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Worm peptidomics
2014
EuPA Open Proteomics
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FMRFamide-like peptide Neuropeptide-like protein Insulin Neuropeptide Processing enzyme a b s t r a c t Bioactive peptides are present in all metazoan species where they orchestrate diverse functions. ...
In this respect, it is very likely that nearly all neurons secrete neuropeptides and many roles for peptides in key physiological processes and behaviours have been characterized [4] [5] [6] . http://dx ...
C. elegans KPC-2 is also named EGL-3 as mutants were initially discovered in a genetic screen for egg-laying deficiency about 30 years ago [97] . ...
doi:10.1016/j.euprot.2014.04.005
fatcat:bbbv5cv4rngerk4ophzzcvidey
Lead Modulates trans- and cis-Expression Quantitative Trait Loci (eQTLs) in Drosophila melanogaster Heads
2018
Frontiers in Genetics
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of genes in a lead-dependent manner. ...
This trans-eQTL hotspot validates one identified in a previous study using different recombinant inbred lines. ...
Great thanks to the High Performance Computing Services offered by Wayne State University for making the entire statistical analysis fast and efficient. ...
doi:10.3389/fgene.2018.00395
pmid:30294342
pmcid:PMC6158337
fatcat:3fd6p4ylujainmen3cdmev4siy
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
2015
Nature Biotechnology
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For a sequence s, DeepBind computes a binding score f (s) using four stages: )) = net pool rect conv The convolution stage (conv M ) scans a set of motif detectors with parameters M across the sequence ...
bound sequences of varying length, and HT-SELEX 11 generates a set of very high affinity sequences. ...
Hughes for helpful discussions. ...
doi:10.1038/nbt.3300
pmid:26213851
fatcat:6uvobbdnkvgytkybarlksceysi
Deciphering the Retinal Epigenome during Development, Disease and Reprogramming: Advancements, Challenges and Perspectives
2022
Cells
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This pipeline is virtually applicable to the study of genetic programs and candidate pioneer factors in any developmental context. ...
Herein, this review presents the state-of-the-art approaches to investigate the retinal epigenome during development, disease, and reprogramming. ...
A generalized linear mixed model and a two-part hurdle model with a random effect for the individual (MAST with RE) have recently been developed to correct for type 1 error rates, hence false positives ...
doi:10.3390/cells11050806
pmid:35269428
pmcid:PMC8908986
fatcat:5pewk6zas5ch7j65hyx7nktpra
Bioinformatics with soft computing
2006
IEEE Transactions on Systems Man and Cybernetics Part C (Applications and Reviews)
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RSes for modeling ambiguity, searching potential of genetic algorithms for efficiently traversing large search spaces, and the generalization capability of SVMs for minimizing errors. ...
The major pattern-recognition and data-mining tasks considered here are clustering, classification, feature selection, and rule generation. ...
The different techniques of soft computing considered include FSs, artificial neural networks (ANNs), GAs, evolutionary programming, RSes, SVMs, and various hybridizations like neuro-fuzzy (NF) models. ...
doi:10.1109/tsmcc.2006.879384
fatcat:owim7m6genf6xc7s2bbhjuz7gu
General sessions (1B-01 - 3F-12)
2011
Genes & Genetic Systems
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For a complete graph the dual is Kingman's coalescent. But in general the dual is a random collision model. ...
Arts and Sci., Univ. of Tokyo, 2 Adv. Sci. ...
Sci., Univ. of Tokyo) Dual genetic structure of the Japanese population based on autosomal SNPs and haplotypes Although the Japanese population has a rather low genetic diversity, it appears to have a ...
doi:10.1266/ggs.86.407
fatcat:wcfsqf2edvffdfqeoz7hqdld5e
Acoustic signatures in cavefish populations inhabiting different caves
[article]
2022
bioRxiv
pre-print
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The river-dwelling and the Pachon cave-adapted morphs of the fish Astyanax mexicanus share a repertoire of sounds, but their trigger, use and meaning has changed in cavefish after their recent colonization ...
Acknowledgments Work supported by a Lidex Neuro-Saclay collaborative grant to SR and JA, an Equipe FRM grant (DEQ20150331745) to SR, a prize from Fondation des Treilles to CH, and an Ecos-Nord exchange ...
We thank Luis Espinasa, Julien Fumey, and Stéphane Père and all other members of the Rétaux's lab for their helpful spirit in the field, and Patricia Ornelas-Garcia for obtaining shared fieldwork permits ...
doi:10.1101/2022.03.29.486255
fatcat:bhevjqgok5gs7cdur7b4cuv444
Polymeric biomaterials and nanomedicines
2015
Journal of Drug Delivery Science and Technology
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Then, the lessons learned for the design of watersoluble polymers as drug carriers are highlighted. ...
The latter is mediated by biorecognition of complementary motifs; no low molecular weight drug is needed. ...
A new strategy of hybrid hydrogel synthesis entails the non-covalent attachment of genetically engineered coiled-coil protein motifs to hydrophilic synthetic HPMA copolymer backbone. ...
doi:10.1016/j.jddst.2015.05.012
pmid:26688694
pmcid:PMC4681002
fatcat:ifjm7i2wfnawxghy7jwzpnf4ge
Endogenous archeological sciences: Physiology, Neuroscience, Biochemistry, Immunology, Pharmacology, Oncology and Genetics as instrument for a new field of investigation? Modern global aspects for a new discipline
2018
Journal of Neuroscience and Neurological Disorders
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Endogenous archeological sciences: Physiology, Neuroscience, Biochemistry, Immunology, Pharmacology, Oncology and Genetics as instrument for a new fi eld of investigation? ...
Modern global aspects for a new discipline. ...
of a number of induced mutations and the introduction of an F1 hybrid system. ...
doi:10.29328/journal.jnnd.1001017
fatcat:a6mltukg4vf5dabpwlusv5e5hi
Molecular epigenetics of Angelman syndrome
2007
Cellular and Molecular Life Sciences (CMLS)
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The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
A. (2000) Genetic studies in autistic disorder and chromosome 15. Neuro- genetics 2, 219 — 26. ...
E. and Beaudet, A. L. (2004) A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am. J. Med. Genet. A 131, 1 - 10. ...
doi:10.1007/s00018-007-6460-0
pmid:17347796
fatcat:e5nwnyxqzfazzafcecrs2dskoi
Cloning and Biochemical Characterization of the Hectochlorin Biosynthetic Gene Cluster from the Marine CyanobacteriumLyngbya majuscula
2007
Journal of natural products
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Initial attempts to isolate the hectochlorin biosynthetic gene cluster led to the identification of a mixed PKS/NRPS gene cluster, LMcryl, whose genetic architecture did not substantiate its involvement ...
This gene cluster was designated as a cryptic gene cluster because a corresponding metabolite ...
Labeled probes were used at a concentration of 20 ng/mL. Detection was also carried out as described for colony hybridizations. ...
doi:10.1021/np0704250
pmid:18001088
fatcat:y72dhwjie5gydhdodyd4a65y3u
Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
2013
Cancer Gene Therapy
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) sequencing, next-generation sequencing, DNA-arrays, methylation analyses, and so on) to be applicable for formalin-fixed paraffinembedded (FFPE) tissue. ...
To meet this challenge, surgical pathology has adapted a number of molecular methods (semi-quantitative immunohistochemistry, fluorescence in situ hybridization), PCR and its multiple variants, (pyro/Sanger ...
This review considers state-of-the-art of molecular pathology for guiding targeted cancer treatment. ...
doi:10.1038/cgt.2013.13
pmid:23492822
fatcat:zhkziohh7ffxzfsk4tugvrwfeu
A High-Sensitivity, Medium-Density, and Target Amplification-Free Planar Waveguide Microarray System for Gene Expression Analysis of Formalin-Fixed and Paraffin-Embedded Tissue
2009
Clinical Chemistry
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We observed a correlation coefficient of 0.87 to state-of-the-art RT-qPCR technology with RNA isolated from FFPE tissue, despite a compressed dynamic range for the PWG system (a 2.9-log dynamic range for ...
The ZeptoCARRIER can accommodate 24 arrays in a single run. Also given is the total time for 24 samples, which depends on the hybridization time. b RDAb, RNA/DNA hybrid-specific antibody. ...
Depending on the chip coating, the hybridization time could be shortened from the generally applied overnight incubation to a 4-h incubation with only a small decrease in performance (data not shown). ...
doi:10.1373/clinchem.2009.128215
pmid:19745061
fatcat:25lhwjfihvcxnf44bbxl5sporu
TaqMan (RT-PCR, real time PCR)
[chapter]
2008
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
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[Lond] 289:271; Bacillus subtilis: Gollnick P et al 2005 Annu Rev Genet 39:47.Tryptophan Repressor: Consists of a repressor protein (using a helix-turn-helix motif ) for binding to the operator site of ...
▶mismatch, ▶tran-
sition mismatch
Transversion Mutation: The substitution of a purine for
a pyrimidine, or a pyrimidine for a purine in the
genetic material. ...
The purpose is to generate antitumor immune reaction. Cancer cells may be ex vivo genetically modified and reintroduced into the body. ...
doi:10.1007/978-1-4020-6754-9_16672
fatcat:mxuz2ae7pfbs3dzpwonncixegm
Tetrahydrofolate (THF)
[chapter]
2008
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
Preserved Fulltext
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The file type is application/pdf.
[Lond] 289:271; Bacillus subtilis: Gollnick P et al 2005 Annu Rev Genet 39:47.Tryptophan Repressor: Consists of a repressor protein (using a helix-turn-helix motif ) for binding to the operator site of ...
▶mismatch, ▶tran-
sition mismatch
Transversion Mutation: The substitution of a purine for
a pyrimidine, or a pyrimidine for a purine in the
genetic material. ...
The purpose is to generate antitumor immune reaction. Cancer cells may be ex vivo genetically modified and reintroduced into the body. ...
doi:10.1007/978-1-4020-6754-9_16854
fatcat:24e4irafhfh47bwq3q6vlbdwpu
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