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A national virtual specimen database for early cancer detection

H. Kincaid, D. Crichton, M. Winget, S. Kelly, D. Johnsey, S. Srivastava, M. Thornquist
16th IEEE Symposium Computer-Based Medical Systems, 2003. Proceedings.  
The National Cancer Institute's (NCI) Early Detection Research Network (EDRN) comprises and integrates a large number of cancer research institutions into a network in order to establish a collaborative  ...  As a result, the informatics team initiated an effort to create a virtual biospecimen database whereby scientists could search and retrieve details about specimens located at collaborating institutions  ...  Conclusions The achievements reflect the current progress of rolling out a national virtual specimen database to be used to enhance early cancer detection.  ... 
doi:10.1109/cbms.2003.1212776 dblp:conf/cbms/KincaidKCJWS03 fatcat:sxykbxtgsvejlfp3j3wpgjrbdy

Biorepositories: Let's Not Lose What We Have So Carefully Gathered!

G. E. Goodman
2006 Cancer Epidemiology, Biomarkers and Prevention  
Acknowledgments We thank Benjamin Bodi for research assistance.  ...  Similar repositories exist for many early detection trials and observational studies.  ...  As a step toward accessibility, we propose the establishment of a virtual national biorepository, which would operate with a web-accessible central database where trial investigators can ''deposit'' or  ... 
doi:10.1158/1055-9965.epi-05-0873 pmid:16614097 fatcat:j66coxcf3zaefdynvslcky4jre

A Distributed Information Services Architecture to Support Biomarker Discovery in Early Detection of Cancer

Daniel Crichton, Sean Kelly, Chris Mattmann, Qing Xiao, J. Hughes, Jane Oh, Mark Thornquist, Donald Johnsey, Sudhir Srivastava, Laura Essermann, William Bigbee
2006 2006 Second IEEE International Conference on e-Science and Grid Computing (e-Science'06)  
Partnering with NASA, the Early Detection Research Network (EDRN), a program managed by the National Cancer Institute, has been defining and building an informatics architecture to support the discovery  ...  The architecture established by EDRN serves as a blueprint for constructing a set of services focused on the capture, processing, management and distribution of information through the phases of biomarker  ...  Acknowledgements This work was performed at the Jet Propulsion Laboratory managed by the California Institute of Technology under a contract with the National Aeronautics and Space Administration.  ... 
doi:10.1109/e-science.2006.261128 dblp:conf/eScience/CrichtonKMXHOTJSEB06 fatcat:hmiz4j7cu5c3ln2yan2wiuomy4

Enabling effective curation of cancer biomarker research data

Andrew F. Hart, Chris A. Mattmann, John J. Tran, Daniel J. Crichton, J. Steven Hughes, Heather Kincaid, Sean Kelly, Kristen Anton, Donald Johnsey, Christos Patriotis
2009 2009 22nd IEEE International Symposium on Computer-Based Medical Systems  
National Cancer Institute's Early Detection Research Network (EDRN) is a prime example of a virtual organization, sponsoring distributed, collaborative work at dozens of institutions around the country  ...  As part of a comprehensive informatics infrastructure, The NASA Jet Propulsion Laboratory, in collaboration with Dartmouth Medical School, has developed a web application for the curation of cancer biomarker  ...  National Cancer Institute's Early Detection Research Network (EDRN) initiative [14] , human curation of research results serves as a bridge between data producers.  ... 
doi:10.1109/cbms.2009.5255438 dblp:conf/cbms/HartMTCHKKAJP09 fatcat:7xe4pu5nobeqdalu57r7rf4zzq

To Share or Not to Share? A Survey of Biomedical Researchers in the U.S. Southwest, an Ethnically Diverse Region

Mai H. Oushy, Rebecca Palacios, Alan E. C. Holden, Amelie G. Ramirez, Kipling J. Gallion, Mary A. O'Connell, Xu-jie Zhou
2015 PLoS ONE  
The survey assessed demographics, specimen collection data, and attitudes about virtual biorepositories.  ...  This study confirmed researchers' willingness to participate in a virtual biorepository (n = 50 respondents agreed).  ...  Joe Tomaka for his valuable editorial comments on earlier drafts of this manuscript.  ... 
doi:10.1371/journal.pone.0138239 pmid:26378445 pmcid:PMC4574947 fatcat:53mincgkdvg3penazml5jy4j6m

The EARLY DETECTION RESEARCH NETWORK: A National Infrastructure to Support the Discovery, Development and Validation of Cancer Biomarkers

Sudhir Srivastava, Paul D. Wagner
2020 Cancer Epidemiology, Biomarkers and Prevention  
for the early cancer detection and risk assessment.  ...  In 2000, the US National Cancer Institute established the Early Detection Research Network (EDRN), an investigator-driven network to conduct translational research to identify, develop and validate biomarkers  ...  The authors also thank Dan Crichton of Jet Propulsion Laboratory for his contribution to the EDRN Informatics.  ... 
doi:10.1158/1055-9965.epi-20-0237 pmid:32357955 fatcat:s4ndl2dx4ndc7mbhdfatfzda24

ViBiBa: Virtual BioBanking for the DETECT multicenter trial program - decentralized storage and processing

H. Asperger, J.-P. Cieslik, B. Alberter, C. Köstler, B. Polzer, V. Müller, K. Pantel, S. Riethdorf, A. Koch, A. Hartkopf, L. Wiesmüller, W. Janni (+5 others)
2021 Translational Oncology  
In the DETECT clinical CTC trials we aimed at developing a custom-made, browser-based virtual database to harmonize and organize both decentralized processing and storage of LB specimens and to enable  ...  ViBiBa, which is a highly flexible tool that allows for decentralized sample storage of liquid biopsy specimens, facilitates a solution which promotes collaboration in a user-friendly, federalist and highly  ...  With 24.2% of new cases breast cancer (BC) is the most frequent cancer type in women worldwide and the detection of early disease and curable stages remains difficult [1] .  ... 
doi:10.1016/j.tranon.2021.101132 pmid:34051621 fatcat:akl2ybnjc5gwffskwtmhfkve7e

National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research

Waqas Amin, Anil V Parwani, Linda Schmandt, Sambit K Mohanty, Ghada Farhat, Andrew K Pople, Sharon B Winters, Nancy B Whelan, Althea M Schneider, John T Milnes, Federico A Valdivieso, Michael Feldman (+4 others)
2008 BMC Cancer  
Methods: The National Mesothelioma Virtual Bank architecture is based on three major components: (a) common data elements (based on College of American Pathologists protocol and National North American  ...  The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Grid™  ...  The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research.  ... 
doi:10.1186/1471-2407-8-236 pmid:18700971 pmcid:PMC2533341 fatcat:apzbmyywsne57kmbh3cm72ejtu

The Significance of Biobanking in the Sustainability of Biomedical Research: A Review

Mahshid Zohouri, Abbas Ghaderi
2020 Iranian Biomedical Journal  
Biobank, defined as a functional unit for facilitating and improving research by storing biospecimen and their accompanying data, is a key resource for advancement in life science.  ...  UK biobank as a population-based biobank with about half a million samples, Biobank Graz as one of the largest biobanks in terms of sample size, and IARC biobank as a specialized WHO cancer agency are  ...  ACKNOWLEDGMENTS This work was financially supported by Shiraz Institute for Cancer Research (Grant No. ICR-100-502), Shiraz, Iran.  ... 
doi:10.29252/ibj.24.4.206 pmid:32306718 pmcid:PMC7275812 fatcat:rj7qvj7iqfburduwgcrfncjzei

Small Beginnings: Do They Matter? The Importance of Lymphovascular Invasion in Early Breast Cancer

Mamatha Chivukula, Adam Brufsky, Nancy E. Davidson
2009 Journal of the National Cancer Institute  
It is derived from a population-wide database of virtually all women diagnosed with breast cancer in Denmark over a 7-year period, who were treated according to standard algorithms and whose tumors were  ...  The goal of the study was to assess whether lymphovascular invasion was a single independent prognostic factor in stratifying early breast cancer patients as low risk vs high risk for recurrence.  ...  It is derived from a population-wide database of virtually all women diagnosed with breast cancer in Denmark over a 7-year period, who were treated according to standard algorithms and whose tumors were  ... 
doi:10.1093/jnci/djp098 pmid:19436037 fatcat:6cooi2mncfgc3ldu4bjaahahyy

The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery

Leona W Ayers, Sylvia Silver, Michael S McGrath, Jan M Orenstein
2007 Infectious Agents and Cancer  
The AIDS Cancer and Specimen Resource (ACSR) supports scientific discovery in the area of HIV/ AIDS-associated malignancies.  ...  The ACSR was established as a cooperative agreement between the NCI (Office of the Director, Division of Cancer Treatment and Diagnosis) and regional consortia, University of California, San Francisco  ...  The ACSR has developed a national computerized database of specimens with patient information and clinical history.  ... 
doi:10.1186/1750-9378-2-7 pmid:17335575 pmcid:PMC1851770 fatcat:ow5nq2ygajaitlld66pevtd23a

Data Sharing Challenges and Recommendations for Human Biorepositories: A Systematic Literature Review

Jitendra Jonnagaddala, Toni Rose Jue, Pradeep Ray, Amir Talaei-Khoei
2014 The International Technology Management Review  
Medical research tends to require sharing of biospecimens and associated data at a large scale across multiple biorepositories.  ...  Acknowledgements This project was supported by a Cancer Institute NSW's translational cancer research centre program grant.  ...  The views expressed herein are those of the authors and are not necessarily those of the Cancer Institute NSW.  ... 
doi:10.2991/itmr.2014.4.2.1 fatcat:prwmcw5eojcrhkvtqgfv5eyz7a

Cancer Genome Anatomy Project Set for Take-off

B. Kuska
1996 Journal of the National Cancer Institute  
For example, tracing the changes in active genes as a normal cell is transformed to a malignant one would open many doors for cancer researchers to develop rational approaches to early detection and treatment  ...  virtual colonoscopy, (see News, July 20, 1994), but they are also developing virtual esophageal, airway, and stomach endoscopy to make screening for cancer in these areas easier.  ... 
doi:10.1093/jnci/88.24.1801 pmid:8961968 fatcat:ztlp33asjjdzhnzxckp5rh4efy

Optimal Noninvasive Colon Cancer Screening Modality in Patients Not Receiving Colonoscopy

Akshay N. Narendra
2022 Advances in Aging Research  
Colon cancer is the third most common among cancer deaths in the US for both men and women.  ...  This study focuses on the most recent survey and efficacy of noninvasive methods to prevent and detect colorectal cancer (CRC).  ...  Seema Elahi for her mentorship and guidance.  ... 
doi:10.4236/aar.2022.111001 fatcat:652tbd6xd5eurmaezmaemc77v4

The management of incidental findings of reduction mammoplasty specimens

Jessica T Goodwin, Chantelle Decroff, Emilia Dauway, Amelia Sybenga, Raman C Mahabir
2013 Canadian Journal of Plastic Surgery  
Due to their significant increased risk, they will require a closer follow-up with a breast cancer physician as well as more frequent screening for early detection.  ...  Early detection of malignancy can have a dramatic effect on morbidity and mortality.  ...  ACKnoWLedGeMents: The authors thank Marla Taylor from the pathology department for her assistance with the database query.  ... 
doi:10.1177/229255031302100414 pmid:24497763 pmcid:PMC3910521 fatcat:iwurz3k5azh7zpiszhsteuh47y
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