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A Volumetric Conformal Mapping Approach for Clustering White Matter Fibers in the Brain [chapter]

Vikash Gupta, Gautam Prasad, Paul Thompson
2016 Lecture Notes in Computer Science  
The efficacy of the method is demonstrated with a white matter clustering problem.  ...  Using conformal mapping techniques, we can establish a bijective mapping between the brain and the topologically equivalent sphere.  ...  Acknowledgments This study was supported in part by a Consortium grant (U54 EB020403) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative, including the NIBIB.  ... 
doi:10.1007/978-3-319-51237-2_1 pmid:29177252 pmcid:PMC5699220 fatcat:3g3vf7v6uzgyfewazu2hkcyvda

Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys

Auriel A. Willette, Catherine Gallagher, Barbara B. Bendlin, Donald G. McLaren, Erik K. Kastman, Elisa Canu, Kris J. Kosmatka, Aaron S. Field, Andrew L. Alexander, Ricki J. Colman, Mary-Lou L. Voytko, Richard H. Weindruch (+2 others)
2012 Neurobiology of Aging  
However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys.  ...  Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum.  ...  A. Alexander, Ph.D., and the Waisman Center for Brain Imaging are greatly appreciated. GRECC Manuscript Number XXXX.  ... 
doi:10.1016/j.neurobiolaging.2010.06.003 pmid:20691506 pmcid:PMC3279572 fatcat:kddufbbxnngz3gokiau4w3sinm

Alcohol consumption and premotor corpus callosum in older adults

Dimitrios Kapogiannis, Jason Kisser, Christos Davatzikos, Luigi Ferrucci, Jeffrey Metter, Susan M. Resnick
2012 European Neuropsychopharmacology  
Heavy alcohol consumption is toxic to the brain, especially to the frontal white matter (WM), but whether lesser amounts of alcohol negatively impact the brain WM is unclear.  ...  We used regional analysis of volumes examined in normalized space (RAVENS) maps methodology for WM and GM segmentation and normalization followed by voxel based morphometry statistical parametric mapping  ...  Acknowledgments This research was supported in part by the Intramural Research Program of the NIH/NIA and in part by N01-AG-3-2124.  ... 
doi:10.1016/j.euroneuro.2012.02.003 pmid:22401959 pmcid:PMC3378772 fatcat:2nobxukv7rdd5geh5tnun2t2rm

Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy

Mian Wei, Lingyan Shi, Yihui Shen, Zhilun Zhao, Asja Guzman, Laura J. Kaufman, Lu Wei, Wei Min
2019 Proceedings of the National Academy of Sciences of the United States of America  
We further develop volumetric phasor analysis of multispectral SRS images for chemically specific clustering and segmentation in 3D.  ...  Together, these results support volumetric chemical imaging as a valuable tool for elucidating comprehensive 3D structures, compositions, and functions in diverse biological contexts, complementing the  ...  Swayne and the Confocal and Specialized Microscopy Shared Resource of the Herbert Irving Comprehensive Cancer Center at Columbia University for help with 3D image analysis, supported by NIH Grant P30 CA013696  ... 
doi:10.1073/pnas.1813044116 fatcat:lz54ncsybrfrngs34q44ekqc6q

Serial optical coherence scanner for large-scale brain imaging at microscopic resolution

Hui Wang, Junfeng Zhu, Taner Akkin
2014 NeuroImage  
Volumetric images from serial scans are combined to realize large scale brain maps.  ...  SOCS integrates a multi-contrast optical coherence tomography and a vibratome slicer to establish comprehensive brain anatomy and fiber pathways in three-dimensional space.  ...  Theoden Netoff for generously offering the vibratome slicer, Heidi Rohrich and Core Grant for Vision Research (NIH, P30 EY11374) for histology, and Minnesota Supercomputing Institute for the high-performance  ... 
doi:10.1016/j.neuroimage.2013.09.063 pmid:24099843 pmcid:PMC3928112 fatcat:m5awltbbtvdw5m33ekxik7fieu

Automatic clustering and population analysis of white matter tracts using maximum density paths

Gautam Prasad, Shantanu H. Joshi, Neda Jahanshad, Julio Villalon-Reina, Iman Aganj, Christophe Lenglet, Guillermo Sapiro, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Margaret J. Wright, Arthur W. Toga (+1 others)
2014 NeuroImage  
We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain.  ...  Our results show that the MDP representation reveals important parts of the white matter structure and considerably reduces the dimensionality over comparable fiber matching approaches.  ...  Author disclosure statement The authors have no competing financial interests.  ... 
doi:10.1016/j.neuroimage.2014.04.033 pmid:24747738 pmcid:PMC4065851 fatcat:ymcxjw2lgjai7k7yklijmsnrqm

Capturing intraoperative deformations: research experience at Brigham and Women's hospital

Simon K. Warfield, Steven J. Haker, Ion-Florin Talos, Corey A. Kemper, Neil Weisenfeld, Andrea U.J. Mewes, Daniel Goldberg-Zimring, Kelly H. Zou, Carl-Fredrik Westin, William M. Wells, Clare M.C. Tempany, Alexandra Golby (+3 others)
2005 Medical Image Analysis  
This paper reviews the experience at Brigham and WomenÕs Hospital through the process of developing and applying novel algorithms for capturing intraoperative deformations in support of image guided therapy  ...  and the intraoperative configuration of the patientÕs brain.  ...  Acknowledgements This investigation was supported in part by NIH Grants R21 MH67054, R01 LM007861, P41 RR13218, P01 CA67165, R01 AG19513 and R33 CA99015 and by a research grant from CIMIT.  ... 
doi:10.1016/ pmid:15721230 fatcat:mahu4a6za5gz5lpg3sr2crzkfq

Population-averaged atlas of the macroscale human structural connectome and its network topology

Fang-Cheng Yeh, Sandip Panesar, David Fernandes, Antonio Meola, Masanori Yoshino, Juan C. Fernandez-Miranda, Jean M. Vettel, Timothy Verstynen
2018 NeuroImage  
A comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks.  ...  The trajectories were subsequently clustered and labeled by a team of experienced neuroanatomists in order to conform to prior neuroanatomical knowledge.  ...  This was done by projecting the fiber bundles back to the white matter and looking for areas without track coverage. Using a region-based approach, the senior neuroanatomists (Table S2 ).  ... 
doi:10.1016/j.neuroimage.2018.05.027 pmid:29758339 pmcid:PMC6921501 fatcat:eltzkzjnl5eqtpdv33fd7uouhe

A Hybrid Volume-Surface-Wire Integral Equation for the Anisotropic Forward Problem in Electroencephalography [article]

Maxime Y. Monin, Lyes Rahmouni, Adrien Merlini, Francesco P. Andriulli
2020 arXiv   pre-print
State-of-the-art electromagnetic solvers resort to a computationally expensive volumetric discretization of the full head to account for its complex and heterogeneous electric profile.  ...  The proposed hybrid integral equation formulation thereby avoids the full volumetric discretization of the head medium and allows for a realistic and efficient BEM-like solution of the anisotropic EEG  ...  fiber map of the white matter.  ... 
arXiv:2001.02904v1 fatcat:6jgf7stecbcvdimrvbxwyplaia

Multimodal Magnetic Resonance Imaging Study of Treatment-Naïve Adults with Attention-Deficit/Hyperactivity Disorder

Tiffany M. Chaim, Tianhao Zhang, Marcus V. Zanetti, Maria Aparecida da Silva, Mário R. Louzã, Jimit Doshi, Mauricio H. Serpa, Fabio L. S. Duran, Sheila C. Caetano, Christos Davatzikos, Geraldo F. Busatto, Juan Zhou
2014 PLoS ONE  
Volumetric abnormalities in ADHD subjects were found only at a trend level of significance, including reduced gray matter (GM) in the right angular gyrus, and increased GM in the right supplementary motor  ...  Results: Regarding DTI data, we found higher fractional anisotropy in ADHD relative to HC encompassing the white matter (WM) of the bilateral superior frontal gyrus, right middle frontal left gyrus, left  ...  Acknowledgments The present investigation was supported by a 2010 NARSAD Independent Investigator Award (NARSAD: The Brain and Behavior Research Fund) awarded to Geraldo F. Busatto. Geraldo F.  ... 
doi:10.1371/journal.pone.0110199 pmid:25310815 pmcid:PMC4195718 fatcat:cujjq2bsrreercxph5h3d7pgfy

Population-Averaged Atlas of the Macroscale Human Structural Connectome and Its Network Topology [article]

Fang-Cheng Yeh, Sandip Panesar, David Fernandes, Antonio Meola, Masanori Yoshino, Juan C. Fernandez-Miranda, Jean Vettel, Timothy Verstynen
2017 bioRxiv   pre-print
A comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks.  ...  The trajectories were subsequently clustered and labeled by a team of experienced neuroanatomists in order to conform to prior neuroanatomical knowledge.  ...  This was done by projecting the fiber bundles back to the white matter and looking for areas without track coverage. Using a region-based approach, the senior neuroanatomists (Table S2 ).  ... 
doi:10.1101/136473 fatcat:yhxgl2o6jvgrrl7hmmfirsewqm

Voxel-Wise Co-analysis of Macro- and Microstructural Brain Alteration in Mild Cognitive Impairment and Alzheimer's Disease Using Anatomical and Diffusion MRI

Valerie A. Cardenas, Duygu Tosun, Linda L. Chao, P. Thomas Fletcher, Sarang Joshi, Michael W. Weiner, Norbert Schuff
2013 Journal of Neuroimaging  
and Purpose-To determine if a voxel-wise "co-analysis" of structural and diffusion tensor magnetic resonance imaging (MRI) together reveals additional brain regions affected in mild cognitive impairment  ...  Conclusion-These results suggest that in corpus callosum and temporal regions macro-and microstructural variations in MCI can be congruent, providing potentially new insight into the mechanisms of brain  ...  Acknowledgments We are grateful to the staff at the Center for Imaging of Neurodegenerative Diseases at the San Francisco VA Hospital for MRI scanning.  ... 
doi:10.1111/jon.12002 pmid:23421601 pmcid:PMC3951683 fatcat:3tctoeotw5alrfffpzrzxrrzxe

Cerebral White Matter Changes in Young Healthy Individuals With High Trait Anxiety: A Tract-Based Spatial Statistics Study

Min Lu, Chunlan Yang, Tongpeng Chu, Shuicai Wu
2018 Frontiers in Neurology  
The altered white matter may be a vulnerability marker in individuals at high risk of clinical anxiety.  ...  However, with few literatures examining the association between the integrity of whole brain white matter and trait anxiety levels in the non-clinical populations, whether white matter changes arise in  ...  Therefore, we selected a voxel-wise approach to test the alterations in the entire brain white matter in young healthy individuals with high trait anxiety.  ... 
doi:10.3389/fneur.2018.00704 pmid:30197621 pmcid:PMC6117387 fatcat:2v4jydj2kzb2tfaczcu4hqojli

Mapping Short Association Fibers in the Early Cortical Visual Processing Stream Using In Vivo Diffusion Tractography

2020 Cerebral Cortex  
Short association fibers (U-fibers) connect proximal cortical areas and constitute the majority of white matter connections in the human brain.  ...  This study demonstrates a robust U-fiber connectivity mapping in vivo and is an important step toward construction of a more complete human brain connectome.  ...  N.W. was a speaker at an event organized by Siemens Healthineers and was reimbursed for the travel expenses.  ... 
doi:10.1093/cercor/bhaa049 pmid:32297628 pmcid:PMC7325803 fatcat:i4ha7rw6hncfbo4mf6etwox5su

More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome

F. Hoeft, N. Barnea-Goraly, B. W. Haas, G. Golarai, D. Ng, D. Mills, J. Korenberg, U. Bellugi, A. Galaburda, A. L. Reiss
2007 Journal of Neuroscience  
We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups (typically developing  ...  and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography).  ...  Results First, we used an automated observer-independent approach for assessing groupwise microstructural differences in the major white matter pathways throughout the brain and performed whole-brain voxel-based  ... 
doi:10.1523/jneurosci.3591-07.2007 pmid:17978036 pmcid:PMC6673356 fatcat:ry3sb6fmorcvznun3zbsaavtya
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