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Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel

Vladimir V Cherny, Boris Musset, Deri Morgan, Sarah Thomas, Susan M E Smith, Thomas E DeCoursey
2020 The Journal of General Physiology  
Studied in a C-terminal truncated monomeric construct, V116H channels activated rapidly.  ...  Anomalously, Zn2+ slowed activation, producing a time constant independent of both voltage and Zn2+ concentration.  ...  We were especially interested in identifying positions at which an engineered metal-binding site was differentially accessible to metals in closed and open channels.  ... 
doi:10.1085/jgp.202012664 pmid:32902579 pmcid:PMC7537347 fatcat:72bce2addfcj3g4kbbzoyn3lsu

Cryogenic system configuration for the International Linear Collider (ILC) at mountainous site

H Nakai, T Okamura, D Delikaris, T Peterson, A Yamamoto
2017 IOP Conference Series: Materials Science and Engineering  
Since the most possible site for the ILC is a mountainous region in Japan, the configuration of the ML cryoplants is currently discussed for optimum cryogenic systems.  ...  The most possible site of the ILC is expected in a mountainous region in Japan.  ... 
doi:10.1088/1757-899x/171/1/012036 fatcat:r65v6tsqrfhknkvssbfmjeronm

Comparasion of Different Configuration of Hybrid Electrical Power System – A Case Study of a Site in Peshawar

Raheemullah Khan, US Pakistan center for advance study in energy, university of engineering and technology Peshawar, Pakistan, Jehan Parvez, Abdur Rehman, Muhammad Ibrahim, US Pakistan center for advance study in energy, university of engineering and technology Peshawar, Pakistan, US Pakistan center for advance study in energy, university of engineering and technology Peshawar, Pakistan, US Pakistan center for advance study in energy, university of engineering and technology Peshawar, Pakistan
2020 International Journal of Engineering Works  
HOMER software simulate these configuration find out a system which have least net present cost.  ...  The technical and cost analysis of different system is done for the case study so that a system could be recommended for the site which can fulfill the demand requirement by least net present cost.  ...  For this perfuse we visit the site and gain the information of connected load also interview the owner of the site and make a table of the connected load which is given.  ... 
doi:10.34259/ijew.20.708268273 fatcat:2gpj6cdvzzemra3gtwbwwusgz4

DEVELOPMENT OF METHODS OF OPTIMIZATION AND PROMOTION OF WEB SITE IN SEARCH SYSTEMS

Olexandr Pushkar, Yevhen Hrabovskyi
2020 ScienceRise  
of a site.  ...  In these conditions, today it is very urgent to develop a methodology for optimizing and promoting a site in search engines.  ...  The key stages of the methodology for optimizing and promoting the site in search engines have been developed and analyzed, accounting for which ensures increased site efficiency and get a configured and  ... 
doi:10.21303/sr.v0i1.1155 fatcat:fukthxkgwngufonelh6gnoauxa

The SIMPLE Framework for deploying containerized grid services

Mayank Sharma, Eraldo Silva Junior, Boris Iliev Vasilev, Maarten Litmaath, Renato Santana, C. Doglioni, D. Kim, G.A. Stewart, L. Silvestris, P. Jackson, W. Kamleh
2020 EPJ Web of Conferences  
available at a site.  ...  The Worldwide LHC Computing Grid (WLCG) currently has about 170 sites. In order to support WLCG workloads, each site has to deploy and maintain a number of possibly complex grid services.  ...  After the execution of a stage, any discrepancies between the intended and the observed configuration are reported by the validation engines.  ... 
doi:10.1051/epjconf/202024507017 fatcat:r3lpvesoinagbcfff2kq552krq

Drivenk-mers: Correlations in space and time

Shamik Gupta, Mustansir Barma, Urna Basu, P. K. Mohanty
2011 Physical Review E  
In the limit of large k at a finite density of occupied sites, the appropriately scaled system reduces to a nonequilibrium generalization of the Tonks gas describing the motion of hard rods along a continuous  ...  Steady state properties of hard objects with exclusion interaction and a driven motion along a one-dimensional periodic lattice are investigated.  ...  Now, E(r) for r ≥ k has non-zero contributions from all configurations in which there are two engines at the i-th and (i + r)-th sites, with the gap between the two engines containing r − k sites that  ... 
doi:10.1103/physreve.84.041102 pmid:22181082 fatcat:bvr6jfg2djgnrhnveyrmkqmkcy

Page 626 of American Society of Civil Engineers. Collected Journals Vol. 120, Issue 3 [page]

1994 American Society of Civil Engineers. Collected Journals  
CAD allowed the engineer to replot the site plans at a scale to match the aerial photo, which gave him a direct site overlay for the photo.  ...  Planning Site Development A project engineer used CAD to produce overlays and plan a clearing and grubbing operation for a utility trench.  ... 

Page 210 of American Society of Civil Engineers. Collected Journals Vol. 119, Issue 2 [page]

1993 American Society of Civil Engineers. Collected Journals  
FE EES Wie (ST as Weal RRR ee a 0.0 20 4.0 60 86.0 10.0 0.0 20 40 6.0 8.0 Site length Site length posterior PDF posterior PDF Configuration B Configuration C FIG. 12.  ...  Probability contour Probability contour 0.0 4.0 6.0 80 10.0 0.0 20 40 60 8.0 Site length Site length prior PDF posterior PDF Configuration A - boring locations Probability contour Probability contour *  ... 

Page 690 of American Society of Civil Engineers. Collected Journals Vol. 123, Issue EE7 [page]

1997 American Society of Civil Engineers. Collected Journals  
In conjunction with economic data and remediation-time modeling results, the engineer can hypothe- size alternative well configurations to determine if it is more cost-effective to remediate the site using  ...  The flow nets indicate that, although both configu- rations will ultimately remediate the contaminated zone, the configuration in Fig. 6(b) will remediate the site approximately 50% faster than the configuration  ... 

Demonstrating the Impact of 6to4 Tunneling on IPV4 and IPV6 Network Coexistence

E. Osa, S. Konyeha, E. Evbuomwan
2020 European Journal of Electrical Engineering and Computer Science  
The flow of traffic from servers to workstations in native IPv6 sites shows the effect of the tunnel configured.  ...  In order for traffic to flow from an Internet Protocol version 4(IPv4) website to a native Internet Protocol version 6(IPv6) website, an additional configuration must be added to the network, as this cannot  ...  In this paper the routing of traffic from a 6to4 site via an ISP relay to a native IPv6 site is shown. V.  ... 
doi:10.24018/ejece.2020.4.5.245 fatcat:7p6d23jpuvbdbj5xqbrfngjeta

Configuration of high performance apartment buildings renovation: A constraint based approach

E. Vareilles, A. F. Barco Santa, M. Falcon, M. Aldanondo, P. Gaborit
2013 2013 IEEE International Conference on Industrial Engineering and Engineering Management  
This paper looks at the possibility of configuring high performance renovation of apartment buildings by the use of a constraint satisfaction problem (CSP).  ...  A new thermal envelope wraps the whole building and allows it to achieve a really low energy performance of 25 kWh/m²/year.  ...  This point is quite a revolution for the civil engineering field where only few industrial engineering methods are applied and in particular in SMEs.  ... 
doi:10.1109/ieem.2013.6962498 fatcat:ufnpm67ebvgcrfyqcivsewwzuy

Configuration and Maintenance Management of Highway Engineering Machinery and Equipment

Hui Sun
2019 Journal of Architectural Research and Development  
Firstly, this paper analyzes the necessity of highway engineering construction machinery and equipment management, discusses the configuration management of highway engineering machinery and equipment,  ...  Finally, the management and maintenance measures of highway engineering machinery construction equipment are discussed in a targeted manner.  ...  Configuration management of highway engineering construction machinery and equipment 2.1 Configuring construction equipment according to the construction environment When constructing a highway project  ... 
doi:10.26689/jard.v3i5.873 fatcat:cgbo2jew3bachajwuwd6irk5ee

Highly Optimized Tolerance: Robustness and Design in Complex Systems

J. M. Carlson, John Doyle
2000 Physical Review Letters  
We study the development of a designed configuration (see Fig. 1 ) as we incrementally increase the density by occupying sites one at a time.  ...  A key quantity is the yield Y , defined to be the average density of trees left unburned in a configuration after a single spark hits. If a spark hits an unoccupied site, nothing burns.  ...  A test configuration at density r ͑n 1 1͒͞N 2 is generated from the previous configuration at density r n͞N 2 (where n is the number of occupied sites) by adding a grain to a previously unoccupied site  ... 
doi:10.1103/physrevlett.84.2529 pmid:11018927 fatcat:atgtbwnvv5f6flheulv3i52f7q

Searching the deep web

Valerie S. Allen, Abe Lederman
2001 Proceedings of the 24th annual international ACM SIGIR conference on Research and development in information retrieval - SIGIR '01  
In 1999 a directed query distributed search engine was integrated into a new Department of Energy Virtual Library of Energy Science and Technology.  ...  Millions of pages of government information across multiple agencies were made immediately searchable via one query, setting the stage for the development of a variety of interagency initiatives and applications  ...  of common search engines [1] .  ... 
doi:10.1145/383952.384097 dblp:conf/sigir/AllenL01 fatcat:sy6ws4nwrjb4botxgsx3v5zxsu

K-Site Rules at the RuleML Challenge 2009

José Luis Martínez-Fernández, José Carlos González Cristóbal, Paloma Martínez
2009 International Web Rule Symposium  
K-Site Rules does not include its own rule engine implementation but acts as a broker to the preferred rule engine.  ...  The K-Site Rules tool is part of ITECBAN, a project devoted to the definition of a new platform core for banking applications.  ...  of obtaining rule expressions according to a specific rule engine.  ... 
dblp:conf/ruleml/Martinez-FernandezCM09 fatcat:6ixkw5ljijafhbg5nncydlr6vu
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