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Pharmacogenomics competencies in pharmacy practice: A blueprint for change

Mary W. Roederer, Grace M. Kuo, David F. Kisor, Reginald F. Frye, James M. Hoffman, Jean Jenkins, Kristin Wiisanen Weitzel
2017 Journal of the American Pharmacists Association  
In 2011, the Pharmacogenomics Special Interest Group of the American Association of Colleges of Pharmacy led a process to update this competency statement using a consensus-based method that incorporated  ...  The first pharmacogenomics competency statement for pharmacists was published in 2002.  ...  In addition to the need for a standardized, competency-based approach to pharmacogenomics education, efforts that support identification and dissemination of best practice models for integrating clinical  ... 
doi:10.1016/j.japh.2016.08.014 pmid:27816542 pmcid:PMC5373920 fatcat:4pruyvx7wbawvcd2gfawvtj7k4

A Continuing Professional Development Program for Pharmacists Implementing Pharmacogenomics into Practice

Natalie Crown, Beth A. Sproule, Miles J. Luke, Micheline Piquette-Miller, Lisa M. McCarthy
2020 Pharmacy  
A continuing professional development (CPD) program for pharmacists practicing in community and team-based primary care settings was developed and evaluated using Moore's framework for the assessment of  ...  integrate this new service into their practices.  ...  Determining the optimal strategies for meeting the educational needs of practicing pharmacists is needed to implement pharmacogenomics services as a common offering within community-based pharmacy practices  ... 
doi:10.3390/pharmacy8020055 pmid:32231164 fatcat:kclbfodk6zblfl7fgimmbsmyzq

Pharmacists Leading the Way to Precision Medicine: Updates to the Core Pharmacist Competencies in Genomics

Roseann S. Gammal, Yee Ming Lee, Natasha J. Petry, Otito Iwuchukwu, James M. Hoffman, David F. Kisor, Philip E. Empey
2021 American Journal of Pharmaceutical Education  
Competencies available through the Genetics/Genomics Competency Center provide a framework for pharmacogenomics instruction in both pharmacy school curricula and continuing education programs.  ...  The process used a systematic approach which included mapping pharmacogenomics-specific competencies to the entrustable professional activities for pharmacists and seeking consensus from key stakeholders  ...  the Genetics/Genomics Competency Center website and disseminating the updated pharmacist competencies in genomics on that platform; and members of the AACP Pharmacogenomics Special Interest Group for  ... 
doi:10.5688/ajpe8634 pmid:34301570 fatcat:7wpnizj27natffie36ra4oxp3m

Integrating pharmacogenomics into pharmacy practice via medication therapy management

James A. Owen
2011 Journal of the American Pharmacists Association  
New applications and processes for using this emerging pharmacogenomics data are needed to effectively integrate this information into clinical practice.  ...  Conclusion: To achieve integration of pharmacogenomics into clinical practice via MTM, the pharmacy profession must define a process for the application of pharmacogenomic data into pharmacy clinical practice  ...  Through a number of working groups, the program also establishes a framework for electronic transmission of pharmacogenomic data from current EHR databases.  ... 
doi:10.1331/japha.2011.11543 pmid:22001957 fatcat:ghnfyo6renccbjgfn3emv2ld4i

A collaborative translational research framework for evaluating and implementing the appropriate use of human genome sequencing to improve health

Muin J. Khoury, W. Gregory Feero, David A. Chambers, Lawrence E. Brody, Nazneen Aziz, Robert C. Green, A. Cecile J.W. Janssens, Michael F. Murray, Laura Lyman Rodriguez, Joni L. Rutter, Sheri D. Schully, Deborah M. Winn (+1 others)
2018 PLoS Medicine  
integration of sequencing alongside other medical services.  ...  OPEN ACCESS Citation: Khoury MJ, Feero WG, Chambers DA, Brody LE, Aziz N, Green RC, et al. (2018) A collaborative translational research framework for evaluating and implementing the appropriate use of  ...  Institutes for Health.  ... 
doi:10.1371/journal.pmed.1002631 pmid:30071015 pmcid:PMC6071954 fatcat:dajkdqdgnrh5fmvdmrnt3h5l6m

Evolving Research and Stakeholder Perspectives on Pharmacogenomics

Amber L. Beitelshees, David L. Veenstra
2011 Journal of the American Medical Association (JAMA)  
Several large pharmacy benefits managers have taken a proactive role in providing pharmacogenomics services, and in establishing the systems and evidence base to support their use.  ...  There are no uniform evidentiary standards for clinical implementation, but frameworks have been created by groups such as EGAPP and CPIC. 2, 10 Clinicians considering a pharmacogenomic test should consider  ...  Table Checklist for consideration of a pharmacogenomic test 1 Is there a relationship between the test result and response to drug therapy? 2 Have the initial results been validated?  ... 
doi:10.1001/jama.2011.1343 pmid:21934059 pmcid:PMC3559013 fatcat:gm2qoluedvfprbty6cfwfexlua

Towards pharmacogenomics knowledge discovery with the semantic web

M. Dumontier, N. Villanueva-Rosales
2009 Briefings in Bioinformatics  
Several XML markup languages have been developed to capture pharmacogenomic and related information so as to facilitate data sharing.  ...  However, recent advances in semantic web technologies have presented exciting new opportunities for pharmacogenomics knowledge discovery by representing the information with machine understandable semantics  ...  Data integration in the HCLS has been enormously facilitated by the use of the eXtensible Markup Language (XML), which provides a validation procedure for document structure based on a corresponding XML  ... 
doi:10.1093/bib/bbn056 pmid:19240125 fatcat:p53mx2t3gbeupmz625c6jyykui

Towards an interoperable information infrastructure providing decision support for genomic medicine

Matthias Samwald, Holger Stenzhorn, Michel Dumontier, M Scott Marshall, Joanne Luciano, Klaus-Peter Adlassnig
2011 Studies in Health Technology and Informatics  
Here we describe our work and future visions around the creation of a distributed infrastructure for pharmacogenetic data and medical decision support, based on industry standards such as the Web Ontology  ...  Genetic dispositions play a major role in individual disease risk and treatment response.  ...  We expect the research programme outlined in this paper to have several implications for clinical practice, such as improving the translation of basic pharmacogenomic findings into clinical practice, increasing  ... 
pmid:21893735 fatcat:v5vvyj6jwndrlmf46rchf6idxm

Semantically enabling pharmacogenomic data for the realization of personalized medicine

Matthias Samwald, Adrien Coulet, Iker Huerga, Robert L Powers, Joanne S Luciano, Robert R Freimuth, Frederick Whipple, Elgar Pichler, Eric Prud'hommeaux, Michel Dumontier, M Scott Marshall
2012 Pharmacogenomics (London)  
play a critical role in data integration.  ...  Many of the datasets listed in [12] to represent pharmacogenomic findings, and creating services for accessing the nascent infrastructure.  ... 
doi:10.2217/pgs.11.179 pmid:22256869 pmcid:PMC3957334 fatcat:q7o2vfijn5hmlasoaskcjjopkq

Pharmacogenomic testing to support prescribing in primary-care: a structured review of implementation models

Judith Hayward, John McDermott, Nadeem Qureshi, William Newman
2021 Pharmacogenomics (London)  
This review identified 13 studies describing eight implementation models utilizing a multi-gene pharmacogenomic panel within a primary care or community setting.  ...  They demonstrated importance and feasibility of pre-test counseling, the role of the pharmacist, data integration into the electronic medical record and point-of-care clinical decision support systems  ...  A condition-based PGx MDSS in primary care integrating patient data with PGx data to give medication and dosage recommendations is feasible and accessed regularly, being utilized 236-times for 190 patients  ... 
doi:10.2217/pgs-2021-0032 pmid:34467776 pmcid:PMC8438972 fatcat:yjj5tslr4bazrnrfi2e7ztskga

Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network

Benjamin Q Duong, Meghan J Arwood, J Kevin Hicks, Amber L Beitelshees, Francesco Franchi, John T Houder, Nita A Limdi, Kelsey J Cook, Aniwaa Owusu Obeng, Natasha Petry, Sony Tuteja, Amanda R Elsey (+2 others)
2020 Pharmacogenomics and Personalized Medicine  
This expansion was led by a multidisciplinary team that developed an evidence-based, structured framework for the guides, oversaw the technical process/build, and pilot tested the first guide, CYP2C19-  ...  Sixty-five resources were collected from 12 institutions and categorized according to a seven-step implementation framework for the pilot CYP2C19-Clopidogrel Testing Implementation Guide.  ...  Step 4: Integrate genetic data into the EHR Build clinical decision support and integrate genetic test results into the EHR.  ... 
doi:10.2147/pgpm.s241599 pmid:32765043 pmcid:PMC7373415 fatcat:hxc4mphzfbh2xokq6r7u3eo35q

Engineering Requirements of a Herpes Simplex Virus Patient Registry: Discovery Phase of a Real-World Evidence Platform to Advance Pharmacogenomics and Personalized Medicine

Svitlana Surodina, Ching Lam, Caroline de Cock, Michelle van Velthoven, Madison Milne-Ives, Edward Meinert
2019 Biomedicines  
and allow for this data to be used as a complement to genomic and clinical data to further the treatment of HSV.  ...  Comprehensive pharmacogenomic understanding requires both robust genomic and demographic data. Patient registries present an opportunity to collect large amounts of robust, patient-level data.  ...  Acknowledgments: We would like to thank Skein Ltd. for their continued work in the development of this platform. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biomedicines7040100 pmid:31847458 fatcat:3bfnj2kk7bcbjgqrwmi42jj3jy

Using systems approaches to address challenges for clinical implementation of pharmacogenomics

Jason H. Karnes, Sara Van Driest, Erica A. Bowton, Peter E. Weeke, Jonathan D. Mosley, Josh F. Peterson, Joshua C. Denny, Dan M. Roden
2013 Wiley Interdisciplinary Reviews: Systems Biology and Medicine  
framework that views drug response as a dynamic system and maps  ...  decision-making through complex biological models, improving strategies for integrating genomics into clinical practice, and evaluating the impact of implementation programs on public health.  ...  Manual integration of an extensive and ever-changing pharmacogenomic knowledge base into the point of care is unreasonable for most clinicians. 51 Provision of electronic decision support will mitigate  ... 
doi:10.1002/wsbm.1255 pmid:24319008 pmcid:PMC3944797 fatcat:sszvdpramzes3a5fi4ujq6zf2a

Professional opportunity for pharmacists to integrate pharmacogenomics in medication therapy

Iris Cohn, Ronald D. Cohn, Shinya Ito
2018 Canadian Pharmacists Journal / Revue des Pharmaciens du Canada  
the framework of a research project  ...  Professional opportunity for pharmacists to integrate pharmacogenomics in medication therapy Iris Cohn, MSc(Pharm), RPh; Ronald D.  ... 
doi:10.1177/1715163518766376 pmid:29796128 pmcid:PMC5958433 fatcat:laxf5ee3ujejrbl23kkuvarvqq

Integration of Genomics Data and Electronic Health Records Toward Personalized Medicine: A Targeted Review

Ali Najafi, Neda Emami, Taha Samad-Soltani
2021 Frontiers in Health Informatics  
much as possible, an integrated online patient portal, multiple data source handling, machine-readable storing and reporting, research-oriented requirements, pharmacogenomics decision support capabilities  ...  Integration requirements also consisted of nine functional cases including a uniform approach to the interpretation of genetic tests, standardized terminologies and ontologies, structured data entry as  ...  At a higher level, knowledge sharing requires appropriate standards for interoperable data representations. Messaging frameworks adapted with HIT terminologies are also a critical task.  ... 
doi:10.30699/fhi.v10i1.299 fatcat:5rzxdhkovrhbbnsave35i2i42a
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