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Characterisation and Bioactivity Analysis of Peridinin-Chlorophyll a-Protein (PCP) Isolated from Symbiodinium tridacnidorum CS-73

Kanoknate M. Supasri, Manoj Kumar, Anna Segečová, Janice I. McCauley, Andrei Herdean, Matthew P. Padula, Tim O'Meara, Peter J. Ralph
2021 Journal of Marine Science and Engineering  
PCP consists of a peridinin carotenoid; thereby, it can potentially be used as a bioactive compound in pharmaceutical applications. However, the biological activities of PCP are yet to be explored.  ...  PCP conjugates (PerCP) are widely used as fluorescent probes for cellular and tissue analysis in the biomedical field.  ...  Acknowledgments: The authors would like to thank T.O. and AKTA specialists for their help with operating the AKTA purification system and UTS proteomics core facility for nano-LC-MS/MS.  ... 
doi:10.3390/jmse9121387 fatcat:ubjgydzsgzdgdg3g3wnhpd4kc4

Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases

Balachandran Manavalan, Senthil K Murugapiran, Gwang Lee, Sangdun Choi
2010 BMC Structural Biology  
Results: We present here a three-dimensional (3D) model of the reductase domain based on the crystal structure of vestitone reductase (VR).  ...  The docking results of the ligand in the active site of the R domain showed that reductase side chains have a high affinity towards ligand binding, while the thioester oxygen of each substrate forms a  ...  After minimization and equilibration (~360 ps), 2ns MD simulation was performed and data were collected for analysis. The potential energy (E pot ) of the R domain is shown in Additional file 4.  ... 
doi:10.1186/1472-6807-10-1 pmid:20067617 pmcid:PMC2835699 fatcat:ulwysuxsi5hojithkwgsezpt3i

Single-cell trajectory inference guided enhancement of thyroid maturation in vitro using TGF-beta inhibition [article]

Mirian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Sumeet Pal Singh, Sabine Costagliola
2021 bioRxiv   pre-print
Our single-cell atlas of mouse organoid systematically and comprehensively identifies, for the first time, the cell types generated during production of thyroid organoids.  ...  Our study highlights the potential of single-cell molecular characterization in understanding and improving thyroid maturation and paves the way for identification of therapeutic targets against thyroid  ...  The thyroid differentiation program is complete when the gland reaches its final location and TFCs express a series of specific proteins which are essential for thyroid hormonogenesis.  ... 
doi:10.1101/2021.01.18.427103 fatcat:xrnebld6wffofdgh2xzye2btrm

Dynamic rewiring of the human interactome by interferon signaling

Craig H. Kerr, Michael A. Skinnider, Daniel D. T. Andrews, Angel M. Madero, Queenie W. T. Chan, R. Greg Stacey, Nikolay Stoynov, Eric Jan, Leonard J. Foster
2020 Genome Biology  
Our map of the IFN interactome provides a global view of the complex cellular networks activated during the antiviral response, placing IFN-stimulated genes in a functional context, and serves as a framework  ...  Here, we apply a combination of quantitative proteomic approaches to describe the effects of IFN signaling on the human proteome, and apply protein correlation profiling to map IFN-induced rearrangements  ...  Acknowledgements We thank Nichollas Scott (University of Melbourne) for advice on experimental design and assistance in shotgun proteomics data acquisition, Kyung-Mee Moon for assisting with manuscript  ... 
doi:10.1186/s13059-020-02050-y pmid:32539747 pmcid:PMC7294662 fatcat:54oi3vwngvbfxktucggkf4p7uy

A general LC-MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures

2019 Nucleic Acids Research  
Here, we present the first direct and modification type-independent RNA sequencing method via introduction of a 2-dimensional hydrophobic end-labeling strategy into traditional mass spectrometry-based  ...  A complete understanding of the structural and functional potential of RNA requires understanding of chemical modifications and non-canonical bases; this in turn requires advances in current sequencing  ...  L. and New York Institute of Technology (NYIT) Institutional Support for Research and Creativity grants to S. Z., which supported this work.  ... 
doi:10.1093/nar/gkz731 pmid:31504795 pmcid:PMC6847078 fatcat:3x5rozdbgbdkxcy472xr4dnxhy

Interventions for improving patients' trust in doctors and groups of doctors

Alix Rolfe, Lucinda Cash-Gibson, Josip Car, Aziz Sheikh, Brian McKinstry
2014 The Cochrane library  
Interventions for improving patients' trust in doctors and groups of doctors. Cochrane Database of Systematic Reviews, 2014(3), CD004134.  ...  time series design to test the effects of such interventions.  ...  the same study (see Thom 1999) and one, an interrupted time series study, had insufficient data points before and after the intervention (Barkin 2003).  ... 
doi:10.1002/14651858.cd004134.pub3 pmid:24590693 fatcat:lxbad2rq6rhzngz4hotu3qp5fi

Problems of Drug Dependence, 1979: Proceedings of the 41st Annual Scientific Meeting

Nechama Tec, Louis S. Harris
1981 Contemporary Sociology  
ACKNOWLEDGEMENTS The research reported in this paper was supported in part by then National Institute on Drug Abuse grants DA00016 and F32DA05091 and in part by a grant from the Committee on Problems of  ...  Robert Willette, Division of Research, NIDA for the morphine sulfate used in many of these experiments. ACKNOWLEDGEMENTS The work was supported by the Medical Research Council, the U.S.  ...  Summary and Conclusions of PCP Studies 1. PCP preparations may be contaminated with precursors which are used for synthesis of PCP homologues. 2.  ... 
doi:10.2307/2066581 fatcat:ha6u7zmc3ffftdivwftp34a2fu

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

A. L. Rodriguez, M. D. Grier, C. K. Jones, E. J. Herman, A. S. Kane, R. L. Smith, R. Williams, Y. Zhou, J. E. Marlo, E. L. Days, T. N. Blatt, S. Jadhav (+8 others)
2010 Molecular Pharmacology  
)-1,2,4oxadiazol-5-yl)benzonitrile (VU0285683) was developed as a novel selective mGluR5 NAM with high affinity for the 2-methyl-6-(phenylethynyl)-pyridine (MPEP) binding site.  ...  Although compounds have been developed to better understand the physiological roles of mGluR5 and potential usefulness for the treatment of these disorders, there are limitations in the tools available  ...  Venable, Rocio Zamorano, Qingwei Luo, and Kiran K. Gogi for invaluable technical assistance.  ... 
doi:10.1124/mol.110.067207 pmid:20923853 pmcid:PMC2993468 fatcat:lzvwvonjwfd7pgwwetc2kmimli

Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis

Andrés Cruz-Herranz, Frederike C Oertel, Kicheol Kim, Ester Cantó, Garrett Timmons, Jung H Sin, Michael Devereux, Nicholas Baker, Brady Michel, Ryan D Schubert, Lakshmisahithi Rani, Christian Cordano (+2 others)
2021 JCI Insight  
The time sequence and dynamic evolution of the opposing functions are especially unclear.  ...  by a marked reduction in the number of innate immune cells and change in cell morphology.  ...  Acknowledgments We thank Collin Spencer for his support and expert advice. We thank the Gladstone Flow Cytometry (N. Raman) and Genomics Cores (N.  ... 
doi:10.1172/jci.insight.149228 pmid:34100385 pmcid:PMC8262300 fatcat:mnmtjqyu3fdcppx2ugvng45lda

Redressing Underrecognition of "Cold Drink Heart": Patients Teaching Physicians about Atrial Fibrillation Triggered by Cold Drink and Food

David Vinson
2020 The Permanente Journal  
Acknowledgments I thank Andrea Altschuler, PhD, and Lisa Herrinton, PhD, from the Division of Research at Kaiser Permanente Northern California for their guidance, the time they spent reviewing and editing  ...  Minggui Pan, MD, was a treating physician, provided data analysis, and participated in drafting the final manuscript. All authors have given final approval to the manuscript.  ...  At the core of the data warehouse are a series of standardized file definitions. Content areas and data elements are documented in data dictionaries.  ... 
doi:10.7812/tpp/19.238 fatcat:62vosmkefrf55f72lutiwqavyy

Robotic Versus Laparoscopic Surgery for Rectal Cancer: A Comprehensive Review of Oncological Outcomes

Jessica Lam
2021 The Permanente Journal  
The treatment of rectal cancer is complex and involves specialized multidisciplinary care, although the tenet is still rooted in a high-quality total mesorectal excision.  ...  This article is a comprehensive review of the oncological outcome comparing robotic vs laparoscopic rectal cancer resection, with a particular focus on total mesorectal excision.  ...  John Vaughn, MD, Brian Quaranta, MD, MA, and Karen Jooste, MD, MPH, acquired the data for the work and revised the work critically for important intellectual content.  ... 
doi:10.7812/tpp/21.050 pmid:35348098 pmcid:PMC8782436 fatcat:omoynaudnbecrp7wtxmslgieou

High-entropy ceramics: Present status, challenges, and a look forward

Huimin Xiang, Yan Xing, Fu-zhi Dai, Hongjie Wang, Lei Su, Lei Miao, Guojun Zhang, Yiguang Wang, Xiwei Qi, Lei Yao, Hailong Wang, Biao Zhao (+2 others)
2021 Journal of Advanced Ceramics  
Although in the infant stage, the emerging of this new family of materials has brought new opportunities for material design and property tailoring.  ...  As a response to the rapid development in this nascent field, this article gives a comprehensive review on the structure features, theoretical methods for stability and property prediction, processing  ...  Xiaohui Wang from Institute of Metal Research, Chinese Academy of Sciences, for their helpful discussions.  ... 
doi:10.1007/s40145-021-0477-y fatcat:vs3dwnclcfbh7eacobzr6kgt4q

Polymer nanofilms with enhanced microporosity by interfacial polymerization

Maria F. Jimenez-Solomon, Qilei Song, Kim E. Jelfs, Marta Munoz-Ibanez, Andrew G. Livingston
2016 Nature Materials  
Synthesis of an ultrathin free-standing PAR nanofilm by interfacial polymerisation.  ...  Enhanced microporosity and higher interconnectivity of intermolecular network voids, as rationalised by molecular simulations, are achieved by utilising contorted monomers for the interfacial polymerisation  ...  Permeability data are calculated based on the thickness of the PAR layer. Robeson's upper bound (2008) is plotted 45 .  ... 
doi:10.1038/nmat4638 pmid:27135857 fatcat:gmu6jmn4yzbxfnrnrtdljxsxe4

Introduction [chapter]

2016 Music Data Analysis  
This series aims to foster the integration between the computer sciences and statistical, numerical, and probabilistic methods by publishing a broad range of reference works, textbooks, and handbooks.  ...  The interface between the computer and statistical sciences is increasing, as each discipline seeks to harness the power and resources of the other.  ...  Outliers, as well as possible cluster structures, can be recognized for high dimensional data spaces.  ... 
doi:10.1201/9781315370996-5 fatcat:avooqogcpnbjngqmzuonil3exq

Abstracts of papers presented at the ISLAR (International Symposium on Laboratory Automation and Robotics) 1998

1999 Journal of automated methods & management in chemistry (Print)  
Abstracts of papers presented at the 1998 ISLAR the role of the quality control and quality assurance laboratories, measures of accountability and progress, and an example of how our robotics program is  ...  State-of-the-art development in laboratory automation and robotics were reflected in the symposium programme which included papers and posters on all aspects of the technology--drug discovery research,  ...  Customized spreadsheets, macros and presentation graphics templates allow for rapid data reduction and plotting.  ... 
doi:10.1155/s1463924699000115 fatcat:obpx5wtp5bhmhpb2ufuym5lphu
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