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A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease

Jörg Menche, Amitabh Sharma, Michael H Cho, Ruth J Mayer, Stephen I Rennard, Bartolome Celli, Bruce E Miller, Nick Locantore, Ruth Tal-Singer, Soumitra Ghosh, Chris Larminie, Glyn Bradley (+4 others)
2014 BMC Systems Biology  
Results: We developed a novel unbiased method called diVIsive Shuffling Approach (VIStA) that identifies subgroups of patients by maximizing the difference in their gene expression patterns.  ...  A pathway analysis of the differentially expressed genes in the identified subtypes suggests that VIStA is capable of capturing specific molecular signatures within in each group.  ...  Principal investigators and centers participating in ECLIPSE  ... 
doi:10.1186/1752-0509-8-s2-s8 pmid:25032995 pmcid:PMC4101699 fatcat:ga2pd6aot5ee5g6pmoem3snfny

Network medicine, multimorbidity and the lung in the elderly

R. Faner, T. Cruz, A. Lopez-Giraldo, A. Agusti
2014 European Respiratory Journal  
The pathobiology of ageing, chronic obstructive pulmonary disease (COPD) and concomitant disorders is complex.  ...  Most noncommunicable diseases are related to the ageing process and often co-occur in the same individual.  ...  FIGURE 7 a 7 ) Schematic representation of the diVIsive Shuffling Approach (VIStA). b) Network representation of the clinical characteristics identified by VIStA.  ... 
doi:10.1183/09031936.00078714 pmid:25063242 fatcat:md727h37abaqtbed223nqmk2di

Systems medicine: evolution of systems biology from bench to bedside

Rui-Sheng Wang, Bradley A. Maron, Joseph Loscalzo
2015 Wiley Interdisciplinary Reviews: Systems Biology and Medicine  
Indeed, systems biology is evolving to systems medicine as a new discipline that aims to offer new approaches for addressing the diagnosis and treatment of major human diseases uniquely, effectively, and  ...  human diseases on a global level.  ...  This work was supported in part by NIH grants 1K08HL111207-01A1 (to BAM), and HL061795, HL108630 (MAPGen Consortium), HG007690 (to JL), and the Pulmonary Hypertension Association (to BAM).  ... 
doi:10.1002/wsbm.1297 pmid:25891169 pmcid:PMC4457580 fatcat:l4446pjeazanxakj2jwlt26l5m