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Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease

Kelvin K. Leung, Josephine Barnes, Gerard R. Ridgway, Jonathan W. Bartlett, Matthew J. Clarkson, Kate Macdonald, Norbert Schuff, Nick C. Fox, Sebastien Ourselin
2010 NeuroImage  
Volume and change in volume of the hippocampus are both important markers of Alzheimer's disease (AD).  ...  In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD.  ...  The research of STAPLE was supported in part by NIH R01 RR021885 from the National Center For Research Resources, and by an award from the Neuroscience Blueprint I/C through R01 EB008015 from the National  ... 
doi:10.1016/j.neuroimage.2010.03.018 pmid:20230901 pmcid:PMC2873209 fatcat:ocutewqrx5g7njnbrsfpqcmvqm

Science to Practice: Translating Automated Brain MRI Volumetry in Alzheimer's Disease from Research to Routine Diagnostic Use in the Work-Up of Dementia

Bharath Gopal Rathakrishnan, P. Murali Doraiswamy, Jeffrey R. Petrella
2014 Frontiers in Neurology  
completely automated, userindependent calculations of neural volumes.  ...  A semi-automated tracing-threshold technique for segmenting the hippocampus yielded a sensitivity of 82% and specificity of 80% in identifying patients with AD as compared to controls (14) .  ... 
doi:10.3389/fneur.2013.00216 pmid:24409168 pmcid:PMC3885875 fatcat:tdmq6exjrjgnxavzmtzmactc4u

Comparison of manual direct and automated indirect measurement of hippocampus using magnetic resonance imaging

Frederik L. Giesel, Philipp A. Thomann, Horst K. Hahn, Maria Politi, Bram Stieltjes, Marc-André Weber, Johannes Pantel, I.D. Wilkinson, Paul D. Griffiths, Johannes Schröder, Marco Essig
2008 European Journal of Radiology  
A significant volume difference was found between controls and AD patients (p < 0.001) with both the manual and the semi-automated approach.  ...  Conclusion: The presented indirect approach for hippocampus volumetry is equivalent to the direct approach and offers the advantages of observer independency, time reduction and thus usefulness for clinical  ...  However, having a t-test as the fundamental statistical tool, the latter method is unsuitable for the comparison of one subject with a normative template and thus solely allows group comparisons.  ... 
doi:10.1016/j.ejrad.2007.06.009 pmid:17643890 fatcat:7oamcn6cm5dzxbtxmxv3b4jury

Automatic Morphological Analysis of Medial Temporal Lobe

Andrea Chincarini, Mirko Corosu, Gianluca Gemme, Piero Calvini, Roberta Monge, Maria Antonietta Penco, Luca Rei, Sandro Squarcia, Patrizia Boccacci, Guido Rodriguez
2010 The Open Nuclear Medicine Journal  
Nowadays the efforts are directed toward finding an automated, unsupervised method of evaluating atrophy in some specific brain region, such as the medial temporal lobe (MTL).  ...  In this work we provide an extensive review of the state of the art on the automatic and semi-automatic image processing techniques for the early assessment of patients at risk of developing AD.  ...  [66] used the boundary shift integral analysis applied to a volume of interest centered on the hippocampus to calculate the rate of MTL atrophy.  ... 
doi:10.2174/1876388x01002010031 fatcat:qix37g6d4ngoper5be7kzlwuky

Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry

R. Rhys Davies, Victoria L. Scahill, Andrew Graham, Guy B. Williams, Kim S. Graham, John R. Hodges
2009 Neuroradiology  
Comparison of rating scores across disease groups showed involvement of the anterior fusiform gyrus, anterior hippocampus and temporal pole in semantic dementia, while anterior cingulate and orbitofrontal  ...  Introduction We aimed to devise a rating method for key frontal and temporal brain regions validated against quantitative volumetric methods and applicable to a range of dementia syndromes.  ...  Since we had a strong prior hypothesis that we would find atrophy at the location of rated regions, we used a small volume correction to correct for multiple comparisons [24] (see Table 1 for coordinates  ... 
doi:10.1007/s00234-009-0521-z pmid:19308367 fatcat:lljlx72fffhxva7tkqkae2xpgy

Automated Template-Based Hippocampal Segmentations from MRI: The Effects of 1.5T or 3T Field Strength on Accuracy

Kate E. Macdonald, Kelvin K. Leung, Jonathan W. Bartlett, Melanie Blair, Ian B. Malone, Josephine Barnes, Sebastien Ourselin, Nick C. Fox
2014 Neuroinformatics  
The SDs of the difference between volumes from manual and automated segmentations were similar at 1.5T and 3T, with a relatively narrow CI for their ratios.  ...  This study supports the use of our automated hippocampal voluming methods, developed using 1.5T images, with 3T images.  ...  Annualised atrophy rate as a percentage of baseline volume was calculated using the BSIs on a log scale and backtransformed.  ... 
doi:10.1007/s12021-013-9217-y pmid:24395058 pmcid:PMC4104163 fatcat:asg6arajznb25fkf2egngufk5i

Application of Automated Medial Temporal Lobe Atrophy Scale to Alzheimer Disease

Basil H. Ridha, Josephine Barnes, Laura A. van de Pol, Jonathan M. Schott, Richard G. Boyes, Musib M. Siddique, Martin N. Rossor, Philip Scheltens, Nick C. Fox
2007 Archives of Neurology  
Objective: To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods.  ...  Rates of HC atrophy and decline in the ATLAS score were significantly higher in patients with AD compared with controls.  ...  Acknowledgment: We are grateful to Dave MacManus, MSc, and Philippa Bartlett, DCR, for their help with this study. We particularly thank the subjects who participated in this study.  ... 
doi:10.1001/archneur.64.6.849 pmid:17562933 fatcat:26gqax34mjf7fdgqznxcqluzmu

Segmentation errors and intertest reliability in automated and manually traced hippocampal volumes

Benjamin H. Brinkmann, Hari Guragain, Daniel Kenney‐Jung, Jay Mandrekar, Robert E. Watson, Kirk M. Welker, Jeffrey W. Britton, Robert J. Witte
2019 Annals of Clinical and Translational Neurology  
To rigorously compare automated atlas-based and manual tracing hippocampal segmentation for accuracy, repeatability, and clinical acceptability given a relevant range of imaging abnormalities in clinical  ...  Acknowledgments The authors thank P. Weishaar, L. Padgett, and B. Knoepke of the Mayo 3D lab for performing manual hippocampal tracing.  ...  Guragain was supported during this study by National Institutes of Health R01NS097719 and a gift from Mr. and Mrs. David Hawk.  ... 
doi:10.1002/acn3.50885 pmid:31489797 pmcid:PMC6764491 fatcat:kktg2gsrjnazvl6324gepb4xc4

Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia

Yuan-Yu Hsu, Norbert Schuff, An-Tao Du, Kevin Mark, Xiaoping Zhu, Dawn Hardin, Michael W. Weiner
2002 Journal of Magnetic Resonance Imaging  
Conclusion-Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in  ...  Materials and Methods-Reliability was determined for an automatic and a manual method on nine volunteers (22-83 years old) who underwent MRI twice in 1 day.  ...  Louis, and to Dr. Sarang Joshi, University of North Carolina, Chapel Hill, for providing an image template and for helpful discussions.  ... 
doi:10.1002/jmri.10163 pmid:12205587 pmcid:PMC1851676 fatcat:iytei544lvf6relrgg4pud5cn4

Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson's Disease

Jin-Woo Park, Chan-Nyoung Lee, Youngbo Sim, Hyung-Kyu Ham, Woo-Suk Tae, Byung-Jo Kim
2019 Parkinson's Disease  
Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders.  ...  The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding  ...  To correct for multiple comparisons, the false discovery rate (FDR) introduced by Benjamini and Hochberg [14] was applied in the comparisons of total and subfield volumes in patients with PD vs. healthy  ... 
doi:10.1155/2019/8254263 pmid:30854188 pmcid:PMC6378059 fatcat:sklpymdrt5cvxjnw2fsdckz3sm

Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease

Keith S. Cover, Ronald A. van Schijndel, Adriaan Versteeg, Kelvin K. Leung, Emma R. Mulder, Remko A. Jong, Peter J. Visser, Alberto Redolfi, Jerome Revillard, Baptiste Grenier, David Manset, Soheil Damangir (+5 others)
2016 Psychiatry Research : Neuroimaging  
Abstract The purpose of this study is to assess the reproducibility of hippocampal atrophy rate measurements of commonly used fully-automated algorithms in Alzheimer disease (AD).  ...  The reproducibility of hippocampal atrophy rate for FSL/FIRST, AdaBoost, FreeSurfer, MAPS independently and MAPS combined with the boundary shift integral (MAPS-HBSI) were calculated.  ...  Hippocampal atrophy rate measurement A total of seven methods for measuring hippocampi atrophy rates were included in the studymanual segmentation and six fully automatic methods: the automated methods  ... 
doi:10.1016/j.pscychresns.2016.04.006 pmid:27179313 fatcat:czuhtwha2rb7doxpmvy72ggm5e

Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

Lies Clerx, Ineke A. van Rossum, Leah Burns, Dirk L. Knol, Philip Scheltens, Frans Verhey, Pauline Aalten, Pablo Lapuerta, Laura van de Pol, Ronald van Schijndel, Remko de Jong, Frederik Barkhof (+11 others)
2013 Neurobiology of Aging  
Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared.  ...  At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (  ...  There are several ways to determine the degree of MTL atrophy in the brain including manual delineation, (semi-) automated techniques to measure hippocampal volume, qualitative ratings of MTL atrophy (  ... 
doi:10.1016/j.neurobiolaging.2013.02.002 pmid:23540941 fatcat:wrwvbaunprcmllkue6vezirfva

Detecting Primary Progressive Aphasia Atrophy Patterns: A Comparison of Visual Assessment and Quantitative Neuroimaging Techniques

Stephanie Franczak, Jessica Pommy, Greta Minor, Chandler Zolliecoffer, Manav Bhalla, Mohit Agarwal, Andrew Nencka, Yang Wang, Andrew Klein, Darren O'Neill, Jude Henry, Glass Umfleet
2022 Journal of Alzheimer s Disease Reports  
There are now clinically available automated MRI analysis software programs that compare brain volumes of patients to a normative sample and provide z-score data for various brain regions.  ...  There were significantly lower z-scores in the left compared to right for the hippocampus, as well as parietal, occipital, and temporal cortices in lvPPA.  ...  both methods: lobar regions and the hippocampus.  ... 
doi:10.3233/adr-220036 fatcat:r7lfimdf65c2zhpdas2uwzfi5u

Progression from selective to general involvement of hippocampal subfields in schizophrenia

N F Ho, J E Iglesias, M Y Sum, C N Kuswanto, Y Y Sitoh, J De Souza, Z Hong, B Fischl, J L Roffman, J Zhou, K Sim, D J Holt
2016 Molecular Psychiatry  
In addition, follow-up scans were collected for a subset of Data set 1.  ...  In this study, we aimed to determine whether volume deficits in schizophrenia are confined to specific subfields of the hippocampus and to measure the subfield volume trajectories over the course of the  ...  CONFLICT OF INTEREST The authors declare no conflict of interest. We thank Dr. Jean Augustinack for her valuable comments on the manuscript. We  ... 
doi:10.1038/mp.2016.4 pmid:26903271 pmcid:PMC4995163 fatcat:4tyfvrktxnc3nixgakg55vrhee

A direct morphometric comparison of five labeling protocols for multi-atlas driven automatic segmentation of the hippocampus in Alzheimer's disease

Sean M. Nestor, Erin Gibson, Fu-Qiang Gao, Alex Kiss, Sandra E. Black
2013 NeuroImage  
However, there are several protocols to define the hippocampus anatomically in vivo, and the method used to generate atlases may impact automatic accuracy and sensitivity - particularly in pathologically  ...  Voxel-overlap accuracies between automatic and manual labels were lower for the more pathologically heterogeneous Sunnybrook study in comparison to the ADNI-1 sample.  ...  We would like to thank Gregory Szilagyi for coding a multiplexing batch script in Python and the anonymous reviewers for their helpful comments.  ... 
doi:10.1016/j.neuroimage.2012.10.081 pmid:23142652 pmcid:PMC3606906 fatcat:l4je6rxxjjdvdj2gqjampsjnii
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