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A Differentiable Transition Between Additive and Multiplicative Neurons [article]

Wiebke Köpp, Patrick van der Smagt, Sebastian Urban
2016 arXiv   pre-print
, differentiablely adjusted between addition and multiplication.  ...  Existing approaches to combine both additive and multiplicative neural units either use a fixed assignment of operations or require discrete optimization to determine what function a neuron should perform  ...  ACKNOWLEDGMENTS This project was funded in part by the German Research Foundation (DFG) SPP 1527 Autonomes Lernen and by the TACMAN project, EC Grant agreement no. 610967, within the FP7 framework programme  ... 
arXiv:1604.03736v1 fatcat:k7qrqgyd7rf6jaqe6wsahbwiqm

Single-Cell Transcriptome Analysis of Developing and Regenerating Spiral Ganglion Neurons

Kelvin Y. Kwan
2016 Current Pharmacology Reports  
Repurposing transcriptional regulatory networks to promote SGN differentiation from progenitor cells is a strategy for regeneration.  ...  Pseudotemporal ordering of transcriptomes describes the differentiation trajectory, allows monitoring of transcriptional changes, and determines molecular barriers that prevent the progression of progenitors  ...  Additional network analysis reveals a distinct group of transitioning cells between the two neuroblast populations which reflects the progression of different cellular states during neuronal development  ... 
doi:10.1007/s40495-016-0064-z pmid:28758056 pmcid:PMC5531199 fatcat:eyh3l2jlkfectcc2nl4p5zkhse

A Neural Transfer Function for a Smooth and Differentiable Transition Between Additive and Multiplicative Interactions [article]

Sebastian Urban, Patrick van der Smagt
2016 arXiv   pre-print
, differentiablely adjusted between addition and multiplication.  ...  Existing approaches to combine both additive and multiplicative neural units either use a fixed assignment of operations or require discrete optimization to determine what function a neuron should perform  ...  Therefore we will try to find more ad-hoc interpolations with a monotonic transition between addition and multiplication. 2.  ... 
arXiv:1503.05724v3 fatcat:afidyuj7yvcdppdpaykzgubfb4

Neuronal firing rates diverge during REM and homogenize during non-REM

Hiroyuki Miyawaki, Brendon O. Watson, Kamran Diba
2019 Scientific Reports  
Our results across two different regions, and with statistical corrections, indicate that the hippocampus and neocortex show a mixture of differences and similarities as they cycle between sleep states  ...  Neurons fire at highly variable intrinsic rates and recent evidence suggests that low- and high-firing rate neurons display different plasticity and dynamics.  ...  For additive and multiplicative increase simulations, baseline firing rates in epoch j were increased (by addition of 0.05 Hz or multiplication by 1.1 for additive and multiplicative increases, respectively  ... 
doi:10.1038/s41598-018-36710-8 pmid:30679509 pmcid:PMC6345798 fatcat:j4tkpp2minezhdja4qxg2f3dry

Differential variability and correlation of gene expression identifies key genes involved in neuronal differentiation

Tatsuya Ando, Ryuji Kato, Hiroyuki Honda
2015 BMC Systems Biology  
During the neural differentiation process, genes exhibiting both differential variance and differential correlation between undifferentiated and differentiating states were related to developmental functions  ...  such as body axis development, neuronal movement, and transcriptional regulation.  ...  Toyoshiba and S. Tasaki for helpful discussions and suggestions.  ... 
doi:10.1186/s12918-015-0231-6 pmid:26586157 pmcid:PMC4653947 fatcat:5iucv5fakbcs5hxhz4unkmkzri

Translating neural stem cells to neurons in the mammalian brain

Siraj K. Zahr, David R. Kaplan, Freda D. Miller
2019 Cell Death and Differentiation  
A subpopulation of these embryonic neural precursors persists into adulthood as neural stem cells, which give rise to inhibitory interneurons and glia.  ...  During mammalian embryogenesis, radial glial precursor cells sequentially give rise to diverse populations of excitatory cortical neurons, followed by astrocytes and oligodendrocytes.  ...  This work was funded by grants from the Canadian Institutes for Health Research to FDM and Medicine by Design/Canadian First Research Excellence Fund to DRK and FDM.  ... 
doi:10.1038/s41418-019-0411-9 pmid:31551564 pmcid:PMC7224185 fatcat:ozritjhxwzeglisqcao23gmyee

Neuronal firing rates diverge during REM and homogenize during non-REM [article]

Hiroyuki Miyawaki, Brendon Watson, Kamran Diba
2016 bioRxiv   pre-print
Our results across two different regions and with statistical corrections indicate that the hippocampus and neocortex show a mixture of differences and similarities as they cycle between sleep states with  ...  Neurons fire at highly variable innate rates and recent evidence suggests that low and high firing rate neurons display different plasticity and dynamics.  ...  Simulation of additive and multiplicative changes.  ... 
doi:10.1101/069237 fatcat:m3ezr5imnrerjavh4vw3wtv5nu

A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies

Xiaoqing Zhu, Bo Li, Zongyong Ai, Zheng Xiang, Kunshang Zhang, Xiaoyan Qiu, Yongchang Chen, Yuemin Li, Joshua D. Rizak, Yuyu Niu, Xintian Hu, Yi Eve Sun (+2 others)
2016 Stem Cell Reports  
Single NESCs can produce functional neurons in vitro, survive, and extensively regenerate neuron axons in monkey brain.  ...  The transition is accurately regulated by Wnt signaling through regulation of Notch signaling and adhesion molecules.  ...  NTs, complete RGPC transition, and give rise to functional neurons.  ... 
doi:10.1016/j.stemcr.2015.10.007 pmid:26584544 pmcid:PMC4750068 fatcat:wd52nso52vcrvje5dbd3hnucyu

Multipotent and restricted precursors in the central nervous system

Mahendra S. Rao
1999 The Anatomical Record  
Analysis in multiple species illustrates similarities between rat, mouse, and human cell differentiation raising the possibility that similar factors and markers may be used to isolate precursor cells  ...  Neuronal precursors termed neuronal-restricted precursors (NRPs), multiple classes of glial precursors termed glial-restricted precursors (GRPs), oligodendrocyte-type 2 astrocytes (O2As), astrocyte precursor  ...  NEURON-RESTRICTED PRECURSORS ARE PRESENT IN MULTIPLE REGIONS OF THE BRAIN In addition to neural crest stem cells (NCSCs) and GRPs, precursors limited in their differentiation potential to neurons have  ... 
doi:10.1002/(sici)1097-0185(19990815)257:4<137::aid-ar7>3.3.co;2-h pmid:10467245 fatcat:3yxdir5js5hsxhni2cetixdp7i

Multipotent and restricted precursors in the central nervous system

Mahendra S. Rao
1999 The Anatomical Record  
Analysis in multiple species illustrates similarities between rat, mouse, and human cell differentiation raising the possibility that similar factors and markers may be used to isolate precursor cells  ...  Neuronal precursors termed neuronal-restricted precursors (NRPs), multiple classes of glial precursors termed glial-restricted precursors (GRPs), oligodendrocyte-type 2 astrocytes (O2As), astrocyte precursor  ...  NEURON-RESTRICTED PRECURSORS ARE PRESENT IN MULTIPLE REGIONS OF THE BRAIN In addition to neural crest stem cells (NCSCs) and GRPs, precursors limited in their differentiation potential to neurons have  ... 
doi:10.1002/(sici)1097-0185(19990815)257:4<137::aid-ar7>3.0.co;2-q pmid:10467245 fatcat:nwlholusbveyvgmete7pzeljha

Nonlinear Control in the Nematode C. elegans

Megan Morrison, Charles Fieseler, J. Nathan Kutz
2021 Frontiers in Computational Neuroscience  
It remains unclear how a network of neurons can produce fast and slow timescale dynamics that control transitions between stable states in a single model.  ...  Long and short time-scale changes in transition statistics can be characterized via changes in a single parameter in the control model.  ...  AUTHOR CONTRIBUTIONS MM was the primary producer of the model with input from CF and JK. The figures for the manuscript were created by MM and the content written by MM, CF, and JK.  ... 
doi:10.3389/fncom.2020.616639 pmid:33551783 pmcid:PMC7862714 fatcat:6o6w6effqzaarbzqaauupjzbge

Spatiotemporal Regulation of Rho GTPases in Neuronal Migration

Zhenyan Xu, Yuewen Chen, Yu Chen
2019 Cells  
Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar–bipolar transition, locomotion, and translocation  ...  Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and the atypical Rnd members, play critical roles in neuronal migration by regulating both actin and microtubule cytoskeletal components  ...  In addition, the intact organization of the RGPs maintains homeostasis between proliferation and differentiation.  ... 
doi:10.3390/cells8060568 pmid:31185627 pmcid:PMC6627650 fatcat:xnvhlzeohjbzhj77klg3akfpq4

Nervous decision-making: to divide or differentiate

Laura J.A. Hardwick, Anna Philpott
2014 Trends in Genetics  
the existence of multiple links between components of the cell cycle and differentiation machinery.  ...  9], nor always a consequence of neuronal differentiation [10].  ...  Acknowledgements We would like to acknowledge helpful discussions with Fahad Ali and Kevin Cheng. A.P. is supported by MRC grant G0700758 and a Neuroblastoma Society Grant.  ... 
doi:10.1016/j.tig.2014.04.001 pmid:24791612 pmcid:PMC4046230 fatcat:26cxrx6dunhuziq43ujnumdony

Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis

Mariya M Kucherenko, Halyna R Shcherbata
2013 Fly  
EXTRA VIEW Extra View to: Kucherenko MM, Barth J, Fiala A, Shcherbata HR. Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain.  ...  Acknowledgments We thank all members of the Shcherbata lab, Vinodh Ilangovan, Roman Shcherbatyy for comments on the manuscript and the Max Planck Society for funding.  ...  cerebellar hypoplasia and developmental failure of several neuronal types. 71 By coherently repressing multiple proneurogenic genes in a timely manner this BTB protein supports neuronal differentiation  ... 
doi:10.4161/fly.25241 pmid:23839338 pmcid:PMC4049850 fatcat:g5ynldzflfebpoorylj3ieihwe

Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution

Russell B. Fletcher, Diya Das, Levi Gadye, Kelly N. Street, Ariane Baudhuin, Allon Wagner, Michael B. Cole, Quetzal Flores, Yoon Gi Choi, Nir Yosef, Elizabeth Purdom, Sandrine Dudoit (+2 others)
2017 Cell Stem Cell  
Adult stem cells maintain and regenerate multiple mature cell lineages in the olfactory epithelium.  ...  A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating mechanisms governing cell fate decisions and tissue homeostasis.  ...  D.D. and K.N.S. were supported by a training grant from the National Human Genome Research Institute (T32HG000047), L.G. by a training grant from the National Institute of General Medical Sciences (T32GM098218  ... 
doi:10.1016/j.stem.2017.04.003 pmid:28506465 pmcid:PMC5484588 fatcat:yytnoj4s3vcb3a5umneclkmev4
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