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A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Walter K Schlage, Jurjen W Westra, Stephan Gebel, Natalie L Catlett, Carole Mathis, Brian P Frushour, Arnd Hengstermann, Aaron Van Hooser, Carine Poussin, Ben Wong, Michael Lietz, Jennifer Park (+5 others)
2011 BMC Systems Biology  
Results: We have built a detailed network model that captures the biology underlying the physiological cellular response to endogenous and exogenous stressors in non-diseased mammalian pulmonary and cardiovascular  ...  Conclusions: The results presented here describe the construction of a cellular stress network model and its application towards the analysis of environmental stress using transcriptomic data.  ...  Maria for project management and support with preparation of this manuscript, Sam Ansari and Stephanie Boué for reviewing the manuscript, and Lynda Conroy for editorial support.  ... 
doi:10.1186/1752-0509-5-168 pmid:22011616 pmcid:PMC3224482 fatcat:xt3v56y65reopk72xl3is2kmw4

Systems biology in heart diseases

G E Louridas, I E Kanonidis, K G Lourida
2010 Hippokratia  
Systems biology based on integrative computational analysis and high technology is in a position to construct networks, to study the interactions between molecular components and to develop models of cardiac  ...  clinical phenotypes is a promising strategy that optimize diagnosis and treatment in cardiovascular disease.  ...  Soulis et al investigated the wall shear stress oscillation in a normal human left coronary artery bifurcation computational model by applying non-Newtonian blood properties and phasic flow.  ... 
pmid:20411053 pmcid:PMC2843564 fatcat:uftlhpfuszc53a423pngq7qydm

Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research

Andrew E Hale, Kevin White, Stephen Y Chan
2012 Cardiovascular Diagnosis and Therapy  
A maladaptive imbalance of these hypoxic phenotypes often drives many ischemic cardiovascular diseases, such as pulmonary hypertension -- an enigmatic vascular disorder characterized by pronounced and  ...  As a result, a more sophisticated understanding of their pervasive roles in pathogenesis could set the stage for unique diagnostic and therapeutic strategies in pulmonary hypertension.  ...  Acknowledgements This work was supported in part by the NIH, the Pulmonary Hypertension Association, Gilead Sciences, and the Lerner, Harris, and Watkins funds (S.Y.C.). We thank Ms.  ... 
doi:10.3978/j.issn.2223-3652.2012.08.01 pmid:23745175 pmcid:PMC3671932 fatcat:6emxgjxktvg4ffd56s3odzwonm

Systems analysis of oxidant stress in the vasculature

Diane E. Handy, Joseph Loscalzo, Jane A. Leopold
2013 IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology  
Networks offer a method to organize experimentally derived factors, including proteins, metabolites, and DNA, that are represented as nodes into an unbiased comprehensive platform for study.  ...  When these systems are perturbed, conditions are permissive for oxidant stress, which, in turn, promotes vascular dysfunction and structural remodeling.  ...  Acknowledgments This work was supported by NIH grants HL61795, HL48743, HL107192, HL070819, and HL108630 (J.L.); and HL105301 and the Thomas W. Smith MD Foundation (to J.A.L.).  ... 
doi:10.1002/iub.1221 pmid:24265198 pmcid:PMC4189813 fatcat:d6b4e67n4fhidkq5xblylnjghm

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart

Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R Bezzina, Ilze Bot, Bianca Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli, Dana Dawson (+49 others)
2022 Cardiovascular Research  
In particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and co-morbidities.  ...  , bioinformatic models based on large datasets, and improved current animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease.  ...  2 and 3  ... 
doi:10.1093/cvr/cvab370 pmid:34999816 fatcat:xwsham5baza43nx6la5nqpvtli

Multi-scale modeling of hemodynamics in the cardiovascular system

Hao Liu, Fuyou Liang, Jasmin Wong, Takashi Fujiwara, Wenjing Ye, Ken-iti Tsubota, Michiko Sugawara
2015 Acta Mechanica Sinica  
The human cardiovascular system is a closedloop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena.  ...  Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation  ...  He also thanks RIKEN for supporting the computing facilities essential for the completion of this study. Financial support provided by HKUST to JW is acknowledged.  ... 
doi:10.1007/s10409-015-0416-7 fatcat:v6wtgwz3rfa7taa7chvf27zxom

Bioengineering of the heart

Alberto Redaelli, Justin Cooper-White
2020 APL Bioengineering  
cellular and tissue level dysfunctions and diseases-more people die of cardiovascular disease (CVD) than any other disease globally.  ...  tissue models.  ...  that give rise to a multitude of cellular and tissue level dysfunctions and diseases-more people die of cardiovascular disease (CVD) than any other disease globally.  ... 
doi:10.1063/1.5144525 pmid:32161832 pmcid:PMC7056452 fatcat:cj23ripavbce7o2t6ki7gzfgj4

Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine

Julie A. Phillippi, Elena Aikawa, Josh Hutcheson
2019 Frontiers in Cardiovascular Medicine  
Tissue biomechanics can also influence cellular phenotype and understanding how different forces affect cell behavior is critical to developing clinically relevant cardiovascular disease models.  ...  in the heart and are attractive biomaterials for repair of injured or diseased myocardium and perhaps other cardiovascular tissues.  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fcvm.2019.00013 pmid:30873414 pmcid:PMC6401650 fatcat:fcpzcck7hvgzfptihdleqmoyqu

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

Valérie Françoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barberà, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
2019 Frontiers in Molecular Biosciences  
CVD comprise a range of diseases affecting the functionality of the heart and blood vessels, including acute myocardial infarction (AMI) and pulmonary hypertension (PH).  ...  Cardiovascular diseases (CVD) are the leading cause of death worldwide.  ...  PAH ECs display faster growth rates as compared to non-diseased pulmonary ECs, as shown by enhanced cellular survival signals and increased cell division.  ... 
doi:10.3389/fmolb.2018.00120 pmid:30723719 pmcid:PMC6349769 fatcat:hw6yxfhtevh7xlqexdn7nvhc2i

Systems Biology Approaches to Redox Metabolism in Stress and Disease States

Rui-Sheng Wang, William M. Oldham, Bradley A. Maron, Joseph Loscalzo
2018 Antioxidants and Redox Signaling  
This article will review these systems biology approaches and their potential application to the study of redox metabolism in stress and disease states.  ...  Indeed, redox stress contributes to the pathobiology of many human diseases.  ...  Under oxidative or reductive stress (redox stress), several enzymatic and non-enzymatic antioxidants are activated in cells to protect them from redox injury through a redoxsensitive network.  ... 
doi:10.1089/ars.2017.7256 pmid:29121773 pmcid:PMC6104248 fatcat:ij7btm5j6vc6zcrdch7wx2x4e4

Underlying Mechanisms of Cardiovascular Disease in Chronic Obstructive Pulmonary Disease

William MacNee, John D. Maclay
2016 Barcelona Respiratory Network  
Chronic obstructive pulmonary disease is a lung condition characterized by persistent airflow limitation and is associated with several extrapulmonary manifestations and comorbidities.  ...  Cardiovascular diseases are among the most frequent comorbid conditions affecting patients with chronic obstructive pulmonary disease and contribute significantly to the severity, morbidity, and mortality  ...  Cox proportional hazards model for patients with COPD and coronary artery calcium score (CACS; Agatston score) adjusted for age, gender, pack-years, severity of COPD, and self-reported cardiovascular disease  ... 
doi:10.23866/brnrev:2016-0017 fatcat:utmted4qqfbmfdf63sffcl2sce

Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence

Stephan Gebel, Rosemarie B. Lichtner, Brian Frushour, Walter K. Schlage, Vy Hoang, Marja Talikka, Arnd Hengstermann, Carole Mathis, Emilija Veljkovic, Michael Peck, Manuel C. Peitsch, Renee Deehan (+2 others)
2013 Bioinformatics and Biology Insights  
Maria for project management and support with preparation of this manuscript, Stephanie Boue and Vincenzo Belcastro for reviewing the manuscript, and Natalie Catlett for methodological assistance.  ...  In order to build a network model that describes the DACS-related biological mechanisms in non-diseased pulmonary and cardiovascular cells/tissues, we first defined and applied a set of criteria for selecting  ...  to pulmonary and cardiovascular diseases.  ... 
doi:10.4137/bbi.s11154 pmid:23515068 pmcid:PMC3596057 fatcat:kvou7t5zafc3pigjaxvdipmxvu

Deciphering the molecular basis of human cardiovascular disease through network biology

Stephen Y. Chan, Kevin White, Joseph Loscalzo
2012 Current Opinion in Cardiology  
'Network medicine' has already led to tangible discoveries of novel disease genes and pathways as well as improved mechanisms for rational drug development.  ...  human cardiovascular disease.  ...  the NIH and the Pulmonary Hypertension Association (S.Y.C.); NIH grants HL061795, HL48743, HL107192, HL070819, and HL108630 (J.L.).  ... 
doi:10.1097/hco.0b013e3283515b31 pmid:22382498 pmcid:PMC3521498 fatcat:6ntm4zrqlbbqfdcqoufxdae6gi

Enhancement of COPD biological networks using a web-based collaboration interface

Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer Park, Manuel C. Peitsch, Walter K. Schlage, Marja Talikka, Ilona Binenbaum, Vladimir Bondarenko, Oleg V. Bulgakov, Vera Cherkasova, Norberto Diaz-Diaz (+21 others)
2015 F1000Research  
Schlage WK, Westra JW, Gebel S, et al.: A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue. BMC Syst Biol. 2011; 5: 168.  ...  Westra JW, Schlage WK, Hengstermann A, et al.: A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue. Bioinform Biol Insights. 2013; 7: 167-192.  ...  Acknowledgements The authors thank IBM for their help in organizing the Network Verification Challenge and jamboree, and Michael Maria and Jean Binder for their help in project management and preparation  ... 
doi:10.12688/f1000research.5984.1 pmid:25767696 pmcid:PMC4350443 fatcat:f3eihadqrvftbjtwljegaa3ovu

Can We Grow Valves Inside the Heart? Perspective on Material-based In Situ Heart Valve Tissue Engineering

Carlijn V. C. Bouten, Anthal I. P. M. Smits, Frank P. T. Baaijens
2018 Frontiers in Cardiovascular Medicine  
To provide for a mechanistic understanding, these models include collagen synthesis and degradation profiles, as well as the impact of cellular traction forces resulting from intracellular actin stress  ...  A significant example is the development of a predictive computational model to generate new testable hypotheses for scaffold properties that favor tissue engineered neovessel formation and function (  ... 
doi:10.3389/fcvm.2018.00054 pmid:29896481 pmcid:PMC5987128 fatcat:gkyoa2joybevfg6tqudppudfm4
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