images from different layers and membranes of the cornea.  ...  In this paper, an automatic corneal subbasal nerve registration system is proposed.  ...  Image Segmentation In this paper, the nerve tracing task is performed using a fully automatic corneal sub-basal nerve segmentation system.  ... 
doi:10.1109/cit/iucc/dasc/picom.2015.157 dblp:conf/IEEEcit/Al-FahdawiQAI15 fatcat:hqirye6rebdorcf7yfkxp7um3q

Deep learning-based analysis of macaque corneal sub-basal nerve fibers in confocal microscopy images

Jonathan D. Oakley, Daniel B. Russakoff, Megan E. McCarron, Rachel L. Weinberg, Jessica M. Izzi, Stuti L. Misra, Charles N. McGhee, Joseph L. Mankowski
2020 Eye and Vision  
To develop and validate a deep learning-based approach to the fully-automated analysis of macaque corneal sub-basal nerves using in vivo confocal microscopy (IVCM).  ...  Deep learning-based segmentation of sub-basal nerves in IVCM images shows high to very high correlation to manual segmentations in macaque data and is indistinguishable across readers.  ...  the sub-basal layer.  ... 
doi:10.1186/s40662-020-00192-5 pmid:32420401 pmcid:PMC7206808 fatcat:3tdcia4mp5f6ff6iqafhvzya2u

Automatic corneal nerve fiber segmentation and geometric biomarker quantification

Dan Zhang, Fan Huang, Maziyar Khansari, Tos T. J. M. Berendschot, Xiayu Xu, Behdad Dashtbozorg, Yue Sun, Jiong Zhang, Tao Tan
2020 The European Physical Journal Plus  
In this paper, we establish a fully convolutional network method to precisely enhance and segment corneal nerve fibers in microscopy images.  ...  Currently, most of the analysis are performed based on manual annotations of the nerve fiber segments, while a fully automatic corneal nerve fiber extraction and analysis framework is still needed.  ...  We also validate both our segmentation and tortuosity measurement methods on the corneal nerve tortuosity (CNT) dataset [43] which consists of 30 images from the sub-basal corneal nerve plexus, acquired  ... 
doi:10.1140/epjp/s13360-020-00127-y fatcat:li72mbtawbh7jmuiyqqqfhsw7m

A fully automated tortuosity quantification system with application to corneal nerve fibres in confocal microscopy images

Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Pedram Hamrah, Emanuele Trucco
2016 Medical Image Analysis  
We thank the VAMPIRE project members for useful discussions. We are also grateful to the anonymous reviewers for their valuable comments and suggestions, which contributed to improve this paper.  ...  Hamrah is supported by the National Eye Institute Grant R01EY022695, Falk Medical Research Trust and Research to Prevent Career Development Award.  ...  A C C E P T E D M A N U S C R I P T Figure 10 : Examples from segmentation experiments. First row: original images showing corneal nerve fibres in the subbasal layer.  ... 
doi:10.1016/ pmid:27136674 fatcat:cl3ropkdwfabpbaiehm6ffcq4e

Application of generative adversarial networks (GAN) for ophthalmology image domains: a survey

Aram You, Jin Kuk Kim, Ik Hee Ryu, Tae Keun Yoo
2022 Eye and Vision  
A generative adversarial network (GAN), which consists of two competing types of deep neural networks, including a generator and a discriminator, has demonstrated remarkable performance in image synthesis  ...  The search identified 48 peer-reviewed papers in the final review. The type of GAN used in the analysis, task, imaging domain, and the outcome were collected to verify the usefulness of the GAN.  ...  [37] Conditional GAN In vivo corneal confocal microscopy images Sub-basal nerves Automatic segmentation of sub-basal nerves in in vivo confocal microscopy images was performed using the U-Net and  ... 
doi:10.1186/s40662-022-00277-3 pmid:35109930 pmcid:PMC8808986 fatcat:z3oycm6ybrbs5bgrinxqba6g64

Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities

Adrian Guerrero-Moreno, Christophe Baudouin, Stéphane Melik Parsadaniantz, Annabelle Réaux-Le Goazigo
2020 Frontiers in Cellular Neuroscience  
Ocular pain, in particular, that driven by corneal nerves, is considered to be a core symptom of inflammatory and traumatic disorders of the ocular surface.  ...  A better understanding of the corneal nerve abnormalities as well as neuroimmune interactions may contribute to the identification of a novel therapeutic targets for alleviating corneal pain.  ...  Excellent reviews have described the broad changes in the sub-basal nerve layer by using IVCM imaging in healthy controls and patients (Cruzat et al., 2017; Al-Aqaba et al., 2019; Labetoulle et al., 2019  ... 
doi:10.3389/fncel.2020.610342 pmid:33362474 pmcid:PMC7758484 fatcat:ttxr4ugw35b4xazurcqtqjjkba

Eye [chapter]

Leandro Teixeira, Richard R. Dubielzig
2013 Haschek and Rousseaux's Handbook of Toxicologic Pathology  
The lamination in this epithelium consists of a deep layer of basal cells resting on a basal lamina, an intermediate layer of wing cells, and a surface composed of one to several layers of squamous cells  ...  It is also involved in formation of the orbital connective tissues and nerves, the extraocular muscles, and the sub-epidermal layers of the eyelids.  ... 
doi:10.1016/b978-0-12-415759-0.00053-4 fatcat:3kl6az2vo5dxpgbhey2qzwggdu

Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty

Wen-jia Xie, Ye-sheng Xu, Xia Zhang, Yu-feng Yao
2018 Journal of Zhejiang University SCIENCE B  
Methods: This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period.  ...  DALK did not induce a significant change in tear volume compared with the fellow eye.  ...  Similar to other corneal surgeries, such as laser in situ keratomileusis (LASIK), the impaired sub-basal and stromal nerves induced by corneal transplantation usually cause postoperative corneal hypoesthesia  ... 
doi:10.1631/jzus.b1700095 pmid:29504315 pmcid:PMC5854637 fatcat:jlamehscgfdzzd5rdytw7vmyom

New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency - Review from the European Vision Institute (EVI) Special Interest Focus Group Meeting

Simona L. Schlereth, Deniz Hos, Mario Matthaei, Pedram Hamrah, Leopold Schmetterer, Olivia O'Leary, Christoph Ullmer, Jens Horstmann, Felix Bock, Katrin Wacker, Hannes Schröder, Maria Notara (+8 others)
2020 Ophthalmic Research  
To discuss and evaluate new technologies for a better diagnosis of corneal diseases and limbal stem cell deficiency the outcomes of a consensus process within the European Vision Institute ((EVI), and  ...  of a workshop at the University of Cologne) are outlined.  ...  Acknowledgement The authors thank the organizers for the professional realization of the meeting.  ... 
doi:10.1159/000509954 pmid:32634808 fatcat:ai72n44iwrg4thlwg7vzj7qwxm

Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography

Maciej Wojtkowski, Bartosz L. Sikorski, Iwona Gorczynska, Michalina Gora, Maciej Szkulmowski, Danuta Bukowska, Jakub Kaluzny, James G. Fujimoto, Andrzej Kowalczyk
2009 Optics Express  
A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps.  ...  The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 μm) spectral OCT prototype instrument operating in the ophthalmology clinic.  ...  IV. automatic segmentation of the entire set of three-dimensional data and identification of lines representing the basal part of the RPE and the IS/OS junction. b.  ... 
doi:10.1364/oe.17.004189 pmid:19259255 pmcid:PMC2743201 fatcat:zwfyw7pv3vgi7cgrhuaodic2pu

Automatic macular edema identification and characterization using OCT images

Gabriela Samagaio, Aída Estévez, Joaquim de Moura, Jorge Novo, María Isabel Fernández, Marcos Ortega
2018 Computer Methods and Programs in Biomedicine  
The Optical Coherence Tomography (OCT) consists of a non-invasive and contactless medical image technique that evaluates in vivo the histopathology of the tissue.  ...  Therefore, the proposed project aims to develop an automatic system capable of detecting and characterizing these three types of ME using OCT images.  ...  A.2 Conferences  ... 
doi:10.1016/j.cmpb.2018.05.033 pmid:30119857 fatcat:aqvrmoq2wnbxvfyo6ltix5kmtm

Corticosteroids and Anti-Complement Therapy in Retinal Diseases [chapter]

Raja Narayanan, Baruch D. Kuppermann
2016 Handbook of Experimental Pharmacology  
Acknowledgments This was supported in part by the NIH grants EY022097, EY024072, and EY018940 and the US FDA grants FD004929 and FD004719. The authors are thankful to Dr. Ryan A.  ...  Conflict of Interest Johns Hopkins has filed a patent application on the use of technology to modulate the levels of ANGPTL4 for the treatment of ocular neovascular disease (US patent 14/394, 152).  ...  The epithelium is comprised of a basal layer of columnar cells, two to three layers of wing cells, and one or two outermost layers of squamous superficial cells.  ... 
doi:10.1007/164_2016_22 pmid:27815789 fatcat:i5n3rqpvk5dwpp2xmlzh6aq4ei


2013 Der Ophthalmologe  
OCT was used to study the effects of both endotamponades on retinal layers by using a newly developed sub-segmentation algorithm for thickness measurements. Methods. Nine patients were included.  ...  quantify the data about density of corneal nerve fibers in connection with the form of diabetic retinopathy.  ...  In addition, hard exudates could be segmented automatically based on depolarizing properties of the retina and the corresponding pathologies.  ... 
doi:10.1007/s00347-013-2942-7 pmid:23949844 fatcat:q26cwwy4g5curnynotyu6uflye

Assessment Methods of Angiogenesis and Present Approaches for Its Quantification

Ghulam Jilany Khan
2014 Cancer Research Journal  
To quantify the effect of an agent on angiogenesis, a standardized preclinical screening assay is necessary.  ...  It is an essential process in the formation and development of blood vessels, so it is supportive in healing of wound while its inhibition may help to restrict the size of tumor.  ...  Pain can also be stimulated by the sensitization of sensory nerves by inflammatory mediators and these sensitized nerves can be a source of neurogenic inflammation and start angiogenesis [21] .  ... 
doi:10.11648/j.crj.20140203.12 fatcat:reihe73mybhodehcq57igkesne
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