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A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media

Dandan Li, Moonkwang Jeong, Eran Oren, Tingting Yu, Tian Qiu
2019 Robotics  
One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids.  ...  Here, we report that a special twisted helical shape together with a high aspect ratio in cross-section permit a microrobot with a diameter of hundreds-of-micrometers to move through mouse liver tissue  ...  The authors thank Thomas Meisner, Arnold Weible and the mechanical workshop in the Max Planck Institute for the help in the fabrication of the propeller.  ... 
doi:10.3390/robotics8040087 fatcat:2lxxrk5oaretxprnrcnl6taoqu

Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

Shrishti Singh, Jeffrey Moran
2021 Micromachines  
The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency.  ...  directions for future research toward clinical translation of SPPs in diverse biomedical settings.  ...  to design SPPs with bespoke shapes for a given ECM application. 5.  ... 
doi:10.3390/mi12101216 pmid:34683267 fatcat:tpoqbxzqhnayjov5s6s5jkgefa

Micro/Nano-Scale Magnetic Robots for Biomedical Applications

M. Koleoso, X. Feng, Y. Xue, Q. Li, T. Munshi, X. Chen
2020 Materials Today Bio  
gap in studies and the difficulties that have persisted in the optimization of the use of these devices.  ...  In addition, alternative biomedical applications are also suggested for some of the technologies that show potential for other functions.  ...  The nanorobots size has allowed them to propel through complex viscoelastic media, far outperforming the microrobot in all viscoelastic media despite producing negligible propulsion in water [72] .  ... 
doi:10.1016/j.mtbio.2020.100085 pmid:33299981 pmcid:PMC7702192 fatcat:w2jqty476razfer7iwc3wr3pqe

Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications

Longchen Wang, Zheying Meng, Yu Chen, Yuanyi Zheng
2021 Advanced Intelligent Systems  
[23] Moreover, benefiting from US imaging guidance, a magnetic helical robot could remove blood clots with an optimal rubbing frequency.  ...  The authors demonstrated that the morphology of the δ*-optimal propeller strongly deviates from the bioinspired slim helix and finally results in a surprising chubby skew-symmetric shape. [21] 3.  ...  He is now a full professor in Shanghai Jiaotong University Affiliated Sixth People's Hospital.  ... 
doi:10.1002/aisy.202000267 fatcat:v62vjfno3fbyzkli4uh2y4ale4

Mobile microrobots for bioengineering applications

Hakan Ceylan, Joshua Giltinan, Kristen Kozielski, Metin Sitti
2017 Lab on a Chip  
devices with live cells.  ...  Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic  ...  Acknowledgements The authors acknowledge funding from the Max Planck Society and the Max Planck ETH Center for Learning Systems. M.  ... 
doi:10.1039/c7lc00064b pmid:28480466 fatcat:qoq47cl7cjdq7bx37ctxkhlqia

Assessing the Dynamic Performance of Microbots in Complex Fluid Flows

Laura Campo-Deaño
2016 Applied Sciences  
The use of microbots in biomedicine is a powerful tool that has been an object of study in the last few years.  ...  This article provides a useful guide for the characterization of the dynamic performance of microbots and also highlights the necessity to consider the viscoelastic character of blood in their design.  ...  [33] reported the fabrication of the smallest magnetically actuated helical propellers in complex viscoelastic media.  ... 
doi:10.3390/app6120410 fatcat:4tfryk5mqzaj5kpt67asyhl5sa

Enhanced low-Reynolds-number propulsion in heterogeneous viscous environments

A. M. Leshansky
2009 Physical Review E  
The results of the rigorous numerical simulation of the rotating helical filament propelled through a random sparse array of stationary obstructions are in close agreement with predictions of the proposed  ...  It is demonstrated that for prescribed propulsion gaits, including propagating surface distortions and rotating helical filament, the propulsion speed is enhanced when compared to swimming in purely viscous  ...  value of αa = α * (a/b) = 1.52 and the optimal velocity of propulsion is U/ωr ≃ 0.49 which is an improvement of ≈ 40% comparative to the optimal speed of a helix propelled through viscous medium (U/rω  ... 
doi:10.1103/physreve.80.051911 pmid:20365010 fatcat:siftaw75hrenvodw65ynkzvppi

A swarm of slippery micropropellers penetrates the vitreous body of the eye

Zhiguang Wu, Jonas Troll, Hyeon-Ho Jeong, Qiang Wei, Marius Stang, Focke Ziemssen, Zegao Wang, Mingdong Dong, Sven Schnichels, Tian Qiu, Peer Fischer
2018 Science Advances  
The propulsion is achieved by helical magnetic micropropellers that have a liquid layer coating to minimize adhesion to the surrounding biopolymeric network.  ...  Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye.  ...  Notably, nanosized helical propellers can also move with a high relative velocity of ~3 body lengths per second in biological viscoelastic media (24) .  ... 
doi:10.1126/sciadv.aat4388 pmid:30406201 pmcid:PMC6214640 fatcat:5kxftrdlsffopkrgdohmomvlwu

Engineering Active Micro and Nanomotors

Mingwei Liu, Kun Zhao
2021 Micromachines  
Next, we highlight recent fascinating applications of MNMs in two examplary fields, water remediation and biomedical microrobots, and conclude this review with a brief discussion of challenges in the field  ...  In this review, we first briefly overview the methods used to propel motors and then present the main strategies used to design proper MNMs.  ...  biological media.  ... 
doi:10.3390/mi12060687 fatcat:ijmol5bnavaa7hvmkkzgps3moq

Hemodynamics Challenges for the Navigation of Medical Microbots for the Treatment of CVDs

Erica Doutel, Francisco J. Galindo-Rosales, Laura Campo-Deaño
2021 Materials  
This paper presents a critical analysis of the state-of-the-art literature related to pulsatile blood flow around microbots.  ...  It is expected that these microdevices traveling along the microvascular system can remove clots, deliver drugs, or even look for specific cells or regions to diagnose and treat.  ...  They analyzed the effect of some geometric parameters and validated them with experimental results reported in the literature, obtaining an optimal shape for the speed and the power efficiency.  ... 
doi:10.3390/ma14237402 pmid:34885556 fatcat:fyayy36f2fbrthu4mu2izsyxjy

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

Xinyi Lin, Borui Xu, Hong Zhu, Jinrun Liu, Alexander Solovev, Yongfeng Mei
2020 Research  
in vivo and in vitro bioapplications.  ...  This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors, which become increasingly important for  ...  The development of various environment-sensitive hydrogels with optimal sizes, shapes, propulsion modes, and methods of cargo release for therapeutical uses together with hydrogel micromotors is the next  ... 
doi:10.34133/2020/7659749 pmid:32728669 pmcid:PMC7368969 fatcat:ighw2hzf5za7bctnyjkf3pxdtq

Swimming by reciprocal motion at low Reynolds number

Tian Qiu, Tung-Chun Lee, Andrew G. Mark, Konstantin I. Morozov, Raphael Münster, Otto Mierka, Stefan Turek, Alexander M. Leshansky, Peer Fischer
2014 Nature Communications  
Biological microorganisms swim with flagella and cilia that execute non-reciprocal motions for low Reynolds number (Re) propulsion in viscous fluids.  ...  It should therefore be possible to realize a micro-swimmer that moves with reciprocal periodic body-shape changes in non-Newtonian fluids.  ...  These include helically-shaped micro-propellers that use rigid chiral structures to break symmetry under non-reciprocal unidirectional rotation 5, 6, 7, 8, 9, 10 .  ... 
doi:10.1038/ncomms6119 pmid:25369018 pmcid:PMC4241991 fatcat:2hm3gp3ygbejxejix6uge37rye

The 2020 motile active matter roadmap

Gerhard Gompper, Roland G Winkler, Thomas Speck, Alexandre Solon, Cesare Nardini, Fernando Peruani, Hartmut Löwen, Ramin Golestanian, U Benjamin Kaupp, Luis Alvarez, Thomas Kiørboe, Eric Lauga (+25 others)
2020 Journal of Physics: Condensed Matter  
This has stimulated the new field of 'active matter' in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced emergent collective behavior of a larger number  ...  Inspired by biological microswimmers, various designs of autonomous synthetic nano- and micromachines have been proposed.  ...  Time evolution of the density profiles (color maps) and orientation profiles (white arrows) for an ensemble of pusher microswimmers in an external trapping potential.  ... 
doi:10.1088/1361-648x/ab6348 pmid:32058979 fatcat:ss5lwoujvvambe5ts5ynjsmfjy

The 2019 Motile Active Matter Roadmap [article]

Gerhard Gompper, Roland G. Winkler, Thomas Speck, Alexandre Solon, Cesare Nardini, Fernando Peruani, Hartmut Loewen, Ramin Golestanian, U. Benjamin Kaupp, Luis Alvarez, Thomas Kioerboe, Eric Lauga, Wilson Poon, Antonio De Simone (+21 others)
2019 arXiv   pre-print
This has stimulated the new field of active matter in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced emergent collective behavior of a larger number  ...  Such machines provide the basis for multifunctional, highly responsive, intelligent (artificial) active materials, which exhibit emergent behavior and the ability to perform tasks in response to external  ...  The BiPMS group is a member of IPGG and a member of the CelTisPhyBio Labex that we acknowledge for funding. VY acknowledges partial funding from the EU PRESTIGE program.  ... 
arXiv:1912.06710v1 fatcat:7hv3b5l2vbedveybk2hkj67y4q

Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release

Haifeng Xu, Mariana Medina-Sánchez, Oliver G. Schmidt
2020 Angewandte Chemie International Edition  
An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented as a novel strategy for the in-situ selection and transport  ...  The proposed system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs in scenarios where tens to hundreds of sperm are required for an effective  ...  were also able to move in biological media but they exhibited a very short lifespan (few minutes).  ... 
doi:10.1002/anie.202005657 pmid:32392393 fatcat:ddatyqlrefaqpa5l5gsifhq6bu
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