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Optically programming DNA computing in microflow reactors
2001
Biosystems (Amsterdam. Print)
The specific problem is encoded in an initial labeling pattern of each module with one of 2N DNA oligonucleotides, identical for all instances of maximal clique. ...
Thirdly, a method for optically programming the DNA labeling process via photochemical lithography is proposed, allowing different problem instances to be specified. ...
Acknowledgements The author would like to thank R. Penchovsky and D. van Noort for a careful reading of the manuscript. ...
doi:10.1016/s0303-2647(01)00099-5
pmid:11267740
fatcat:ewyjbpdzdjhlnfcmugk2rhsepy
Ligation module for in vitro selection in DNA computing
2005
Biomedical Applications of Micro- and Nanoengineering II
In this paper a classical AI problem is proposed to be solved by DNA computing: theorem proving. ...
Since the complexity grows exponentially with the size of the problem, the solving process should be done in parallel. Massive parallelism is one of the advantages of DNA computers. ...
Furthermore the support from the Molecular Evolutionary Computing (MEC) project of the Korean Ministry of Commerce, Industry and Energy, and the National Research Laboratory (NRL) Program from the Korean ...
doi:10.1117/12.582210
fatcat:pqkb34ddkfaglbfrdkdl5zf3wi
DNA Computing in Microreactors
[chapter]
2002
Lecture Notes in Computer Science
This contrasts with conventional DNA computing where the individual sequence of biochemical operations depends on the specific problem. ...
The goal of this research is to improve the programmability of DNA-based computers. ...
Acknowledgement The authors wish to acknowledge the support of the GMD for DNA computing and the German Ministry of Science (BMBF) for BioMIP's start-up grant (#01SF9952). ...
doi:10.1007/3-540-48017-x_4
fatcat:rvwodb3l6fft3on4wffjnl6m3u
DNA computing in microreactors
2001
BioMEMS and Smart Nanostructures
This contrasts with conventional DNA computing where the individual sequence of biochemical operations depends on the specific problem. ...
The goal of this research is to improve the programmability of DNA-based computers. ...
Acknowledgement The authors wish to acknowledge the support of the GMD for DNA computing and the German Ministry of Science (BMBF) for BioMIP's start-up grant (#01SF9952). ...
doi:10.1117/12.454623
fatcat:qwg7zryacfhexotsgnjjyu5or4
DNA Computing: A Complete Overview
2016
International Journal of Science and Research (IJSR)
DNA computing is a nascent technology that seeks to capitalize on the enormous informational capacity of DNA, biological molecules that can store huge amounts of information and are able to perform operations ...
Computers made of genes' building blocks. Because of their speed, miniaturization and Data Storage potential DNA computers are being considered as a replacement for silicon-based computers. ...
He also demonstrated how DNA computing solves a two variable SAT problem. Lipton proposed a solution to the SAT. The proposed DNA algorithm can solve an n-variable m-clause SAT problem in m steps. ...
doi:10.21275/v5i1.nov152943
fatcat:hylmrplbdreifigzdaj6knczyy
DNA Computing: Challenges and Application
2017
International Journal of Interactive Mobile Technologies
Some of these applications are those require fast processing, at which DNA computers would be able to solve the hardest problems faster than the traditional ones. ...
For example, 10 trillion DNA molecules can fit in one cubic centimeter that would result in a computer that holds 10 terabytes of data. ...
A "knight problem" with the condition that the knights must not attack each other on a 3 ! 3 chessboard was interpreted as an SAT problem using DNA (Faulhammer, et al 2000) . ...
doi:10.3991/ijim.v11i2.6564
fatcat:ozsmi3yhlrdepl2ooducsnsppy
Soft magnetic tweezers: A proof of principle
2011
Review of Scientific Instruments
Finally, we propose a simple way to modify the experimental design of electromagnets that should bring the performances of the device to a competitive level. ...
They take advantage of a nonlinear coupling regime that appears when a fast rotating magnetic field is applied to a superparamagnetic bead immersed in a viscous fluid. ...
ACKNOWLEDGMENTS
814 The authors would like to thank David Bensimon, 815 Charlie Gosse, and Giovanni Cappello for precious discussion 816 and suggestions. ...
doi:10.1063/1.3531959
pmid:21456769
fatcat:cgihi34svbgb3mofy5ju34nlui
A Surface-Based Approach to DNA Computation
1998
Journal of Computational Biology
A simple, surface-based model of computation is described and it is shown how to implement an exhaustive search algorithm for the SAT problem on this model. ...
A new model of DNA-based computation is presented. The main di erence between this model and that of Adleman is in manipulation of DNA strands that are rst immobilized on a surface. ...
Their work has led to hopes of a DNA computer that can outperform the fastest realizable super computers at such problems. ...
doi:10.1089/cmb.1998.5.255
pmid:9672831
fatcat:xlal3c6iczf63m3hsffx7cvud4
Formal Verification of Molecular Computational Models in ACL2: A Case Study
[chapter]
2004
Lecture Notes in Computer Science
Theorem proving is a classical AI problem with a broad range of applications. ...
Since its complexity is exponential in the size of the problem, many methods to parallelize the process has been proposed. ...
We have presented a recursive formalization, in opposite to the iterative version presented in [14] . This fact is due to the applicative nature of ACL2. ...
doi:10.1007/978-3-540-25945-9_34
fatcat:ejnq7yyyo5etlpy4wp4wp3frrq
New field of cryptography: DNA cryptography
2006
Science Bulletin
Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. 60473028). We thank the review experts for their very valued revise advice. ...
The computing model proposed by Adleman is also used by Lipton to solve SAT problems [17] . ...
In 2002, a team led by Adleman solved a 3-SAT problem with more than 1 million possibilities on a simple DNA computer after an exhaustive searching [13] . ...
doi:10.1007/s11434-006-2012-5
fatcat:wjh73wmrgzdvlmdfruq5ia6kfi
DNA Library Design for Molecular Computation
2003
Journal of Computational Biology
It aims to achieve a practical discrimination between perfectly matched DNA oligomers and those with mismatches in a large pool of different molecules. ...
The approach takes into account the ability of DNA strands to hybridize in complex structures like hairpins, internal loops, or bulge loops and computes the stability of the hybrids formed based on thermodynamic ...
(Detroit, USA) for permission to use his DNA energy parameters. ...
doi:10.1089/106652703321825973
pmid:12804092
fatcat:44vid2vm3baipp4etxo2sho2zq
Computing with DNA
2000
Msphere
The most recent attempt to break down these barriers is to replace, once more, the tools for performing computations with biological ones instead of electrical ones. ...
DNA computing (also sometimes referred to as biomolecular computing or molecular computing) is a new computational paradigm that employs (bio)molecule manipulation to solve computational problems, at the ...
A Formal Model for DNA Computing and its Computational Power One aspect of theoretical research on DNA computing is the search for a suitable formal model to describe molecular computations. ...
pmid:10547850
fatcat:kdccyasr2baezknjmefmzq2ynq
DNA computing on surfaces
2000
Nature
Correspondence and requests for materials should be addressed to L.F.C. (e-mail:chi@nwz.uni-muenster. ...
surfaces. 25 DNA computing was proposed 1 as a means of solving a class of intractable computational problems in which the computing time can grow exponentially with problem size (the`NP-complete' or ...
All methods for solving the SAT problem (on any realizable computing device) that have been analysed require a number of steps that grows exponentially with the number of variables. ...
doi:10.1038/35003155
pmid:10646598
fatcat:uyx3bwgiubgslp5unooj6srf5a
Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems
2018
Interface Focus
On-chip network-based computation, using biological agents, is a new hardware-embedded approach which attempts to find solutions to combinatorial problems, in principle, in a shorter time than the fast ...
Given the brute force approach of network-based systems for solving a problem of input size C, 2C solutions must be visited. ...
However, the alternative computation approaches, including DNA, quantum, and networks-based computing, to name a few, propose in the first instance computing devices with associated operational procedures ...
doi:10.1098/rsfs.2018.0034
pmid:30443332
pmcid:PMC6227808
fatcat:3gl3whrp45ezloxjxf7jawfamu
Solution of a 20-Variable 3-SAT Problem on a DNA Computer
2002
Science
A 20-variable instance of the NP-complete three-satisfiability (3-SAT ) problem was solved on a simple DNA computer. ...
Problems of this size appear to be beyond the normal range of unaided human computation. ...
A 20-variable instance of a 3-SAT problem was solved using (except during input and output) DNA Watson-Crick pairing and melting as the sole "operation." ...
doi:10.1126/science.1069528
pmid:11896237
fatcat:ljrgzpq7gvh5bdvkz3iv5moiky
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