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Harnessing Systems Biology Approaches to Engineer Functional Microvascular Networks

Lauren S. Sefcik, Jennifer L. Wilson, Jason A. Papin, Edward A. Botchwey
2010 Tissue engineering. Part B, Reviews  
This review focuses on how systems biology approaches have been applied to microvascular growth and remodeling, and how network analysis tools can be utilized to aid novel pro-angiogenic drug discovery  ...  Most pro-angiogenic clinical trials to date have focused on increasing neovascularization via the delivery of a single growth factor or gene.  ...  Acknowledgments Funding support was provided by NIAMS grant K01AR052352-01A1 to Dr. E.A. Botchwey and NSF CAREER award #0643548 to Dr. J.A. Papin.  ... 
doi:10.1089/ten.teb.2009.0611 pmid:20121415 pmcid:PMC2946904 fatcat:64beiuj6qvhqvkrlw2dttqnc7i

Gene therapy from the perspective of systems biology

Feilim Mac Gabhann, Brian H Annex, Aleksander S Popel
2010 Current opinion in molecular therapeutics (Print)  
; anti-angiogenic gene therapy in cancer is also discussed.  ...  Specific tissues or cell types are targeted in order to decrease the risks of systemic or side effects.  ...  Genomic and proteomic approaches have been used to identify new targets for gene therapy in cardiovascular applications [16] and cancer [17] .  ... 
pmid:20886389 pmcid:PMC3021921 fatcat:vhb4b5cdqfhnrcwt5oriiywfeq

Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels

Dylan T. Jones, Tanguy Lechertier, Richard Mitter, John M. J. Herbert, Roy Bicknell, J. Louise Jones, Ji-Liang Li, Francesca Buffa, Adrian L. Harris, Kairbaan Hodivala-Dilke, Soumitro Pal
2012 PLoS ONE  
Overall, our results provide proof-of-principle that our approach can identify a cohort of potentially novel anti-angiogenic targets that are likley to be, but not exclusivley, relevant to breast cancer  ...  Thus, the discovery of novel anti-angiogenic targets, relevant to individual cancer types, is required.  ...  I would also like to thank Marwa Dawoud and Stephen Robinson for ideas, support and guidance in this project.  ... 
doi:10.1371/journal.pone.0044294 pmid:23056178 pmcid:PMC3462779 fatcat:eioppigszjd3fo6i6u3mi6kbi4

Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature [chapter]

Wouter H.P. Driessen, Michael G. Ozawa, Wadih Arap, Renata Pasqualini
2009 Advances in Genetics  
Gene therapy strategies in cancer have remained an active area of preclinical and clinical research.  ...  While identification of functional and systemically accessible molecular targets is challenging, approaches, such as in vivo phage display and phage-based viral delivery vectors, provide a platform upon  ...  St Croix et al. utilized microdissection combined with serial analysis of gene expression (SAGE) to identify several candidate tumor endothelial markers in human colorectal cancers (Saha et al., 2001;  ... 
doi:10.1016/s0065-2660(09)67004-8 pmid:19914451 pmcid:PMC7172741 fatcat:d5kflvevsbbhthmnwfxv6cl4iu

Systems biology of pro-angiogenic therapies targeting the VEGF system

Feilim Mac Gabhann, Amina A. Qutub, Brian H. Annex, Aleksander S. Popel
2010 Wiley Interdisciplinary Reviews: Systems Biology and Medicine  
A systems biology approach to designing pro-angiogenic therapies, using a combination of quantitative experimental approaches and detailed computational models, is essential to deal with this complexity  ...  and to understand the effects of drugs targeting the system.  ...  Off-target and side effects Along with therapeutic predictions based on the impact of a strategy on a target, combined experimental-computational systems biology approaches also allow us to pre-emptively  ... 
doi:10.1002/wsbm.92 pmid:20890966 pmcid:PMC2990677 fatcat:z3iur22cafcwtec475jcv7d6oi

Recent advances on the molecular mechanism of cervical carcinogenesis based on systems biology technologies

Min Lin, Miaomiao Ye, Junhan Zhou, Z. Peter Wang, Xueqiong Zhu
2019 Computational and Structural Biotechnology Journal  
Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics  ...  These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic  ...  To achieve this goal, system biology approaches would Fig. 1 . Systems biology approaches are utilized in personalized medicine of cervical cancer.  ... 
doi:10.1016/j.csbj.2019.02.001 pmid:30847042 pmcid:PMC6389684 fatcat:rh2mnldderab5as4vn7iy7zmki

Role of microRNAs in vascular diseases, inflammation, and angiogenesis

C. Urbich, A. Kuehbacher, S. Dimmeler
2008 Cardiovascular Research  
Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs.  ...  Although multiple growth factors have been shown to regulate angiogenesis and vascular development, little is known about the complex upstream regulation of gene expression and translation.  ...  Thus, the pro-angiogenic miR-130a is expressed at low levels in quiescent HUVEC and is upregulated in response to foetal bovine serum. 37 miR-130a downregulates the anti-angiogenic homeobox proteins  ... 
doi:10.1093/cvr/cvn156 pmid:18550634 fatcat:5k5ikgv7w5altbrwccfq2oojqy

miRNAs: micro-managers of anticancer combination therapies

Judy R. van Beijnum, Elisa Giovannetti, Dennis Poel, Patrycja Nowak-Sliwinska, Arjan W. Griffioen
2017 Angiogenesis  
However, single targeted agents have not fully lived up to the initial promise of anti-angiogenic therapy.  ...  Angiogenesis is one of the hallmarks of cancer progression and as such has been considered a target of therapeutic interest.  ...  Acknowledgements The authors acknowledge European Research Council (ERC-StG-2015-680209 to PNS), and the Dutch Cancer Society (VU2012-5480 to JRvB; VU2014-7234 to AWG and PNS) for financial support.  ... 
doi:10.1007/s10456-017-9545-x pmid:28474282 pmcid:PMC5519663 fatcat:u4iihngfazgwpf4m6g5xshd4nm

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Zhiwei Hu, Samira A. Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung Lin, Thierry Massfelder, W.Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei (+19 others)
2015 Carcinogenesis  
We also consider the cross-hallmark relationships of a number of important angiogenic pathway targets with other cancer hallmarks and we make recommendations for future research.  ...  Understanding of the role of low-dose exposure of chemicals with disruptive potential could help us refine our approach to cancer risk assessment, and may ultimately aid in preventing cancer by reducing  ...  Specifically, Z.H. for overall, Prioritized Targets, TF Signaling Pathways and In vitro and In vitro Angiogenesis Assays including Figure 1  ... 
doi:10.1093/carcin/bgv036 pmid:26106137 pmcid:PMC4492067 fatcat:utmywlt7e5hm3nzxxdrryvt2yi

A multi-layer post-transcriptional gene regulatory program fuels cancer angiogenesis and metastasis

Ali Nehme, Hamed S. Najafabadi, Yasser Riazalhosseini
2019 Biotarget  
HS Najafabadi holds a CIHR Canada Research Chair in Systems Biology of Gene Regulation. Conflicts of Interest: The authors have no conflicts of interest to declare.  ...  MicroRNAs are master regulators of gene expression and have the capacity to target hundreds of genes simultaneously, which makes them attractive candidates as prognostic biomarkers and therapeutic targets  ... 
doi:10.21037/biotarget.2019.07.02 fatcat:qitpivg455bvhdpduramuocr6y

MicroRNAs As Novel Regulators of Angiogenesis

Y. Suarez, W. C. Sessa
2009 Circulation Research  
MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression.  ...  Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases  ...  For this gene, a group of candidate regulatory miRNAs has been identified recently and the miRNA regulation of VEGF under hypoxia was investigated in cancer cells. 111 Interestingly, most of the miRNAs  ... 
doi:10.1161/circresaha.108.191270 pmid:19246688 pmcid:PMC2760389 fatcat:nr5zuwjfn5fbfaqggubvoohqxu

New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Ye Wang, Liya Wang, Cheng Chen, Xiaoyuan Chu
2018 Molecular Cancer  
In this review, we summarize the regulatory role of miRNA in tumor angiogenesis, with a highlight on clinical implications of miRNAs as biomarkers for anti-angiogenic therapy response, and as therapeutic  ...  Recent advances have further highlighted the role of tumor-derived extracellular vesicles in the regulation of tumor angiogenesis via transferring miRNAs to endothelial cells.  ...  However, a recent study illustrated an anti-angiogenic role of miR-126 during tumor angiogenesis by targeting a pro-angiogenic gene adrenomedullin (ADM) [89] .  ... 
doi:10.1186/s12943-018-0766-4 pmid:29415727 pmcid:PMC5804051 fatcat:sbdzfduckzayjjyzkyewyhf3i4

The biological basis for antiangiogenic therapy

R Giavazzi, A Albini, F Bussolino, F DeBraud, M Presta, M Ziche, A Costa
2000 European Journal of Cancer  
In fact, in HIF-1a À/À mice, hypoxia, as well as hypoglycaemia, do not upregulate VEGF-A expression. In immature vessels, hyperoxia downregulates VEGF-A expression and promotes vascular regression.  ...  Certainly we need to understand much more about the biology of tumour angiogenesis. By identifying the key molecular targets of the angiogenesis process, selective antagonists can be developed.  ... 
doi:10.1016/s0959-8049(00)00276-8 pmid:11000570 fatcat:ypsi4rfptfahjlrxpwkhr5dffu

Hypoxia-inducible factor-1 in human breast and prostate cancer

K S Kimbro, J W Simons
2006 Endocrine-Related Cancer  
, as well as a target for new approaches to inhibiting angiogenesis.  ...  HIF-1α has emerged as an important transcription factor in breast cancer and prostate cancer biology, and is expressed in the early stages of mammary and prostate carcinogenesis.  ...  Acknowledgements This work is supported by Jean Sindab Endowment for Breast Cancer Research Gift, Avon Foundation and NIH P60 MD 000525-04.  ... 
doi:10.1677/erc.1.00728 pmid:16954428 fatcat:i4nznum62bfqtf2z4m6h5233mq

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

Itzel Alejandra Hernández-Romero, Lissania Guerra-Calderas, Marisol Salgado-Albarrán, Tatiana Maldonado-Huerta, Ernesto Soto-Reyes
2019 Frontiers in Oncology  
These ncRNAs can act in cis or trans and alter gene transcription by several mechanisms including epigenetic processes.  ...  Additionally, we will describe the contribution of Next-Generation Sequencing (NGS) techniques to the discovery and understanding of the role of ncRNAs in angiogenesis.  ...  MiR-20a MiR-20a belongs to the miR-17-92 cluster and has been linked to breast cancer cells with a high angiogenic profile.  ... 
doi:10.3389/fonc.2019.01091 pmid:31709179 pmcid:PMC6821677 fatcat:k3if62a3sbaubb76vplfftiwkm
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