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Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
2015
Cell
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Research in I.A. and A. ...
Colors are as indicated inFigure 2A.(C) Color-coded expression of key genes that mark the enriched subpopulation. ...
AUTHOR CONTRIBUTIONS Figure 2 . 2 Transcriptional Networks Define Myeloid Progenitor Populations (A) Schematic showing mean expression of a single gene across clusters C1-C18 colored by the index sorting ...
doi:10.1016/j.cell.2015.11.013
pmid:26627738
fatcat:x5wvmeckybcdzfpzzky4c7mb6q
Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors
2017
Nature Immunology
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lineage bias defined by specific transcriptional programs correlated with the relative IRF8/PU.1 ratios, which is transmitted to most progeny and reinforced by FLT3Ldriven IRF8 upregulation over division ...
monocytes, lymphocytes and three subsets of DCs from single human CD34 + progenitor cells, we show DC lineage specification occurs in parallel with myeloid and lymphoid lineages in HSCs, starting as a ...
Boxes correspond to the gates for relative IRF8 and PU.1 expression level in each of the six mature cell lineages. t-SNE maps in b (bottom) show distribution of clones derived from progenitors, with colors ...
doi:10.1038/ni.3789
pmid:28650480
pmcid:PMC5743223
fatcat:4fqxxquabjc7jof6ycgd43ctzm
Chromatin state dynamics during blood formation
2014
Science
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An important model system for differentiation is hematopoiesis where a single hematopoietic stem cell gives rise to a large number of cell types (comprising the blood) through a series of characterized ...
According to this model, differentiation is a gradual transition from an open chromatin state in multipotent stem cells to a compacted chromatin state in differentiated cells. ...
A patent application for iChIP has been filed by Yeda, Weizmann Institute of Science, Israel. ...
doi:10.1126/science.1256271
pmid:25103404
pmcid:PMC4412442
fatcat:ap43vx3pkne6livl5ruya7ydpa
Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells
2014
Genes & Development
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Chromatin dynamics in hematopoiesis provide a useful foundation to consider classical observations such as cellular reprogramming and multilineage locus priming. ...
This work was supported by National Institutes of Health grants R01HL63143 (R.A.S.) and R01GM099409 (X.S.L.) and a fellowship from the Leukemia and Lymphoma Society (C.Z.). ...
j on gene i, and j refers to a dynamic process between two consecutive differentiation steps; i.e., HSC to CMP, CMP to GMP or MEP, GMP to GRAN IMM , GRAN IMM to GRAN MAT , etc. ...
doi:10.1101/gad.240101.114
pmid:25128499
pmcid:PMC4197967
fatcat:suvgfg3fyndjne4rbdhwyayafi
Sequestration of a two-component response regulator by a riboswitch-regulated noncoding RNA
2014
Science
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In contrast, enhancer loss is a more gradual process that initiates in the CMP or MEP stage (for myeloid and erythrocyte development, respectively) with a large proportion (40 to 50%) of enhancers lost ...
An important model system for differentiation is hematopoiesis, in which a single hematopoietic stem cell gives rise to a large number of cell types (comprising the blood) through a series of characterized ...
doi:10.1126/science.1255083
pmid:25146292
fatcat:pn26wgzhwna7ldope23pqffcie
Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiation
[article]
2017
bioRxiv
pre-print
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While epigenomic landscapes of this process have been explored in immunophenotypically-defined populations, the single-cell regulatory variation that defines hematopoietic differentiation has been hidden ...
, and observe relatively simple TF motif dynamics give rise to a broad diversity of accessibility dynamics at cis-regulatory elements. ...
In concordance with these findings we find four CMP clusters, with significant variability across GATA1, BCL11A and SPI1 (PU.1), TFs implicated in myeloid/erythroid specification (Fig. 4a) . ...
doi:10.1101/109843
fatcat:qgxj7zqhnrdtrnxklwtf53abh4
Mapping Cellular Hierarchy by Single-Cell Analysis of the Cell Surface Repertoire
2013
Cell Stem Cell
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The strategy has broad applicability in other cellular systems. ...
The comprehensive single cell data set permits mapping of the mouse hematopoietic stem cell differentiation hierarchy by computational lineage progression analysis. ...
Examples of single-cell GEDI map from different cell types are presented. Color scale is as described in Figure 1B . ...
doi:10.1016/j.stem.2013.07.017
pmid:24035353
pmcid:PMC3845089
fatcat:d57jpv6grzg3dahjwyctku66re
Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells
2015
Journal of Leukocyte Biology
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The PU.1-expressing CMPs were found to have myeloid potential, whereas PU.1-deficient CMPs had erythroid potential, suggesting that PU.1 expression determines the developmental fate of a CMP [35] . ...
A description of sample preparation, quality control, and data processing is provided in Supplemental Methods. ...
doi:10.1189/jlb.6ta1014-477rr
pmid:25717144
pmcid:PMC4398258
fatcat:bxlskkzlavhxvohahx4223nfcy
Intelligent Trace and Evaluation for Parallel Programming Based on Architectural Details
2009
Journal of Computers
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As CMP became the main stream of processer design, parallel programming is a new challenge for programmer. ...
How could programmers figure out if their programs, which based on specific multi-processing architectures and mapping strategies, are efficient and even portable? ...
It maps computing task into 9 Of objects, and the shared memory is mapped to hierarchy memory system of TriBA. ...
doi:10.4304/jcp.4.11.1125-1132
fatcat:2psiet5uijheppq53xplzkyplq
A microRNA expression signature of osteoclastogenesis
2011
Blood
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Diminished PDCD4 removes a repression from c-Fos, a critical transcription factor for osteoclastogenesis and osteoclast-specific downstream target genes. ...
Thus, our studies provide a new molecular mechanism, including a positive feedback loop of c-Fos/miR-21/PDCD4, regulating osteoclastogenesis. (Blood. 2011;117(13): 3648-3657) ...
because PU.1-deficient mice have a decreased number of macrophages and no osteoclasts. 2, 3 CMPs are classified into Ն 2 subpopulations which are PU.1-expressing CMPs and PU.1 nonexpressing CMPs. 35 ...
doi:10.1182/blood-2010-10-311415
pmid:21273303
pmcid:PMC3072882
fatcat:phhhlrhlnjfpnobbggoa4uamxa
THE INFLUENCE OF ULTRASONIC TREATMENT ON THE BLEACHING OF CMP REVEALED BY SURFACE AND CHEMICAL STRUCTURAL ANALYSES
2010
BioResources
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Before single-stage hydrogen peroxide bleaching, CMP was sonicated at 1.5% pulp consistency and 50oC for 20min with 90% amplitude and 20s pulse; these conditions showed the most favorable effect of a 3.5% ...
ISO increase of brightness, reaching a final value of 80.2% ISO. ...
bleaching process. ...
doaj:da3802b05bfc4a4b9d1cdf2ea884e46d
fatcat:vdkfmx4j4rfufmlfudbrdvxwri
MultiMaKe
2013
ACM Transactions on Embedded Computing Systems
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The increasing demand for low-power and high-performance multimedia embedded systems has motivated the need for effective solutions to satisfy application bandwidth and latency requirements under a tight ...
Our approach decomposes the application's tasks into smaller units of computations called kernels, which are distributed and pipelined across the different processing resources. ...
For example, if |β| 2 is bigger than the random variable, the Q-bit can be mapped to C PU 1 processor and if not it is mapped to C PU 0 . ...
doi:10.1145/2435227.2435255
fatcat:cgyrtmttoff6hfdxgo2bwsakqq
Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation
2018
Cell
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We observe that the 4 CMP clusters within our data show significant variability across motifs associated with GATA1, BCL11A and SPI1 (PU.1), TFs implicated in myeloid/erythroid specification ( Figure ...
Given these differences, we assigned CMP clusters as CMP-K3 (early erythroid), CMP-K5 (late erythroid), CMP-K4 (unknown) and CMP-K2 (myeloid primed). ...
Highlights
• Single-cell chromatin accessibility reveals a heterogeneous hematopoietic landscape ...
doi:10.1016/j.cell.2018.03.074
pmid:29706549
pmcid:PMC5989727
fatcat:2jcbbnm4gbdolonx5r7hux4lda
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations
2016
Molecular Cell
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We present a highly sensitive and selective chemical labeling and capture approach for genomewide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA isolated from ~1,000 cells (nano-hmC-Seal). ...
.), a Starr Cancer Consortium grant (R.L.L. and A.M.M) and a Leukemia Lymphoma Society (LLS) SCOR grant 7006-13 (A.M.M.). A.H.S is a Special Fellow of the LLS and RLL is a Scholar of the LLS. ...
Genes in the same terms were linked to each other.The genes within the same clusters are surrounded by a common background color. ...
doi:10.1016/j.molcel.2016.06.028
pmid:27477909
pmcid:PMC4992443
fatcat:2ldgunirbvdshe3j5kj3srpgh4
Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice
2007
Leukemia
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Moreover, we showed that EDAG was a transcriptional regulator which had transactivation activity and regulated the expression of several key transcription factors such as PU.1 and Pax5 in transgenic hematopoietic ...
Erythroid differentiation-associated gene (EDAG) is a hematopoietic tissue-specific gene that is highly expressed in the earliest CD34 þ lin À bone marrow (BM) cells and involved in the proliferation and ...
For the analysis of CMP, BM CMPs were seeded at a density of 5 Â 10 2 cells/ml. For the analysis of CLP, BM CLPs were seeded at a density of 5 Â 10 3 cells/ml. ...
doi:10.1038/sj.leu.2404901
pmid:17690693
fatcat:twd4ymrj7vcjzehlbalppbsagu
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