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Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis

Vitaliy L Rayz, Aaron A Cohen-Gadol
2020 Annual Review of Biomedical Engineering  
In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal  ...  This review presents the state of the art in cerebral aneurysm imaging and image-based modeling, discussing the advantages and limitations of each approach and focusing on the translational value of hemodynamic  ...  Two comprehensive recent reviews specifically evaluated state-of-the-art CFD modeling practices applied to cerebral aneurysms and provided recommendations for reliable simulations of intra-aneurysmal hemodynamics  ... 
doi:10.1146/annurev-bioeng-092419-061429 pmid:32212833 fatcat:jrvzsszb5vcwjfxbwhctafqvoq

Computational fluid dynamics modelling in cardiovascular medicine

Paul D Morris, Andrew Narracott, Hendrik von Tengg-Kobligk, Daniel Alejandro Silva Soto, Sarah Hsiao, Angela Lungu, Paul Evans, Neil W Bressloff, Patricia V Lawford, D Rodney Hose, Julian P Gunn
2015 Heart  
Combined with cardiovascular imaging, CFD simulation enables detailed characterisation of complex physiological pressure and flow fields and the computation of metrics which cannot be directly measured  ...  Patient-specific (incorporating data unique to the individual) and multi-scale (combining models of different length-and time-scales) modelling enables individualised risk prediction and virtual treatment  ...  Acknowledgements Dr Morris is funded by a Clinical Research Training Fellowship from the British Heart Foundation. Figure 4 was kindly provided by Dr Alberto Marzo, University of Sheffield.  ... 
doi:10.1136/heartjnl-2015-308044 pmid:26512019 pmcid:PMC4717410 fatcat:nvi4g5bbcffi7gvqapy3nclpja

Initial Clinical Experience with AView—A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management

Jianping Xiang, Nicole Varble, Jason M. Davies, Ansaar T. Rai, Kenichi Kono, Shin-ichiro Sugiyama, Mandy J. Binning, Rabih G. Tawk, Hoon Choi, Andrew J. Ringer, Kenneth V. Snyder, Elad I. Levy (+3 others)
2017 World Neurosurgery  
In one stent-assisted coiling case, flow visualization predicted that the Xiang et al. intuitive choice for stent placement could have resulted in sacrifice of an anterior cerebral artery due to blockage  ...  We developed a prototype of a clinically-oriented, streamlined, computational platform, AView, for rapid assessment of hemodynamics and morphometrics in clinical settings.  ...  Dressel BFA for preparation of the illustrations and Debra J. Zimmer for editorial assistance. Funding  ... 
doi:10.1016/j.wneu.2017.09.030 pmid:28919570 pmcid:PMC5705258 fatcat:2ocolcv7kjfbfnd3urq3rmciie

Influence of different computational approaches for stent deployment on cerebral aneurysm haemodynamics

A. Bernardini, I. Larrabide, H. G. Morales, G. Pennati, L. Petrini, S. Cito, A. F. Frangi
2011 Interface Focus  
Cerebral aneurysms are abnormal focal dilatations of artery walls.  ...  The interest in virtual tools to help clinicians to value the effectiveness of different procedures for cerebral aneurysm treatment is constantly growing.  ...  This work was partially supported within the CENIT programme, as part of CDTEAM and cvREMOD projects funded by the Spanish CDTI and partly within the framework of the @neurIST Project (IST-2005-027703)  ... 
doi:10.1098/rsfs.2011.0004 pmid:22670204 pmcid:PMC3262449 fatcat:u5fy24zgwffehfwxcfssi2nyee

Patient-Specific Cerebral Aneurysm Hemodynamics: Comparison of in vitro Volumetric Particle Velocimetry, Computational Fluid Dynamics (CFD), and in vivo 4D Flow MRI [article]

Melissa C. Brindise, Sean Rothenberger, Benjamin Dickerhoff, Susanne Schnell, Michael Markl, David Saloner, Vitaliy L. Rayz, Pavlos P. Vlachos
2019 arXiv   pre-print
Typical approaches to patient-specific hemodynamic studies of cerebral aneurysms use image based computational fluid dynamics (CFD) and seek to statistically correlate parameters such as wall shear stress  ...  In this work, we conducted tomographic particle velocimetry experiments using two patient-specific cerebral aneurysm models (basilar tip and internal carotid artery) under pulsatile flow conditions and  ...  Patient-specific waveforms obtained from 4D Flow were prescribed at the inlet and outlets of the CFD models.  ... 
arXiv:1903.01303v1 fatcat:ysqzaz7pgjg6bnv6wexzyr2sza

Multi-modality cerebral aneurysm haemodynamic analysis: in vivo 4D flow MRI, in vitro volumetric particle velocimetry and in silico computational fluid dynamics

Melissa C. Brindise, Sean Rothenberger, Benjamin Dickerhoff, Susanne Schnell, Michael Markl, David Saloner, Vitaliy L. Rayz, Pavlos P. Vlachos
2019 Journal of the Royal Society Interface  
In this work, we used in vivo 4D flow MRI data to inform in vitro particle velocimetry and CFD modalities in two patient-specific cerebral aneurysm models (basilar tip and internal carotid artery).  ...  Typical approaches to patient-specific haemodynamic studies of cerebral aneurysms use image-based computational fluid dynamics (CFD) and seek to statistically correlate parameters such as wall shear stress  ...  Patient-specific waveforms obtained from 4D flow were prescribed at the inlet and outlets of the CFD models.  ... 
doi:10.1098/rsif.2019.0465 pmid:31506043 pmcid:PMC6769317 fatcat:in44s7fayvakpcb3yuj6bhikjm

Quantitative Assessment of Changes in Hemodynamics After Obliteration of Large Intracranial Carotid Aneurysms Using Computational Fluid Dynamics

Yongsheng Liu, Guinan Jiang, Feng Wang, Xiangbo An
2021 Frontiers in Neurology  
Parametric models with intracranial carotid aneurysm were created. Patient-specific geometries were generated by three-dimensional rotational angiography.  ...  We retrospectively reviewed data of 12 patients with intracranial carotid aneurysms.  ...  Further study with a larger number of patients would be necessary to validate our findings. Patient-specific flow-boundary information was unavailable, which might affect the results.  ... 
doi:10.3389/fneur.2021.632066 pmid:33995243 pmcid:PMC8116698 fatcat:mipyi77uovdztajz62ldpymqvi

Virtual Reality Visualization of CFD Simulated Blood Flow in Cerebral Aneurysms Treated with Flow Diverter Stents

Sima Baheri Islami, Mike Wesolowski, William Revell, Xiongbiao Chen
2021 Applied Sciences  
Virtual reality (VR) has the potential to be a powerful tool for the visualization of simulated blood flow in cerebral aneurysms.  ...  This paper presents our study aimed at developing the VR visualization of computational fluid dynamics (CFD) simulations of cerebral aneurysms treated with flow-diverting (FD) stents.  ...  Acknowledgments: We would like to thank Arjun Puri from Luxsonic Technologies for the provision of the headset to carry out visualization in the virtual reality environment.  ... 
doi:10.3390/app11178082 fatcat:larzeja5svckznequxhg5xxuzm

Comparison of existing aneurysm models and their path forward [article]

John Friesen, Jonas Bergner, Mohammad Ibrahim Aftab Khan, Stefan Triess, Andreas Zoll, Peter F. Pelz, Farzin Adili
2020 arXiv   pre-print
We perform a comprehensive literature review, using the Web of Science database.  ...  The two most important aneurysm types are cerebral aneurysms (CA) and abdominal aortic aneurysms (AAA), accounting together for over 80\% of all fatal aneurysm incidences.  ...  Commonly used imaging techniques to simulate patient specific blood flows are magnetic resonance angiography (MRT), computed tomography angiography (CTA) and 3D rotational angiography (3DRA).  ... 
arXiv:2010.00379v1 fatcat:auyljlqy35hzfnyic3qjd6y2bu

Comparison of existing aneurysm models and their path forward

John Friesen, Jonas Bergner, Mohammad Ibrahim Aftab Khan, Stefan Triess, Andreas Zoll, Peter F. Pelz, Farzin Adili
2021 Computer Methods and Programs in Biomedicine Update  
We perform a comprehensive literature review, using Web-of-Science.  ...  In addition to the specific evaluation of current models to determine the rupture probability of aneurysms, we show that an increased interdisciplinary exchange between specialists can boost comprehension  ...  Commonly used imaging techniques to simulate patient specific blood flows are magnetic resonance angiography (MRT), computed tomography angiography (CTA) and 3D 470 rotational angiography (3DRA).  ... 
doi:10.1016/j.cmpbup.2021.100019 fatcat:vy4dt4wlmfar5augmpjg2yr73q

Numerical simulation techniques to predict aneurysm recanalization after coil embolization and their problems

Soichiro Fujimura, Masaaki Shojima, Shigeru Nemoto, Yasuyuki Umeda, Tomohiro Yamada, Takumi Ishii, Fuki Wakabayashi, on behalf of CFD-BIO
2019 Journal of Biorheology  
Although various validations are required, CFD analysis may be a useful tool for predicting recanalization of aneurysms after coil embolization in the future.  ...  Various coil modeling techniques have been applied for computational fluid dynamics (CFD) analysis to predict recanalization after aneurysm coil embolization.  ...  Misaki et al. conducted a CFD analysis with the method of artificially deleting the aneurysm for patients who had recanalized and on stable patients, focusing on Pcom aneurysms.  ... 
doi:10.17106/jbr.33.65 fatcat:xbqc3dopkjalxik33etj6n5i3i

In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials

Ali Sarrami-Foroushani, Toni Lassila, Michael MacRaild, Joshua Asquith, Kit C. B. Roes, James V. Byrne, Alejandro F. Frangi
2021 Nature Communications  
We present the flow diverter performance assessment (FD-PASS) in-silico trial, which models the treatment of intracranial aneurysms in 164 virtual patients with 82 distinct anatomies with a flow-diverting  ...  In-silico trials rely on virtual populations and interventions simulated using patient-specific models and may offer a solution to lower these costs.  ...  To achieve this aim, we simulated post-flow diversion clot formation in our virtual patients with ICA aneurysms.  ... 
doi:10.1038/s41467-021-23998-w pmid:34162852 fatcat:a46qpoydybgfvc3n7etjk5owva

In vivo visualization and analysis of 3-D hemodynamics in cerebral aneurysms with flow-sensitized 4-D MR imaging at 3 T

Stephan Meckel, Aurelien F. Stalder, Francesco Santini, Ernst-Wilhelm Radü, Daniel A. Rüfenacht, Michael Markl, Stephan G. Wetzel
2008 Neuroradiology  
Relatively stable vortical flow was observed in aneurysms with a lower aspect ratio.  ...  Methods Five cerebral aneurysms were examined using ECG-gated, flow-sensitized 4-D MR imaging at 3 T in three patients.  ...  Conflict of interest statement We declare that we have no conflict of interest.  ... 
doi:10.1007/s00234-008-0367-9 pmid:18350286 fatcat:gkm4ebcpq5gczcwrkdu7ifcrtq

Evaluation of flow changes after telescopic stenting of a giant fusiform aneurysm of the vertebrobasilar junction

Sergey Sindeev, Jan Stephan Kirschke, Sascha Prothmann, Sergey Frolov, Dieter Liepsch, Philipp Berg, Claus Zimmer, Benjamin Friedrich
2019 BioMedical Engineering OnLine  
A patient-specific aneurysm model was acquired by rotational angiography, and three SILK flow-diverters (4.5 × 40, 5 × 40 and 5.5 × 40 mm) were virtually deployed in series along the basilar and right  ...  The use of flow-diverters for non-saccular cerebral posterior circulation aneurysms requires complex deployment techniques and is associated with high mortality and morbidity.  ...  of the Open Access Publishing Program.  ... 
doi:10.1186/s12938-019-0699-1 pmid:31340820 pmcid:PMC6657177 fatcat:vcyst5esmvfpjouhosdu43hqs4

Comparison of Two Stents in Modifying Cerebral Aneurysm Hemodynamics

Minsuok Kim, Dale B. Taulbee, Markus Tremmel, Hui Meng
2008 Annals of Biomedical Engineering  
There is a general lack of quantitative understanding about how specific design features of endovascular stents (struts and mesh design, porosity) affect the hemodynamics in intracranial aneurysms.  ...  From this, we propose a methodology to cost-effectively compare different stent designs before running a full 3D simulation.  ...  Patient-Specific Aneurysm Model The modeling techniques used in this study were applied to an anatomically realistic aneurysm geometry, which was reconstructed from Computed Tomographic Angiography (CTA  ... 
doi:10.1007/s10439-008-9449-4 pmid:18264766 pmcid:PMC2698293 fatcat:2uuu5v2zcbfpvow4mbnqn62pj4
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