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A Model of Pattern Separation by Single Neurons

Hubert Löffler, Daya Shankar Gupta
2022
A new computational model with physiologically plausible parameters shows how the neuronal process referred to as "pattern separation" can be very well achieved by single neurons if the temporal qualities  ...  Spike patterns generated by a varying number of neurons firing with fixed different frequencies within a gamma range are used as input.  ...  A new computational model with physiologically plausible parameters shows how the neuronal process referred to as "pattern separation" can be very well achieved by single neurons if the temporal qualities  ... 
doi:10.3389/fncom.2022.858353 pmid:35573263 pmcid:PMC9103200 fatcat:itcpzveftnerradvhov2hpiox4

A computational model of pattern separation efficiency in the dentate gyrus with implications in schizophrenia

Faramarz Faghihi, Ahmed A. Moustafa
2015 Frontiers in Systems Neuroscience  
In this study, encoding by the DG is modeled such that single neurons and pattern separation efficiency are measured using simulations of different parameter values.  ...  For this purpose, a probabilistic model of single neurons efficiency is presented to study the role of structural and physiological parameters.  ...  Acknowledgment The research is supported by NSF grant number IIS-1302256.  ... 
doi:10.3389/fnsys.2015.00042 pmid:25859189 pmcid:PMC4373261 fatcat:a4wgcwv74vdivlxrxtkweuyzxm

Compound stimuli reveal the structure of visual motion selectivity in macaque MT neurons

Andrew D Zaharia, Robbe L T Goris, J Anthony Movshon, Eero P Simoncelli
2019 eNeuro  
Surprisingly, when tested with single drifting gratings, most MT neurons' responses are fit equally well by models with either form of separability.  ...  We designed a set of experiments to distinguish frequency-separable and velocity-separable models and executed them with single-unit recordings in macaque V1 and MT.  ...  (a,b) Two example component neurons, one better fit by the frequency-separable model (a) and one better fit by the velocity-separable model (b).  ... 
doi:10.1523/eneuro.0258-19.2019 pmid:31604815 pmcid:PMC6868477 fatcat:dbpskjrnuvda5ktzphg5333wza

Compound stimuli reveal the structure of visual motion selectivity in macaque MT neurons [article]

Andrew David Zaharia, Robbe L T Goris, J. Anthony Movshon, Eero Simoncelli
2019 bioRxiv   pre-print
Surprisingly, when tested with single drifting gratings, most MT neurons' responses are fit equally well by models with either form of separability.  ...  Models for area MT neurons posit that their selectivity arises by combining direction-selective V1 afferents whose tuning is organized around a tilted plane in the frequency domain, specifying a particular  ...  (a,b) Two example component neurons, one better fit by the 921 frequency-separable model (a) and one better fit by the velocity-separable model (b).  ... 
doi:10.1101/692533 fatcat:lx3gxpxlsvaj7ozl2lux5aem3e

Imbalanced pattern completion vs. separation in cognitive disease: network simulations of synaptic pathologies predict a personalized therapeutics strategy

Jesse E Hanson, Daniel V Madison
2010 BMC Neuroscience  
cognitive therapeutics guided by assay of pattern completion vs. pattern separation function.  ...  in a simulation of autoassociative memory.  ...  B) Pattern completion is tested by stimulating only 9 of the 10 neurons in a stored pattern.  ... 
doi:10.1186/1471-2202-11-96 pmid:20704756 pmcid:PMC2931521 fatcat:e4qh3jp2r5fihplm5yv6s7usam

Integration and segregation of multiple motion signals by neurons in area MT of primate

J. Scott McDonald, Colin W. G. Clifford, Selina S. Solomon, Spencer C. Chen, Samuel G. Solomon
2014 Journal of Neurophysiology  
Integration and segregation of multiple motion signals by neurons in area MT of primate.  ...  D: a model pattern cell, as formulated by Simoncelli and Heeger (1998 are compatible with a previously proposed model (Simoncelli and Heeger 1998) , where pattern cells have receptive fields that are  ...  Alternatively, the cascade model, in which V1 neurons are subject to gain control and their responses summed by MT neurons, with an accelerating nonlinearity output, can also predict pattern cells' responses  ... 
doi:10.1152/jn.00254.2013 pmid:24155007 fatcat:63xqo2n5wzg6loewf67h72jyue

Responses of Primate Visual Cortical V4 Neurons to Simultaneously Presented Stimuli

Timothy J. Gawne, Julie M. Martin
2002 Journal of Neurophysiology  
However, for a substantial fraction of the neurons we found that the firing rate was well modeled as the maximum firing rate of each stimulus presented separately.  ...  We show here that a substantial fraction of V4 visual cortical neurons have responses to two stimuli presented simultaneously that are well predicted by the maximum of the response to each stimulus separately  ...  Bolding, A. Yildirim, and J. Millican for technical assistance, A. Dobbins for general comments, R. Weller for assistance with the anatomy, and D. Gawne for editorial assistance.  ... 
doi:10.1152/jn.2002.88.3.1128 pmid:12205134 fatcat:3wmotyn2srdubkioi5pnp2govm

Pattern separation by neuronal turnover in a feed-forward network

Anthony J DeCostanzo, Tomoki Fukai
2013 BMC Neuroscience  
While several computational studies have modeled the effect of neuronal turnover on learning in simple [1-3] and more detailed networks [4], the computational advantage of neurogenesis for pattern separation  ...  Our model consists of a three-layer network including entorhinal cortical inputs (EC), dentate gyrus (DG) as the hidden layer, and a single CA3 readout unit.  ...  Acknowledgements This work was partly supported by Grants-in-Aid for Scientific Research on Innovative Areas (KAKENHI, no. 22115013) and CREST, Japan Science and Technology. Published: 8 July 2013  ... 
doi:10.1186/1471-2202-14-s1-p135 pmcid:PMC3704609 fatcat:4l52d3xsvnaxzlezktro6ivd5m

Neural Correlates of the Perception of Sound Source Separation [chapter]

Mitchell L. Day, Bertrand Delgutte
2013 Advances in Experimental Medicine and Biology  
We examined changes in the target azimuth tuning functions of IC neurons in unanesthetized rabbits caused by the concurrent presentation of an interferer at a fixed spatial location.  ...  Because firing rates of most neurons in the inferior colliculus (IC) are sensitive to these binaural cues, we hypothesized that these neurons would be sensitive to source separation.  ...  Acknowledgments This work was supported by NIDCD (US) grants R01 DC002258 and P30 DC005209.  ... 
doi:10.1007/978-1-4614-1590-9_29 pmid:23716231 pmcid:PMC3729225 fatcat:s3wce6pt6vhr7nq6sreexvum4a

Information encoding and computation with spikes and bursts

A. Kepecs, J. Lisman
2003 Network  
We simulated a bursting neuron model driven by random current input signal and superposed noise.  ...  We consider two issues: the timing reliability of different spike patterns and the computation performed by the neuron.  ...  This again suggests that certain spike patterns are not separable by only considering a single ISI threshold.  ... 
doi:10.1080/net.14.1.103.118 pmid:12613553 fatcat:fkxz4x4ntrgxznttvqhairodme

Random neuronal ensembles can inherently do context dependent coarse conjunctive encoding of input stimulus without any specific training

Jude Baby George, Grace Mathew Abraham, Zubin Rashid, Bharadwaj Amrutur, Sujit Kumar Sikdar
2018 Scientific Reports  
We reproduce this behavior in a mathematical model to show that a random neuronal network with a mix of excitatory and inhibitory neurons and sufficient connectivity creates similar coarse-conjunctive  ...  The random neuronal ensembles allow for pattern generalization and novel sequence classification without needing any specific learning or training of the ensemble.  ...  Acknowledgements This work was supported by Ministry of Electronics and Information Technology, Government of India.  ... 
doi:10.1038/s41598-018-19462-3 pmid:29362477 pmcid:PMC5780417 fatcat:2oia35prwrbgho7yki6f6bli6u

Distributed and Dynamic Neural Encoding of Multiple Motion Directions of Transparently Moving Stimuli in Cortical Area MT

J. Xiao, X. Huang
2015 Journal of Neuroscience  
that were separated by a small angle--less than the tuning width to unidirectional stimuli.  ...  In this scheme of response pooling, the ability to segment two simultaneously presented motion directions is limited by the width of the tuning curve to motion in a single direction.  ...  Model fits of the response tuning curves elicited by bidirectional stimuli separated by 60°. A, PV accounted for by the LWS and the SNL model.  ... 
doi:10.1523/jneurosci.2175-15.2015 pmid:26658869 pmcid:PMC4682784 fatcat:xzfreze5fbazzjncs2m7v5numy

Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations

Mark S. Goldman, Jorge Golowasch, Eve Marder, L.F. Abbott
2000 Neurocomputing  
We construct maps of the intrinsic "ring state (silent, tonically "ring, or bursting) of a model neuron as a function of its maximal ionic conductances.  ...  This suggests that neurons may have similar functional properties despite widely varying conductance densities.  ...  Acknowledgements This work was supported by Grants MH 46742, NSF-IBN-9817194, and the W.M. Keck Foundation.  ... 
doi:10.1016/s0925-2312(00)00155-7 fatcat:fo2njjccnjbalpgvcek3lurd3y

Decoding Sound Source Location and Separation Using Neural Population Activity Patterns

M. L. Day, B. Delgutte
2013 Journal of Neuroscience  
The strategies by which the central nervous system decodes the properties of sensory stimuli, such as sound source location, from the responses of a population of neurons are a matter of debate.  ...  We further show that the pattern decoder accurately distinguishes two concurrent, spatially separated sources from a single source, consistent with human behavior.  ...  by a single source.  ... 
doi:10.1523/jneurosci.2034-13.2013 pmid:24089491 pmcid:PMC3787502 fatcat:rfwzwsknkfduno5utvmf5adf4u

Pattern Separation and Completion in Olfaction

Donald A. Wilson
2009 Annals of the New York Academy of Sciences  
Pattern separation and completion by cortical circuits contribute to these processes, respectively.  ...  Based on theoretical and computational models of the piriform cortex and experimental designs developed for hippocampal spatial memory, we provide evidence for pattern separation and completion in the  ...  Acknowledgments Supported by grant DC 003906 to D.A.W and grant DC008982 to Rob Rennaker and D.A.W.  ... 
doi:10.1111/j.1749-6632.2009.04017.x pmid:19686152 pmcid:PMC2771856 fatcat:prmkt4hdrvddxlsn2wqhip4zxq
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