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A Volumetric Conformal Mapping Approach for Clustering White Matter Fibers in the Brain
[chapter]
2016
Lecture Notes in Computer Science
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The efficacy of the method is demonstrated with a white matter clustering problem. ...
Using conformal mapping techniques, we can establish a bijective mapping between the brain and the topologically equivalent sphere. ...
Acknowledgments This study was supported in part by a Consortium grant (U54 EB020403) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative, including the NIBIB. ...
doi:10.1007/978-3-319-51237-2_1
pmid:29177252
pmcid:PMC5699220
fatcat:3g3vf7v6uzgyfewazu2hkcyvda
Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
2012
Neurobiology of Aging
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However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys. ...
Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum. ...
A. Alexander, Ph.D., and the Waisman Center for Brain Imaging are greatly appreciated. GRECC Manuscript Number XXXX. ...
doi:10.1016/j.neurobiolaging.2010.06.003
pmid:20691506
pmcid:PMC3279572
fatcat:kddufbbxnngz3gokiau4w3sinm
Alcohol consumption and premotor corpus callosum in older adults
2012
European Neuropsychopharmacology
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Heavy alcohol consumption is toxic to the brain, especially to the frontal white matter (WM), but whether lesser amounts of alcohol negatively impact the brain WM is unclear. ...
We used regional analysis of volumes examined in normalized space (RAVENS) maps methodology for WM and GM segmentation and normalization followed by voxel based morphometry statistical parametric mapping ...
Acknowledgments This research was supported in part by the Intramural Research Program of the NIH/NIA and in part by N01-AG-3-2124. ...
doi:10.1016/j.euroneuro.2012.02.003
pmid:22401959
pmcid:PMC3378772
fatcat:2nobxukv7rdd5geh5tnun2t2rm
Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy
2019
Proceedings of the National Academy of Sciences of the United States of America
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We further develop volumetric phasor analysis of multispectral SRS images for chemically specific clustering and segmentation in 3D. ...
Together, these results support volumetric chemical imaging as a valuable tool for elucidating comprehensive 3D structures, compositions, and functions in diverse biological contexts, complementing the ...
Swayne and the Confocal and Specialized Microscopy Shared Resource of the Herbert Irving Comprehensive Cancer Center at Columbia University for help with 3D image analysis, supported by NIH Grant P30 CA013696 ...
doi:10.1073/pnas.1813044116
fatcat:lz54ncsybrfrngs34q44ekqc6q
Serial optical coherence scanner for large-scale brain imaging at microscopic resolution
2014
NeuroImage
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Volumetric images from serial scans are combined to realize large scale brain maps. ...
SOCS integrates a multi-contrast optical coherence tomography and a vibratome slicer to establish comprehensive brain anatomy and fiber pathways in three-dimensional space. ...
Theoden Netoff for generously offering the vibratome slicer, Heidi Rohrich and Core Grant for Vision Research (NIH, P30 EY11374) for histology, and Minnesota Supercomputing Institute for the high-performance ...
doi:10.1016/j.neuroimage.2013.09.063
pmid:24099843
pmcid:PMC3928112
fatcat:m5awltbbtvdw5m33ekxik7fieu
Automatic clustering and population analysis of white matter tracts using maximum density paths
2014
NeuroImage
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We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. ...
Our results show that the MDP representation reveals important parts of the white matter structure and considerably reduces the dimensionality over comparable fiber matching approaches. ...
Author disclosure statement The authors have no competing financial interests. ...
doi:10.1016/j.neuroimage.2014.04.033
pmid:24747738
pmcid:PMC4065851
fatcat:ymcxjw2lgjai7k7yklijmsnrqm
Capturing intraoperative deformations: research experience at Brigham and Women's hospital
2005
Medical Image Analysis
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This paper reviews the experience at Brigham and WomenÕs Hospital through the process of developing and applying novel algorithms for capturing intraoperative deformations in support of image guided therapy ...
and the intraoperative configuration of the patientÕs brain. ...
Acknowledgements This investigation was supported in part by NIH Grants R21 MH67054, R01 LM007861, P41 RR13218, P01 CA67165, R01 AG19513 and R33 CA99015 and by a research grant from CIMIT. ...
doi:10.1016/j.media.2004.11.005
pmid:15721230
fatcat:mahu4a6za5gz5lpg3sr2crzkfq
Population-averaged atlas of the macroscale human structural connectome and its network topology
2018
NeuroImage
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A comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks. ...
The trajectories were subsequently clustered and labeled by a team of experienced neuroanatomists in order to conform to prior neuroanatomical knowledge. ...
This was done by projecting the fiber bundles back to the white matter and looking for areas without track coverage. Using a region-based approach, the senior neuroanatomists (Table S2 ). ...
doi:10.1016/j.neuroimage.2018.05.027
pmid:29758339
pmcid:PMC6921501
fatcat:eltzkzjnl5eqtpdv33fd7uouhe
A Hybrid Volume-Surface-Wire Integral Equation for the Anisotropic Forward Problem in Electroencephalography
[article]
2020
arXiv
pre-print
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State-of-the-art electromagnetic solvers resort to a computationally expensive volumetric discretization of the full head to account for its complex and heterogeneous electric profile. ...
The proposed hybrid integral equation formulation thereby avoids the full volumetric discretization of the head medium and allows for a realistic and efficient BEM-like solution of the anisotropic EEG ...
fiber map of the white matter. ...
arXiv:2001.02904v1
fatcat:6jgf7stecbcvdimrvbxwyplaia
Multimodal Magnetic Resonance Imaging Study of Treatment-Naïve Adults with Attention-Deficit/Hyperactivity Disorder
2014
PLoS ONE
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Volumetric abnormalities in ADHD subjects were found only at a trend level of significance, including reduced gray matter (GM) in the right angular gyrus, and increased GM in the right supplementary motor ...
Results: Regarding DTI data, we found higher fractional anisotropy in ADHD relative to HC encompassing the white matter (WM) of the bilateral superior frontal gyrus, right middle frontal left gyrus, left ...
Acknowledgments The present investigation was supported by a 2010 NARSAD Independent Investigator Award (NARSAD: The Brain and Behavior Research Fund) awarded to Geraldo F. Busatto. Geraldo F. ...
doi:10.1371/journal.pone.0110199
pmid:25310815
pmcid:PMC4195718
fatcat:cujjq2bsrreercxph5h3d7pgfy
Population-Averaged Atlas of the Macroscale Human Structural Connectome and Its Network Topology
[article]
2017
bioRxiv
pre-print
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A comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks. ...
The trajectories were subsequently clustered and labeled by a team of experienced neuroanatomists in order to conform to prior neuroanatomical knowledge. ...
This was done by projecting the fiber bundles back to the white matter and looking for areas without track coverage. Using a region-based approach, the senior neuroanatomists (Table S2 ). ...
doi:10.1101/136473
fatcat:yhxgl2o6jvgrrl7hmmfirsewqm
Voxel-Wise Co-analysis of Macro- and Microstructural Brain Alteration in Mild Cognitive Impairment and Alzheimer's Disease Using Anatomical and Diffusion MRI
2013
Journal of Neuroimaging
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and Purpose-To determine if a voxel-wise "co-analysis" of structural and diffusion tensor magnetic resonance imaging (MRI) together reveals additional brain regions affected in mild cognitive impairment ...
Conclusion-These results suggest that in corpus callosum and temporal regions macro-and microstructural variations in MCI can be congruent, providing potentially new insight into the mechanisms of brain ...
Acknowledgments We are grateful to the staff at the Center for Imaging of Neurodegenerative Diseases at the San Francisco VA Hospital for MRI scanning. ...
doi:10.1111/jon.12002
pmid:23421601
pmcid:PMC3951683
fatcat:3tctoeotw5alrfffpzrzxrrzxe
Cerebral White Matter Changes in Young Healthy Individuals With High Trait Anxiety: A Tract-Based Spatial Statistics Study
2018
Frontiers in Neurology
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The altered white matter may be a vulnerability marker in individuals at high risk of clinical anxiety. ...
However, with few literatures examining the association between the integrity of whole brain white matter and trait anxiety levels in the non-clinical populations, whether white matter changes arise in ...
Therefore, we selected a voxel-wise approach to test the alterations in the entire brain white matter in young healthy individuals with high trait anxiety. ...
doi:10.3389/fneur.2018.00704
pmid:30197621
pmcid:PMC6117387
fatcat:2v4jydj2kzb2tfaczcu4hqojli
Mapping Short Association Fibers in the Early Cortical Visual Processing Stream Using In Vivo Diffusion Tractography
2020
Cerebral Cortex
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Short association fibers (U-fibers) connect proximal cortical areas and constitute the majority of white matter connections in the human brain. ...
This study demonstrates a robust U-fiber connectivity mapping in vivo and is an important step toward construction of a more complete human brain connectome. ...
N.W. was a speaker at an event organized by Siemens Healthineers and was reimbursed for the travel expenses. ...
doi:10.1093/cercor/bhaa049
pmid:32297628
pmcid:PMC7325803
fatcat:i4ha7rw6hncfbo4mf6etwox5su
More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome
2007
Journal of Neuroscience
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We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups (typically developing ...
and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography). ...
Results First, we used an automated observer-independent approach for assessing groupwise microstructural differences in the major white matter pathways throughout the brain and performed whole-brain voxel-based ...
doi:10.1523/jneurosci.3591-07.2007
pmid:17978036
pmcid:PMC6673356
fatcat:ry3sb6fmorcvznun3zbsaavtya
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