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Review—Opportunities for Rapid, Sensitive Detection of Troponin and Cerebral Spinal Fluid Using Semiconductor Sensors

Patrick H. Carey, Brian C. Lobo, Michael P. Gebhard, Marino E. Leon, Sherri D. Flax, Neil S. Harris, Yu-Te Liao, Chin-Wei Chang, Jenshan Lin, Fan Ren, S. J. Pearton
2019 Journal of the Electrochemical Society  
Cardiac troponin I (cTnI) in cardiac muscle tissue is a standard clinical biomarker for AMI, as its concentration rises quickly in the blood during release from myocardial cells following cell death.  ...  The challenge is to develop a real-time, accurate, low-cost point-of-care heart attack sensor.  ...  Acknowledgments The work at UF is partially supported by a Research Opportunity Fund award from UF Office of Research. ORCID Patrick H.  ... 
doi:10.1149/2.0072003jes fatcat:csyvsaqcdnhh5op7pagxysdwyi

Table of Contents

2020 IEEE Transactions on Biomedical Circuits and Systems  
Wong 1346 A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement . . . . . . . . . . . . . . . . . . . . . . . . . .S.-S. Shan, S.-Y. Lu, Y.-P. Yang, S.-P. Lin, P.  ...  Gosselin 1287 Spintronic Sensors Based on Magnetic Tunnel Junctions for Wireless Eye Movement Gesture Control . . . . . . . . . . . . . . . .  ... 
doi:10.1109/tbcas.2020.3044345 fatcat:vlmkojzsu5g4bdwzjwfjjg2rlq

Nanosensor networks for health-care applications [chapter]

Jiancheng Yang, Patrick Carey, Fan Ren, Brian C. Lobo, Michael Gebhard, Marino E. Leon, Jenshan Lin, S.J. Pearton
2020 Nanosensors for Smart Cities  
Acknowledgments The work at UF was partially supported by a grant from the NSF I/UCRC of the Multi-functional Integrated System Technology (MIST Center) IIP-1439644.  ...  The authors acknowledge the use of the Nanoscale Research Facility (NRF) in the Nanoscience Institute for Medical and Engineering Technology at the University of Florida.  ...  Troponin Cardiac troponin I (cTnI) and the complex involving cTnI, cardiac troponin T, and cardiac troponin C in the cardiac muscle tissue are standard clinical biomarkers for acute myocardial infarction  ... 
doi:10.1016/b978-0-12-819870-4.00023-2 fatcat:vnnxynay4rfgvlh3wtxt2nh4xm

Muscle-Cell-Based "Living Diodes" [article]

Uryan Isik Can, Neerajha Nagarajan, Dervis Can Vural, Pinar Zorlutuna
2017 arXiv   pre-print
These two cell types in a rectangular pattern allow the signal initiated on the excitable side to pass to the nonexcitable side, and not in the opposite direction.  ...  A new type of diode that is made entirely of electrically excitable muscle cells and nonexcitable fibroblast cells is designed, fabricated, and characterized.  ...  Biphasic pulses were achieved by using two electrodes simultaneously for stimulations.  ... 
arXiv:1706.00383v1 fatcat:xnyaabylavcfpkpupiq5eni7b4

Label-free detection of C-reactive protein using a carbon nanofiber based biosensor

Rakesh K. Gupta, Adaikkappan Periyakaruppan, M. Meyyappan, Jessica E. Koehne
2014 Biosensors & bioelectronics  
Biochemistry --Faculty Publications. 122. a b s t r a c t We report the sensitive detection of C-reactive protein (CRP), a biomarker for cardiac disease, using a carbon nanofiber based biosensor platform  ...  The CV responses show a 25% reduction in redox current upon the immobilization of anti-CRP on the electrode where as a 30% increase in charge transfer resistance is seen from EIS.  ...  Acknowledgment JK acknowledges a Presidential Early Career Award.  ... 
doi:10.1016/j.bios.2014.03.027 pmid:24709327 pmcid:PMC4103195 fatcat:gwdbf2jjs5eyri4lljacbyiune

Fundamentals and Applications of Impedimetric and Redox Capacitive Biosensors

Adriano Santos
2014 Journal of Analytical & Bioanalytical Techniques  
When applied to surfaces which have been specifically engineered so as to recruit targets from an analytical solution, potent sensors can be derived.  ...  Electroanalyses have brought a huge amount to our understanding of interfaces generally.  ...  When compared to the clinically relevant levels of cardiac biomarkers, such as myoglobin, cTnI (Troponin I) and CRP (C-reactive protein), for example, all at 10 -2 to 10 3 ng/mL, the demands are clear  ... 
doi:10.4172/2155-9872.s7-016 fatcat:y6gmytqxzjha7bjl2xxqajpfry

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

Célia Silveira, Tiago Monteiro, Maria Almeida
2016 Biosensors  
Stencil-, inkjet-, or screen-printing are the preferential techniques for electrode manufacturing.  ...  Not surprisingly, we witnessed a rapid increase in the number of publications on paper based screen-printed sensors at the turn of the past decade.  ...  CMS and TM thank the financial support from Fundação para a Ciência e Tecnologia (Fellowships SFRH/ BPD/79566/2011 and PD/BD/109687/2015).  ... 
doi:10.3390/bios6040051 pmid:27690119 pmcid:PMC5192371 fatcat:nv5764mfqrbu3hxohvxaklib2q

Rapid antifouling nanocomposite coating enables highly sensitive multiplexed electrochemical detection of myocardial infarction and concussion markers [article]

Sanjay Sharma Timilsina, Nolan Durr, Mohamed Yafia, Hani Sallum, Pawan Jolly, Donald E Ingber
2021 medRxiv   pre-print
Here we describe an ultra-fast (< 1 min) method for coating electrochemical (EC) sensors with an anti-fouling nanocomposite layer that can be stored at room temperature for months, which provides unprecedented  ...  We leveraged this method to develop a multiplexed diagnostic platform for detection of biomarkers that could potentially be used to triage patients with myocardial infarction and traumatic brain injury  ...  Value of cardiac troponin I 7 cutoff concentrations below the 99th percentile for clinical decision-making. Clinical 8 chemistry 55, 85-92 (2009). 9 30.  ... 
doi:10.1101/2021.06.13.21258856 fatcat:f6cjvj7xgzctleju6un3l2xp4q

Energy Autonomous Wearable Sensors for Smart Healthcare: A Review [article]

Abhishek Singh Dahiya, Jamila Boudaden, Yan Zhang, Peter Ramm (Fraunhofer IZM), Tim Kiessling, Cian O'Murchu, Fredrik Sebelius, Jonas Tilly, Colm Glynn, Kafil Razeeb, Alain Lacampagne, Aida Todri-Sanial
2019 arXiv   pre-print
Energy Autonomous Wearable Sensors (EAWS) have attracted a large interest due to their potential to provide reliable measurements and continuous bioelectric signals, which help to reduce health risk factors  ...  The third is the flexible and stretchable energy harvesting module to recharge batteries for continuous operation of wearable sensors.  ...  An open circuit voltage of about 315 mV was measured for a temperature difference of 10 K using a complete device with 210 TE pairs.  ... 
arXiv:1912.02596v1 fatcat:hjsl62fpazdllnokyshj5wtcqa

Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes

Markos Athanasiadis, Dzmitry Afanasenkau, Wouter Derks, Christoph Tondera, Francesca Murganti, Volker Busskamp, Olaf Bergmann, Ivan R. Minev
2020 npj Flexible Electronics  
Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study, repair and engineering of cardiac tissues.  ...  Here we present an algorithm for direct writing of elastic membranes with embedded electrodes, optical waveguides and microfluidics using a commercial 3D printing system and a palette of silicone elastomers  ...  ACKNOWLEDGEMENTS We thank the Light Microscopy and iPSC core facilities of BIOTEC/CRTD for their help with imaging and stem cell protocols, Simon Klapper and Anka Kempe for help with electroporation of  ... 
doi:10.1038/s41528-020-0075-z fatcat:3slceacqqjgrxmsvzjn5w6m7za

Recent Advances in Metal−Oxide Thin−Film Transistors: Flexible/Stretchable Devices, Integrated Circuits, Biosensors and Neuromorphic Applications

Yunchae Jeon, Dongyun Lee, Hocheon Yoo
2022 Coatings  
Compatibility with conventional semiconductor processes, such as photolithography of the metal oxide offers the possibility to develop integrated circuits on a larger scale.  ...  Here, this paper provides a timely overview of metal−oxide−based thin−film transistors focusing on emerging applications, including flexible/stretchable devices, integrated circuits, biosensors, and neuromorphic  ...  Agarwal et al. reported a ZnO-based transistor that could detect cardiac troponin-T (cTnT) as a biomarker of cardiovascular disease.  ... 
doi:10.3390/coatings12020204 fatcat:kqbszq7mwjhq3f5wqrvb5jfkc4

From Small Molecules Toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Robert Ziółkowski, Marta Jarczewska, Łukasz Górski, Elżbieta Malinowska
2021 Sensors  
This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs,  ...  neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses.  ...  In another approach, cardiac troponin I was detected using gold disk electrodes that were modified with thiolated aptamer strands specific to troponin I.  ... 
doi:10.3390/s21030724 pmid:33494499 pmcid:PMC7866209 fatcat:ndzopm2worf7nci5l262ufxoa4

Voltage clamp methods for the study of membrane currents and SR Ca2+ release in adult skeletal muscle fibres

Erick O. Hernández-Ochoa, Martin F. Schneider
2012 Progress in Biophysics and Molecular Biology  
In studying the origin and mechanism of voltage dependency of E-C coupling a variety of different techniques have been used to control the voltage in adult skeletal fibres.  ...  Skeletal muscle excitation-contraction (E-C) 1 coupling is a process composed of multiple sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR) 2 Ca 2+ release and subsequent  ...  Acknowledgments We are grateful to the National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), for their continuing support to my laboratory  ... 
doi:10.1016/j.pbiomolbio.2012.01.001 pmid:22306655 pmcid:PMC3321118 fatcat:2dg5qar6pbatlnl26crz6bnh3i

Review—Energy Autonomous Wearable Sensors for Smart Healthcare: A Review

Abhishek Singh Dahiya, Jerome Thireau, Jamila Boudaden, Swatchith Lal, Umair Gulzar, Yan Zhang, Thierry Gil, Nadine Azemard, Peter Ramm, Tim Kiessling, Cian O'Murchu, Fredrik Sebelius (+8 others)
2020 Journal of the Electrochemical Society  
Energy Autonomous Wearable Sensors (EAWS) have attracted a large interest due to their potential to provide reliable measurements and continuous bioelectric signals, which help to reduce health risk factors  ...  A representative summary of the performances of mechanical strain/pressure wearable sensors is provided in Table I (piezoresistive and capacitive) and Table II (piezoelectric and triboelectric).  ...  and simple readout circuits. 20, [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42] The important requirements for resistive strain sensors to be employed for wearable applications are: (i) high  ... 
doi:10.1149/2.0162003jes fatcat:a2o34apwc5d7lc7rh34sro353a

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Larysa Baraban, Bergoi Ibarlucea, Eunhye Baek, Gianaurelio Cuniberti
2019 Advanced Science  
Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics.  ...  The second group is represented by devices for optoelectronics that acquire higher optical sensitivity or efficiency due to the specific photosensitive decoration of the nanowires.  ...  Later this group demonstrated [188] a monolithic integration of an array of FETs onto a CMOS chip with the readout circuit on the same substrate and conducted cardiac troponin T for ten nanowires.  ... 
doi:10.1002/advs.201900522 pmid:31406669 pmcid:PMC6685480 fatcat:lzjyp3mpuzbxvonrsxgqufjgae
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