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A Longitudinal Method for Simultaneous Whole-Brain and Lesion Segmentation in Multiple Sclerosis [article]

Stefano Cerri, Andrew Hoopes, Douglas N. Greve, Mark Mühlau, Koen Van Leemput
<span title="2020-09-15">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
In this paper we propose a novel method for the segmentation of longitudinal brain MRI scans of patients suffering from Multiple Sclerosis.  ...  The method builds upon an existing cross-sectional method for simultaneous whole-brain and lesion segmentation, introducing subject-specific latent variables to encourage temporal consistency between longitudinal  ...  Research Foundation No 428223038, and the NIH NINDS No R01NS112161.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2008.05117v2">arXiv:2008.05117v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t2uqmaydsjdkfoeynfcn6cqdne">fatcat:t2uqmaydsjdkfoeynfcn6cqdne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200920103310/https://arxiv.org/pdf/2008.05117v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2008.05117v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Use Case I: Imaging Biomarkers in Neurological Disease. Focus on Multiple Sclerosis [chapter]

Diana M. Sima, Dirk Loeckx, Dirk Smeets, Saurabh Jain, Paul M. Parizel, Wim Van Hecke
<span title="2016-11-03">2016</span> <i title="Springer International Publishing"> Imaging Biomarkers </i> &nbsp;
Focus on Multiple Sclerosis  ...  Longitudinal methods for brain atrophy typically try to match two MRI scans using registration techniques and directly extract small changes in brain volume from this process.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-319-43504-6_15">doi:10.1007/978-3-319-43504-6_15</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jjue6uryjba3vpnm3eblmlauge">fatcat:jjue6uryjba3vpnm3eblmlauge</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190709193356/https://icometrix.com/assets/publications/Sima2016.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/76/65/76656649cb14a33657ea4ecc00bc5898886eb070.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-319-43504-6_15"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

OUP accepted manuscript

<span title="">2018</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
See Aly and Korn (doi:10.1093/brain/awy269) for a scientific commentary on this article.  ...  Recent studies support its utility for tracking neurodegeneration and disease progression in vivo in multiple sclerosis.  ...  Acknowledgements The authors would like to thank the patients who made this study possible and all those who helped in carrying out this project.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy245">doi:10.1093/brain/awy245</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30312381">pmid:30312381</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6202573/">pmcid:PMC6202573</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5hmw5li2ljckljjhvtmfyfhsea">fatcat:5hmw5li2ljckljjhvtmfyfhsea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206103533/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6202573&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6a/49/6a49fdaad3b71fc7b212fe67122250387e85a6d2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy245"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202573" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study

Shiv Saidha, Omar Al-Louzi, John N. Ratchford, Pavan Bhargava, Jiwon Oh, Scott D. Newsome, Jerry L. Prince, Dzung Pham, Snehashis Roy, Peter van Zijl, Laura J. Balcer, Elliot M. Frohman (+3 others)
<span title="2015-10-01">2015</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5vmklzorebg4xigcwju5rdx6ai" style="color: black;">Annals of Neurology</a> </i> &nbsp;
Objective-The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical  ...  Subsequently, MPRAGE and FLAIR images were analyzed using Lesion-TOADS, an automated segmentation method, described elsewhere.  ...  Longitudinal OCT-FLAIR Lesion Volume Relationships In addition to correlating with rates of brain atrophy, a faster rate of GCIP thinning was also associated with a more rapid rate of increase in FLAIR-lesion  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/ana.24487">doi:10.1002/ana.24487</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26190464">pmid:26190464</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4703093/">pmcid:PMC4703093</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/eu5vhupxxjburhzea47eci6vry">fatcat:eu5vhupxxjburhzea47eci6vry</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191127084828/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4703093&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0f/7c/0f7c42c14b9b5bb7f498e270cf0282191086f3ac.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/ana.24487"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703093" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis

R Zivadinov
<span title="2001-06-01">2001</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hy257cksnngbdoh3z3erevh7h4" style="color: black;">Journal of Neurology, Neurosurgery and Psychiatry</a> </i> &nbsp;
Methods-For 2 years 53 patients with clinically definite relapsing-remitting multiple sclerosis with disease duration 1-5 years and expanded disability status scale<5.0 at baseline were monitored.  ...  Patients also underwent PD/T2 and T1 weighted brain MRI. T2 and T1 lesion volumes were measured by a semiautomatic technique.  ...  A stereoatactic atlas was used as a reference for segmenting the diVerent brain structures.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.70.6.773">doi:10.1136/jnnp.70.6.773</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11385012">pmid:11385012</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1737379/">pmcid:PMC1737379</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/oolvmpoc75gu3j2ybfl7pt5cne">fatcat:oolvmpoc75gu3j2ybfl7pt5cne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430130546/https://jnnp.bmj.com/content/jnnp/70/6/773.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/94/d4/94d4ad66d9573db128496dd6dbb877b540d1074f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.70.6.773"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> bmj.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737379" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Agreement of MSmetrix with established methods for measuring cross-sectional and longitudinal brain atrophy

Martijn D. Steenwijk, Houshang Amiri, Menno M. Schoonheim, Alexandra de Sitter, Frederik Barkhof, Petra J.W. Pouwels, Hugo Vrenken
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/47gmsc3hojdm5kdlgbg4peyvyi" style="color: black;">NeuroImage: Clinical</a> </i> &nbsp;
Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain.  ...  In this subgroup, we additionally analyzed the whole-brain and GM volume change using the longitudinal pipeline of MSmetrix and compared the results with those of FreeSurfer (longitudinal pipeline) and  ...  Introduction In the past decade, brain atrophy in multiple sclerosis (MS) has been recognized as a crucial component of the disease (Bermel and Bakshi, 2006) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2017.06.034">doi:10.1016/j.nicl.2017.06.034</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28794970">pmid:28794970</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5540882/">pmcid:PMC5540882</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lsgvfselnjdg7dilkzc23yoibu">fatcat:lsgvfselnjdg7dilkzc23yoibu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724102613/http://discovery.ucl.ac.uk/1566771/9/Barkhof_1-s2.0-S2213158217301651-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9c/35/9c359ce42f63ca2608894498655b12512f6710ce.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2017.06.034"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540882" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Axonal damage correlates with disability in patients with relapsing- remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study

N De Stefano
<span title="1998-08-01">1998</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
It has been difficult to establish a strong correlation between total brain T 2 -weighted lesion volume on MRI and clinical disability in multiple sclerosis, in part because of the lack of pathological  ...  Here we report a 30-month longitudinal study of 29 patients with multiple sclerosis who had either a relapsing or a secondary progressive clinical course.  ...  Acknowledgements We wish to thank Ms Arlene Cohen for co-ordinating the study and Mr Gilles Leroux and Mr Andre Cormier for  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/121.8.1469">doi:10.1093/brain/121.8.1469</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/9712009">pmid:9712009</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/krj2creszrg7dps6yi5fkrprzm">fatcat:krj2creszrg7dps6yi5fkrprzm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20150226110959/http://brain.oxfordjournals.org:80/content/brain/121/8/1469.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/77/85/77858ec7ccf58c31d6a2270387152a6d1a59871c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/121.8.1469"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

STREM: A Robust Multidimensional Parametric Method to Segment MS Lesions in MRI [chapter]

L. S. Aït-Ali, S. Prima, P. Hellier, B. Carsin, G. Edan, C. Barillot
<span title="">2005</span> <i title="Springer Berlin Heidelberg"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2w3awgokqne6te4nvlofavy5a4" style="color: black;">Lecture Notes in Computer Science</a> </i> &nbsp;
We propose to segment Multiple Sclerosis (MS) lesions overtime in multidimensional Magnetic Resonance (MR) sequences.  ...  We use a robust algorithm that allows the segmentation of the abnormalities using the whole time series simultaneously and we propose an original rejection scheme for outliers.  ...  Impact of the longitudinal analysis. The longitudinal analysis allows to detect both MS lesions and their evolution. Our method treats in a unified manner the segmentation and tracking of MS lesions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/11566465_51">doi:10.1007/11566465_51</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/u6zpp7psyvg23e5h5r6g2ocfpe">fatcat:u6zpp7psyvg23e5h5r6g2ocfpe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724065706/https://link.springer.com/content/pdf/10.1007%2F11566465_51.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4c/50/4c50bd55b0685ad35215456f94837fa1791d3205.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/11566465_51"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis

Z Khaleeli, J Sastre-Garriga, O Ciccarelli, D H Miller, A J Thompson
<span title="2007-10-01">2007</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hy257cksnngbdoh3z3erevh7h4" style="color: black;">Journal of Neurology, Neurosurgery and Psychiatry</a> </i> &nbsp;
Normalised MT histograms were generated for whole brain, normal appearing brain tissue (NABT) and normal appearing white and grey matter (NAWM and NAGM) segments.  ...  Progression rates in primary progressive multiple sclerosis (PPMS) vary widely and brain magnetisation transfer imaging (MTI) has potential as an early prognostic indicator.  ...  ACKNOWLEDGEMENTS We would like to thank all participants in this study, and also Mara Cercignani, Daniel Tozer and Daniel Altmann for help and advice.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.2006.107565">doi:10.1136/jnnp.2006.107565</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17287235">pmid:17287235</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2117577/">pmcid:PMC2117577</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ntlqil6maredjifaz5nwfieuvm">fatcat:ntlqil6maredjifaz5nwfieuvm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209105257/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2117577&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1f/65/1f6543f2a4251a5fa546ffc4a3e7788d24d692ad.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.2006.107565"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> bmj.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117577" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Regional grey matter atrophy in clinically isolated syndromes at presentation

R G Henry, M Shieh, D T Okuda, A Evangelista, M L Gorno-Tempini, D Pelletier
<span title="2008-06-05">2008</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hy257cksnngbdoh3z3erevh7h4" style="color: black;">Journal of Neurology, Neurosurgery and Psychiatry</a> </i> &nbsp;
Methods: This study used a modified voxel-based morphometry (VBM) method to correct for lesion effects to analyse regional atrophy and perform voxel-wise correlations between volume and clinical metrics  ...  , and whole brain or whole normalised grey matter analyses have not demonstrated significant atrophy in CIS cohorts at clinical presentation.  ...  Acknowledgements We would like to acknowledge the funding of this work by the National Multiple Sclerosis Society research grant RG3240A1.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.2007.134825">doi:10.1136/jnnp.2007.134825</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18469033">pmid:18469033</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4827711/">pmcid:PMC4827711</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kwq6jk6whjehfnj2hldjbmfrsi">fatcat:kwq6jk6whjehfnj2hldjbmfrsi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209100924/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4827711&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3e/7f/3e7fee5ee24a155d6b526cc0c38ce9f397d463d8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp.2007.134825"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> bmj.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827711" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

Jesper Hagemeier, Robert Zivadinov, Michael G. Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R. Reichenbach, Ferdinand Schweser
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/47gmsc3hojdm5kdlgbg4peyvyi" style="color: black;">NeuroImage: Clinical</a> </i> &nbsp;
A B S T R A C T In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron-and myelin-sensitive  ...  Brain magnetic susceptibility was measured in major DGM structures.  ...  Future longitudinal studies contrasting different disease stages and deep gray matter structures as well as a meta-analysis of the current literature on brain iron in multiple sclerosis should shed light  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2017.04.008">doi:10.1016/j.nicl.2017.04.008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29868452">pmid:29868452</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5984575/">pmcid:PMC5984575</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nguyibh45nghlc24fosyhqn7g4">fatcat:nguyibh45nghlc24fosyhqn7g4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209071141/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5984575&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/51/87/51879406757f5bd30af8f472394afb0348039882.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2017.04.008"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984575" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

<span title="2019-09-01">2019</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
Using a recently developed method to identify slowly expanding/evolving lesions in vivo from longitudinal conventional T2- and T1-weighted brain MRI scans, we measured the relative amount of chronic lesion  ...  Using conventional brain MRI, T1-weighted intensity-based measures of chronic white matter lesion activity predict clinical progression in primary progressive multiple sclerosis and may qualify as a longitudinal  ...  Multiple Sclerosis Society, and Swiss National Research Foundation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awz212">doi:10.1093/brain/awz212</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31497864">pmid:31497864</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6736181/">pmcid:PMC6736181</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vafmf7dxejahrmsinegbfpleuy">fatcat:vafmf7dxejahrmsinegbfpleuy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201103010850/https://discovery.ucl.ac.uk/id/eprint/10083530/1/Chronic%20white%20matter%20lesion%20activity%20predicts%20clinical%20progression%20in%20primary%20progressive%20multiple%20sclerosis.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b7/07/b70742698a25b47d7556918ab041c758aadaa977.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awz212"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736181" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Whole brain 3D MR fingerprinting in multiple sclerosis: a pilot study

Thomaz R. Mostardeiro, Ananya Panda, Norbert G. Campeau, Robert J. Witte, Nicholas B. Larson, Yi Sui, Aiming Lu, Kiaran P. McGee
<span title="2021-05-22">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/65e5jydmjzhjbldqtsyy7j5wia" style="color: black;">BMC Medical Imaging</a> </i> &nbsp;
Background MR fingerprinting (MRF) is a novel imaging method proposed for the diagnosis of Multiple Sclerosis (MS).  ...  Methods Three-dimensional (3D) MRF data were acquired on a 3.0T MRI system resulting in isotropic voxels (1 × 1 × 1 mm3) and a total acquisition time of 4 min 38 s.  ...  Fig. 1 1 Region of Interest segmentations within MRF maps: MRF T 1 relaxometry map demonstrating an active lesion in a patient with multiple sclerosis. a Depicts the lesion Figure 5 depicts the distribution  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12880-021-00620-5">doi:10.1186/s12880-021-00620-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34022832">pmid:34022832</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8141188/">pmcid:PMC8141188</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vsnvvhcf6jb25k3s6s5kokrb7e">fatcat:vsnvvhcf6jb25k3s6s5kokrb7e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210529075706/https://bmcmedimaging.biomedcentral.com/track/pdf/10.1186/s12880-021-00620-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/93/de/93de108eb95573dce35c13f0e1c0026122070749.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12880-021-00620-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141188" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis

Ferran Prados, Manuel Jorge Cardoso, Baris Kanber, Olga Ciccarelli, Raju Kapoor, Claudia A.M. Gandini Wheeler-Kingshott, Sebastien Ourselin
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
The proposed method is modality-agnostic and can be applied to multiple time-points simultaneously.  ...  Multiple sclerosis lesions influence the process of image analysis, leading to tissue segmentation problems and biased morphometric estimates.  ...  This work was also supported by the Medical Research Council (MR/J01107X/1), the UK Multiple Sclerosis Society (892/08) and the Brain Research Trust. The authors are grateful to Professor David H.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2016.06.053">doi:10.1016/j.neuroimage.2016.06.053</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27377222">pmid:27377222</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4988790/">pmcid:PMC4988790</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/u6ngwkbsafcjxblxrc4zonhmyi">fatcat:u6ngwkbsafcjxblxrc4zonhmyi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724100626/http://discovery.ucl.ac.uk/1502239/1/1-s2.0-S1053811916303020-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/53/fe/53fe3dacfa638864d85e56031f8def97da2ad35a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2016.06.053"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988790" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Insights into smouldering MS brain pathology with multimodal diffusion tensor and PET imaging [article]

Svetlana Bezukladova, Jouni Tuisku, Markus Matilainen, Anna Vuorimaa, Marjo Nylund, Sarah Smith, Marcus Sucksdorff, Mehrbod Mohammadian, Virva Saunavaara, Sini Laaksonen, Johanna Rokka, Juha Rinne (+2 others)
<span title="2020-01-10">2020</span> <i title="Cold Spring Harbor Laboratory"> medRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Objective: To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter damage in multiple sclerosis (MS) brain, and to examine their association with clinical disability  ...  These structural abnormalities correlated with increased TSPO binding in the whole NAWM and in the temporal NAWM (p<0.05 for all correlations; p<0.01 for RD in the temporal NAWM).  ...  We are also sincerely thankful to Professor Jarmo Hietala and Dr. Heikki Laurikainen for providing the additional healthy control DTI data for the analyses.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.01.09.20017012">doi:10.1101/2020.01.09.20017012</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tkxdaz5efrfzvhzvnesiqos26y">fatcat:tkxdaz5efrfzvhzvnesiqos26y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200709182413/https://www.medrxiv.org/content/10.1101/2020.01.09.20017012v1.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/05/cc/05ccc49cbe5f8a26779fd5542ffc139ebe3c0f4b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.01.09.20017012"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> medrxiv.org </button> </a>
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