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A new open-access platform for measuring and sharing mTBI data
2021
Scientific Reports
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To that end, this paper puts forth two contributions: (1) a centralized, open-access platform for storing and sharing head impact data, in collaboration with the Federal Interagency Traumatic Brain Injury ...
However, as the number of institutions operating these studies grows, there is a growing need for a platform to share these data to facilitate our understanding of concussion mechanisms and aid in the ...
Acknowledgements The authors would like to thank Stanford Athletics and the football team for their support in this research. ...
doi:10.1038/s41598-021-87085-2
pmid:33820939
fatcat:xec3ngo4wzfj5jfmyku43yebsy
A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study
2017
BMJ Open
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Surveillance studies involving emergency department (ED) and hospital-based data need to be prioritised as these provide incident mTBI estimates. ...
more of the following: post-traumatic amnesia (PTA) of less than 24 hours' duration, confusion or disorientation, a witnessed loss of consciousness for ≤30 min and/or a positive CT brain scan. ...
Open Access emotional symptoms for several months or years postinjury in a subgroup of individuals. ...
doi:10.1136/bmjopen-2017-016222
pmid:28780552
pmcid:PMC5629740
fatcat:t7d5ywxpcrdmlbzkg6hjalncje
New method to induce mild traumatic brain injury in rodents produces differential outcomes in female and male Sprague Dawley rats
2017
Journal of Neuroscience Methods
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New Method-Our new model for inducing mTBI in rodents entails acceleration of the animal toward a stationary impact zone to produce rapid rotational movement of the head. ...
Results-mTBI produced the most widespread effects in females: they were more active during recovery within minutes of mTBI and more active in the center of the open field 4 days after mTBI. ...
data collection, and Stephanie Desrochers and Sarah Steimel for their editorial assistance. ...
doi:10.1016/j.jneumeth.2017.07.030
pmid:28780369
pmcid:PMC5790318
fatcat:lc7khyysdngdtfn2njq35uague
Quality of psychoeducational apps for military members with mild traumatic brain injury: An evaluation utilizing the Mobile Application Rating Scale (Preprint)
2020
JMIR mHealth and uHealth
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Psychoeducational interventions have a good evidence base as a treatment for mTBI and PCS. ...
specificity, and privacy and security of data. ...
as long as data sharing, privacy, and security are considered [26] . ...
doi:10.2196/19807
pmid:32808937
fatcat:nozzfl4n4jbtzmocgztv4h2l6e
Sensorimotor conflict tests in an immersive virtual environment reveal subclinical impairments in mild traumatic brain injury
2020
Scientific Reports
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Patient-reported symptoms can be significant and have a huge impact on daily life, but impairments may remain undetected or poorly quantified using clinical measures. ...
This augmentation is vital in order to robustly detect the presence of balance impairments after mTBI and potentially define a phenotype of balance dysfunction that enhances risk of injury. ...
Each data point represents the score on the clinical test for subjects in the control group (black open circles) or subject in the mTBI group (green open circles). ...
doi:10.1038/s41598-020-71611-9
pmid:32901067
pmcid:PMC7479615
fatcat:x2kezfyijng33ev2vrvpr37xsa
Mild traumatic brain injury induces memory deficits with alteration of gene expression profile
2017
Scientific Reports
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Traumatic brain injury (TBI), a brain damage caused by an external mechanic force, is a serious issue to public health. It is the leading cause of death and disability for people under 45. ...
This study suggests that long-term monitoring and interventions for rmTBI individuals are essential for memory function recovery and reducing the risk of developing neurodegenerative diseases. ...
Therefore, we developed a new rmTBI model in which the mice were injured once a day for 25 uninterrupted days. ...
doi:10.1038/s41598-017-11458-9
pmid:28883638
pmcid:PMC5589921
fatcat:jc2emme6xvbrxgs3bny7hxut4a
Celecoxib in a Preclinical Model of Repetitive Mild Traumatic Brain Injury: Hippocampal Learning Deficits Persist with Inflammatory and Excitotoxic Neuroprotection
2021
Trauma Care
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Celecoxib is a selective COX-2 inhibitor that is prescribed in some conditions of mTBI to alleviate symptoms of concussion, and has shown benefits in neurodegenerative conditions. ...
We investigated molecular pathways of neuroinflammation in response to celecoxib treatment in a mouse model of repetetive mTBI. ...
Acknowledgments: The authors would like to express their gratitude to Kristal Parmenter and Peta-Anne Clark for their time and assistance with the laboratory experiments. ...
doi:10.3390/traumacare1010003
fatcat:iye6jsedebddfh2n3ypy5rtp3y
Kids' Outcomes And Long-term Abilities (KOALA): protocol for a prospective, longitudinal cohort study of mild traumatic brain injury in children 6 months to 6 years of age
2020
BMJ Open
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A comprehensive battery of prognostic and outcome measures will be collected in the PED, at 10 days, 1, 3 and 12 months postinjury. ...
of function using developmental and neuropsychological measures and parent questionnaires. ...
Acknowledgements We would like to thank the research coordinators and assistants at all of the three sites for their contributions to this project, in particular Maria Tran for overall coordination of ...
doi:10.1136/bmjopen-2020-040603
pmid:33077571
fatcat:63pf4uwk3nbcpmhti2x3xxegbi
Behavioral, blood and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury
2016
Scientific Reports
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MRI and blood proteomics might provide objective measures of pathophysiological changes in mTBI, and indicate when the brain is no longer in a state of ICV. ...
This study assessed behavioral, MRI, and blood-based markers in a rat model of mTBI. ...
John Olson for his assistance with the blood biomarker assays and acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility at the Florey Institute of Neuroscience ...
doi:10.1038/srep28713
pmid:27349514
pmcid:PMC4923906
fatcat:5el3tvchnfhhvjusnhret7b47a
Toward an International Initiative for Traumatic Brain Injury Research
2013
Journal of Neurotrauma
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and sharing; injury classification; outcome measures; clinical study design; and statistical analysis. ...
The workshop participants recommended that InTBIR initially focus on collecting, standardizing, and sharing clinical TBI data for comparative effectiveness research, which will ultimately result in better ...
Open access to the data has led to impressive sharing and utilization and to more than 400 publications thus far. ...
doi:10.1089/neu.2013.2896
pmid:23731282
pmcid:PMC3713440
fatcat:fp4cmv6zajcsdjhu6wlaoygkxa
The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)
2010
Psychopharmacology
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Minimal traumatic brain injury (mTBI) a common consequence of MVAs-produces short-and long-term physical, cognitive, and emotional impairments. ...
Behavioral tests were conducted 7 and 30 days post-injury. In addition to the behavioral tests, phosphorylation of IGF-1R, ERK, and levels of tyrosine hydroxylase (TH) were measured. ...
After the first run, the mouse was put back into its home cage for 2 min. The second run lasted 2 min when all three arms were open. Time spent in each of the arms was measured. ...
doi:10.1007/s00213-010-2098-y
pmid:21120456
fatcat:p6ekabqbujgffhaa2qymsj7zry
Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms
2016
PLoS ONE
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as a therapeutic for TBI. ...
Together these data suggest that multiple phenserine-associated actions underpin this compound's ability to ameliorate cognitive deficits caused by mTBI, and support the further evaluation of the compound ...
Tel-Aviv University, and (iii) a grant from the Israel Science Foundation, grant number 108/ 09. ...
doi:10.1371/journal.pone.0156493
pmid:27254111
pmcid:PMC4890804
fatcat:s7byqs7suvflfpcrzqx6c6jutq
Mild Traumatic Brain Injury in Translation
2013
Journal of Neurotrauma
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Translation of interventions that are developed in animal models to patients with mTBI is a priority for the research agenda. ...
This Introduction to a Special Issue on Mild Traumatic Brain Injury (mTBI) highlights the methodological challenges in outcome studies and clinical trials involving patients who sustain mTBI. ...
Post-Traumatic Stress Disorder and Traumatic Brain Injury (PTSD/TBI) Research Program), and award 26244 from The Center of Excellence for Traumatic Brain Injury Award from the Department of Veterans Affairs ...
doi:10.1089/neu.2012.2394
pmid:23046349
pmcid:PMC3638686
fatcat:if6qt3bubzh4lnhjb4tbfvhbqi
Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury
2018
Metabolites
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Using untargeted and targeted high-performance liquid chromatography-mass spectrometry we identified metabolomic biomarker profiles in a cohort of symptomatic mild TBI (mTBI) subjects (n = 75) 3–12 months ...
following injury (subacute) and TBI controls (n = 20), and a PD cohort with known PD (n = 20) or PD dementia (PDD) (n = 20) and PD controls (n = 20). ...
the OPDC Data Access Committee. ...
doi:10.3390/metabo8030050
pmid:30205491
pmcid:PMC6161135
fatcat:v6pm2mzomre6tpnykqxpj2vxqa
Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat
2019
Scientific Reports
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A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. ...
measures as RmTBI biomarkers. ...
Following surgery, rats were housed individually under a 12 h:12 h light/dark cycle with ad libitum access to water and food for the duration of the study. ...
doi:10.1038/s41598-019-51267-w
pmid:31602002
pmcid:PMC6787341
fatcat:56jxuqkxwvezxoml2qrxoopcvm
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