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A cytoarchitecture-driven myelin model reveals area-specific signatures in human primary and secondary areas using ultra-high resolution in-vivo brain MRI

J. Dinse, N. Härtwich, M.D. Waehnert, C.L. Tardif, A. Schäfer, S. Geyer, B. Preim, R. Turner, P.-L. Bazin
2015 NeuroImage  
The modelled myelin patterns are quantitatively compared with data from human ultra-high resolution in-vivo 7 T brain MR images (9 subjects).  ...  For the first time, it is possible to estimate intracortical contrast visible in quantitative ultra-high resolution MR images in specific primary and secondary cytoarchitectonic areas.  ...  We thank Daniel Rose for pushing the MP2RAGE sequence in post-mortem scanning at 7 T to 0.25 mm isotropic resolution and Markus Morawski (Paul Flechsig Institute for Brain Research, University Leipzig,  ... 
doi:10.1016/j.neuroimage.2015.04.023 pmid:25896931 fatcat:z7u6yrzipnezfhz3vle7mxsdlu

Microstructural imaging of human neocortex in vivo

Luke J. Edwards, Evgeniya Kirilina, Siawoosh Mohammadi, Nikolaus Weiskopf
2018 NeuroImage  
We review recent literature that has applied and developed MRI-based in vivo histology to probe the microstructure of the human neocortex, focusing specifically on myelin, iron, and neuronal fibre mapping  ...  The neocortex of the human brain is the seat of higher brain function.  ...  A cytoarchitecture-driven myelin model reveals area-1115 specific signatures in human primary and secondary areas using ultra-high resolution 1116 in-vivo brain MRI.  ... 
doi:10.1016/j.neuroimage.2018.02.055 pmid:29588229 fatcat:bqpmgy66xbchpfjllfdoapg374

Linking cortical circuit models to human cognition with laminar fMRI

Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini
2021 Neuroscience and Biobehavioral Reviews  
During the last five years, human studies have demonstrated the value of high-resolution fMRI to study laminar-specific activity in the human brain.  ...  Then, we discuss how the use of laminar fMRI can help bridge the gap between cortical circuit models and human cognition.  ...  Figure 7 . 7 Cortical layer assignment by comparison between ex vivo high-resolution postmortem and in vivo data. (A) Postmortem histological and T1 MRI data identifying laminar landmarks.  ... 
doi:10.1016/j.neubiorev.2021.07.005 pmid:34245758 fatcat:vxiltrg3s5fk5ilkq7ekvqhnqe

Using diffusion MRI to discriminate areas of cortical grey matter

Tharindu Ganepola, Zoltan Nagy, Aurobrata Ghosh, Theodore Papadopoulo, Daniel C. Alexander, Martin I. Sereno
2017 NeuroImage  
Reliable area-specific contrast in the dMRI signal has previously been demonstrated in selected occipital and sensorimotor areas.  ...  Reliable area-specific contrast in the dMRI signal has previously been demonstrated in selected occipital and sensorimotor areas.  ...  Hence, using T1 as a sole marker is less informative in areas with low, relatively uniform myelination that are found outside primary and secondary sensory and motor cortices (Ganepola et al., 2017; Glasser  ... 
doi:10.1016/j.neuroimage.2017.12.046 pmid:29274501 pmcid:PMC6189525 fatcat:i6mmcacxujeknnmt5nl6tvkniu

Relationships between cortical myeloarchitecture and electrophysiological networks

Benjamin A. E. Hunt, Prejaas K. Tewarie, Olivier E. Mougin, Nicolas Geades, Derek K. Jones, Krish D. Singh, Peter G. Morris, Penny A. Gowland, Matthew J. Brookes
2016 Proceedings of the National Academy of Sciences of the United States of America  
Using ultra-high field MRI and the principle of structural covariance, we derive a structural network showing how myelin density differs across cortical regions and how separate regions can exhibit similar  ...  The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition.  ...  Glasser MF, Van Essen DC (2011) Mapping human cortical areas in vivo based on myelin content as revealed by T1-and T2-weighted MRI. J Neurosci 31(32):11597-11616. 14.  ... 
doi:10.1073/pnas.1608587113 pmid:27830650 pmcid:PMC5127325 fatcat:tss44bits5gyfoxtezah3nua4i

Cartography and Connectomes

David C. Van Essen
2013 Neuron  
MRI and cortical myelin maps derived from them).  ...  On the other hand, conventional histological atlases can be complemented by specialized MR-based imaging that reveals considerably greater neuroanatomical detail using ultra-high field strength (7T or  ... 
doi:10.1016/j.neuron.2013.10.027 pmid:24183027 pmcid:PMC3855872 fatcat:nsrernbfkvctlbgaigmef7bedy

Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation

Jakob Seidlitz, František Váša, Maxwell Shinn, Rafael Romero-Garcia, Kirstie J. Whitaker, Petra E. Vértes, Konrad Wagstyl, Paul Kirkpatrick Reardon, Liv Clasen, Siyuan Liu, Adam Messinger, David A. Leopold (+6 others)
2018 Neuron  
In three cohorts (two human, one macaque), we find that the resulting morphometric similarity networks (MSNs) have a complex topological organisation comprising modules and high-degree hubs.  ...  We introduce a new technique for cortical network mapping, based on inter-regional similarity of multiple morphometric parameters measured using multimodal MRI.  ...  Acknowledgments We would like to thank the participants in the NSPN and NIH studies of human brain development.  ... 
doi:10.1016/j.neuron.2017.11.039 pmid:29276055 pmcid:PMC5763517 fatcat:nyvj5lexfjegznbceczob2um4u

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

2014 Multiple Sclerosis  
High resolution (1x1x3mm 3 ) brain GEPCI data (T1 weighted and R2* maps) were acquired from 10 relapsing remitting (RM), 10 primary progressive (PP) and 10 secondary progressive (SP) MS subjects using  ...  In-vivo brain MRI was performed on a 7.0 Tesla Bruker scanner.  ...  Objectives: In this multi-center study we aimed at characterizing whether there are venous density changes in NMO using 7 Tesla MRI with high-resolution and high-susceptibility contrast imaging.  ... 
doi:10.1177/1352458514547846 pmid:25205049 pmcid:PMC4244175 fatcat:gj757y4jlvejpnrfw22guoit7m

A comprehensive transcriptional map of primate brain development

Trygve E. Bakken, Jeremy A. Miller, Song-Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng, Aaron Szafer, Rachel A. Dalley, Joshua J. Royall, Tracy Lemon, Sheila Shapouri, Kaylynn Aiona (+87 others)
2016 Nature  
We describe a high resolution transcriptional atlas of rhesus monkey brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical parcellation of cortical  ...  The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates.  ...  Acknowledgments The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors also thank Dr.  ... 
doi:10.1038/nature18637 pmid:27409810 pmcid:PMC5325728 fatcat:c2egfiu54vfppjbnjv53wwg3pa

American Association of Neuropathologists, Inc. Abstracts of the 88th Annual Meeting June 21–24, 2012 Chicago, IL

2012 Journal of Neuropathology and Experimental Neurology  
Conclusions: Primary GBMO is a subgroup of GBM associated with longer survival and a younger age group but shows no difference in the frequency of LOH of 1p/19q, MGMT and IDH1 mutation compared with other  ...  Methods: We examined 288 cases of primary GBM and assessed the molecular markers in 57 GBMO and 50 cases of other primary GBM, correlating the data with clinical parameters and outcome.  ...  Recently, clinical applications of high resolution MRI are now feasible with ultra-high field 7 Tesla (7T) magnet, which can achieve the in-plane resolution of up to 200 Â 200 micron.  ... 
doi:10.1097/nen.0b013e31825c0526 fatcat:ar5fg5erg5dxffwuyjhyuau7zi

Abstracts of the 12th Annual Meeting of Israel Society for Neuroscience

2003 Neural Plasticity  
Alzheimer's disease is a devastating neurodegenerative disorder in which extracellular deposits of fibrillar [3-amyloid form plaques in the brain.  ...  Ex-vivo experiments using mce ippocampal slices showed that microglia become cytotoxic on encountenng aggregated [-amyloid but protective when they encounter a T cell-derived cytokine such as interferon  ...  Recent studies using single-unit recording in the alert monkey, as well as functional MRI in human subjects suggested that neuronal activity, in high order visual areas could be the neural correlate of  ... 
doi:10.1155/np.2003.179 pmid:14712829 pmcid:PMC2565426 fatcat:4midzhgcurdejakjjwizqvpguq

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
Neurochemical analyses were performed on the brains of postnatal offspring using high-performance liquid chromatography and protein concentration analysis.  ...  Using mice as a model organism, we implemented a chronic unpredictable stress (CUS) paradigm in dams during the mid-to late stages of pregnancy.  ...  of drug use in animal models, and to drug-taking in humans.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334

Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012

Heike Anderson-Schmidt, Olga Beltcheva, Mariko D. Brandon, Enda M. Byrne, Eric J. Diehl, Laramie Duncan, Suzanne D. Gonzalez, Eilis Hannon, Katri Kantojärvi, Iordanis Karagiannidis, Mark Z. Kos, Eszter Kotyuk (+14 others)
2013 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
However, the speakers are not responsible for any of the information contained in this report.  ...  Acknowledgments This report was made possible by grants from NIMH and NIDA: R13MH060596 and R13DA022792. Each summary is the subjective understanding of the rapporteur for each session.  ...  He displayed a video analyzing a fiber tract with ultra-high resolution polarized light imaging (PLI) in human striate cortex (Axer et al., 2011) , and projected to the level of myelinated fiber with  ... 
doi:10.1002/ajmg.b.32132 pmid:23341144 pmcid:PMC4090768 fatcat:j27eevlpvnf75fqqli5ojamec4

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Schizophrenia is a highly debilitating brain disorder with a heritability of up to 80% and a complex genetic architecture.  ...  Here, much interest has been devoted to functional MRI (fMRI)-based phenotypes related to the genetic risk for the disorder; in particular, functional connectivity of the DLPFC and hippocampus during working  ...  Methods: Here we used high-resolution structural magnetic resonance imaging (MRI) and network analyses of bloodbased gene expression data to investigate the hypothesis that specific dosage effects of genes  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

Poster Session II

2012 Neuropsychopharmacology  
Whole-brain high-resolution coronal structural scans were collected using a T1-weighted magnetization-prepared rapid gradient echo pulse sequence, and functional scans were acquired using a T2*sensitive  ...  Echoplanar imaging was conducted with a 3T MRI scanner and a 32-element array of receive-only head surface coils which granted superior image quality at high spatial resolution.  ...  In a human in vivo structural MRI study, we assessed gray matter volume of intraparietal sulcus (IPS) as a function of genotype at rs13223593 in 279 healthy Caucasian subjects.  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm
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