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A New Algorithm for Cortical Bone Segmentation with Its Validation and Applications to In Vivo Imaging [chapter]

Cheng Li, Dakai Jin, Trudy L. Burns, James C. Torner, Steven M. Levy, Punam K. Saha
2013 Lecture Notes in Computer Science  
An automated cortical bone segmentation algorithm for in vivo MD-CT imaging of distal tibia is presented.  ...  Cortical bone segmentation is needed for quantitative analyses and the task is nontrivial for in vivo multi-row detector CT (MD-CT) imaging due to limited resolution and partial volume effects.  ...  This work was supported by the NIH grants R01-AR054439 and R01-DE012101. The authors wish to thank Mr. Jered Sieren for performing MD-CT cadaveric and human bone imaging.  ... 
doi:10.1007/978-3-642-41184-7_36 pmid:27398415 pmcid:PMC4936402 fatcat:aw63rbybnzh5jkuxr4umm27fbe

Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis

Helen R. Buie, Graeme M. Campbell, R. Joshua Klinck, Joshua A. MacNeil, Steven K. Boyd
2007 Bone  
The use of high resolution peripheral quantitative computed tomography (HR-pQCT) and in vivo micro-CT for studies of bone disease and treatment has become increasingly common, and with these methods comes  ...  A simple, robust, and fullyautomated segmentation algorithm is presented that efficiently segments bone regions.  ...  Acknowledgments The authors would like to thank Dr. Andres Laib from Scanco Medical AG for his invaluable assistance with the image processing methodology of the gold standard patient analysis.  ... 
doi:10.1016/j.bone.2007.07.007 pmid:17693147 fatcat:blltfhrh7rfqvorioj2bl2ds2e

Validation of HR-pQCT against Micro-CT for Morphometric and Biomechanical Analyses: A Review

Nicholas Ohs, Caitlyn J. Collins, Penny R. Atkins
2020 Bone Reports  
Given the recent improvements in image resolution, from 82 to 61 μm, this technology may be used to accurately quantify in vivo bone microarchitecture, a key biomarker of degenerative bone diseases.  ...  With more recent advancements in HR-pQCT, the community must learn from its past and provide properly validated technologies to ensure that HR-pQCT can truly provide value in patient diagnosis and care  ...  agreement 841316), and the ETH Postdoctoral Fellowship for financial support.  ... 
doi:10.1016/j.bonr.2020.100711 pmid:33392364 pmcid:PMC7772687 fatcat:xkobvt2bwfarjourhoneukmmc4

Structural analysis of cortical porosity applied to HR-pQCT data

Willy Tjong, Jasmine Nirody, Andrew J. Burghardt, Julio Carballido-Gamio, Galateia J. Kazakia
2013 Medical Physics (Lancaster)  
With the emergence of HR-pQCT as a noninvasive tool suitable for clinical use, cortical porosity at appendicular sites can be directly visualized in vivo.  ...  In vivo precision error for these parameters ranged from 2.31 to 9.68 RMSCV%.  ...  This ex vivo validation study establishes the accuracy and voxel size dependence of pore microstructure and topology analysis as a basis for application to in vivo studies.  ... 
doi:10.1118/1.4851575 pmid:24387533 pmcid:PMC3895089 fatcat:bjpowpkgavg2neofrrixo6yu44

A New Straightforward Method for Automated Segmentation of Trabecular Bone from Cortical Bone in Diverse and Challenging Morphologies [article]

Eva C. Herbst, Alessandro A. Felder, Lucinda A. E. Evans, Sara Ajami, Behzad Javaheri, Andrew A. Pitsillides
2021 bioRxiv   pre-print
Here, we characterise and share this recipe, and demonstrate its application to a range of murine and human bone types, including normal and osteoarthritic specimens, and bones with distinct embryonic  ...  Our aim is that this method will be adopted widely to create a more standardized and time efficient method of segmenting trabecular and cortical bone.  ...  Acknowledgements and Funding We thank the OA Tech+ Network (grant EP/N027264/1) the Anatomical Society (grant SSD 011018SEAL -v1-011217) for funding this project. We thank Alessandro Borghi and Great  ... 
doi:10.1101/2021.03.02.433409 fatcat:d5o6kwllxrf2xoavodndli7zge

Synchrotron Radiation Micro-CT Imaging of Bone Tissue [chapter]

Zsolt-Andrei Peter, Franoise Peyri
2011 Theory and Applications of CT Imaging and Analysis  
A fundamental process in bone biology is remodeling which replaces old bones with new one and allows bone to adapt its properties to mechanical constraints.  ...  A third perspective, is the development of new image analysis methods to provide smart solutions to image segmentation and analysis in this domain, which also requires multidisciplinary vision on bone  ...  This book discloses recent advances and new ideas in theories and applications for CT imaging and its analysis.  ... 
doi:10.5772/14995 fatcat:cbm6zwce6vcofegvcvwnb7cadm

Precision of Digital Volume Correlation Approaches for Strain Analysis in Bone Imaged with Micro-Computed Tomography at Different Dimensional Levels

Enrico Dall'Ara, Marta Peña-Fernández, Marco Palanca, Mario Giorgi, Luca Cristofolini, Gianluca Tozzi
2017 Frontiers in Materials  
Moreover, for in vivo μCT applications, DVC analyses should be performed only with relatively course spatial resolution for achieving a reasonable precision of the method.  ...  However, for the first time, large differences in the precision of both local and global DVC approaches have been highlighted when SRμCT or in vivo μCT images were used instead of conventional ex vivo  ...  DiscUssiOn The goal of this study was to compare the precision of two DVC algorithms in different applications for measuring bone strains at different dimensional levels and based on images acquired with  ... 
doi:10.3389/fmats.2017.00031 fatcat:x7ouxmuomjdyxlru6kudc6tzle

High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group

Angela M. Cheung, Jonathan D. Adachi, David A. Hanley, David L. Kendler, K. Shawn Davison, Robert Josse, Jacques P. Brown, Louis-Georges Ste-Marie, Richard Kremer, Marta C. Erlandson, Larry Dian, Andrew J. Burghardt (+1 others)
2013 Current Osteoporosis Reports  
vivo, with accuracy previously unachievable and with relatively low-dose radiation.  ...  The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in  ...  Bone. 2013. (in press). Description of a new method to segment cortical and trabecular compartments and estimate cortical porosity.  ... 
doi:10.1007/s11914-013-0140-9 pmid:23525967 pmcid:PMC3641288 fatcat:tztktdfhzreahg5a2cr5ubs5xi

High-Resolution Imaging Techniques for the Assessment of Osteoporosis

Roland Krug, Andrew J. Burghardt, Sharmila Majumdar, Thomas M. Link
2010 The Radiologic clinics of North America  
In addition Multidetector-CT has been used for high-resolution imaging of trabecular bone structure, however, the radiation dose is a limiting factor.  ...  Synopsis The importance of assessing the bone's microarchitectural make-up in addition to its mineral density in the context of osteoporosis has been emphasized in a number of publications.  ...  Acknowledgments This work was supported by NIH R01 AR057336 (RK), NIH AG017762 (SM), 1RC1AR058405-01 (TML) and UC Discovery Grants (7Tesla) LSIT01-10107 and ITL-BIO04-10148.  ... 
doi:10.1016/j.rcl.2010.02.015 pmid:20609895 pmcid:PMC2901255 fatcat:fz2mbtlssjcq7kvbxyu5pre4yi

High-resolution Computed Tomography for Clinical Imaging of Bone Microarchitecture

Andrew J. Burghardt, Thomas M. Link, Sharmila Majumdar
2011 Clinical Orthopaedics and Related Research  
The application of high-resolution imaging in evaluating bone structure has evolved from an in vitro technology for small specimens to an emerging clinical research tool for in vivo studies in humans.  ...  Results Specimens can be imaged by micro-CT at a resolution starting at 1 lm, but in vivo human imaging is restricted to a voxel size of 82 lm (with actual spatial resolution of * 130 lm) due to technical  ...  for in vivo human imaging studies, and (4) recent studies using HR-pQCT to characterize bone structure in the context of skeletal disease, particularly its ability to discriminate between subjects with  ... 
doi:10.1007/s11999-010-1766-x pmid:21344275 pmcid:PMC3126972 fatcat:lkcdoxu6zzdtnkbcgaesfdz4zi

Multimodal μCT/μMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic/osteoblastic metastases

Seyed-Parsa Hojjat, Warren Foltz, Lisa Wise-Milestone, Cari M. Whyne
2012 Medical Physics (Lancaster)  
Multimodal μCT/μMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic/osteoblastic metastases. Med Phys. 2012 May;39(5):284853.  ...  This coil was specifically designed for good signal to noise 131 ratio in imaging ex vivo bone. The coil was fixed tuned to an average load as load change is not 132 essential for small sizes.  ...  The µCT and µMR images were registered using a 3D rigid 32 registration algorithm with a mutual information metric.  ... 
doi:10.1118/1.3703590 pmid:22559657 fatcat:uiyaxaautrfznnurvw734h5cha

Methodology for Measurement of in vivo Tibiotalar Kinematics After Total Ankle Replacement Using Dual Fluoroscopy

Dylan J. Blair, Alexej Barg, K. Bo Foreman, Andrew E. Anderson, Amy L. Lenz
2020 Frontiers in Bioengineering and Biotechnology  
The successful implementation of our new tracking methodology with a hybrid model presents a new approach to evaluate in vivo TAR kinematics.  ...  One challenge with this approach is dealing with metal artifact in the CT images that distorts implant visualization and the surrounding bone to implant interfaces.  ...  Albert Burstein and Dr. Charles Saltzman are thanked for their research consultation.  ... 
doi:10.3389/fbioe.2020.00375 pmid:32432091 pmcid:PMC7214754 fatcat:pbztykay6rfmtfe5fkq7kdfmqu

Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care

Lorenzo Grassi, Sami P. Väänänen, Hanna Isaksson
2021 Current Osteoporosis Reports  
Recent Findings Recent developments have increased their ability to accurately segment bones, as well as to perform 3D reconstruction and classify bone anatomies, all features of high interest in the field  ...  Heterogeneities in validation hinder a thorough comparison between the different methods and represent one of the future challenges to be addressed to reach clinical implementation.  ...  It is characterized by reduced bone mass and altered bone quality, thus resulting in increased bone fragility and fracture risk.  ... 
doi:10.1007/s11914-021-00711-w pmid:34773211 pmcid:PMC8716351 fatcat:dpoulvkcf5expdndzocmgir45a

Noninvasive imaging of bone microarchitecture

Janina M. Patsch, Andrew J. Burghardt, Galateia Kazakia, Sharmila Majumdar
2011 Annals of the New York Academy of Sciences  
With increasing availability of in vivo high-resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross-site validations.  ...  In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses.  ...  J-3079 (Austrian Science Fund) to J.M.P.  ... 
doi:10.1111/j.1749-6632.2011.06282.x pmid:22172043 pmcid:PMC4461066 fatcat:fzgvqw6zkvf6bgwhlb7jljpwsi

Automated segmentation of swine skulls for finite element model creation using high resolution μ-CT images

Zimo Zhu, Donna Jones, Gui-Rong Liu, Sajjad Soleimani, Xu Huang, Zhengyuan Shan, Jacob Knorr, Montserrat Caballero, John A. Van Aalst
2017 Figshare  
In this study, a method is proposed to automatically segment microcomputed tomography (μ-CT) scan images of bone pieces to build an FE model of a full swine hemi-skull.  ...  Using the Digital Imaging and Communications in Medicine (DICOM) files from scanned bones, the complete geometry of each bone piece is recreated through seven customized processing algorithms.  ...  To account for this, the Gaussian smoothing algorithm calculates a new grayscale number with a weighted average around its neighbor for each pixel by convolving the images.  ... 
doi:10.6084/m9.figshare.5071561.v1 fatcat:qiv7k7oforfufnxyjql7bd67u4
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