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Acute In Vivo Testing of a Polymer Cuff Electrode with Integrated Microfluidic Channels for Stimulation, Recording, and Drug Delivery on Rat Sciatic Nerve

Sahar Elyahoodayan, Christopher Larson, Angelica M. Cobo, Ellis Meng, Dong Song
2020 Journal of Neuroscience Methods  
Extraneural cuffs are among the least invasive peripheral nerve interfaces as they remain outside the nerve.  ...  In vivo electrical evaluation demonstrates the ability of microelectrodes placed within microfluidic channels to successfully stimulate and record compound action potentials from rat sciatic nerve.  ...  For example, electrical stimulation of the peripheral nerve i.e. sciatic, ulnar, and occipital nerve have been used to treat chronic pain [1] , [2] .  ... 
doi:10.1016/j.jneumeth.2020.108634 pmid:32068010 fatcat:qwolm7czfvbptbw7ns3l64iupe

Printable microscale interfaces for long-term peripheral nerve mapping and precision control [article]

Timothy M Otchy, Christos Michas, Blaire Lee, Krithi Gopalan, Jeremy Gleick, Dawit Semu, Louis Darkwa, Bradley J Holinsky, Daniel J Chew, Alice E White, Timothy J Gardner
2019 biorxiv/medrxiv   pre-print
Here, we present a microscale implantable device - the nanoclip - for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints.  ...  These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.  ...  The nanoclip has been described in a patent filing (US Patent PR66142P, US Serial No. 62/367,975).  ... 
doi:10.1101/688218 fatcat:lwftc6wpwjfdbnuoqgoikxrsgq

A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals

Akhil Srinivasan, John Tipton, Mayank Tahilramani, Adel Kharbouch, Eric Gaupp, Chao Song, Poornima Venkataraman, Jessica Falcone, Stéphanie P. Lacour, Garrett B. Stanley, Arthur W. English, Ravi V. Bellamkonda (+1 others)
2015 European Journal of Neuroscience  
This marks a significant advance in microchannel interfacing, demonstrating the capability of microchannels to be used for peripheral nerve interfacing.  ...  Peripheral nerve interfacing could provide a rich controlling link between the body and these advanced prosthetics in order to increase their overall utility.  ...  Pai for support with the scientific principles employed in this study. Abbreviations AP, action potential; DRG, dorsal root ganglia; GT-RE, Georgia Tech.  ... 
doi:10.1111/ejn.13080 pmid:26370722 fatcat:viwddzzxtbbjtp7qh2cwaromxm

SenseBack - An Implantable System for Bidirectional Neural Interfacing

Ian Williams, Emma Brunton, Adrien Rapeaux, Yan Liu, Song Luan, Kianoush Nazarpour, Timothy Constandinou
2020 IEEE Transactions on Biomedical Circuits and Systems  
The large number of channels for a peripheral neural interface, coupled with fully implantable hardware and complete software flexibility enable complex in-vivo studies where the system can adapt to evolving  ...  To resolve this problem we present the SenseBack system, a post-implantation reprogrammable wireless 32-channel bidirectional neural interfacing device that can enable chronic peripheral electrophysiology  ...  ACKNOWLEDGMENT The authors would like to thank Jack Pearson for his help with the silicone encapsulation.  ... 
doi:10.1109/tbcas.2020.3022839 pmid:32915746 fatcat:dwikqzy47vb67gnjvodrjai5tm

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain

Sun Kwang Kim, Hideaki Hayashi, Tatsuya Ishikawa, Keisuke Shibata, Eiji Shigetomi, Youichi Shinozaki, Hiroyuki Inada, Seung Eon Roh, Sang Jeong Kim, Gihyun Lee, Hyunsu Bae, Andrew J. Moorhouse (+4 others)
2016 Journal of Clinical Investigation  
Kano for the gift of Elvax beads; D.X. Li  ...  The behavioral tests were performed during the daytime. Open-skull chronic cranial window implantation and long-term in vivo 2-photon imaging of spine dynamics.  ...  To implant the cranial window for chronic imaging (60), 2-month-old male C57BL/6 mice expressing EGFP under the control of the Thy1 promoter in a small subset of cortical neurons (GFP-M line mice) (31  ... 
doi:10.1172/jci82859 pmid:27064281 pmcid:PMC4855913 fatcat:w453gj7iwzfeblwajd47krze54

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Timothy M. Otchy, Christos Michas, Blaire Lee, Krithi Gopalan, Vidisha Nerurkar, Jeremy Gleick, Dawit Semu, Louis Darkwa, Bradley J. Holinski, Daniel J. Chew, Alice E. White, Timothy J. Gardner
2020 Nature Communications  
Here, we present a microscale implantable device - the nanoclip - for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints.  ...  In addition, we show that multi-channel, current-steering-based stimulation within the confines of the small device can achieve multi-dimensional control of a small nerve.  ...  We also thank Ian Davison, Benjamin Scott, Jeff Gavornik, Alberto Cruz-Martin, and members of the Gardner Lab for helpful comments on drafts of this paper.  ... 
doi:10.1038/s41467-020-18032-4 pmid:32826892 fatcat:fkwihw42dfczja46wlkimb3kui

BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury

Lianyan Huang, Jianhua Jin, Kai Chen, Sikun You, Hongyang Zhang, Alexandra Sideris, Monica Norcini, Esperanza Recio-Pinto, Jing Wang, Wen-Biao Gan, Guang Yang, Mikael Simons
2021 PLoS Biology  
Using in vivo two-photon imaging and Cx3cr1CreER;Bdnfflox mice, we show that conditional knockout of BDNF from microglia prevents nerve injury–induced synaptic remodeling and pyramidal neuron hyperactivity  ...  Following peripheral nerve injury, microglia in the S1 maintain ramified morphology and normal density but up-regulate the mRNA expression of brain-derived neurotrophic factor (BDNF).  ...  Acknowledgments We thank Gan lab and Yang lab members for helpful discussions. Author Contributions Conceptualization: Lianyan Huang, Wen-Biao Gan, Guang Yang.  ... 
doi:10.1371/journal.pbio.3001337 pmid:34292944 pmcid:PMC8346290 fatcat:6djeoefkyrdrhl2woccyom6cve

Additional tests to investigate neuropathic pain. The value of electroneuromyography for neuropathic pain

Fábio Henrique de Gobbi Porto, Gislaine Cristina Lopes Machado Porto, Mario Wilson Lervolino Brotto
2016 Revista Dor  
inside the device.  ...  A major complementary exam for the etiologic investigation of NP is electroneuromyography (ENMG), which examines the function of PNS large myelinated fibers by means of nervous conduction velocities and  ... 
doi:10.5935/1806-0013.20160042 fatcat:f37uvse3h5cczbp4oovpizosue

In Vivo Cellular‐Level 3D Imaging of Peripheral Nerves Using a Dual‐Focusing Technique for Intra‐Neural Interface Implantation

Min Woo Lee, Namseon Jang, Nara Choi, Sungwook Yang, Jinwoo Jeong, Hyeong Soo Nam, Sang‐Rok Oh, Keehoon Kim, Donghyun Hwang
2021 Advanced Science  
Thus far, no imaging devices can provide a cellular-level three-dimensional (3D) structural images of a peripheral nerve in vivo.  ...  In vivo volumetric imaging of the microstructural changes of peripheral nerves with an inserted electrode could be key for solving the chronic implantation failure of an intra-neural interface necessary  ...  Acknowledgements The authors would like to thank Editage (www.editage.co.kr) for English language editing. This  ... 
doi:10.1002/advs.202102876 pmid:34845862 pmcid:PMC8787432 fatcat:gnuxqnxbnrgupk5r4a7v4qvu3u

Real-time epidural anesthesia guidance using optical coherence tomography needle probe

Qinggong Tang, Chia-Pin Liang, Kyle Wu, Anthony Sandler, Yu Chen
2015 Quantitative Imaging in Medicine and Surgery  
To improve the accuracy of epidural space identification, we developed a small hand-held optical coherence tomography (OCT) forward-imaging needle device for real-time epidural anesthesia surgery guidance  ...  Due to lack of visual feedback to guide needle navigation, failure rate of epidural anesthesia is up to 20%, and the complication rate of peripheral nerve block approaches 10%, with the potential of permanent  ...  Acknowledgements We would like to thank the support from UMCP-CNMC Seed Grant Program. Disclosure: The authors declare no conflict of interest.  ... 
doi:10.3978/j.issn.2223-4292.2014.11.28 pmid:25694961 pmcid:PMC4312299 fatcat:542esgwyd5h4zlajai2r3vhgzy

Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation

Kelsey M. Greathouse, Steven P. Palladino, Chaoling Dong, Eric S. Helton, Eroboghene E. Ubogu
2016 Journal of Neuroinflammation  
data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain.  ...  Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational  ...  The funding sources had no involvement in the conduct of the research, manuscript preparation, data collection/analyses, or decision to submit this work for publication.  ... 
doi:10.1186/s12974-015-0469-3 pmid:26732309 pmcid:PMC4702318 fatcat:tdrfztnlv5g4vdqaj276u4inse

Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces

Kang-Il Song, Hyunseon Seo, Duhwan Seong, Seunghoe Kim, Ki Jun Yu, Yu-Chan Kim, Jinseok Kim, Seok Joon Kwon, Hyung-Seop Han, Inchan Youn, Hyojin Lee, Donghee Son
2020 Nature Communications  
Realizing a clinical-grade electronic medicine for peripheral nerve disorders is challenging owing to the lack of rational material design that mimics the dynamic mechanical nature of peripheral nerves  ...  In view of our materials strategy and in vivo feasibility, the mechanically adaptive self-healing neural interface would be considered a new implantable platform for a wide range application of electronic  ...  /low delay/self-power suppliable RF simultaneous information and power transfer system and stretchable electronic epineurium for wireless nerve bypass implementation).  ... 
doi:10.1038/s41467-020-18025-3 pmid:32826916 fatcat:gir332pf5bet3np4hpsvodnzde

A Brief Review of In Vitro Models for Injury and Regeneration in the Peripheral Nervous System

Parvathi Varier, Gayathri Raju, Pallavi Madhusudanan, Chinnu Jerard, Sahadev A. Shankarappa
2022 International Journal of Molecular Sciences  
Nerve axonal injury and associated cellular mechanisms leading to peripheral nerve damage are important topics of research necessary for reducing disability and enhancing quality of life.  ...  In addition to in vivo and mathematical models, in vitro axonal injury models provide a simple, robust, and reductionist platform to partially understand nerve injury pathogenesis and regeneration.  ...  Acknowledgments: We thank Neeraj Katiyar and Jitin Rajappan for their assistance in fabricating the aligned rake pin device shown in this article.  ... 
doi:10.3390/ijms23020816 pmid:35055003 pmcid:PMC8775373 fatcat:6k4nwpzofjdpbk6jquoad2bpwa

Cranial and Spinal Window Preparation for in vivo Optical Neuroimaging in Rodents and Related Experimental Techniques

Chanmi Yeon, Jeong Myo Im, Minsung Kim, Young Ro Kim, Euiheon Chung
2022 Experimental Neurobiology  
Such advancements in the cranial and spinal window have resulted in a paradigm shift in neuroscience, enabling in vivo investigation of the brain function and dysfunction at the microscopic, cellular level  ...  Either thinning down or removing portions of the skull or spine is necessary for unobstructed long-term in vivo observations, for which types of the cranial and spinal window and applied materials vary  ...  ACKNOWLEDGEMENTS The work was supported by The GIST  ... 
doi:10.5607/en22015 pmid:35786637 pmcid:PMC9272117 fatcat:nvfxh4e2fvc43jq4fxgoe5woje

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs

David M. Sokal, Alex McSloy, Matteo Donegà, Joseph Kirk, Romain A. Colas, Nikola Dolezalova, Esteban A. Gomez, Isha Gupta, Cathrine T. Fjordbakk, Sebastien Ouchouche, Paul B. Matteucci, Kristina Schlegel (+8 others)
2021 Frontiers in Immunology  
The development of neuromodulation therapy for the clinic requires chronic efficacy and safety testing in a large animal model.  ...  This manuscript describes the effects of longitudinal conscious splenic nerve neuromodulation in chronically-implanted pigs.  ...  The authors acknowledge Biorender.com for generation of graphics contained in the manuscript figures.  ... 
doi:10.3389/fimmu.2021.649786 pmid:33859641 pmcid:PMC8043071 fatcat:o5lzyqdgbjcorbiiy6ghgalqtq
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