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A Petri Net Model of Granulomatous Inflammation: Implications for IL-10 Mediated Control of Leishmania donovani Infection

Luca Albergante, Jon Timmis, Lynette Beattie, Paul M. Kaye, Denis Thieffry
2013 PLoS Computational Biology  
To shed new light on fundamental aspects of granuloma formation and function, we have developed an in silico Petri net model that simulates hepatic granuloma development throughout the course of infection  ...  The model was extensively validated by comparison with data derived from experimental studies in mice, and the model robustness was assessed by a sensitivity analysis.  ...  Here, we describe a stochastic Petri net model of granulomatous inflammation in the liver of mice infected with L. donovani, which faithfully reproduces many of the characteristics of experimental infection  ... 
doi:10.1371/journal.pcbi.1003334 pmid:24363630 pmcid:PMC3867212 fatcat:cli3cdhqbbhuzaq7sq5g6pyj5e

The effect of essential oil of Syzygium cumini on the development of granulomatous infl ammation in mice

Rachel R.P. Machado, Deborah F. Jardim, Andrezza R. Souza, Elita Scio, Rodrigo L. Fabri, Arthur G. Carpanez, Richard M. Grazul, José Paulo R.F. de Mendonça, Bernhard Lesche, Fernando M. Aarestrup
2013 Revista Brasileira de Farmacognosia  
The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found.  ...  The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system.  ...  The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice Rachel R. P. Machado et al. Acknowledgements  ... 
doi:10.1590/s0102-695x2013005000030 fatcat:bml44r5g6rawpihhtw6iqyiucu

Lessons from other diseases: granulomatous inflammation in leishmaniasis

Paul M. Kaye, Lynette Beattie
2015 Seminars in Immunopathology  
As a simplified, noncaseating granuloma composed of relatively few and largely mononuclear cell populations, it provides a tractable model system to investigate intragranuloma cellular dynamics, immune  ...  Here, the occurrence of granulomatous pathology across the spectrum of leishmaniasis, in humans and animal reservoir hosts, is first described.  ...  Our approach in modeling the L. donovani granuloma has been twofold-first, the generation of agent-based models of early granuloma formation and, second, the use of Petri net modeling of granuloma heterogeneity  ... 
doi:10.1007/s00281-015-0548-7 pmid:26678994 pmcid:PMC4779128 fatcat:4eunjply2rgmbcj2qzhn7fgjl4

Functional complexity of the Leishmania granuloma and the potential of in silico modeling

John W. J. Moore, Daniel Moyo, Lynette Beattie, Paul S. Andrews, Jon Timmis, Paul M. Kaye
2013 Frontiers in Immunology  
In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development.  ...  In this mini-review, we discuss the factors involved in the formation and function of Leishmania donovani -induced hepatic granulomas, as well as their importance in protecting against inflammation-associated  ...  A more complex stochastic Petri-net model investigated novel therapeutic interventions for host protection during L. donovani infection (manuscript submitted).  ... 
doi:10.3389/fimmu.2013.00035 pmid:23423646 pmcid:PMC3573688 fatcat:35fkzlocwve3vblhgzud36fr7u

EFFECT OF ULTRA-DILUTED HISTAMINE ON HYPOXIC CHICK LUNG TISSUE INFLAMMATORY CHANGES

PRITAM GOSWAMI, SWAIF ALI SK, SAYAK GHOSH, ANAMIKA BASU, JOYDEEP KHANRA, SATADAL DAS
2019 Asian Journal of Pharmaceutical and Clinical Research  
Objectives: Since its discovery, the role of histamine in inflammation is controversial; thus, according to some authority, it is mainly pro-inflammatory, and according to others, it is anti-inflammatory  ...  In this scenario, we thought that the contradictory results are dose dependent, thus in this study, our aim was to find the specific role of ultra-diluted histamine in pulmonary inflammation.  ...  In histidine decarboxylase gene, knockout mice controlled granulomatous type of inflammation occurs in the lungs along with activation of CD4 type of T-cells and dendritic cells.  ... 
doi:10.22159/ajpcr.2019.v12i7.33651 fatcat:xu7uahecm5byppoompdulhohzi

The complex roles of NADPH oxidases in fungal infection

Deborah Hogan, Robert T. Wheeler
2014 Cellular Microbiology  
Chronic granulomatous disease due to NADPH oxidase deficiency was one of the first Mendelian traits linked to a gene and assigned a physiological basis (Babior, 2004 , Nauseef, 2008 , Segal et al., 2012  ...  The past decade has brought a new appreciation for the diversity of roles played by ROS in signaling associated with inflammation and immunity.  ...  Acknowledgments The authors gratefully acknowledge their funding from the National Institutes of Health (Grant # R15AI094406 to RTW & # R01AI091702, R01GM108492, and P30GM106394 to DAH) and USDA (Project  ... 
doi:10.1111/cmi.12320 pmid:24905433 pmcid:PMC4198337 fatcat:6kufdrun5vgqdejv42zs26d77u

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger, Mona Saffarzadeh, Alexander N. R. Weber, Nikolaus Rieber, Markus Radsak, Horst von Bernuth, Charaf Benarafa, Dirk Roos, Julia Skokowa, Dominik Hartl, Christoph Dehio
2015 PLoS Pathogens  
injury have expanded our understanding of their diverse role in infection and inflammation.  ...  While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue  ...  Acknowledgments We thank Niels Borregaard, University of Copenhagen, and Anna-Lena Schaupp, University of Oxford, for helpful comments on the manuscript.  ... 
doi:10.1371/journal.ppat.1004651 pmid:25764063 pmcid:PMC4357453 fatcat:x7q6myqcbndw7m2nzmft4chodi

Exogenous Local Hyperthermia at 41℃ Is Effective to Eliminate Mouse Model of Sporotrichosis, Independent of Neutrophil Extracellular Traps Formation

Ya-Lan Wang, Rui-Qun Qi, Jing Lan, Zheng-Xiu Li, Xing-Hua Gao
2021 Annals of Dermatology  
Moreover, NETs were formed after interaction with S. globosa, and the percentage of NETs formed was not significantly different at 41℃ or 37℃.  ...  Hyperthermia was significantly more effective in clearing the lesions in the mouse model, as compared to sham treatment.  ...  CONFLICTS OF INTEREST The authors have nothing to disclose. FUNDING SOURCE DATA SHARING STATEMENT Research data are not shared.  ... 
doi:10.5021/ad.2021.33.1.37 pmid:33911810 pmcid:PMC7875223 fatcat:hcky7etxfbb5pj4oguf3pq37u4

A Fragile Balance: Does Neutrophil Extracellular Trap Formation Drive Pulmonary Disease Progression?

Helena Block, Alexander Zarbock
2021 Cells  
Neutrophils act as the first line of defense during infection and inflammation.  ...  This review highlights recent findings on the pathophysiological influence of NET formation in different bacterial, viral, and non-infectious lung diseases and summarizes medical treatment strategies.  ...  However, additional preclinical testing and investigation of different disease models is needed to further validate this promising inhibitor as a therapeutic agent during inflammation.  ... 
doi:10.3390/cells10081932 pmid:34440701 pmcid:PMC8394734 fatcat:ddjoyy5u4vdjlflojgyydedida

Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses [article]

Stanzin Dawa, Dilip Menon, Prabhakar Arumugam, Akash Kumar Bhaskar, Moumita Mondal, Vivek K Rao, Sheetal Gandotra
2021 bioRxiv   pre-print
Here, we identified diacylglycerol O-acyltransferase 1 (DGAT1) to be essential for accumulation of triglyceride in necrotic TB granulomas using the C3HeB/FeJ murine model of infection.  ...  Accumulation of the neutral lipid triglyceride, as lipid droplets at the cellular cuff of necrotic granulomas, is a peculiar feature of pulmonary tuberculosis.  ...  LTB4 is a major determinant of disease susceptibility in the zebrafish model of mycobacterial granulomatous disease, with an imbalance in LTB4 to LXA4 levels driving disease susceptibility in both directions  ... 
doi:10.1101/2021.05.10.443218 fatcat:qegubmetrbewpmtjx5fvquerva

High Levels of IL-18 and IFN-γ in Chronically Inflamed Tissue in Chronic Granulomatous Disease

Virginia Meda Spaccamela, Rocio G. Valencia, Oleksandr Pastukhov, Andrea Duppenthaler, Matthias S. Dettmer, Juliane Erb, Urs C. Steiner, Sven Hillinger, Carsten Speckmann, Stephan Ehl, Janine Reichenbach, Ulrich Siler
2019 Frontiers in Immunology  
Chronic granulomatous disease (CGD) is caused by a malfunctioning nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex in phagocytes, leading to impaired bacterial and fungal killing and  ...  Immunofluorescence analysis identified macrophages as one source of IL-18 in inflamed tissue.  ...  of NET formation.  ... 
doi:10.3389/fimmu.2019.02236 pmid:31681257 pmcid:PMC6813411 fatcat:7mfw7ahwtrduzbkyptczpq2oqe

Differential clearance and host-pathogen interactions of YopE- and YopK- YopL- Yersinia pestis in BALB/c mice

S C Straley, M L Cibull
1989 Infection and Immunity  
Both strains caused acute inflammation in liver that evolved into structured lesions surrounded by progressively mononuclear inflammation suggestive of a granulomatous response.  ...  The parent Y. pestis showed net growth in the spleen by 2 h and in the liver after 7 h; exponential growth in both the liver and spleen culminated in death of the mice starting on day 4, with total bacterial  ...  The fluorescence-activated cell sorter was operated by Catherine Nowack of the University of Kentucky Flow Cytometry Core Facility.  ... 
pmid:2925246 pmcid:PMC313251 fatcat:75e42k4plbhoxbvvcnen5pzuo4

Inhibition of Granuloma Triglyceride Synthesis Imparts Control of Mycobacterium tuberculosis Through Curtailed Inflammatory Responses

Stanzin Dawa, Dilip Menon, Prabhakar Arumugam, Akash Kumar Bhaskar, Moumita Mondal, Vivek Rao, Sheetal Gandotra
2021 Frontiers in Immunology  
Here, we identified diacylglycerol O-acyltransferase 1 (DGAT1) to be essential for accumulation of triglyceride in necrotic TB granulomas using the C3HeB/FeJ murine model of infection.  ...  Accumulation of the neutral lipid triglyceride, as lipid droplets within the cellular cuff of necrotic granulomas, is a peculiar feature of pulmonary tuberculosis.  ...  LTB4 is a major determinant of disease susceptibility in the zebrafish model of mycobacterial granulomatous disease, with an imbalance in LTB4 to LXA4 levels driving disease susceptibility in both directions  ... 
doi:10.3389/fimmu.2021.722735 pmid:34603294 pmcid:PMC8479166 fatcat:qw6vvy6pxffnph2qz7jcpgo7ym

Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models

Janet Taylor, Joseph O. Anyango, Marnie Potgieter, Karlien Kallmeyer, Vinny Naidoo, Michael S. Pepper, John R. N. Taylor
2014 Journal of Biomedical Materials Research. Part A  
The safety and biocompatibility of kafirin implants in two forms was determined in rodent models. One week post subcutaneous injection of kafirin micropatticles (size S[!  ...  m diameter) in mice, chronic inflammation, abnormal red blood cells and gross fibrin formation were observed.  ...  Pretorius, Mr A. Hall, Mr C. van der Merwe, Mr A. Botha and Ms A. Buys  ... 
doi:10.1002/jbm.a.35394 pmid:25524818 fatcat:qegjgl2saze5pltqq2lduj4jka

Differential clearance and host-pathogen interactions of YopE- and YopK- YopL- Yersinia pestis in BALB/c mice

S C Straley, M L Cibull
1989 Infection and Immunity  
These progressed to large areas of necrosis, with a disproportionate loss of accompanying inflammation, such that on day 3, inflammation exceeded necrosis (Fig. 3A ) but by day 5 necrosis far exceeded  ...  This is suggestive of a toxogenic disease, and we hypothesize that toxicity makes a major contribution to death in our experimental plague model.  ...  In contrast to the parent or YopK-YopL-Y. pestis, the YopE-strain killed mice between days 4 and 6 only when the dose was at least 106; a dose of 4 x 105 was still cleared by the mice.  ... 
doi:10.1128/iai.57.4.1200-1210.1989 fatcat:u6ty5npznncptk3ihxai2hu7ke
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