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A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media
2019
Robotics
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One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids. ...
Here, we report that a special twisted helical shape together with a high aspect ratio in cross-section permit a microrobot with a diameter of hundreds-of-micrometers to move through mouse liver tissue ...
The authors thank Thomas Meisner, Arnold Weible and the mechanical workshop in the Max Planck Institute for the help in the fabrication of the propeller. ...
doi:10.3390/robotics8040087
fatcat:2lxxrk5oaretxprnrcnl6taoqu
Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices
2021
Micromachines
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The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. ...
directions for future research toward clinical translation of SPPs in diverse biomedical settings. ...
to design SPPs with bespoke shapes for a given ECM application.
5. ...
doi:10.3390/mi12101216
pmid:34683267
fatcat:tpoqbxzqhnayjov5s6s5jkgefa
Micro/Nano-Scale Magnetic Robots for Biomedical Applications
2020
Materials Today Bio
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gap in studies and the difficulties that have persisted in the optimization of the use of these devices. ...
In addition, alternative biomedical applications are also suggested for some of the technologies that show potential for other functions. ...
The nanorobots size has allowed them to propel through complex viscoelastic media, far outperforming the microrobot in all viscoelastic media despite producing negligible propulsion in water [72] . ...
doi:10.1016/j.mtbio.2020.100085
pmid:33299981
pmcid:PMC7702192
fatcat:w2jqty476razfer7iwc3wr3pqe
Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications
2021
Advanced Intelligent Systems
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[23] Moreover, benefiting from US imaging guidance, a magnetic helical robot could remove blood clots with an optimal rubbing frequency. ...
The authors demonstrated that the morphology of the δ*-optimal propeller strongly deviates from the bioinspired slim helix and finally results in a surprising chubby skew-symmetric shape. [21] 3. ...
He is now a full professor in Shanghai Jiaotong University Affiliated Sixth People's Hospital. ...
doi:10.1002/aisy.202000267
fatcat:v62vjfno3fbyzkli4uh2y4ale4
Mobile microrobots for bioengineering applications
2017
Lab on a Chip
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devices with live cells. ...
Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic ...
Acknowledgements The authors acknowledge funding from the Max Planck Society and the Max Planck ETH Center for Learning Systems. M. ...
doi:10.1039/c7lc00064b
pmid:28480466
fatcat:qoq47cl7cjdq7bx37ctxkhlqia
Assessing the Dynamic Performance of Microbots in Complex Fluid Flows
2016
Applied Sciences
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The use of microbots in biomedicine is a powerful tool that has been an object of study in the last few years. ...
This article provides a useful guide for the characterization of the dynamic performance of microbots and also highlights the necessity to consider the viscoelastic character of blood in their design. ...
[33] reported the fabrication of the smallest magnetically actuated helical propellers in complex viscoelastic media. ...
doi:10.3390/app6120410
fatcat:4tfryk5mqzaj5kpt67asyhl5sa
Enhanced low-Reynolds-number propulsion in heterogeneous viscous environments
2009
Physical Review E
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2009 pre-print arXiv:0910.3579v2 fatcat:f6thxies35gr5hyn7htmdaiizqOther Versions
The results of the rigorous numerical simulation of the rotating helical filament propelled through a random sparse array of stationary obstructions are in close agreement with predictions of the proposed ...
It is demonstrated that for prescribed propulsion gaits, including propagating surface distortions and rotating helical filament, the propulsion speed is enhanced when compared to swimming in purely viscous ...
value of αa = α * (a/b) = 1.52 and the optimal velocity of propulsion is U/ωr ≃ 0.49 which is an improvement of ≈ 40% comparative to the optimal speed of a helix propelled through viscous medium (U/rω ...
doi:10.1103/physreve.80.051911
pmid:20365010
fatcat:siftaw75hrenvodw65ynkzvppi
A swarm of slippery micropropellers penetrates the vitreous body of the eye
2018
Science Advances
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The propulsion is achieved by helical magnetic micropropellers that have a liquid layer coating to minimize adhesion to the surrounding biopolymeric network. ...
Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye. ...
Notably, nanosized helical propellers can also move with a high relative velocity of ~3 body lengths per second in biological viscoelastic media (24) . ...
doi:10.1126/sciadv.aat4388
pmid:30406201
pmcid:PMC6214640
fatcat:5kxftrdlsffopkrgdohmomvlwu
Engineering Active Micro and Nanomotors
2021
Micromachines
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Next, we highlight recent fascinating applications of MNMs in two examplary fields, water remediation and biomedical microrobots, and conclude this review with a brief discussion of challenges in the field ...
In this review, we first briefly overview the methods used to propel motors and then present the main strategies used to design proper MNMs. ...
biological media. ...
doi:10.3390/mi12060687
fatcat:ijmol5bnavaa7hvmkkzgps3moq
Hemodynamics Challenges for the Navigation of Medical Microbots for the Treatment of CVDs
2021
Materials
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This paper presents a critical analysis of the state-of-the-art literature related to pulsatile blood flow around microbots. ...
It is expected that these microdevices traveling along the microvascular system can remove clots, deliver drugs, or even look for specific cells or regions to diagnose and treat. ...
They analyzed the effect of some geometric parameters and validated them with experimental results reported in the literature, obtaining an optimal shape for the speed and the power efficiency. ...
doi:10.3390/ma14237402
pmid:34885556
fatcat:fyayy36f2fbrthu4mu2izsyxjy
Requirement and Development of Hydrogel Micromotors towards Biomedical Applications
2020
Research
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in vivo and in vitro bioapplications. ...
This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors, which become increasingly important for ...
The development of various environment-sensitive hydrogels with optimal sizes, shapes, propulsion modes, and methods of cargo release for therapeutical uses together with hydrogel micromotors is the next ...
doi:10.34133/2020/7659749
pmid:32728669
pmcid:PMC7368969
fatcat:ighw2hzf5za7bctnyjkf3pxdtq
Swimming by reciprocal motion at low Reynolds number
2014
Nature Communications
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Biological microorganisms swim with flagella and cilia that execute non-reciprocal motions for low Reynolds number (Re) propulsion in viscous fluids. ...
It should therefore be possible to realize a micro-swimmer that moves with reciprocal periodic body-shape changes in non-Newtonian fluids. ...
These include helically-shaped micro-propellers that use rigid chiral structures to break symmetry under non-reciprocal unidirectional rotation 5, 6, 7, 8, 9, 10 . ...
doi:10.1038/ncomms6119
pmid:25369018
pmcid:PMC4241991
fatcat:2hm3gp3ygbejxejix6uge37rye
The 2020 motile active matter roadmap
2020
Journal of Physics: Condensed Matter
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This has stimulated the new field of 'active matter' in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced emergent collective behavior of a larger number ...
Inspired by biological microswimmers, various designs of autonomous synthetic nano- and micromachines have been proposed. ...
Time evolution of the density profiles (color maps) and orientation profiles (white arrows) for an ensemble of pusher microswimmers in an external trapping potential. ...
doi:10.1088/1361-648x/ab6348
pmid:32058979
fatcat:ss5lwoujvvambe5ts5ynjsmfjy
The 2019 Motile Active Matter Roadmap
[article]
2019
arXiv
pre-print
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This has stimulated the new field of active matter in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced emergent collective behavior of a larger number ...
Such machines provide the basis for multifunctional, highly responsive, intelligent (artificial) active materials, which exhibit emergent behavior and the ability to perform tasks in response to external ...
The BiPMS group is a member of IPGG and a member of the CelTisPhyBio Labex that we acknowledge for funding. VY acknowledges partial funding from the EU PRESTIGE program. ...
arXiv:1912.06710v1
fatcat:7hv3b5l2vbedveybk2hkj67y4q
Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release
2020
Angewandte Chemie International Edition
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An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented as a novel strategy for the in-situ selection and transport ...
The proposed system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs in scenarios where tens to hundreds of sperm are required for an effective ...
were also able to move in biological media but they exhibited a very short lifespan (few minutes). ...
doi:10.1002/anie.202005657
pmid:32392393
fatcat:ddatyqlrefaqpa5l5gsifhq6bu
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