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Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein is an apoptotic milk factor in mammary gland involution

Julie A Sharp, Christophe Lefevre, Kevin R Nicholas
2008 BMC Biology  
which time mammary glands remain active without initiating apoptosis/involution.  ...  Results: We show the molecular basis by which alpha-lactalbumin (LALBA), a secreted milk protein, is absent in Cape fur seals and demonstrate an apoptotic function for LALBA when exposed to mammary cells  ...  Intersuckling intervals have been recorded in otariid seals of up to 23 days and are among the longest ever recorded for a mammal [1] .  ... 
doi:10.1186/1741-7007-6-48 pmid:18986549 pmcid:PMC2600633 fatcat:h2xmzk4rrzfutbc3ss3r2idqne