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A layered behavioural model of platelets

S. Schneider, A. Cavalcanti, H. Treharne, J. Woodcock
11th IEEE International Conference on Engineering of Complex Computer Systems (ICECCS'06)  
Our work is based on a case study: the clotting behaviour of (artificial) platelets. We present a model, and discuss its analysis and uses.  ...  We present a modelling technique based on CSP and B as a starting point for simulation of networks of nanorobots.  ...  Acknowledgements The collaboration that resulted in this piece of work is funded by the EPSRC.  ... 
doi:10.1109/iceccs.2006.1690359 fatcat:xlf5ckg7rrgd7ghns4yood6icm

An Architecture for Modelling Emergence in CA-Like Systems [chapter]

Fiona Polack, Susan Stepney, Heather Turner, Peter Welch, Fred Barnes
2005 Lecture Notes in Computer Science  
We consider models of emergence, adding downward causation to conventional models where causation permeates from low-level elements to high-level behaviour.  ...  We describe an architecture and prototype simulation medium for tagging and modelling emergent features in CA-like systems. This is part of ongoing work on engineering emergence.  ...  The work presented here is part of the TUNA feasibility study, EPSRC grant EP/C516966/1. Thanks are due to S. A. Schneider for the inspiration for the vacuum CA model.  ... 
doi:10.1007/11553090_44 fatcat:iuwchs45j5erlc35ks4kjwyk5y

Toughening mechanisms in bioinspired multilayered materials

S. Askarinejad, N. Rahbar
2014 Journal of the Royal Society Interface  
It is also shown that the roughness induced interactions between the organic matrix and aragonite platelet, represented in the model by asperity elements, play a key role in strength and toughness of abalone  ...  A micromechanical model for multilayered biological materials is proposed to simulate their mechanical deformation and toughening mechanisms.  ...  Finite-element models Aragonite platelets were modelled as beam elements with a bending stiffness set to represent the flexural behaviour of hexagonal platelets with E tab ¼ 100 GPa, although they carry  ... 
doi:10.1098/rsif.2014.0855 pmid:25551150 pmcid:PMC4277076 fatcat:vrfpbvrguzdpnkaqt6savkzwoq

Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer

B. J. M. van Rooij, G. Závodszky, V. W. Azizi Tarksalooyeh, A. G. Hoekstra
2019 Journal of the Royal Society Interface  
In this enlarged cell-depleted layer, the probability to find a platelet is higher than in the rest of the microfluidic device.  ...  Additionally, the need of cell-based modelling in these microfluidic devices is demonstrated by comparing our results with macroscopic models, wherein blood is modelled as a continuous fluid.  ...  Cell-based models can be used to study the suspension behaviour of blood with phenomena, such as the cell-depleted layer [26, 27] and the margination of platelets [24, 27, 28] .  ... 
doi:10.1098/rsif.2019.0148 pmid:31575344 pmcid:PMC6833312 fatcat:q535i7dgobdl7otvjio4mucjfq

Molecular order and disorder of surfactants in clay nanocomposites

Tim J. Tambach, Edo S. Boek, Berend Smit
2006 Physical Chemistry, Chemical Physics - PCCP  
is that the surfactants form all-trans conformations between the clay platelets, 8 either in layers or tilted in a liquid crystalline ordered phase.  ...  Out of several available molecular clay models, 6,14,15 we choose a clay model 15 that has proven to be successful in predicting the basal spacing of natural clay minerals with water, 15,16 the swelling  ...  A. Laird for helpful discussions.  ... 
doi:10.1039/b601373b pmid:16763700 fatcat:koaquel5cjddta6e5p7l54qkfu

Influence of the mineral staggering on the elastic properties of the mineralized collagen fibril in lamellar bone

Ana Vercher-Martínez, Eugenio Giner, Camila Arango, F. Javier Fuenmayor
2015 Journal of The Mechanical Behavior of Biomedical Materials  
Abstract In this work, a three-dimensional finite element model of the staggered distribution of the mineral within the mineralized collagen fibril has been developed to characterize the lamellar bone  ...  directions of the fibril, through the variation of the lateral space between platelets.  ...  In the model of this work, we assume a value of 335 nm (5D, D = 67 nm) for this dimension, according to a five 1D-staggered collagen molecule layers (Silver and Landis, 2012) .  ... 
doi:10.1016/j.jmbbm.2014.11.022 pmid:25498297 fatcat:zkwztx6qr5bkfge5emnfngdtpi

Percolation networks inside 3D model of the mineralized collagen fibril

Fabiano Bini, Andrada Pica, Andrea Marinozzi, Franco Marinozzi
2021 Scientific Reports  
In this work, we developed a 3D continuum model of the mineral phase in the framework of percolation theory, that describes the transition from isolated to spanning cluster of connected platelets.  ...  The formation of spanning clusters of minerals represents a condition of instability for the MCF, as it could be the onset of a high susceptibility to fracture.  ...  Acknowledgements Financial supports from the "Sapienza" University of Rome (Grant Number RM116154CA7BCFC2) are gratefully acknowledged.  ... 
doi:10.1038/s41598-021-90916-x pmid:34059767 fatcat:qlx4wyyj4rdzpdoakfuxklwk4q

Where do the platelets go? A simulation study of fully resolved blood flow through aneurysmal vessels

L. Mountrakis, E. Lorenz, A. G. Hoekstra
2013 Interface Focus  
The connection of the platelet-rich cellfree layer (CFL) with the outer regions of the recirculation zones leads to their increased platelet concentration.  ...  In this paper we simulated red blood cells and platelets to explore their transport behaviour in aneurysmal geometries.  ...  RBCs are depleted close to the wall, whereas platelets occupy this RBC-free layer. Figure 3 . 3 Platelet distributions across a channel of d ¼ 100 mm without RBCs.  ... 
doi:10.1098/rsfs.2012.0089 pmid:24427532 pmcid:PMC3638486 fatcat:o5m6sffjrzagfk37ntyl27sc24

Modelling of mechanical behaviour of polyamide nanocomposite fibres using a three-phase Halpin-Tsai model

Emilia Garofalo, Giovanna Maria Russo, Luciano Di Maio, Loredana Incarnato
2009 E-Polymers  
For this reason, a three-phase Halpin-Tsai model, based on polyamide-6 matrix, exfoliated clay platelets and nanolayer intercalated clusters, was used to fit the experimental data.This method was applied  ...  Moreover, the model was used for predicting the effect of various morphological parameters including the exfoliation degree, clay layer and cluster aspect ratio.  ...  Scheme of the application of Halpin-Tsai model for a three-phase nanocomposite system (method A).  ... 
doi:10.1515/epoly.2009.9.1.670 fatcat:vo2lt36cc5codmr2o57gbcxi4y

A process-oriented architecture for complex system modelling

C. G. Ritson, P. H. Welch
2010 Concurrency and Computation  
A fine-grained massively-parallel process-oriented model of platelets (potentially artificial) within a blood vessel is presented.  ...  The aim for this model is to engineer emergent behaviour from the platelets, such that they respond to a wound in the blood vessel wall in a way similar to that found in the human body -i.e. the formation  ...  Layers of Agents So far, agents have occupied a single site.  ... 
doi:10.1002/cpe.1433 fatcat:imzbustncbgsnd66ltezrle4y4

Melt rheological investigation of polylactide-nanographite platelets biopolymer composites

Esmaeil Narimissa, Rahul K. Gupta, Nhol Kao, Hyoung J. Choi, Margaret Jollands, Sati N. Bhattacharya
2013 Polymer Engineering and Science  
The composites were fabricated via dry mixing and melt-blending of biodegradable polylactide (PLA) and nano graphite platelets (NGP) in a Brabender twin screw extruder.  ...  A range of different nanofiller contents (1, 3, 5, 7 and 10 wt%) were studied for NGP containing composites.  ...  McKinley (Massachusetts Institute of Technology) who made several valuable suggestions that have led to significant improvements of this manuscript.  ... 
doi:10.1002/pen.23550 fatcat:xwxlwsu7cjcenfvuyxe7b4ydv4

Nacre: An orthotropic and bimodular elastic material

K. Bertoldi, D. Bigoni, W.J. Drugan
2008 Composites Science And Technology  
A new micromechanical model for nacre (mother-of-pearl) is proposed, based on an accurate description of the actual microstructure of the material.  ...  A simple closed-form analytical solution, and a highly-accurate boundary-elements-based numerical analysis, are developed to evaluate the macroscopic behaviour of nacre from the mechanical properties of  ...  Fig. 5 . 5 Sketch of the model for the mechanical behaviour of nacre, where aragonite platelets are modeled as 'bricks' glued by a 'mortar' of organic matrix along the basal planes, but in unbonded unilateral  ... 
doi:10.1016/j.compscitech.2007.11.016 fatcat:4iokh32ckjgchluwikfe64qguy

Structure of laponite-styrene precursor dispersions for production of advanced polymer-clay nanocomposites

R. Fartaria, N. Javid, R. A. Pethrick, J. J. Liggat, J. Sefcik, M. B. Sweatman
2011 Soft Matter  
One method for production of polymer-clay nanocomposites involves dispersal of surface-modified clay in a polymerisable monomeric solvent, followed by fast in situ polymerisation.  ...  However, this agreement could only be obtained by introducing a permanent electrostatic dipole moment into the plane of each Laponite particle, which we explain in terms of the distribution of substituted  ...  The second is to add a third cutsphere to the model (see Fig. 2d ) representing a layer of attractive surfactant.  ... 
doi:10.1039/c1sm05935a fatcat:icx5l4ebhrbvnk7ly623ei6gnu

Blood Rheology Influence on False Lumen Thrombosis in Type B Aortic Dissection

Alireza Jafarinia, Thomas Stephan Müller, Ursula Windberger, Günter Brenn, Thomas Hochrainer
2020 Journal of Biomedical Engineering and Biosciences  
Aortic dissection is a disease caused by the occurrence of a rupture in the innermost layer of the aortic wall.  ...  Considering the dominant influence of shear rate in FL thrombosis, the non-Newtonian rheological properties and behaviour of blood play a crucial role.  ...  Acknowledgements The authors gratefully acknowledge funding by TU Graz within the LEAD project "Mechanics, Modelling, and Simulation of Aortic Dissection."  ... 
doi:10.11159/jbeb.2020.002 fatcat:7rdtdeztcjhzhp4zhiqtpq437i

Bone's bridged layers

Pep Pàmies
2014 Nature Materials  
Now, Melinda Duer and colleagues propose a model of bone mineral where mineral platelets are bridged by disordered citrate ions residing within inter-platelet hydrated layers.  ...  In their experiment, the authors built a seismic metamaterial constituted of a 'mesh' of vertical cylindrical voids dug out of silty clay soil and analysed its masking behaviour by shocking it with 50-  ... 
doi:10.1038/nmat3967 fatcat:tvmq5vxyxfdnhhzwkk55ticgfa
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