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A Finite Element CFD Simulation for Predicting Patient-Specific Hemodynamics of an Aortic Coarctation [chapter]

Idit Avrahami
2014 Lecture Notes in Computer Science  
This paper presents a numerical simulation of the flow characteristics through a patient-specific model of an aortic coarctation.  ...  The purpose of the study was to predict the pressure gradient at rest and at exercise conditions.  ...  In the present manuscript, a computational fluid dynamics (CFD) simulation of the CoA hemodynamics is presented using the finite-element commercial software ADINA (ADINA R&D, Inc., MA).  ... 
doi:10.1007/978-3-642-54268-8_13 fatcat:d3emwn7vj5cunfaeqadcuhe32i

A reduced-order model based on the coupled 1D-3D finite element simulations for an efficient analysis of hemodynamics problems

Eduardo Soudah, Riccardo Rossi, Sergio Idelsohn, Eugenio Oñate
2014 Computational Mechanics  
First a coupled 1D-3D Finite Element Simulation is performed and the results are used to adjust a reduced-order model of the 3D patient-specific area of interest.  ...  The methodology proposed is validated using a patient-specific aortic coarctation model under rest and non-rest conditions  ...  We also thank Dr.Pooyan Dadvand for his support on the implementation of the reduced-order model in KRATOS and Mr.Maurizio Bordone for his help during the fitting of the terminal resistances during training  ... 
doi:10.1007/s00466-014-1040-2 fatcat:slvwr4ntmfbydjau7jcnwx4d5u

In Vivo Validation of Numerical Prediction for Turbulence Intensity in an Aortic Coarctation

Amirhossein Arzani, Petter Dyverfeldt, Tino Ebbers, Shawn C. Shadden
2011 Annals of Biomedical Engineering  
Magnetic resonance imaging (MRI) was carried out on a 60-year-old female with a restenosed aortic coarctation.  ...  Results indicate relative agreement (error %10%) between the in vivo measurements and the CFD predictions of TKE.  ...  the Center for Industrial Information Technology.  ... 
doi:10.1007/s10439-011-0447-6 pmid:22016327 pmcid:PMC3880395 fatcat:hp4a4ubsczaozdoioe43xeo73m

Assessment of hemodynamic responses to exercise in aortic coarctation using MRI-ergometry in combination with computational fluid dynamics

Charlotte Schubert, Jan Brüning, Leonid Goubergrits, Anja Hennemuth, Felix Berger, Titus Kühne, Marcus Kelm
2020 Scientific Reports  
This concept has the potential to serve as an alternative to cardiac catheterization with pharmacological stress testing and provides hemodynamic information valuable for studying the pathophysiology of  ...  aortic coarctation.  ...  J.B. contributed to segmentation of aortic geometry and numerical simulations. C.S., J.B. and  ... 
doi:10.1038/s41598-020-75689-z pmid:33144605 fatcat:gyvk42tjx5cbngav2cmovtbuzi

Quantification of Local Hemodynamic Alterations Caused by Virtual Implantation of Three Commercially Available Stents for the Treatment of Aortic Coarctation

Sung Kwon, Jeffrey A. Feinstein, Ronak J. Dholakia, John F. LaDisa
2013 Pediatric Cardiology  
We created the first patient-specific computational fluid dynamics (CFD) model of a CoA patient treated by Palmaz stenting to date, and compared resulting WSS distributions to those from virtual implantation  ...  Patients with coarctation of the aorta (CoA) are prone to morbidity including atherosclerotic plaque that has been shown to correlate with altered wall shear stress (WSS) in the descending thoracic aorta  ...  Simulations incorporating aortic deformation [6, 17] , downstream vascular resistance and compliance [32, 31] were performed using a novel stabilized finite element method to solve the conservation  ... 
doi:10.1007/s00246-013-0845-7 pmid:24259013 pmcid:PMC3959287 fatcat:nzb4hq4voffzvbep5beskefa5y

Computational modeling and engineering in pediatric and congenital heart disease

Alison L. Marsden, Jeffrey A. Feinstein
2015 Current opinion in pediatrics  
Recent Findings-Multiscale modeling combining patient specific hemodynamics with reduced order (i.e. mathematically and computationally simplified) circulatory models has become the defacto standard for  ...  Purpose of review-Recent methodological advances in computational simulations are enabling increasingly realistic simulations of hemodynamics and physiology, driving increased clinical utility.  ...  ACKNOWLEDGEMENTS This work was supported by the Leducq Foundation as part of a Transatlantic Network of Excellence for Cardiovascular Research, a Burroughs Wellcome Fund Career award at the Scientific  ... 
doi:10.1097/mop.0000000000000269 pmid:26262579 pmcid:PMC4666705 fatcat:yrvwdzyqtjbfno4gg4uxhffcta

Effects of Uncertainty of Outlet Boundary Conditions in a Patient-Specific Case of Aortic Coarctation

Maria Nicole Antonuccio, Alessandro Mariotti, Benigno Marco Fanni, Katia Capellini, Claudio Capelli, Emilie Sauvage, Simona Celi
2021 Annals of Biomedical Engineering  
We evaluated the effect of using three-element Windkessel models as the outflow boundary conditions of a patient-specific aortic coarctation model.  ...  Physiologically suitable boundary conditions at the inlet and outlet of the computational domain are needed to perform a patient-specific CFD analysis.  ...  Kim et al. introduced a method to strongly couple a lumped parameter heart model to a 3D finite element model of the aorta with CoA. 16 Itu et al. proposed a CFD-based approach for non-invasive hemodynamic  ... 
doi:10.1007/s10439-021-02841-9 pmid:34431017 pmcid:PMC8671284 fatcat:tomkj4ciqzburijqndz6d3gfaa

Noninvasive hemodynamic assessment, treatment outcome prediction and follow-up of aortic coarctation from MR imaging

Kristóf Ralovich, Lucian Itu, Dime Vitanovski, Puneet Sharma, Razvan Ionasec, Viorel Mihalef, Waldemar Krawtschuk, Yefeng Zheng, Allen Everett, Giacomo Pongiglione, Benedetta Leonardi, Richard Ringel (+3 others)
2015 Medical Physics (Lancaster)  
dynamics (CFD) to estimate the pre-and postoperative hemodynamics for coarctation patients.  ...  Purpose: Coarctation of the aorta (CoA) is a congenital heart disease characterized by an abnormal narrowing of the proximal descending aorta.  ...  We use a finite difference solver with patient-specific fixed time step and explicit stability constraints. 23 In all of our computations, we apply a Newtonian rheological model, where the blood density  ... 
doi:10.1118/1.4914856 pmid:25979009 fatcat:f5bj3xgxejh7thvmyec6xcpvci

In silico modeling for personalized stenting in aortic coarctation [article]

Dandan Ma, Yong Wang, Mueed Azhar, Ansgar Adler, Michael Steinmetz, Martin Uecker
2022 arXiv   pre-print
Stent intervention is a recommended therapy to reduce the pressure gradient and restore blood flow for patients with coarctation of the aorta (CoA).  ...  In this work, we developed a framework for personalized stent intervention in CoA using in silico modeling, combining computational fluid dynamics (CFD) and image-based prediction of the geometry of the  ...  in the pre-interventional geometry of an aorta of a patient with CoA simulated by CFD.  ... 
arXiv:2205.04518v1 fatcat:2zbso7kamnaprnjmmsifg765qq

Patient-specific modeling of left ventricular electromechanics as a driver for haemodynamic analysis

Christoph M. Augustin, Andrew Crozier, Aurel Neic, Anton J. Prassl, Elias Karabelas, Tiago Ferreira da Silva, Joao F. Fernandes, Fernando Campos, Titus Kuehne, Gernot Plank
2016 Europace  
Methods and results-EM models of the LV and aortic root were created for four pediatric patients treated for either aortic coarctation or aortic valve disease.  ...  We report our recent advancements in developing an automated workflow for the creation of such CFD ready kinematic models to serve as drivers of blood flow simulations.  ...  Acknowledgements This research was supported by the grant F3210-N18 from the Austrian Science Fund (FWF) within the SFB Mathematical Optimization and Applications in Biomedical Sciences and is part of  ... 
doi:10.1093/europace/euw369 pmid:28011839 pmcid:PMC5386137 fatcat:rnzctif33bgtxfr6ofnf2qqbfq

Computational Simulations Demonstrate Altered Wall Shear Stress in Aortic Coarctation Patients Treated by Resection with End-to-end Anastomosis

John F. Jr. LaDisa, Ronak J. Dholakia, C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Margaret M. Samyn, Joseph R. Cava, Charles A. Taylor, Jeffrey A. Feinstein
2011 Congenital Heart Disease  
Computational fluid dynamics (CFD) models were created from imaging and blood pressure data for control subjects and age-and gendermatched CoA patients treated by RWEA (4 male, 2 female, 15±8 years).  ...  These indices were quantified longitudinally and circumferentially in the dAo, and several visualization methods were used to highlight regions of potential hemodynamic susceptibility.  ...  Sources of funding: This work was supported by a Dean's Postdoctoral Fellowship (to JFL), the Vera Moulton Wall Center for Pulmonary Vascular Disease at the Stanford University School of Medicine, and  ... 
doi:10.1111/j.1747-0803.2011.00553.x pmid:21801315 pmcid:PMC3208403 fatcat:b5rhlb3fpzao3kspaxfcox2huu

Effects of pulmonary artery banding and retrograde aortic arch obstruction on the hybrid palliation of hypoplastic left heart syndrome

Catriona E. Baker, Chiara Corsini, Daria Cosentino, Gabriele Dubini, Giancarlo Pennati, Francesco Migliavacca, Tain-Yen Hsia
2013 Journal of Thoracic and Cardiovascular Surgery  
Methods: A computational modeling technique was used to couple a 3-dimensional geometry of the hybrid palliation with a hydraulic network of the entire circulation based on pre-stage 2 hemodynamics.  ...  Conclusions: These computational simulations of the stage 1 hybrid palliation for hypoplastic left heart syndrome with aortic atresia suggest that small differences in the degree of branch pulmonary arterial  ...  were developed with Gambit (ANSYS, Inc, Canonsburg, Pa) using approximately 160,000 4-node tetrahedral volumetric elements for each computational fluid dynamics (CFD) model, after conducting a mesh sensitivity  ... 
doi:10.1016/j.jtcvs.2013.01.038 pmid:23434295 fatcat:is6ni44jnng5bpmx6gy5hw6hzq

MRI-based computational hemodynamics in patients with aortic coarctation using the lattice Boltzmann methods: Clinical validation study

Hanieh Mirzaee, Thomas Henn, Mathias J. Krause, Leonid Goubergrits, Christian Schumann, Mathias Neugebauer, Titus Kuehne, Tobias Preusser, Anja Hennemuth
2016 Journal of Magnetic Resonance Imaging  
Purpose: To introduce a scheme based on a recent technique in computational hemodynamics, known as the lattice Boltzmann methods (LBM), to noninvasively measure pressure gradients in patients with a coarctation  ...  Materials and Methods: Pre-and posttreatment LBM-based pressure gradients for 12 patients with CoA were simulated for the time point of peak systole using the open source library OpenLB.  ...  a means for a computer-aided treatment planning and predicting possible hemodynamic alterations.  ... 
doi:10.1002/jmri.25366 pmid:27384018 pmcid:PMC5213689 fatcat:rwqo2xgg2zcfbdohsvnnili3mu

Towards a Computational Framework for Modeling the Impact of Aortic Coarctations Upon Left Ventricular Load

Elias Karabelas, Matthias A. F. Gsell, Christoph M. Augustin, Laura Marx, Aurel Neic, Anton J. Prassl, Leonid Goubergrits, Titus Kuehne, Gernot Plank
2018 Frontiers in Physiology  
A biophysically detailed finite element (FE) model of LV EM was coupled with a FE-based CFD solver for moving domains using an arbitrary Eulerian-Lagrangian (ALE) formulation.  ...  Two clinical cases of patients suffering from aortic coarctations (CoA) were built and parameterized based on clinical data under pre-treatment conditions.  ...  We acknowledge PRACE for awarding us access to resource ARCHER based in the UK at EPCC (grant CAMEL) and the Vienna Scientific Cluster VSC-3.  ... 
doi:10.3389/fphys.2018.00538 pmid:29892227 pmcid:PMC5985756 fatcat:mqsbm3lepbfophx2kuak3hvycq

Hodge Decomposition of the wall shear stress vector fields characterizing biological flows [article]

Faniry H. Razafindrazaka, Pavlo Yevtushenko, Konstantin Poelke, Konrad Polthier, Leonid Goubergrits
2018 arXiv   pre-print
Finally, a comparative analysis of 11 patients with coarctation of the aorta (CoA) before and after treatment as well as 10 controls patient was done.  ...  A discrete boundary-sensitive Hodge decomposition is proposed as a central tool for the analysis of wall shear stress (WSS) vector fields in aortic blood flows.  ...  Yevtushenko was responsible in acquiring the patient models, reconstructing the geometry, and doing the numerical simulations. K. Poelke, and K.  ... 
arXiv:1808.01998v3 fatcat:3ya2lll5wvahxejese77iekh2m
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