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Bayesian Estimation of the ntPET Model in Single-Scan Competition PET Studies

Zacharie Irace, Inés Mérida, Jérôme Redouté, Clara Fonteneau, Marie-Françoise Suaud-Chagny, Jérôme Brunelin, Benjamin Vidal, Luc Zimmer, Anthonin Reilhac, Nicolas Costes
2020 Frontiers in Physiology  
The results showed that the b-ntPET method is substantially more robust to noise and much more sensitive and accurate than lp-ntPET.  ...  These improvements lead to the possibility of detecting and characterizing dynamic drug occupancy from a single PET scan more efficiently.  ...  CF, MS-C, and JB designed the human study and aided in analyzing the associated data and interpreting the results.  ... 
doi:10.3389/fphys.2020.00498 pmid:32508679 pmcid:PMC7248280 fatcat:wahbkpkzlbau5aga62cmgzyxam

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  This study was funded by MINECO SAF2014-54070-JIN. Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
in response to a traumatic event.  ...  This work contributes to the understanding of noradrenergic drugs as therapeutic aids for PTSD patients.  ...  PET data were modeled using a modified parametric ntPET model (lp-ntPET; Normandin et al., 2012) that estimated the kinetics of neurotransmitter release from dynamic PET data. M63.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334