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A new open-access platform for measuring and sharing mTBI data

August G. Domel, Samuel J. Raymond, Chiara Giordano, Yuzhe Liu, Seyed Abdolmajid Yousefsani, Michael Fanton, Nicholas J. Cecchi, Olga Vovk, Ileana Pirozzi, Ali Kight, Brett Avery, Athanasia Boumis (+15 others)
2021 Scientific Reports  
To that end, this paper puts forth two contributions: (1) a centralized, open-access platform for storing and sharing head impact data, in collaboration with the Federal Interagency Traumatic Brain Injury  ...  However, as the number of institutions operating these studies grows, there is a growing need for a platform to share these data to facilitate our understanding of concussion mechanisms and aid in the  ...  Acknowledgements The authors would like to thank Stanford Athletics and the football team for their support in this research.  ... 
doi:10.1038/s41598-021-87085-2 pmid:33820939 fatcat:xec3ngo4wzfj5jfmyku43yebsy

A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study

Ilaria Pozzato, Ian D Cameron, Susanne Meares, Annette Kifley, Kim Van Vu, Anthony Liang, Mark Gillett, Ashley Craig, Bamini Gopinath
2017 BMJ Open  
Surveillance studies involving emergency department (ED) and hospital-based data need to be prioritised as these provide incident mTBI estimates.  ...  more of the following: post-traumatic amnesia (PTA) of less than 24 hours' duration, confusion or disorientation, a witnessed loss of consciousness for ≤30 min and/or a positive CT brain scan.  ...  Open Access emotional symptoms for several months or years postinjury in a subgroup of individuals.  ... 
doi:10.1136/bmjopen-2017-016222 pmid:28780552 pmcid:PMC5629740 fatcat:t7d5ywxpcrdmlbzkg6hjalncje

New method to induce mild traumatic brain injury in rodents produces differential outcomes in female and male Sprague Dawley rats

Peter Wirth, Waylin Yu, Amanda L. Kimball, Jennifer Liao, Paul Berkner, Melissa J. Glenn
2017 Journal of Neuroscience Methods  
New Method-Our new model for inducing mTBI in rodents entails acceleration of the animal toward a stationary impact zone to produce rapid rotational movement of the head.  ...  Results-mTBI produced the most widespread effects in females: they were more active during recovery within minutes of mTBI and more active in the center of the open field 4 days after mTBI.  ...  data collection, and Stephanie Desrochers and Sarah Steimel for their editorial assistance.  ... 
doi:10.1016/j.jneumeth.2017.07.030 pmid:28780369 pmcid:PMC5790318 fatcat:lc7khyysdngdtfn2njq35uague

Quality of psychoeducational apps for military members with mild traumatic brain injury: An evaluation utilizing the Mobile Application Rating Scale (Preprint)

Chelsea Jones, Kaitlin O'Toole, Kevin Jones, Suzette Bremault-Phillips
2020 JMIR mHealth and uHealth  
Psychoeducational interventions have a good evidence base as a treatment for mTBI and PCS.  ...  specificity, and privacy and security of data.  ...  as long as data sharing, privacy, and security are considered [26] .  ... 
doi:10.2196/19807 pmid:32808937 fatcat:nozzfl4n4jbtzmocgztv4h2l6e

Sensorimotor conflict tests in an immersive virtual environment reveal subclinical impairments in mild traumatic brain injury

Hrishikesh M Rao, Tanya Talkar, Gregory Ciccarelli, Michael Nolan, Anne O'Brien, Gloria Vergara-Diaz, Delsey Sherrill, Ross Zafonte, Jeffrey S Palmer, Thomas F Quatieri, Ryan J McKindles, Paolo Bonato (+1 others)
2020 Scientific Reports  
Patient-reported symptoms can be significant and have a huge impact on daily life, but impairments may remain undetected or poorly quantified using clinical measures.  ...  This augmentation is vital in order to robustly detect the presence of balance impairments after mTBI and potentially define a phenotype of balance dysfunction that enhances risk of injury.  ...  Each data point represents the score on the clinical test for subjects in the control group (black open circles) or subject in the mTBI group (green open circles).  ... 
doi:10.1038/s41598-020-71611-9 pmid:32901067 pmcid:PMC7479615 fatcat:x2kezfyijng33ev2vrvpr37xsa

Mild traumatic brain injury induces memory deficits with alteration of gene expression profile

Yawen Luo, Haiyan Zou, Yili Wu, Fang Cai, Si Zhang, Weihong Song
2017 Scientific Reports  
Traumatic brain injury (TBI), a brain damage caused by an external mechanic force, is a serious issue to public health. It is the leading cause of death and disability for people under 45.  ...  This study suggests that long-term monitoring and interventions for rmTBI individuals are essential for memory function recovery and reducing the risk of developing neurodegenerative diseases.  ...  Therefore, we developed a new rmTBI model in which the mice were injured once a day for 25 uninterrupted days.  ... 
doi:10.1038/s41598-017-11458-9 pmid:28883638 pmcid:PMC5589921 fatcat:jc2emme6xvbrxgs3bny7hxut4a

Celecoxib in a Preclinical Model of Repetitive Mild Traumatic Brain Injury: Hippocampal Learning Deficits Persist with Inflammatory and Excitotoxic Neuroprotection

Matthew Hiskens, Rebecca Vella, Anthony Schneiders, Andrew Fenning
2021 Trauma Care  
Celecoxib is a selective COX-2 inhibitor that is prescribed in some conditions of mTBI to alleviate symptoms of concussion, and has shown benefits in neurodegenerative conditions.  ...  We investigated molecular pathways of neuroinflammation in response to celecoxib treatment in a mouse model of repetetive mTBI.  ...  Acknowledgments: The authors would like to express their gratitude to Kristal Parmenter and Peta-Anne Clark for their time and assistance with the laboratory experiments.  ... 
doi:10.3390/traumacare1010003 fatcat:iye6jsedebddfh2n3ypy5rtp3y

Kids' Outcomes And Long-term Abilities (KOALA): protocol for a prospective, longitudinal cohort study of mild traumatic brain injury in children 6 months to 6 years of age

Miriam H Beauchamp, Fanny Dégeilh, Keith Yeates, Isabelle Gagnon, Ken Tang, Jocelyn Gravel, Antonia Stang, Brett Burstein, Annie Bernier, Catherine Lebel, Ramy El Jalbout, Sonia Lupien (+4 others)
2020 BMJ Open  
A comprehensive battery of prognostic and outcome measures will be collected in the PED, at 10 days, 1, 3 and 12 months postinjury.  ...  of function using developmental and neuropsychological measures and parent questionnaires.  ...  Acknowledgements We would like to thank the research coordinators and assistants at all of the three sites for their contributions to this project, in particular Maria Tran for overall coordination of  ... 
doi:10.1136/bmjopen-2020-040603 pmid:33077571 fatcat:63pf4uwk3nbcpmhti2x3xxegbi

Behavioral, blood and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

David K. Wright, Jack Trezise, Alaa Kamnaksh, Ramsey Bekdash, Leigh A. Johnston, Roger Ordidge, Bridgette D. Semple, Andrew J. Gardner, Peter Stanwell, Terence J. O'Brien, Denes V. Agoston, Sandy R. Shultz
2016 Scientific Reports  
MRI and blood proteomics might provide objective measures of pathophysiological changes in mTBI, and indicate when the brain is no longer in a state of ICV.  ...  This study assessed behavioral, MRI, and blood-based markers in a rat model of mTBI.  ...  John Olson for his assistance with the blood biomarker assays and acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility at the Florey Institute of Neuroscience  ... 
doi:10.1038/srep28713 pmid:27349514 pmcid:PMC4923906 fatcat:5el3tvchnfhhvjusnhret7b47a

Toward an International Initiative for Traumatic Brain Injury Research

Patrizia Tosetti, Ramona R. Hicks, Elizabeth Theriault, Anthony Phillips, Walter Koroshetz, Ruxandra Draghia-Akli, and the Workshop Part
2013 Journal of Neurotrauma  
and sharing; injury classification; outcome measures; clinical study design; and statistical analysis.  ...  The workshop participants recommended that InTBIR initially focus on collecting, standardizing, and sharing clinical TBI data for comparative effectiveness research, which will ultimately result in better  ...  Open access to the data has led to impressive sharing and utilization and to more than 400 publications thus far.  ... 
doi:10.1089/neu.2013.2896 pmid:23731282 pmcid:PMC3713440 fatcat:fp4cmv6zajcsdjhu6wlaoygkxa

The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)

Shahaf Edut, Vardit Rubovitch, Shaul Schreiber, Chaim G. Pick
2010 Psychopharmacology  
Minimal traumatic brain injury (mTBI) a common consequence of MVAs-produces short-and long-term physical, cognitive, and emotional impairments.  ...  Behavioral tests were conducted 7 and 30 days post-injury. In addition to the behavioral tests, phosphorylation of IGF-1R, ERK, and levels of tyrosine hydroxylase (TH) were measured.  ...  After the first run, the mouse was put back into its home cage for 2 min. The second run lasted 2 min when all three arms were open. Time spent in each of the arms was measured.  ... 
doi:10.1007/s00213-010-2098-y pmid:21120456 fatcat:p6ekabqbujgffhaa2qymsj7zry

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms

David Tweedie, Koji Fukui, Yazhou Li, Qian-sheng Yu, Shani Barak, Ian A. Tamargo, Vardit Rubovitch, Harold W. Holloway, Elin Lehrmann, William H. Wood, Yongqing Zhang, Kevin G. Becker (+8 others)
2016 PLoS ONE  
as a therapeutic for TBI.  ...  Together these data suggest that multiple phenserine-associated actions underpin this compound's ability to ameliorate cognitive deficits caused by mTBI, and support the further evaluation of the compound  ...  Tel-Aviv University, and (iii) a grant from the Israel Science Foundation, grant number 108/ 09.  ... 
doi:10.1371/journal.pone.0156493 pmid:27254111 pmcid:PMC4890804 fatcat:s7byqs7suvflfpcrzqx6c6jutq

Mild Traumatic Brain Injury in Translation

Harvey S. Levin, Claudia S. Robertson
2013 Journal of Neurotrauma  
Translation of interventions that are developed in animal models to patients with mTBI is a priority for the research agenda.  ...  This Introduction to a Special Issue on Mild Traumatic Brain Injury (mTBI) highlights the methodological challenges in outcome studies and clinical trials involving patients who sustain mTBI.  ...  Post-Traumatic Stress Disorder and Traumatic Brain Injury (PTSD/TBI) Research Program), and award 26244 from The Center of Excellence for Traumatic Brain Injury Award from the Department of Veterans Affairs  ... 
doi:10.1089/neu.2012.2394 pmid:23046349 pmcid:PMC3638686 fatcat:if6qt3bubzh4lnhjb4tbfvhbqi

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury

Massimo Fiandaca, Thomas Gross, Thomas Johnson, Michele Hu, Samuel Evetts, Richard Wade-Martins, Kian Merchant-Borna, Jeffrey Bazarian, Amrita Cheema, Mark Mapstone, Howard Federoff
2018 Metabolites  
Using untargeted and targeted high-performance liquid chromatography-mass spectrometry we identified metabolomic biomarker profiles in a cohort of symptomatic mild TBI (mTBI) subjects (n = 75) 3–12 months  ...  following injury (subacute) and TBI controls (n = 20), and a PD cohort with known PD (n = 20) or PD dementia (PDD) (n = 20) and PD controls (n = 20).  ...  the OPDC Data Access Committee.  ... 
doi:10.3390/metabo8030050 pmid:30205491 pmcid:PMC6161135 fatcat:v6pm2mzomre6tpnykqxpj2vxqa

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

David K. Wright, Rhys D. Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J. McDonald, Richelle Mychasiuk, Scott C. Kolbe, Meng Law, Leigh A. Johnston, Terence J. O'Brien, Denes V. Agoston (+1 others)
2019 Scientific Reports  
A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities.  ...  measures as RmTBI biomarkers.  ...  Following surgery, rats were housed individually under a 12 h:12 h light/dark cycle with ad libitum access to water and food for the duration of the study.  ... 
doi:10.1038/s41598-019-51267-w pmid:31602002 pmcid:PMC6787341 fatcat:56jxuqkxwvezxoml2qrxoopcvm
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