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A Drug-Centric View of Drug Development: How Drugs Spread from Disease to Disease
2016
PLoS Computational Biology
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In this view, drugs are technologies with an inherent therapeutic potential. Once created, they can spread from disease to disease independently of the drug creator's original intentions. ...
A network model can describe the propagation of drugs from disease to disease in which diseases communicate with each other by receiving and sending drugs. ...
Acknowledgments I would like to thank Rohitha P. SriRamaratnam for comments on the manuscript.
Author Contributions Conceived and designed the experiments: RR. Performed the experiments: RR. ...
doi:10.1371/journal.pcbi.1004852
pmid:27124390
pmcid:PMC4849729
fatcat:mowwd5hbdjanddh4cfkenoxhdm
Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise
2016
NAM Perspectives
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This view takes the concepts of disease management, "patient centricity," and "beyond the pill" to new heights, incorporating a commitment to address all aspects of health care delivery beyond pharmaceuticals ...
VISIONS OF A TRANSFORMED ENTERPRISE Many different views were expressed during the interviews of what a transformed drug discovery and development enterprise might look like, although some common themes ...
Are pharmaceutical companies prepared to deal with a future in which a lot of the data may not come from randomized controlled trials and will be collected, stored and owned by someone else? ...
doi:10.31478/201607c
fatcat:bmltbhqrlbam7dt3msi7eyzpou
The Changing Landscape for New Drug Development: Medical Countermeasures (MCMs) as a Case Study
[chapter]
2019
Curious2018
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This is a new market for know-how different from the one in which Big Pharma is the acknowledged leader, like cardiovascular or GI disease markets, where numerous drugs have been developed and an infrastructure ...
as to improve existing ones, and apply this knowledge to the development and production of MCMs, i.e., a market for know-how. ...
doi:10.1007/978-3-030-16061-6_7
fatcat:a3uruuej75cojdrqy5wluuekpa
Sustaining the Development Goals in Drug Approaches in Europe, Norway and Singapore
2019
Beijing Law Review
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Last, the Commission's approach to sustainable development signals a fundamental change in mindset to drug use, control and prohibition amounting to de-linking of drug policy from abstinence. ...
It is recommended that health and development indicators be used in metrics to judge success of drug approaches, given its impact on the five dimensions of sustainable development. ...
Prisoners are given disinfectant material for their syringes and needles to prevent spread of communicable diseases. ...
doi:10.4236/blr.2019.104048
fatcat:goe2ney4ezbrbf4fby4kdaffha
Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types
2016
Assay and drug development technologies
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healthcare strategies without prior knowledge of a drug target. ...
datasets to support the identification of biomarkers and further elucidate drug mechanism-of-action. ...
ACKNOWLEDGMENTS Cancer Research UK Edinburgh Centre studentship award to S.J.W. and Research Councils UK (RCUK) fellowship award to N.O.C. ...
doi:10.1089/adt.2016.730
pmid:27552144
pmcid:PMC5015429
fatcat:n25juqj5abbg7mpp4g5txrzwry
Disease modification and biomarker development in Parkinson disease
2020
Neurology
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Each of these questions reflects a nosologic struggle between the lumper's clinicopathologic model that embraces heterogeneity of one disease and the splitter's focus on a pathobiology-specific set of ...
A fundamental question in advancing Parkinson disease (PD) research is whether it represents one disorder or many. Does each genetic PD inform a common pathobiology or represent a unique entity? ...
; publishing royalties from Lippincott Williams & Wilkins, Cambridge University Press, and Springer; and honoraria from USWorldMeds, Lundbeck, Acadia, Sunovion, the American Academy of Neurology, and the ...
doi:10.1212/wnl.0000000000009107
pmid:32102975
pmcid:PMC7220234
fatcat:guvlq6sidna7nltpkaxpeab4qe
Limiting Damage during Infection: Lessons from Infection Tolerance for Novel Therapeutics
2014
PLoS Biology
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BES ''Parasite and Pathogen Ecology and Evolution'' Special Interest Group for stimulating discussion of these ideas during a retreat at the Gregynog Conference Centre, University of Wales. ...
Acknowledgments The authors thank Jo Lello, Jo Cable, Anaid Diaz, Maria-Gloria Basañez, Sarah Reece, and Andrea Doeschl-Wilson for useful discussion, and the ''Ecology Meets Medicine'' focus group of the ...
These examples underline how the sources of disease may come from both the infection, and from the host response to the infection [21] . ...
doi:10.1371/journal.pbio.1001769
pmid:24465177
pmcid:PMC3897360
fatcat:dpmyqt6yerfmtoftsrabdcaq7i
Drugs and Development in the Urban Setting—Expanding Development-Oriented Interventions Beyond Illicit Drug Crop Cultivation
2021
Journal of Illicit Economies and Development
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It then takes a step into the literature on peacebuilding, examining the possible positioning of drugs and development debates relative to the field of peacebuilding studies. ...
It uses a recent experience in Thailand to showcase the link between drugs and development policies while highlighting the difficult international terrain for forging a common United Nations (UN) position ...
The global community needs to look at how to address the issue from root causes and from a systemic 'prevention' perspective. ...
doi:10.31389/jied.73
fatcat:wprfq2wz4zbidfhsb5atk6u7yu
Model-Informed Drug Development for Anti-Infectives: State of the Art and Future
2021
Clinical Pharmacology and Therapeutics
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Model-informed drug development (MIDD) has a long and rich history in infectious diseases. ...
"MIDD breadth" refers to greater adoption of model-centered approaches to anti-infective development. ...
A full PBPK model for ivermectin that allows prediction of plasma and tissue drug concentrations was developed as part of a program of work to facilitate drug development for parasitic disease, including ...
doi:10.1002/cpt.2198
pmid:33555032
pmcid:PMC8014105
fatcat:v36327nlrvh2xoafvmsa63pwsy
A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment
2017
Molecules
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Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. ...
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. ...
The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH. ...
doi:10.3390/molecules22101777
pmid:29053626
fatcat:vrr6fgmeb5d6dgity3upj66ehu
Development of a biomarker database toward performing disease classification and finding disease interrelations
2021
Database: The Journal of Biological Databases and Curation
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To fulfill this purpose, we have developed a human biomarker database as part of the KNApSAcK family databases which contain a vast quantity of information on the relationships between biomarkers and diseases ...
A biomarker is a measurable indicator of a disease or abnormal state of a body that plays an important role in disease diagnosis, prognosis and treatment. ...
Project for Supporting Drug Discovery and Life Science Research funded by the Japan Agency for Medical Research and Development and the National Bioscience Database Center in Japan. ...
doi:10.1093/database/baab011
pmid:33705530
fatcat:n7ixi3ggv5betmxbx6huevdeyu
Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production
2022
Antibiotics
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Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials ...
The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. ...
From a chemistry point of view, the development of an extraction and isolation process to produce phytochemical compounds in high purity can be very challenging and expensive. ...
doi:10.3390/antibiotics11060766
fatcat:qdzuc3p4pbgh3hmohln3a3t4si
Advancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14–16, 2018; Vienna, Austria
2019
Molecular Imaging and Biology
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During the meeting, cross-speciality participants assessed critical aspects of non-invasive, quantitative biomarker development in view of the need to expand our understanding of disease mechanisms and ...
While it is attractive to focus on technical advances alone, it is important to develop a patient-centric approach, thus asking "What can we do with our expertise to help patients?" ...
In particular, we like to acknowledge contributions from Claudia A. Castro Jaramillo, Stefanie D. Krämer and all faculty/moderators who did not engage in this white paper. ...
doi:10.1007/s11307-019-01361-2
pmid:31049831
fatcat:2zvde6icd5g6zkrrykwywjho6m
Reflections on the development of health economics in low- and middle-income countries
2014
Proceedings of the Royal Society of London. Biological Sciences
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overseas, to all of whom I owe a great debt for 35 years of stimulating research and debate. ...
The views expressed here have been developed through many years of interaction with my fellow health economists at the London School of Hygiene and Tropical Medicine and with numerous research collaborators ...
Moreover, prevailing economic orthodoxy-a shift away from a state-centric view of development, influenced attitudes towards public spending in general, and on health in particular. ...
doi:10.1098/rspb.2014.0451
pmid:25009059
pmcid:PMC4100502
fatcat:wkvclriewrgvzg6zhsehh5es5e
Reprogramming cellular identity during intestinal regeneration
2021
Current Opinion in Genetics and Development
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Transitioning from the single-cell level to tissue scale, we discuss clonal selection following regeneration and associated pathological repurcussions such as cancer and chronic inflammatory diseases. ...
Following tissue damage, the intestine mounts a remarkable regenerative response by reprogramming cellular identity to facilitate reinstatement of homeostasis. ...
Acknowledgements We apologise to colleagues whose work could not be included because of space limitations. We thank members of the Jensen lab for insightful discussion. ...
doi:10.1016/j.gde.2021.05.005
pmid:34062491
fatcat:czqtxj7eszhv5jyl5ifkcbm2xe
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