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The Lipid-RNA World [article]

Saurav Mallik, Sudip Kundu
2013 arXiv   pre-print
layer of a lipid-vesicle, using only physical energies available from our Hadean Ocean model.  ...  The simplest possible beginning of abiogenesis has been a riddle from the last century, which is most successfully solved by the Lipid World hypothesis.  ...  ACKNOWLEDGEMENTS The authors acknowledge the computational facility of DIC and Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta to do the work.  ... 
arXiv:1211.0413v2 fatcat:prulbhmykfejvmn65beiprv5ie

Investigating Prebiotic Protocells for A Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective

Lopez, Fiore
2019 Life  
Certain types of protocells imitate plausible prebiotic compartments, such as giant vesicles, that are formed with the hydration of thin films of amphiphiles.  ...  These constructs can be studied to address the emergence of life from a non-living chemical network.  ...  A.L. is grateful to Aurélie Vialette for precious advices. M.F. wishes to dedicate this work to the memory of his daughter Océane (2015-2017).  ... 
doi:10.3390/life9020049 pmid:31181679 pmcid:PMC6616946 fatcat:jcpxhkqtjnfohkewpcezed5squ

Origins of life: Concepts, data, and debates

Peter Schuster
2009 Complexity  
ing pieces to complete the puzzle.  ...  theory and its applications to problems in other fields.  ...  Today, the historic route to life is entirely in the realm of speculation and, presumably, will stay there forever.  ... 
doi:10.1002/cplx.20302 fatcat:zkrlhradlbfs5kugoqvngxmqi4

Chemical systems, chemical contiguity and the emergence of life

Terrence P Kee, Pierre-Alain Monnard
2017 Beilstein Journal of Organic Chemistry  
This approach is being gradually replaced by a more "systemic" approach that privileges processes inherent to complex chemical systems over specific isolated functional apparatuses.  ...  The complexity of the biochemical machinery of cells with its exquisite intricacies hints at cells being the product of a long evolutionary process.  ...  Acknowledgements The authors acknowledge the discussion opportunity provided during the Beilstein Bozen Symposium "Chemistry, Life and Evolution" in Prien Germany (30 May to 3 June, 2016) and thank colleagues  ... 
doi:10.3762/bjoc.13.155 pmid:28904604 pmcid:PMC5564265 fatcat:6appnvidfrdk3k7myji7bmzmda

Possible Roles of Amphiphilic Molecules in the Origin of Biological Homochirality

Nozomu Suzuki, Yutaka Itabashi
2019 Symmetry  
This review describes how amphiphilic molecules are possibly involved in the scenario of homochirality. Some prebiotic conditions relevant to amphiphilic molecules will also be described.  ...  A review. The question of homochirality is an intriguing problem in the field of chemistry, and is deeply related to the origin of life.  ...  The prebiotic system possibly discovered a way to synthesize ATP and other nucleoside triphosphates.  ... 
doi:10.3390/sym11080966 fatcat:irzaqccrbfbkbbokh2o2ziq7ym

Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments

Dimitri Fayolle, Emiliano Altamura, Alice D'Onofrio, Warren Madanamothoo, Bernard Fenet, Fabio Mavelli, René Buchet, Pasquale Stano, Michele Fiore, Peter Strazewski
2017 Scientific Reports  
We conclude that a decisive driving force for the gradual transition from unstable fatty acid vesicles to robust diacylglyceryl phosphate vesicles was to avoid the accumulation of unphosphorylated diacylglycerols  ...  It is an open question how the chemical structure of prebiotic vesicle-forming amphiphiles complexified to produce robust primitive compartments that could safely host foreign molecules.  ...  It is then possible to cautiously discuss on the mixtures used in this work as it follows.  ... 
doi:10.1038/s41598-017-18053-y pmid:29273739 pmcid:PMC5741756 fatcat:comozlcmwzamtpsgeth63nmrpy

Non-canonical nucleosides and chemistry of the emergence of life

Sidney Becker, Christina Schneider, Antony Crisp, Thomas Carell
2018 Nature Communications  
While phylogenetics allow us to ascertain such information, any events that had occurred prior to LUCA's emergence remain in the dark, leaving us with only the possibility of simulating plausible prebiotic  ...  Prebiotic chemistry, driven by changing environmental parameters provides canonical and a multitude of non-canonical nucleosides.  ...  The use of ribose as a prebiotic starting material for nucleoside formation is sometimes criticised because no clear prebiotically plausible route to ribose has been found.  ... 
doi:10.1038/s41467-018-07222-w fatcat:nldjrlo5tbcotdpsqrtlcwa6ym

Prebiotic macromolecules and today's biomacromolecules in the light of polymerology

Michel Vert
2018 European Polymer Journal  
Acknowledgments: I am indebted to CNRS, University of Rouen, INSA of Rouen and University of Montpellier for personal and financial supports and to the numerous co-workers who contributed indirectly to  ...  the present essay by their contributions to studies of chiral and degradable functional polymers and polyelectrolytes.  ...  Conclusion Basically, there were chemical routes available to make prebiotic macromolecules under prebiotic conditions.  ... 
doi:10.1016/j.eurpolymj.2018.01.012 fatcat:usvsgwlbrna6fd7kas3clt3r2y

Achievements and open questions in the self-reproduction of vesicles and synthetic minimal cells

Pasquale Stano, Pier Luigi Luisi
2010 Chemical Communications  
For example, the self-reproduction of vesicles suggests that the growth in size and number of a vesicle population resembles the pattern of living cells in several aspects, but it take place solely due  ...  ., in order to construct a living cell in the laboratory.  ...  Parts of this paper have been adapted from more extensive discussions on self-reproduction of supramolecular structures. 9 Graphical abstract: courtesy of Paolo Carrara (Uniroma3).  ... 
doi:10.1039/b913997d pmid:20442914 fatcat:rlthvy6q2jcytczwvswdxxazzi

Composing life

Daniel Segré, Doron Lancet
2000 EMBO Reports  
A complex chain of evolutionary events, yet to be deciphered, could then have led to the common ancestors of today's free-living cells, and to the appearance of DNA, RNA and protein enzymes.  ...  Acknowledgements We wish to thank Ora Kedem, David Deamer, Ayellet Falcovitz, Yoav Gilad, Gustavo Glusman and Roberto Ventrella for insightful discussions.  ...  Fig. 2 . 2 Comparison of two possible views for the path leading from a 'primordial soup' to a rudimentary protocellular structure (bottom). (A)  ... 
doi:10.1093/embo-reports/kvd063 pmid:11256602 pmcid:PMC1083737 fatcat:l73s3igan5bwhi4rc6y7rghlbi

Enceladus: First Observed Primordial Soup Could Arbitrate Origin-of-Life Debate

Amit Kahana, Philippe Schmitt-Kopplin, Doron Lancet
2019 Astrobiology  
This appears to represent the first reported extraterrestrial organics-rich water body, a conceivable milieu for early steps in life's origin ("prebiotic soup").  ...  Thus, the Enceladus finds support the possibility of a pre-RNA Lipid World scenario for life's origin.  ...  Raphael Zidovetzki for critically reading the manuscript, and the Minerva foundation for support through a grant ''The emergence & evolution of early life under extreme planetary conditions.''  ... 
doi:10.1089/ast.2019.2029 pmid:31328961 pmcid:PMC6785169 fatcat:ufnkwhc6ibdfrcuk6wi5hkicju

Protocells and RNA Self-Replication

Gerald F. Joyce, Jack W. Szostak
2018 Cold Spring Harbor Perspectives in Biology  
If a sufficient diversity of RNAs could be copied with reasonable rate and fidelity, then Darwinian evolution would begin with RNAs that facilitated their own reproduction enjoying a selective advantage  ...  The concept of a "protocell" refers to a compartment where replication of the primitive genetic material took place and where primitive catalysts gave rise to products that accumulated locally for the  ...  A potential route from arabinose amino-oxazoline to pyrimidine nucleotides first was explored nearly 40 years ago (Tapiero and Nagyvary 1971) and has been reexamined in light of alternative routes to  ... 
doi:10.1101/cshperspect.a034801 pmid:30181195 fatcat:7hri53ticzbzjhbnwv2njp7yrq

Prebiological Evolution and the Metabolic Origins of Life

Andrew J. Pratt
2011 Artificial Life  
Fidelity of information transfer in the reproduction of these increasingly complex autocatalytic networks is a key selection pressure in prebiological evolution that eventually leads to the selection of  ...  A metabolic subsystem is required to provide the building blocks and chemical energy for life. Compartmentalization is required for evolution to act  ...  Acknowledgments I am deeply grateful to Mark Dörr, Vladimir Golovko, Janos Hajdu, Pierre-Alain Monnard, Ant Poole, and Mike Russell for insightful discussions.  ... 
doi:10.1162/artl_a_00032 pmid:21554111 fatcat:ye7sgczf2rb3djxcithqurlobe

Coupled Growth and Division of Model Protocell Membranes

Ting F. Zhu, Jack W. Szostak
2009 Journal of the American Chemical Society  
We show that model protocells can proceed through multiple cycles of reproduction. Encapsulated RNA molecules, representing a primitive genome, are distributed to the daughter vesicles.  ...  Modest shear forces are then sufficient to cause the thread-like vesicles to divide into multiple daughter vesicles without loss of internal contents.  ...  Luisi, A. Luptak, S. Mansy, D. Treco, C. Wong, and S. Zhou for helpful discussions and comments on the manuscript.  ... 
doi:10.1021/ja900919c pmid:19323552 pmcid:PMC2669828 fatcat:xjmsvqfxcbcgvgpjpm5vhcwqii

Prebiotic replicase evolution in a surface-bound metabolic system: parasites as a source of adaptive evolution

Balázs Könnyű, Tamás Czárán, Eörs Szathmáry
2008 BMC Evolutionary Biology  
In seeking for a scientific explanation one has to search for step-by-step evolutionary changes from prebiotic chemistry to the emergence of the first proto-cell.  ...  Results: We try to sketch a plausible scenario for the first steps of prebiotic evolution by exploring the ecological feasibility of a mineral surface-bound replicator system that facilitates a primitive  ...  Acknowledgements The paper is dedicated to Prof. Tibor Gánti on the occasion of his 75 th birthday.  ... 
doi:10.1186/1471-2148-8-267 pmid:18826645 pmcid:PMC2575217 fatcat:4vftco4oljeidb3bk5uj6smona
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