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A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10

D. R. Clutterbuck, A. Leroy, M. A. O'Connell, C. A. M. Semple
2005 Bioinformatics  
Here we present a bioinformatic approach to identify novel sites based on these shared features.  ...  A novel multiply edited transcript, BC10, was identified and experimentally verified. BC10 is highly conserved across a range of metazoa and has been implicated in two forms of cancer.  ...  Confirmation of BC10-a novel A-I editing region The top novel candidate, BC10, shows all the features of the positive controls.  ... 
doi:10.1093/bioinformatics/bti411 pmid:15797904 fatcat:xnol5dty4rbffkshzdnh3wwyxm

Screening of human SNP database identifies recoding sites of A-to-I RNA editing

W. M. Gommans, N. E. Tatalias, C. P. Sie, D. Dupuis, N. Vendetti, L. Smith, R. Kaushal, S. Maas
2008 RNA: A publication of the RNA Society  
In this study, we screened the human SNP database for potential cases of A-to-I RNA editing that cause amino acid changes in the encoded protein.  ...  Our approach sets the stage for effective and comprehensive genome-wide screens for A-to-I editing targets. . Article published online ahead of print.  ...  Identification of novel sites of A-to-I RNA editing among high scoring candidates Next we moved the four known cases of A-to-I editing (two in BC10 and one each in FLNA and CYFIP) that were contained in  ... 
doi:10.1261/rna.816908 pmid:18772245 pmcid:PMC2553741 fatcat:qcuekypewzc7jbxcczpxfowrna

Establishing stable cell lines for the generation of interaction profiles of proteins involved in RNA editing

Cornelia Handl
2012 unpublished
A to I RNA editing.  ...  In addition to the consequences of editing on its targets, mechanisms of regulation of A to I editing are still unclear.  ...  A to I RNA editing.  ... 
doi:10.25365/thesis.18744 fatcat:zz3hfm4l4jga7plz2d2jt36vvq