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A New Algorithm for Cortical Bone Segmentation with Its Validation and Applications to In Vivo Imaging
[chapter]
2013
Lecture Notes in Computer Science
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An automated cortical bone segmentation algorithm for in vivo MD-CT imaging of distal tibia is presented. ...
Cortical bone segmentation is needed for quantitative analyses and the task is nontrivial for in vivo multi-row detector CT (MD-CT) imaging due to limited resolution and partial volume effects. ...
This work was supported by the NIH grants R01-AR054439 and R01-DE012101. The authors wish to thank Mr. Jered Sieren for performing MD-CT cadaveric and human bone imaging. ...
doi:10.1007/978-3-642-41184-7_36
pmid:27398415
pmcid:PMC4936402
fatcat:aw63rbybnzh5jkuxr4umm27fbe
Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis
2007
Bone
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The use of high resolution peripheral quantitative computed tomography (HR-pQCT) and in vivo micro-CT for studies of bone disease and treatment has become increasingly common, and with these methods comes ...
A simple, robust, and fullyautomated segmentation algorithm is presented that efficiently segments bone regions. ...
Acknowledgments The authors would like to thank Dr. Andres Laib from Scanco Medical AG for his invaluable assistance with the image processing methodology of the gold standard patient analysis. ...
doi:10.1016/j.bone.2007.07.007
pmid:17693147
fatcat:blltfhrh7rfqvorioj2bl2ds2e
Validation of HR-pQCT against Micro-CT for Morphometric and Biomechanical Analyses: A Review
2020
Bone Reports
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Given the recent improvements in image resolution, from 82 to 61 μm, this technology may be used to accurately quantify in vivo bone microarchitecture, a key biomarker of degenerative bone diseases. ...
With more recent advancements in HR-pQCT, the community must learn from its past and provide properly validated technologies to ensure that HR-pQCT can truly provide value in patient diagnosis and care ...
agreement 841316), and the ETH Postdoctoral Fellowship for financial support. ...
doi:10.1016/j.bonr.2020.100711
pmid:33392364
pmcid:PMC7772687
fatcat:xkobvt2bwfarjourhoneukmmc4
Structural analysis of cortical porosity applied to HR-pQCT data
2013
Medical Physics (Lancaster)
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With the emergence of HR-pQCT as a noninvasive tool suitable for clinical use, cortical porosity at appendicular sites can be directly visualized in vivo. ...
In vivo precision error for these parameters ranged from 2.31 to 9.68 RMSCV%. ...
This ex vivo validation study establishes the accuracy and voxel size dependence of pore microstructure and topology analysis as a basis for application to in vivo studies. ...
doi:10.1118/1.4851575
pmid:24387533
pmcid:PMC3895089
fatcat:bjpowpkgavg2neofrrixo6yu44
A New Straightforward Method for Automated Segmentation of Trabecular Bone from Cortical Bone in Diverse and Challenging Morphologies
[article]
2021
bioRxiv
pre-print
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Here, we characterise and share this recipe, and demonstrate its application to a range of murine and human bone types, including normal and osteoarthritic specimens, and bones with distinct embryonic ...
Our aim is that this method will be adopted widely to create a more standardized and time efficient method of segmenting trabecular and cortical bone. ...
Acknowledgements and Funding We thank the OA Tech+ Network (grant EP/N027264/1) the Anatomical Society (grant SSD 011018SEAL -v1-011217) for funding this project. We thank Alessandro Borghi and Great ...
doi:10.1101/2021.03.02.433409
fatcat:d5o6kwllxrf2xoavodndli7zge
Synchrotron Radiation Micro-CT Imaging of Bone Tissue
[chapter]
2011
Theory and Applications of CT Imaging and Analysis
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A fundamental process in bone biology is remodeling which replaces old bones with new one and allows bone to adapt its properties to mechanical constraints. ...
A third perspective, is the development of new image analysis methods to provide smart solutions to image segmentation and analysis in this domain, which also requires multidisciplinary vision on bone ...
This book discloses recent advances and new ideas in theories and applications for CT imaging and its analysis. ...
doi:10.5772/14995
fatcat:cbm6zwce6vcofegvcvwnb7cadm
Precision of Digital Volume Correlation Approaches for Strain Analysis in Bone Imaged with Micro-Computed Tomography at Different Dimensional Levels
2017
Frontiers in Materials
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Moreover, for in vivo μCT applications, DVC analyses should be performed only with relatively course spatial resolution for achieving a reasonable precision of the method. ...
However, for the first time, large differences in the precision of both local and global DVC approaches have been highlighted when SRμCT or in vivo μCT images were used instead of conventional ex vivo ...
DiscUssiOn The goal of this study was to compare the precision of two DVC algorithms in different applications for measuring bone strains at different dimensional levels and based on images acquired with ...
doi:10.3389/fmats.2017.00031
fatcat:x7ouxmuomjdyxlru6kudc6tzle
High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group
2013
Current Osteoporosis Reports
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vivo, with accuracy previously unachievable and with relatively low-dose radiation. ...
The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in ...
Bone. 2013. (in press). Description of a new method to segment cortical and trabecular compartments and estimate cortical porosity. ...
doi:10.1007/s11914-013-0140-9
pmid:23525967
pmcid:PMC3641288
fatcat:tztktdfhzreahg5a2cr5ubs5xi
High-Resolution Imaging Techniques for the Assessment of Osteoporosis
2010
The Radiologic clinics of North America
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In addition Multidetector-CT has been used for high-resolution imaging of trabecular bone structure, however, the radiation dose is a limiting factor. ...
Synopsis The importance of assessing the bone's microarchitectural make-up in addition to its mineral density in the context of osteoporosis has been emphasized in a number of publications. ...
Acknowledgments This work was supported by NIH R01 AR057336 (RK), NIH AG017762 (SM), 1RC1AR058405-01 (TML) and UC Discovery Grants (7Tesla) LSIT01-10107 and ITL-BIO04-10148. ...
doi:10.1016/j.rcl.2010.02.015
pmid:20609895
pmcid:PMC2901255
fatcat:fz2mbtlssjcq7kvbxyu5pre4yi
High-resolution Computed Tomography for Clinical Imaging of Bone Microarchitecture
2011
Clinical Orthopaedics and Related Research
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The application of high-resolution imaging in evaluating bone structure has evolved from an in vitro technology for small specimens to an emerging clinical research tool for in vivo studies in humans. ...
Results Specimens can be imaged by micro-CT at a resolution starting at 1 lm, but in vivo human imaging is restricted to a voxel size of 82 lm (with actual spatial resolution of * 130 lm) due to technical ...
for in vivo human imaging studies, and (4) recent studies using HR-pQCT to characterize bone structure in the context of skeletal disease, particularly its ability to discriminate between subjects with ...
doi:10.1007/s11999-010-1766-x
pmid:21344275
pmcid:PMC3126972
fatcat:lkcdoxu6zzdtnkbcgaesfdz4zi
Multimodal μCT/μMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic/osteoblastic metastases
2012
Medical Physics (Lancaster)
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Multimodal μCT/μMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic/osteoblastic metastases. Med Phys. 2012 May;39(5):284853. ...
This coil was specifically designed for good signal to noise 131 ratio in imaging ex vivo bone. The coil was fixed tuned to an average load as load change is not 132 essential for small sizes. ...
The µCT and µMR images were registered using a 3D rigid 32 registration algorithm with a mutual information metric. ...
doi:10.1118/1.3703590
pmid:22559657
fatcat:uiyaxaautrfznnurvw734h5cha
Methodology for Measurement of in vivo Tibiotalar Kinematics After Total Ankle Replacement Using Dual Fluoroscopy
2020
Frontiers in Bioengineering and Biotechnology
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The successful implementation of our new tracking methodology with a hybrid model presents a new approach to evaluate in vivo TAR kinematics. ...
One challenge with this approach is dealing with metal artifact in the CT images that distorts implant visualization and the surrounding bone to implant interfaces. ...
Albert Burstein and Dr. Charles Saltzman are thanked for their research consultation. ...
doi:10.3389/fbioe.2020.00375
pmid:32432091
pmcid:PMC7214754
fatcat:pbztykay6rfmtfe5fkq7kdfmqu
Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care
2021
Current Osteoporosis Reports
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Recent Findings Recent developments have increased their ability to accurately segment bones, as well as to perform 3D reconstruction and classify bone anatomies, all features of high interest in the field ...
Heterogeneities in validation hinder a thorough comparison between the different methods and represent one of the future challenges to be addressed to reach clinical implementation. ...
It is characterized by reduced bone mass and altered bone quality, thus resulting in increased bone fragility and fracture risk. ...
doi:10.1007/s11914-021-00711-w
pmid:34773211
pmcid:PMC8716351
fatcat:dpoulvkcf5expdndzocmgir45a
Noninvasive imaging of bone microarchitecture
2011
Annals of the New York Academy of Sciences
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With increasing availability of in vivo high-resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross-site validations. ...
In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. ...
J-3079 (Austrian Science Fund) to J.M.P. ...
doi:10.1111/j.1749-6632.2011.06282.x
pmid:22172043
pmcid:PMC4461066
fatcat:fzgvqw6zkvf6bgwhlb7jljpwsi
Automated segmentation of swine skulls for finite element model creation using high resolution μ-CT images
2017
Figshare
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In this study, a method is proposed to automatically segment microcomputed tomography (μ-CT) scan images of bone pieces to build an FE model of a full swine hemi-skull. ...
Using the Digital Imaging and Communications in Medicine (DICOM) files from scanned bones, the complete geometry of each bone piece is recreated through seven customized processing algorithms. ...
To account for this, the Gaussian smoothing algorithm calculates a new grayscale number with a weighted average around its neighbor for each pixel by convolving the images. ...
doi:10.6084/m9.figshare.5071561.v1
fatcat:qiv7k7oforfufnxyjql7bd67u4
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