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Mapping Tinnitus-Related Brain Activation: An Activation-Likelihood Estimation Metaanalysis of PET Studies

J.-J. Song, D. De Ridder, P. Van de Heyning, S. Vanneste
2012 Journal of Nuclear Medicine  
Nonetheless, disparities in task dimension among studies, low statistical power due to small sample size, and the intrinsic uncertainty of a modality that measures activity indirectly limit the comprehensive  ...  In tinnitus, PET and other functional imaging modalities have shown functional changes not only in the auditory cortex but also in nonauditory regions such as the limbic, frontal, and parietal areas.  ...  The advent of brain-imaging tools provided neuroscientists with a window into the brain activity that orchestrates tinnitus.  ... 
doi:10.2967/jnumed.112.102939 pmid:22917883 fatcat:egjklndajbcl5gqnypjnpwucfa

Imaging human connectomes at the macroscale

R Cameron Craddock, Saad Jbabdi, Chao-Gan Yan, Joshua T Vogelstein, F Xavier Castellanos, Adriana Di Martino, Clare Kelly, Keith Heberlein, Stan Colcombe, Michael P Milham
2013 Nature Methods  
This review provides a survey of magnetic resonance imaging-based measurements of functional and structural connectivity.  ...  Successful annotation of phenotypic associations with variation in the connectome and cataloguing of neurophenotypes promise to transform our understanding of the human brain.  ...  Thanks to Daniel Lurie for his assistance in the preparation of the manuscript and references, as well as to Zarrar Shehzad, Zhen Yang and Sebastian Urchs for their helpful comments.  ... 
doi:10.1038/nmeth.2482 pmid:23722212 pmcid:PMC4096321 fatcat:ahp5n642fzahpdjl2nke67dwxq

Mapping of Motor Function with Neuronavigated Transcranial Magnetic Stimulation: A Review on Clinical Application in Brain Tumors and Methods for Ensuring Feasible Accuracy

Nico Sollmann, Sandro M. Krieg, Laura Säisänen, Petro Julkunen
2021 Brain Sciences  
Navigated transcranial magnetic stimulation (nTMS) has developed into a reliable non-invasive clinical and scientific tool over the past decade.  ...  Based on this clinical use case of the technique, in this article we review the evidence for the feasibility of motor mapping and derived models (risk stratification and prediction, nTMS-based fiber tracking  ...  The area calculated from active grid squares is presented in green and, for ease of comparison, the spline interpolation area calculated from the active grid sites is shown in blue.  ... 
doi:10.3390/brainsci11070897 fatcat:34m6brg75fbhlc7fhmniroc3ey

A method for spatiotemporal mapping of event-related modulation of cortical rhythmic activity

H. Laaksonen, J. Kujala, R. Salmelin
2008 NeuroImage  
Comparison of this multidipole model with the original signal yields a quantitative measure of goodness for the identified source areas and the analysis approach in general.  ...  Here, we introduce erDICS, an event-related version of Dynamic Imaging of Coherent Sources that allows spatial mapping of the level of oscillatory activity in the brain as a function of time, with respect  ...  Rhythmic activity and synchrony at the neuronal population level are not directly accessible with hemodynamic imaging methods (fMRI; positron emission tomography, PET).  ... 
doi:10.1016/j.neuroimage.2008.04.175 pmid:18538584 fatcat:hku4hrquyjf2hpradzi4pogssi

The role of fMRI in drug development

Owen Carmichael, Adam J. Schwarz, Christopher H. Chatham, David Scott, Jessica A. Turner, Jaymin Upadhyay, Alexandre Coimbra, James A. Goodman, Richard Baumgartner, Brett A. English, John W. Apolzan, Preetham Shankapal (+1 others)
2018 Drug Discovery Today  
We then provide an update on our current understanding of the strengths and limitations of fMRI as a tool for drug developers and recommend activities to enhance its utility.  ...  Functional magnetic resonance imaging (fMRI) has been known for over a decade to have the potential to greatly enhance the process of developing novel therapeutic drugs for prevalent health conditions.  ...  It grew out of discussions that took place at the 'Functional MRI in Clinical Trials: State of the Science and Future Directions' symposium that was held December 1-3, 2015, at Pennington Biomedical Research  ... 
doi:10.1016/j.drudis.2017.11.012 pmid:29154758 pmcid:PMC5931333 fatcat:cpfshk7mnvhlpoh5sxamuuvnxu

Imaging

John C. Mazziotta
2000 Archives of Neurology  
A battery of methods are now available for the preoperative and intraoperative evaluation of patients with lesions in or near critical cortical areas or for targeting purposes when deep nuclei of the brain  ...  The development of probabilistic atlases will soon provide a means of understanding normal variants of human brain structure and function and studying brain disorders and their treatment in an objective  ...  Accepted for publication March 24, 2000  ... 
doi:10.1001/archneur.57.10.1413 pmid:11030792 fatcat:b6etfkilubhaxdgk65qfsn6jsq

Invasive Research Methods [chapter]

Matthew A. Howard, Kirill V. Nourski, John F. Brugge
2012 Springer Handbook of Auditory research  
Acknowledgments Preparation of this chapter was supported by NIH RO1-DC004290, UL1RR024979, and GCRC MO1-RR-59 and by the Hoover Fund.  ...  around the head (see Alain & Winkler, Chapter 4 , and Nagarajan, Chapter 5 ), and brain-imaging methods based on changes in cerebral blood fl ow, including positron emission tomography (PET) and functional  ...  The position of depth electrodes and location of each recording site is then reported in Talairach coordinates.  ... 
doi:10.1007/978-1-4614-2314-0_3 fatcat:ec7grigpjjb7zhdpwvopa7jj3y

Brain Imaging in Alzheimer Disease

K. A. Johnson, N. C. Fox, R. A. Sperling, W. E. Klunk
2012 Cold Spring Harbor Perspectives in Medicine  
Imaging in the Diagnosis and Prognosis of AD The uncertainty inherent in a clinical diagnosis of AD has driven a search for diagnostic imaging markers.  ...  Furthermore, imaging is an established tool in drug discovery, increasingly required in therapeutic trials as part of inclusion criteria, as a safety marker, and as an outcome measure.  ... 
doi:10.1101/cshperspect.a006213 pmid:22474610 pmcid:PMC3312396 fatcat:7gib5qw4onbmxiysvou6jj72le

Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis

Y. Ishiuji, R.C. Coghill, T.S. Patel, Y. Oshiro, R.A. Kraft, G. Yosipovitch
2009 British Journal of Dermatology  
.4 -13 A recent study using positron emission tomography (PET) was the first to image brain processing of itch in patients with AD in remission and demonstrated similar areas of activation to those of  ...  In addition, an association was noted between DLPFC activity and disease severity. Conclusions-Our results demonstrate that ASL fMRI is a promising technique to assess brain activity in chronic itch.  ...  Acknowledgments This study was sponsored by the NEASE (National Eczema Association for Science and Education). G.Y. is supported by NIH AR55902. R.C.C. is supported by NIH NS39426 and DA20168.  ... 
doi:10.1111/j.1365-2133.2009.09308.x pmid:19663870 pmcid:PMC2784001 fatcat:kb4grmzftnbjjmy5tptwbw6zyy

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

Language functional MRI and direct cortical stimulation in epilepsy preoperative planning

Alison Austermuehle, John Cocjin, Richard Reynolds, Shubhi Agrawal, Leigh Sepeta, William D. Gaillard, Kareem A. Zaghloul, Sara Inati, William H. Theodore
2017 Annals of Neurology  
For patients with no language positive stimulation sites, fMRI was a dependable method of excluding eloquent language processing.  ...  For patients with at least one language positive stimulation site, an auditory description decision task provided the best tradeoff between sensitivity and specificity.  ...  This study was supported by the National Institute of Neurological Disorders and Stroke Division of Intramural Research.  ... 
doi:10.1002/ana.24899 pmid:28220524 pmcid:PMC5401636 fatcat:ooisj2p4ffdg3jyqnim5emsxgi

Free Software for PET Imaging [chapter]

Roberto de la Prieta
2012 Positron Emission Tomography - Current Clinical and Research Aspects  
Likewise, it is also a valuable tool in the design and assessment of correction and reconstruction methods (Zaidi & Koral (2004) , Holdsworth et al. (2002) ) and in the study of an imaging system response  ...  An object editor is used for definition of the activity and attenuation objects for the PHG.  ...  Free Software for PET Imaging, Positron Emission Tomography -Current Clinical and Research Aspects, Dr.  ... 
doi:10.5772/31882 fatcat:beoywmjmzzcyfkbrgbk7i4z7am

Examining cortical dynamics and connectivity with simultaneous single-pulse transcranial magnetic stimulation and fast optical imaging

Nathan A. Parks, Edward L. Maclin, Kathy A. Low, Diane M. Beck, Monica Fabiani, Gabriele Gratton
2012 NeuroImage  
Here, we introduce a novel method of imaging TMS-evoked activity using a non-invasive fast optical imaging tool, the event-related optical signal (EROS).  ...  Results demonstrate that concurrent TMS/EROS is a viable and potentially powerful method for studying TMS-induced activity in the human brain.  ...  Gratton, and by a Beckman Institute Postdoctoral Fellowship to Nathan Parks.  ... 
doi:10.1016/j.neuroimage.2011.08.097 pmid:21925608 pmcid:PMC3254814 fatcat:v2qhncx2rfb6hasq6y7jzrnuou

ÉCole De Physique Des Houches [chapter]

2007 Les Houches  
Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  activity in ideal surroundings for skiing, hiking or mountaineering.  ...  ., and Schmittbuhl, M. (2008) correlaTive analysis of recurrenT MulTicolor fluorescence iMaGes To characTerize in vivo The effecT of anTiveGf druGs on GlioBlasToMa TuMor develoPMenT Rodriguez, T.  ... 
doi:10.1016/s0924-8099(13)60020-7 fatcat:jydcwidbbnf3nppqp4x3pyu6ga

École de Physique des Houches [chapter]

2008 Les Houches  
Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  activity in ideal surroundings for skiing, hiking or mountaineering.  ...  ., and Schmittbuhl, M. (2008) correlaTive analysis of recurrenT MulTicolor fluorescence iMaGes To characTerize in vivo The effecT of anTiveGf druGs on GlioBlasToMa TuMor develoPMenT Rodriguez, T.  ... 
doi:10.1016/s0924-8099(13)60004-9 fatcat:nxiezedqabbbtnfqonvw6c3doi
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