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A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola

Gavin H Thomas, Jeremy Zucker, Sandy J Macdonald, Anatoly Sorokin, Igor Goryanin, Angela E Douglas
2009 BMC Systems Biology  
AE 2009, 'A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola' BMC Systems Biology, vol. 3, no. n/a, 24.  ...  Results: We have reconstructed and analysed the metabolic network of the γ-proteobacterium Buchnera aphidicola (symbiont of the pea aphid) as a model for using systems-level approaches to discover key  ...  Gündüz for technical support and BBSRC (AED, SJM), University of Edinburgh (IG) and University of York Anniversary Lectureship (GHT) for financial support.  ... 
doi:10.1186/1752-0509-3-24 pmid:19232131 pmcid:PMC2649895 fatcat:oq4fmdjhxjahhfyce67fil7c54

Determinism and Contingency Shape Metabolic Complementation in an Endosymbiotic Consortium

Miguel Ponce-de-Leon, Daniel Tamarit, Jorge Calle-Espinosa, Matteo Mori, Amparo Latorre, Francisco Montero, Juli Pereto
2017 Frontiers in Microbiology  
In silico knock-out experiments with iBSCc showed that the consortium metabolism is a highly integrated yet fragile network.  ...  Here we present a genome-scale metabolic network (GEM) for the bacterial consortium from the cedar aphid iBSCc.  ...  Altogether, the two metabolic networks involved in the C. cedri consortium are highly constrained and fragile.  ... 
doi:10.3389/fmicb.2017.02290 pmid:29213256 pmcid:PMC5702781 fatcat:jdbf5v2sojg3zldhhuwr6etuse

A genome-scale study of metabolic complementation in endosymbiotic consortia: the case of the cedar aphid [article]

Miguel Ponce-de-Leon, Daniel Tamarit, Jorge Calle-Espinosa, Matteo Mori, Amparo Latorre, Francisco Montero, Juli Pereto
2017 bioRxiv   pre-print
In silico knock-out experiments with iBSCc showed that the consortium metabolism is a highly integrated yet fragile network.  ...  Here we present a genome scale metabolic network (GEM) for the bacterial consortium from the cedar aphid iBSCc.  ...  Acknowledgements 645 We would like to thank the Obra Social Programme of La Caixa Savings Bank for the doctoral 646 fellowship granted to JCE.  ... 
doi:10.1101/179127 fatcat:2odsodi7ufbyjc6pulimzc6vwm

Small genomes and the difficulty to define minimal translation and metabolic machineries

Rosario Gil, Juli Peretó
2015 Frontiers in Ecology and Evolution  
Citation: Gil R and Peretó J (2015) Small genomes and the difficulty to define minimal translation and metabolic machineries. Front. Ecol. Evol. 3:123.  ...  If we take gene essentiality as a proxy of network fragility, small metabolic networks are more fragile against gene FIGURE 1 | Network fragility increases with metabolic minimization.  ...  In other words, the number of alternative pathways able to rescue for a specific deleted enzymatic step is drastically reduced and the consequent fragility of the network could limit its usefulness as  ... 
doi:10.3389/fevo.2015.00123 fatcat:ar6wivkfi5devoyhkzbntpfgr4

The Pine Bark Adelgid, Pineus strobi, Contains Two Novel Bacteriocyte-Associated Gammaproteobacterial Symbionts

Elena R. Toenshoff, Gitta Szabó, Daniela Gruber, Matthias Horn
2013 Applied and Environmental Microbiology  
Our findings lend further support for a complex evolutionary history of the association of adelgids with a phylogenetically diverse set of bacterial symbionts.  ...  The otherP. strobisymbiont ("CandidatusHartigia pinicola") represents a novel symbiont lineage in members of the Adelgidae.  ...  A 313 fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera 314 aphidicola. BMC Syst. Biol. Sandström JP, Russell JA, White JP, Moran NA. 2001.  ... 
doi:10.1128/aem.03310-13 pmid:24271164 pmcid:PMC3911223 fatcat:rkhpbh4ghjfknkvpc6qyux5vpi

Natural selection drove metabolic specialization of the chromatophore in Paulinella chromatophora

Cecilio Valadez-Cano, Roberto Olivares-Hernández, Osbaldo Resendis-Antonio, Alexander DeLuna, Luis Delaye
2017 BMC Evolutionary Biology  
We found that the evolution of free-living to host-restricted lifestyle rendered a fragile metabolic network where >80% of genes in the chromatophore are essential for metabolic functionality.  ...  In addition, our in silico simulations of the evolutionary process leading to the reduced metabolic network of the chromatophore showed that the predicted rate of released reduced-carbon is obtained in  ...  Funding CV thanks to CONACYT for the doctoral fellowship granted. Availability of data and material Data and material will be available from the corresponding author.  ... 
doi:10.1186/s12862-017-0947-6 pmid:28410570 pmcid:PMC5392233 fatcat:llzph6et7jfsnetoeavacetrcu

It Takes a Village: Ecological and Fitness Impacts of Multipartite Mutualism

Elizabeth A. Hussa, Heidi Goodrich-Blair
2013 Annual Review of Microbiology  
metabolic pathways or defense against pathogens.  ...  In many well-studied cases, microbial symbiosis is characterized by a specialized association between a host and a specific microbe that provides it with one or more beneficial functions, such as novel  ...  Aphids engage in a nutritional symbiosis with a so-called primary symbiont, Buchnera aphidicola, but also harbor a secondary bacterial symbiont, Hamiltonella defensa, which confers protection against parasitoid  ... 
doi:10.1146/annurev-micro-092412-155723 pmid:23799814 fatcat:6b3nfyun75crzmx7z5lwmlud74

GUT-BACTERIA SYMBIOSIS IN INSECT PESTS [article]

E.M. Prosdocimi
2015
Violetta Vacchini for the Drosophila section and the time spent together in the lab, Bessem Chouaia for the Rhynchophorus section and the bioinformatics, Elena Gonella, Matteo Montagna, Daniela Lupi, Anna  ...  A special thank is for all the bee-keepers who gave us the possibility to obtain biological samples from their hives.  ...  suitable for model or well-known symbiotic relationships, as for example, the one of Buchnera aphidicola with pea aphids (70).  ... 
doi:10.13130/e-m-prosdocimi_phd2015-01-15 fatcat:khxnxjvma5ad3aso33nf7lvdie

Individuality, the Major Transitions, and the Evolutionary Contingency Thesis [article]

Alison K. McConwell, University Of Calgary, University Of Calgary, Marc Ereshefsky
2017
In this dissertation, I explore the reach of the Evolutionary Contingency Thesis—a view that emphasizes the role of dependency relations and chance in evolution (Gould 1989, Beatty 2006a).  ...  Finally, I extend the contingency analysis to a topic in philosophy of medicine: The nature of cancer.  ...  Buchnera aphidicola "is the obligate symbiotic intracellular bacteria of aphids" (Charles et al. 2011) .  ... 
doi:10.11575/prism/26505 fatcat:c5y4mtedhjbvppx53skhmgu3pa

Structural studies of type III secretion systems by electron microscopy and co-evolutionary analysis

Teige Rowan Seal Matthews-Palmer, Morgan Beeby, William Taylor
2020
We find evidence for overlapping functional roles of the ATPase and the substrate chaperones, as well as heavy binding of the C-ring in the absence of FliH; the top candidate identity for the C-ring binding  ...  In Chapter 4, computational predictions are made for the protein folds of the inner membrane export apparatus proteins.  ...  A separate example of an unusual T3SS is an apparently expressed degenerate flagellar T3SS in Buchnera aphidicola, an organism highly adapted to its endosymbiotic niche inside specialised organs of aphids  ... 
doi:10.25560/80545 fatcat:zdhmamsc7fgyfcjtpo7xsg3dbq