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Here we present a bioinformatic approach to identify novel sites based on these shared features. ... A novel multiply edited transcript, BC10, was identified and experimentally verified. BC10 is highly conserved across a range of metazoa and has been implicated in two forms of cancer. ... Confirmation of BC10-a novel A-I editing region The top novel candidate, BC10, shows all the features of the positive controls. ...doi:10.1093/bioinformatics/bti411 pmid:15797904 fatcat:xnol5dty4rbffkshzdnh3wwyxm
In this study, we screened the human SNP database for potential cases of A-to-I RNA editing that cause amino acid changes in the encoded protein. ... Our approach sets the stage for effective and comprehensive genome-wide screens for A-to-I editing targets. . Article published online ahead of print. ... Identification of novel sites of A-to-I RNA editing among high scoring candidates Next we moved the four known cases of A-to-I editing (two in BC10 and one each in FLNA and CYFIP) that were contained in ...doi:10.1261/rna.816908 pmid:18772245 pmcid:PMC2553741 fatcat:qcuekypewzc7jbxcczpxfowrna