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Accelerating Next-Generation Vaccine Development for Global Disease Prevention

W. C. Koff, D. R. Burton, P. R. Johnson, B. D. Walker, C. R. King, G. J. Nabel, R. Ahmed, M. K. Bhan, S. A. Plotkin
2013 Science  
Recent advances have heralded in a new era of vaccine discovery. However, translation of these advances into vaccines remains impeded by lack of understanding of key vaccinology principles in humans.  ...  We review these advances towards vaccine discovery and suggest that for accelerating successful vaccine development, new human immunology-based clinical research initiatives be implemented with the goal  ...  Acknowledgments The authors acknowledge the assistance of Sandi Glass, Lisa Gieber, Olga Shmaidenko, Michelle Dees and Bill Hayes in the preparation of this manuscript.  ... 
doi:10.1126/science.1232910 pmid:23723240 pmcid:PMC4026248 fatcat:ltxjup67qnhwpccmdwggyom7ee

Designing the Next Generation of Vaccines for Global Public Health

Fabio Bagnoli, Barbara Baudner, Ravi P.N. Mishra, Erika Bartolini, Luigi Fiaschi, Paolo Mariotti, Vincenzo Nardi-Dei, Phil Boucher, Rino Rappuoli
2011 Omics  
Finally, we present a discussion to situate omics-guided rational vaccine design in the broader context of global public health and how it can benefit citizens in both developed and developing countries  ...  Our first project based on omics was initiated in 2000 and was termed reverse vaccinology. At that time, antigen identification was mainly based on bioinformatic analysis of a singular genome.  ...  Acknowledgments We are grateful to Nathalie Norais for critical reading and manuscript editing and to Giorgio Corsi for artwork.  ... 
doi:10.1089/omi.2010.0127 pmid:21682594 fatcat:kelvo65henhtzdrxokql7u5wmq

Development of a GA-Fuzzy-Immune PID Controller with Incomplete Derivation for Robot Dexterous Hand

Xin-hua Liu, Xiao-hu Chen, Xian-hua Zheng, Sheng-peng Li, Zhong-bin Wang
2014 The Scientific World Journal  
In order to improve the performance of robot dexterous hand, a controller based on GA-fuzzy-immune PID was designed.  ...  The control system of a robot dexterous hand and mathematical model of an index finger were presented.  ...  Acknowledgments The support of Fundamental Research Funds for the Central Universities (no. 2014QNA38) and the Priority Academic Program Development of Jiangsu Higher Education Institutions in carrying  ... 
doi:10.1155/2014/564137 pmid:25097881 pmcid:PMC4109120 fatcat:bd3776smmvb5bbuiiqo3dawd7y

Next-Generation Molecular-Diagnostic Tools for Gastrointestinal Nematodes of Livestock, with an Emphasis on Small Ruminants [chapter]

Florian Roeber, Aaron R. Jex, Robin B. Gasser
2013 Advances in Parasitology  
A particular emphasis is placed on the recent development of a robotic PCR-based platform for high-throughput diagnosis, and its significance and implications for epidemiological investigations and for  ...  use in control programmes.  ...  Current evidence indicates that this robotic assay is highly adaptable, allowing the development of a wide range of next-generation diagnostic tools to underpin the control of socioeconomically important  ... 
doi:10.1016/b978-0-12-407705-8.00004-5 pmid:23876874 pmcid:PMC7150098 fatcat:dnfiyiixqrbptgphh5szmfdtoa

How Next-Generation Sequencing and Multiscale Data Analysis Will Transform Infectious Disease Management

Theodore R. Pak, Andrew Kasarskis
2015 Clinical Infectious Diseases  
Recent reviews have examined the extent to which routine next-generation sequencing (NGS) on clinical specimens will improve the capabilities of clinical microbiology laboratories in the short term, but  ...  This review introduces a range of "omics" and patient data sources relevant to managing infections and proposes 3 potentially disruptive applications for these data in the clinical workflow.  ...  We thank Deena Altman, Shirish Huprikar, and members of the Pathogen Surveillance Program at Mount Sinai for critical suggestions on the manuscript. Financial support.  ... 
doi:10.1093/cid/civ670 pmid:26251049 pmcid:PMC4643486 fatcat:hpi3upale5ae3buqsdxahbvak4

Screening of Eurasian Tundra Reindeer for Viral Sequences by Next-Generation Sequencing

Javier Sánchez Romano, Anna Omazic, Mikael Leijon, Åsa Hagström, Morten Tryland, Juha Kantanen, Tiina Reilas, Ulrika Rockström, Valery Fedorov, Ann Albihn
2021 International Journal of Environmental Research and Public Health  
Next-generation sequencing analysis and BLAST-homology searches indicated the presence of viruses of domesticated and wild animals, such as bovine viral diarrhea virus, bovine papillomavirus, alcephaline  ...  Reindeer husbandry is essential for the livelihood and culture of indigenous people in the Arctic.  ...  acknowledged for their involvement in the study.  ... 
doi:10.3390/ijerph18126561 fatcat:nwlyvkrd4zaslhmcls6tcgzmn4

A next generation setup for pre-fractionation of non-denatured proteins reveals diverse albumin proteoforms each carrying several post-translational modifications

Heidrun Rhode, Petra Muckova, Rita Büchler, Sindy Wendler, Bärbel Tautkus, Michaela Vogel, Thomas Moore, Julian Grosskreutz, Andree Klemm, Mary Nabity
2019 Scientific Reports  
In human CSF, we found only a subset of proteoforms with fewer modifications than in plasma.  ...  In blood plasma and cerebrospinal fluid (CSF), most proteins, including candidate biomarkers, distribute into a multitude of chromatographic clusters.  ...  The search for PTM ran successively using Proteome Discoverer © 1.3 (Thermo) with no more than three dynamic modification types per run. We considered only highly confident database matches.  ... 
doi:10.1038/s41598-019-48278-y pmid:31409882 pmcid:PMC6692309 fatcat:glxm22wpvzevrl2uborez5lv4i

Future Perspectives of Oral Delivery of Next Generation Therapies for Treatment of Skin Diseases

Pia Pernille Søgaard, Marianne Lind, Chatpakorn Rassemeena Christiansen, Karsten Petersson, Adam Clauss, Ester Caffarel-Salvador
2021 Pharmaceutics  
For a treatment to be effective, a sufficient amount of a given regimen needs to reach systemic circulation.  ...  Furthermore, the recent clinical success of clustered regularly interspaced short palindromic repeats (CRISPR) for genome editing in humans will undoubtedly contribute to defining a new wave of therapies  ...  Data Availability Statement: No new data were created or analyzed in this study. Data sharing is not applicable to this article. Acknowledgments: We thank Jakob Bendix for the graphical abstract.  ... 
doi:10.3390/pharmaceutics13101722 pmid:34684016 fatcat:x66jefhixvfpbgki4mwoillvji

Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go?

Nadine C. Olthof, Jos M.J.A.A. Straetmans, Robert Snoeck, Frans C.S. Ramaekers, Bernd Kremer, Ernst-Jan M. Speel
2011 Reviews in Medical Virology  
The development of such treatment options is still in a preclinical phase or in early clinical trials.  ...  Detection of biologically active HPV in HNSCC has prognostic relevance, which warrants the separate classification of HPV-induced tumours and is a prerequisite for further optimisation of treatment protocols  ...  Next-generation treatment strategies for HPV-associated cancers should focus on decreasing adjuvant radiotherapy and chemotherapy, whether or not combined with therapeutic options specifically targeting  ... 
doi:10.1002/rmv.714 pmid:21984561 fatcat:4rpqsgimdncjzp5smuvfx5zb2e

Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities

Xi Lin, Wenxue Tang, Shoeb Ahmad, Jingqiao Lu, Candice C. Colby, Jason Zhu, Qing Yu
2012 Hearing Research  
Xi Lin and Wenxue Tang own equity in the Otogenetics Corporation, which offers a commercial service for capturing and next-generation sequencing of human genes implicated in syndromic and non-syndromic  ...  The goal of sequencing the entire human genome for $1,000 is almost in sight.  ...  This research project was supported in part by the GRA genome center of the Emory University School of Medicine. We thank Ms. Anne Lin for proofreading the final version of the manuscript.  ... 
doi:10.1016/j.heares.2012.01.004 pmid:22269275 pmcid:PMC3881369 fatcat:wkbcm73tibcoba7vmakyfqd67e

Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing

Konstantinos Tsioris, Namita T. Gupta, Adebola O. Ogunniyi, Ross M. Zimnisky, Feng Qian, Yi Yao, Xiaomei Wang, Joel N. H. Stern, Raj Chari, Adrian W. Briggs, Christopher R. Clouser, Francois Vigneault (+6 others)
2015 Integrative Biology  
Analysis of the B cell response to West Nile virus by integrated single-cell analysis and next generation sequencing reveals novel neutralizing antibodies.  ...  Acknowledgements The authors are grateful to Stephanie Argraves, Shu Chen, Barbara Siconolfi, and Sui Tsang for expert research support, and to the Human Immunology Project Consortium (HIPC) for insightful  ...  This work was supported in part by the National Institutes of Health (U19AI089992, AI091816, R01AI104739, 1F32AI112359-01, T15LM07056), a pilot project from the HIPC (, and the  ... 
doi:10.1039/c5ib00169b pmid:26481611 pmcid:PMC4754972 fatcat:qaq7fmfitbezzaifaljdwbevlu

Coordination of Cooperative Search and Rescue Robots for Disaster Relief

Henry Y.K. Lau, Albert W.Y. Ko
2008 IFAC Proceedings Volumes  
This paper describes the use of modular robots as the next generation search and rescue robots for humanitarian logistics and developed an immunity-based control framework called General Suppression Control  ...  Framework (GSCF) for controlling these robots.  ...  ACKNOWLEGEMENT The work described in this paper was partly supported by the Research Grant Council of the Hong Kong Special Administrative Region, PRC under the CERG Project No. HKU7142/06E.  ... 
doi:10.3182/20080706-5-kr-1001.00153 fatcat:iq3d2vnz6bdklcbtxrckqu4lfu

On artificial immune systems and swarm intelligence

Jon Timmis, Paul Andrews, Emma Hart
2010 Swarm Intelligence  
We argue that there are many aspects of AIS that have direct parallels with SI and examine the role of AIS and SI in science and also in engineering, with the primary focus being on the immune system.  ...  This position paper explores the nature and role of two bio-inspired paradigms, namely Artificial Immune Systems (AIS) and Swarm Intelligence (SI).  ...  Spawn : no individuals spawned for next generation as none are selected. 6.  ... 
doi:10.1007/s11721-010-0045-5 fatcat:cgkbpoccsneqtezg3o34ynpjiy

Future directions in control in an information-rich world

2003 IEEE Control Systems  
Acknowledgments We would like to thank the panel on Future Directions in Control, Dynamics, and Systems and the many members of the control community who participated in generating the report.  ...  Jacobs and the Air Force Office of Scientific Research (AFOSR) for supporting the activities of the panel.  ...  At the same time, the next generation of problems will require a paradigm shift in control research and education.  ... 
doi:10.1109/mcs.2003.1188769 fatcat:b5fksabbfze5hoktqk4vhnane4

The future of laboratory medicine — A 2014 perspective

Larry J. Kricka, Tracey G. Polsky, Jason Y. Park, Paolo Fortina
2015 Clinica Chimica Acta  
It provides a commentary on the accuracy of the predictions and offers opinions on emerging technologies, economic factors and social developments that may play a role in shaping the future of laboratory  ...  Predicting the future is a difficult task. Not surprisingly, there are many examples and assumptions that have proved to be wrong.  ...  Acknowledgments We thank the Executive Board of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) for their encouragement in the preparation of this review in the context  ... 
doi:10.1016/j.cca.2014.09.005 pmid:25219903 fatcat:ma2hd7o27ffktczkxelmdh2v5q
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