Filters








693 Hits in 7.7 sec

A database on alternative splice forms on the integrated genetic map service (IGMS)

Heike Pospisil, Alexander Herrmann, Harald Pankow, Jens G Reich
2002 In Silico Biology  
The IGMS is a comprehensive information system that combines the knowledge from genomic sequence, genetic map and genetic disorders databases.  ...  The second application maps EST with a specific expression profile. Our third application generates a database of alternative splice forms for nine organisms from EST and mRNA sequence data.  ...  A DATABASE ON ALTERNATIVE SPLICE FORMS ON THE INTEGRATED GENETIC MAP SERVICE (IGMS) Introduction There are over 15 millions sequence records at the GenBank (May, 2002 [1] ), including more than 11 million  ... 
pmid:12762858 fatcat:x4njsiu4qrh2jgn4ehqhe5bw5u

Mystifying Molecular Structure, Expression and Repertoire Diversity of IgM Heavy Chain Genes (Ighμ) in Clarias Catfish and Hybrids: Two Novel Transcripts in Vertebrates

Anurak Bunnoy, Uthairat Na-Nakorn, Prapansak Srisapoome
2022 Frontiers in Immunology  
Two novel immunoglobulin heavy chain (Ighμ) transcripts encoding membrane-bound forms of IgM (mIgM) were discovered in bighead catfish, Clarias macrocephalus.  ...  Fluorescence in situ hybridization (FISH) in bighead catfish, North African catfish (C. gariepinus) and hybrid catfish revealed a single copy of Ighμ in individual parent catfish, while two gene copies  ...  Kornsorn Srikulnath and his laboratory members, Department of Genetics, Faculty of Science, Kasetsart University, Bangkok Thailand, for training in chromosome preparation.  ... 
doi:10.3389/fimmu.2022.884434 pmid:35784299 pmcid:PMC9247300 fatcat:afhfu75a45e3fgmmcqdejhrrsa

Tissue-selective alternate promoters guide NLRP6 expression

Nathan A Bracey, Jaye M Platnich, Arthur Lau, Hyunjae Chung, M Eric Hyndman, Justin A MacDonald, Justin Chun, Paul L Beck, Stephen E Girardin, Paul MK Gordon, Daniel A Muruve
2020 Life Science Alliance  
Human NLRP6 contains an internal alternative promoter within exon 2 of the PYD, resulting in a truncated mRNA in nonintestinal tissue.  ...  The repertoire of PYD-containing genes expressed by a cell type arms tissues with responses against a range of stimuli.  ...  Support was also provided by a team grant under the Canadian Institutes for Health Research (CIHR) Inflammation in Chronic Disease Signature Initiative.  ... 
doi:10.26508/lsa.202000897 pmid:33376129 fatcat:mucehug6qfaqnadnyihmfc3yoa

Functional Analysis of Deep Intronic SNP rs13438494 in Intron 24 of PCLO Gene

Seunghee Seo, Kanako Takayama, Kyosuke Uno, Kazutaka Ohi, Ryota Hashimoto, Daisuke Nishizawa, Kazutaka Ikeda, Norio Ozaki, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta, Chunyu Liu
2013 PLoS ONE  
We constructed minigenes with A and C alleles containing exon 24, intron 24, and exon 25 of PCLO to assess the genetic effect of rs13438494 on splicing.  ...  We found that the C allele of rs13438494 reduces the splicing efficiency of the PCLO minigene.  ...  The central band corresponds to a 676-bp spliced product. The lower band denotes a 575-bp alternative product. GAPDH was used as the control for normalization.  ... 
doi:10.1371/journal.pone.0076960 pmid:24167553 pmcid:PMC3805565 fatcat:z4htx5jk2vdgnii57czrxemmoq

Rat Genome and Model Resources

Mary Shimoyama, Jennifer R. Smith, Elizabeth Bryda, Takashi Kuramoto, Laura Saba, Melinda Dwinell
2017 ILAR journal  
Those profiled here include the Rat Genome Database, PhenoGen, Gene Editing Rat Resource Center, Rat Resource and Research Center, and the National BioResource Project for the Rat in Japan.  ...  Rats remain a major model for studying disease mechanisms and discovery, validation, and testing of new compounds to improve human health.  ...  Department of Health and Human Services, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, grant #R24AA013162 (PhenoGen); the U.S.  ... 
doi:10.1093/ilar/ilw041 pmid:28838068 pmcid:PMC6057551 fatcat:35ugntkgzzc6jl3o546n7cidhy

Down regulation of KLK7 expression in breast tissues and identification of a novel spliced KLK7 mRNA

Samina Ejaz, Faiz-ul-Hassan Nasim, Muhammad Ashraf, Gulzar Ahmad
2017 Applied Cancer Research  
Bioinformatic analysis revealed that the alternatively spliced mRNA (KF963192) will potentially encode a truncated and non-functional protein.  ...  Alternative splicing commonly occurs in cancer cells and many cancer specific splice variants have been reported as potential candidate biomarkers of the disease.  ...  According to one estimate at least 15% of the genetic diseases are the outcome of defective pre-mRNA splicing and alternative splicing is a common phenomenon occurring in cancer cells.  ... 
doi:10.1186/s41241-017-0042-8 fatcat:34vllp5drfcnvjzhtek7eea6y4

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

P. G. Ferreira, P. Jares, D. Rico, G. Gomez-Lopez, A. Martinez-Trillos, N. Villamor, S. Ecker, A. Gonzalez-Perez, D. G. Knowles, J. Monlong, R. Johnson, V. Quesada (+25 others)
2013 Genome Research  
C1/C2 subgroups and the mutational status of the immunoglobulin heavy variable (IGHV) region were the only independent variables in predicting time to treatment in a multivariate analysis with main clinico-biological  ...  In addition, two thousand genes-most of which are not differentially expressed-exhibit CLL-specific splicing patterns.  ...  -P. acknowledge funding from the Spanish Ministry of Science and Technology (grant number SAF2009-06954). S.E. is supported by a fellowship from La Caixa.  ... 
doi:10.1101/gr.152132.112 pmid:24265505 pmcid:PMC3912412 fatcat:5hyx7uin4rhfzarybf6e3swex4

Third Report on Chicken Genes and Chromosomes 2015

Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng (+92 others)
2015 Cytogenetic and Genome Research  
The First Report highlighted the availability of genetic and physical maps, while the Second Report was published as the chicken genome sequence was released.  ...  Following on from the First Report on Chicken Genes and Chromosomes and the Second Report in [Schmid et al., 2005 , we are pleased to publish this long-awaited Third Report on the latest developments in  ...  Prediction of Functional Domains of Splice Forms of Genes in the Actin Cytoskeleton Pathway To predict the function of the alternative splice forms of genes in the actin cytoskeleton pathway, transcript  ... 
doi:10.1159/000430927 pmid:26282327 pmcid:PMC5120589 fatcat:66epxqpbhrdxpno7n5or4gnbzq

Compound heterozygous variants including a novel copy number variation in a child with atypical ataxia-telangiectasia: a case report

Hoo Young Lee, Dae-Hyun Jang, Jae-Won Kim, Dong-Woo Lee, Ja-Hyun Jang, Joungsu Joo
2021 BMC Medical Genomics  
This clinical report extends the genetic and phenotypic spectrum of ATM pathogenic variants in atypical ataxia-telangiectasia, thus making implementation of advanced analysis beyond the routine next-generation  ...  Herein, we report on an ataxia telangiectasia child with atypical phenotype who was identified as compound heterozygous for two ATM variants involving a previously described pathogenic single nucleotide  ...  Acknowledgements We thank the patient and parents in our study for the cooperation and support.  ... 
doi:10.1186/s12920-021-01053-3 pmid:34404412 pmcid:PMC8371864 fatcat:uoptywq6qjbjfaph3gyl5pyytu

Intercistronic Region [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
Splicing mechanisms I genes have more than one splice site pairs which facilitate alternative splicing and the assembly of different mRNAs.  ...  Alternative splicing may be accomplished by using more than a single promoter, resulting in alternative long or short transcripts, depending on the site of transcription initiation.  ...  In a word the cytoplasm may be ignored genetically." In his A History of Genetics (Harper & Row, New York, 1965 ) AH Sturtevant comments on the significance of Walter S. Sutton's papers (Biol.  ... 
doi:10.1007/978-1-4020-6754-9_8599 fatcat:jp2bc5t2t5cdhnsm33wwtlfmyu

Indole [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
Splicing mechanisms I genes have more than one splice site pairs which facilitate alternative splicing and the assembly of different mRNAs.  ...  Alternative splicing may be accomplished by using more than a single promoter, resulting in alternative long or short transcripts, depending on the site of transcription initiation.  ...  In a word the cytoplasm may be ignored genetically." In his A History of Genetics (Harper & Row, New York, 1965 ) AH Sturtevant comments on the significance of Walter S. Sutton's papers (Biol.  ... 
doi:10.1007/978-1-4020-6754-9_8439 fatcat:arap4xz4vfhqjncwvldihbgzb4

Mini-Conferences

2003 Revista do Instituto de Medicina Tropical de São Paulo  
If, on the contrary, the infective forms are the PS negative ones, with the PS positive forms facilitating infectivity, a truly cooperative system is operating here.  ...  Parasite death by apoptosis is, in the present situation, just a side effect.  ...  on trans-splicing or on the polypyrimidine tract used for trans-splicing.  ... 
doi:10.1590/s0036-46652003000700003 fatcat:6as3jvqqvrb7po2ixibuypxlru

Elevated Autoantibodies in Subacute Human Spinal Cord Injury Are Naturally Occurring Antibodies

Angel Arevalo-Martin, Lukas Grassner, Daniel Garcia-Ovejero, Beatriz Paniagua-Torija, Gemma Barroso-Garcia, Alba G. Arandilla, Orpheus Mach, Angela Turrero, Eduardo Vargas, Monica Alcobendas, Carmen Rosell, Maria A. Alcaraz (+8 others)
2018 Frontiers in Immunology  
The increase of these autoantibodies is a fast phenomenon-their levels are already elevated before 5 days after lesion-characteristic of secondary immune responses, further supporting their origin as natural  ...  in the normal spinal cord.  ...  Esteban for his critical reading of the manuscript and the Lopez de Ipiña family for generously supporting the research on SCI in our laboratory.  ... 
doi:10.3389/fimmu.2018.02365 fatcat:l2xyk2b6kbfnldh77eeq3h6hja

First International p53 Isoforms Meeting: 'p53 isoforms through evolution: from identification to biological function'

V Marcel, M Olivier, B Mollereau, P Hainaut, J-C Bourdon
2010 Cell Death and Differentiation  
Even though it was expected that such an important gene would at least generate a back up system by generating genetic expression of alternative spliced forms, only one mouse interesting alternative spliced  ...  Of them, the major form besides the full-length (FL) p53 is p47, which is initiated from the ATG in exon 4, due to alternate IRES entry sites, and also due to alternate splicing of a novel p53 RNA form  ... 
doi:10.1038/cdd.2010.156 pmid:21151028 pmcid:PMC3131990 fatcat:zfwao3653fckle6lkjvtwiap3a
« Previous Showing results 1 — 15 out of 693 results