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Psychological and Educational Intervention to Improve Tuberculosis Treatment Adherence in Ethiopia Based on Health Belief Model: A Cluster Randomized Control Trial

Habteyes Hailu Tola, Davoud Shojaeizadeh, Azar Tol, Gholamreza Garmaroudi, Mir Saeed Yekaninejad, Abebaw Kebede, Luche Tadesse Ejeta, Desta Kassa, Eveline Klinkenberg, Delmiro Fernandez-Reyes
2016 PLoS ONE  
In addition, TB patient's HIV and anti retroviral therapy (ART) status are association with TB treatment non-adherence [11] .  ...  Nominal Discrete Continuous Independent Dependent 16 Perceived barrier TB patient's opinion of the tangible and psychological costs of treatment adherence X X Questionnaire Likert 17 Cues  ...  you and service quality of this health centre now, at the beginning of the study and at the end of your treatment  This study result will be reported through publication with your full approval.  ... 
doi:10.1371/journal.pone.0155147 pmid:27167378 pmcid:PMC4864292 fatcat:3i6wmouuhnc6faxrnvsuknc3aq

Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy

Eunok Jung, Aurelio A. de los Reyes V, Kurt Jan A. Pumares, Yangjin Kim, Joseph Najbauer
2019 PLoS ONE  
Glucose level is controlled to activate miR-451 in the up-stream pathway of the model.  ...  A potential drug blocking the inhibitory pathway of mTOR by AMPK complex is incorporated to explore regulation of the down-stream pathway to the cell cycle.  ...  This paper is also supported by the Korea National Research Foundation (NRF) grant funded by the Korean government (MEST): NRF-2017R1A2B2004651 (E.J.) and the Basic Science Research  ... 
doi:10.1371/journal.pone.0215547 pmid:31009513 pmcid:PMC6476530 fatcat:ck5cb35ht5avzmvvvd7agkyiwq

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model [article]

Jana L. Gevertz, Zahra Aminzare, Kerri-Ann Norton, Judith Perez-Velazquez, Alexandria Volkening, Katarzyna A. Rejniak
2014 arXiv   pre-print
With the goal of better understanding drug resistance and its connection with the tumor microenvironment, we have developed a hybrid discrete-continuous mathematical model.  ...  Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.  ...  APPENDIX Before testing various mechanism of tumor resistance, our model has been calibrated to 1) achieve a stable gradient of oxygen when no cancer cells are present, as would be the case in healthy  ... 
arXiv:1412.0780v1 fatcat:ziixr3tptfafpeqzx32nweareu

Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment

Arvid Edén, Thomas D. Marcotte, Robert K. Heaton, Staffan Nilsson, Henrik Zetterberg, Dietmar Fuchs, Donald Franklin, Richard W. Price, Igor Grant, Scott L. Letendre, Magnus Gisslén, Kersten Kurt Koelsch
2016 PLoS ONE  
HZ is co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Holding-based platform company at the University of Gothenburg.  ...  ., and ViiV Healthcare). RWP reports receiving honoraria as speaker and/or advisor from Gilead, Merck. All other authors declare no conflict of interest.  ...  Methods Study design and subjects We identified subjects from longitudinal neuroAIDS studies at the HIV Neurobehavioral Research Program (HNRP), including the CNS HIV Anti-Retroviral Therapy Effects  ... 
doi:10.1371/journal.pone.0157160 pmid:27295036 pmcid:PMC4905676 fatcat:zrqgojir7zbrpffmbld5j4orca

Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-α in patients with metastatic melanoma: a randomised "proof-of-principle" phase II study

Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati (+6 others)
2014 Journal of Translational Medicine  
However, immunological responses were only induced in about two-thirds of patients, and treatments aimed at improving immunological responsiveness to the vaccine are needed.  ...  All patients will receive four bi-weekly doses of the vaccine during the induction phase and monthly doses thereafter for up to a maximum of 14 vaccinations or until confirmed progression.  ...  Patients with confirmed irPD showing positive DTH may, at the physician's discretion, continue treatment until the next tumor assessment.  ... 
doi:10.1186/1479-5876-12-209 pmid:25053129 pmcid:PMC4223722 fatcat:rdty7l7mnnbargi3r2pqyfnqii

Computational Analysis of Molecular Interaction Networks Underlying Change of HIV-1 Resistance to Selected Reverse Transcriptase Inhibitors

Marcin Kierczak, Michał Dramiński, Jacek Koronacki, Jan Komorowski
2010 Bioinformatics and Biology Insights  
Results: We analyzed a number of HIV-1 RT sequences annotated with drug resistance level using the MCFS-ID method.  ...  Motivation: Despite more than two decades of research, HIV resistance to drugs remains a serious obstacle in developing efficient AIDS treatments.  ...  This paper is unique and is not under consideration by any other publication and has not been published elsewhere. The authors and peer reviewers of this paper report no conflicts of interest.  ... 
doi:10.4137/bbi.s6247 pmid:21234299 pmcid:PMC3020081 fatcat:52otku4qobbyfpdwy6qvwulkem

Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China-SCAN study

Na Cui, Hao Wang, Longxiang Su, Haibo Qiu, Ruoyu Li, Dawei Liu
2017 BMC Infectious Diseases  
The global responses (clinical and microbiological) at the end of the empirical therapy were also assessed.  ...  Results: A total of 268/306 (87.6%) ICI patients received antifungal therapy, including 142/268 (53.0%) initial empirical therapy, 53/268 (19.8%) initial pre-emptive therapy, and 73/268 (27.2%) initial  ...  Acknowledgements We thank all the members of the  ... 
doi:10.1186/s12879-017-2207-1 pmid:28114898 pmcid:PMC5260133 fatcat:giikrieg3fdatcgamqedrphjy4

Mathematical Modeling Reveals That the Administration of EGF Can Promote the Elimination of Lymph Node Metastases by PD-1/PD-L1 Blockade

Mohamed Amine Benchaib, Anass Bouchnita, Vitaly Volpert, Abdelkader Makhoute
2019 Frontiers in Bioengineering and Biotechnology  
The second one is a hybrid discrete-continuous model integrating the mechanical and biochemical mechanisms that define the tumor-immune interplay in the lymph node.  ...  They stimulate the naive CD4+ and CD8+ T lymphocytes which subsequently generate a population of helper and effector cells.  ...  AUTHOR CONTRIBUTIONS All authors contributed to the design of the study and the writing of the manuscript. AB and VV developed the mathematical models. MB and AB conducted the numerical simulations.  ... 
doi:10.3389/fbioe.2019.00104 pmid:31157216 pmcid:PMC6528618 fatcat:ddzcb37utnfovb35ottvtovrji

Systems immunology: a survey of modeling formalisms, applications and simulation tools

Vipin Narang, James Decraene, Shek-Yoon Wong, Bindu S. Aiswarya, Andrew R. Wasem, Shiang Rong Leong, Alexandre Gouaillard
2012 Immunologic research  
A plethora of modeling formalisms and software tools are reported in the literature for systems immunology.  ...  Modeling and simulation refer to building and executing an in silico replica of an immune system.  ...  The model also addressed a controversial issue whether stimulation of pro-and anti-inflammatory cellular responses is concurrent or separated by a time lag.  ... 
doi:10.1007/s12026-012-8305-7 pmid:22528121 fatcat:et6tel52m5bftmia7nnxlgo7jy

Article Commentary: Predictive Modeling of Drug Treatment in the Area of Personalized Medicine

Lesley A. Ogilvie, Christoph Wierling, Thomas Kessler, Hans Lehrach, Bodo M. H. Lange
2015 Cancer Informatics  
In particular, we highlight the mechanistic modeling platform ModCell™ for individualized prediction of patient responses to treatment, emphasizing modeling techniques and avenues of application.  ...  Despite a growing body of knowledge on the mechanisms underlying the onset and progression of cancer, treatment success rates in oncology are at best modest.  ...  Acknowledgments The authors would like to thank their colleagues at Alacris Theranostics GmbH and the Dahlem Centre for Genome Research and Medical Systems Biology (DCGMS) for fruitful discussions and  ... 
doi:10.4137/cin.s19330 fatcat:lhv4nv5wdzfddbjqn243kq3wqi

Protein Design by Algorithm [article]

Mark A. Hallen, Bruce R. Donald
2018 arXiv   pre-print
Finally, computer scientists may be unaware of the almost direct impact of these algorithms for predicting and introducing molecular therapies that have gone in a short time from mathematics to algorithms  ...  The algorithms represent a delicate and beautiful balance between discrete and continuous computation and modeling, analogous to that which is seen in robotics, computational geometry, and other fields  ...  for helpful comments on this manuscript; and all members of the Donald lab for many helpful discussions on protein design.  ... 
arXiv:1806.06064v1 fatcat:z3zscidq55avxaoq7xh54cviwe

HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome

Mahdi Golkaram, Michael L Salmans, Shannon Kaplan, Raakhee Vijayaraghavan, Marta Martins, Nafeesa Khan, Cassandra Garbutt, Aaron Wise, Joyee Yao, Sandra Casimiro, Catarina Abreu, Daniela Macedo (+16 others)
2021 npj Genomic Medicine  
First, we demonstrate that the median expression of hERVs can serve as a potential biomarker for prognosis, relapse, and resistance to chemotherapy in stage II and III CRC.  ...  Overall, our results underscore a previously unknown role for hERVs in leading to a more aggressive subtype of CRC.  ...  ACKNOWLEDGEMENTS The biobanking of CRC from Hospital Santa Maria, Lisbon, Portugal, was supported by a grant from the Official Portuguese Funding Agency for Science and Technology (FCT: PIC/IC/82821/2007  ... 
doi:10.1038/s41525-021-00177-w pmid:33589643 fatcat:rbb6oclyhvg5rnt5zkqxnknzua

Using tuberculosis surveillance data for informed programmatic decision-making

Nobuyuki Nishikiori, Fukushi Morishita
2013 Western Pacific Surveillance and Response  
Ethics and permissions It is the responsibility of authors to gain appropriate ethics approval for their work.  ...  A statement of ethics approval obtained or an explanation of why ethics approval was not required should be included for all articles during the submission process.  ...  All covariates were identified a priori and included in the model as tertile discrete continuous variables ( Table 1) .  ... 
doi:10.5365/wpsar.2013.4.1.007 pmid:23908948 pmcid:PMC3729102 fatcat:tp4c2p475rcozhkuefb2bwblpq

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics [article]

Mahnoor Naseer Gondal, Safee Ullah Chaudhary
2021 bioRxiv   pre-print
The review concludes by highlighting that the absence of a generic, zero-code, panomics-based multi-scale modeling pipeline and associated software framework, impedes the development and seamless deployment  ...  of personalized in silico multi-scale models in clinical settings.  ...  These platforms employ discrete, continuous, and hybrid approaches to develop models of cellular microenvironments towards setting up specific biological contexts such as normoxia, hypoxia, Warburg effect  ... 
doi:10.1101/2021.05.17.444410 fatcat:vbfvmtb5irdapglgkmh5na73je

Tools for Iina (Life): The Journey of the Iina Curriculum to the Glittering World

Arviso
2012 Monografi: ISSN 1046-7750  
ACKNOWLEDGEMENTS We would like to thank the tribes of Idaho, Oregon, and Washington for their public health leadership, and their ongoing support of Project Red Talon.  ...  We also thank John Spence and members of the Portland Area IHS IRB for their constructive reviews of this article.  ...  Age Age was measured as a discrete continuous variable ranging from 18 to 24 years.  ... 
doi:10.5820/aian.1901.2012.124 pmid:22569728 fatcat:hvv3pmryqfaivfykziqyhwul7i
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