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Virus-induced autoimmunity: Molecular mimicry as a route to autoimmune disease

Michael B.A. Oldstone
1989 Journal of Autoimmunity  
This work was supported in part by USPHS grants AI-07007, NS-12428, and AG-04342. 1. 6. 7. 8. 9.  ...  Acknowledgements This is Publication Number 5566-IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.  ...  For example, despite a high degree of similarity between portions of the AChR u-chain (PESDQPDL) and polyoma virus middle T antigen (PKSDQDQL), no cross-reacting antibodies form.  ... 
doi:10.1016/0896-8411(89)90130-3 pmid:2673272 pmcid:PMC7172880 fatcat:kwabhfi6krfofg44izw5tchzw4

Virus-induced Autoimmunity: Molecular Mimicry as a Route to Autoimmune Disease [chapter]

Michael B.A. Oldstone
1989 T–Cell Activation in Health and Disease  
This work was supported in part by USPHS grants AI-07007, NS-12428, and AG-04342.  ...  Acknowledgements This is Publication Number 5566-IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.  ...  For example, despite a high degree of similarity between portions of the AChR a-chain (PESDQPDL) and polyoma virus middle T antigen (PESDQDQL), no cross-reacting antibodies form.  ... 
doi:10.1016/b978-0-12-252682-4.50023-8 fatcat:vtiyr4qlyne3zb47fximj3a74u

Domain analysis of symbionts and hosts (DASH) in a genome-wide survey of pathogenic human viruses

Mileidy W Gonzalez, John L Spouge
2013 BMC Research Notes  
Conclusions: We conclude that gene sharing probably occurs between humans and both DNA and RNA viruses, in viral genomes of differing sizes, regardless of transcription strategies.  ...  We also perform two other comparative genomics studies of human viruses: (1) a broad survey of eleven viruses of disparate sizes and transcription strategies; and (2) a closer examination of forty-one  ...  Acknowledgments The authors would like to thank Drs. Anthony L. DeVico, George K. Lewis, Thomas McCarty, and Barney Graham for helpful discussions.  ... 
doi:10.1186/1756-0500-6-209 pmid:23706066 pmcid:PMC3672079 fatcat:54pzfqcwb5afbaduboqtqjfpgi

Global approaches to study protein–protein interactions among viruses and hosts

Jorge Mendez-Rios, Peter Uetz
2010 Future Microbiology  
While high-throughput protein-protein interaction screens were first published approximately 10 years ago, systematic attempts to map interactions among viruses and hosts started only a few years ago.  ...  Recently, combinations of protein interaction data with RNAi and other functional genomics data allowed researchers to model more complex interaction networks.  ...  Acknowledgments The authors would like to thank SV Rajagopala, Roman Häuser and Jürgen Haas for their permission to quote unpublished data.  ... 
doi:10.2217/fmb.10.7 pmid:20143950 pmcid:PMC2832059 fatcat:b5pfynnhmvfpvnzdpnacxv5sii

Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

Arsham Ghavasieh, Sebastiano Bontorin, Oriol Artime, Nina Verstraete, Manlio De Domenico
2021 Communications Physics  
Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies.  ...  Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID  ...  Noticeably, even when all the considered approaches are combined to reach an integrated view of the virus clusters, we observe the same similarity between SARS-CoV-2 and viruses such as Herpes.  ... 
doi:10.1038/s42005-021-00582-8 doaj:6c3ec879512740d28f17babc13acf0d4 fatcat:c7n75y4cwvflrlzs54z42wil44

Molecular mimicry and immune-mediated diseases

Michael B. A. Oldstone
1998 The FASEB Journal  
For our purpose, molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products.  ...  An immune response against the determinant shared by the host and virus can evoke a tissue-specific immune response that is presumably capable of eliciting cell and tissue destruction.  ...  Antibodies to the human AChR a-subunit bound to herpes simplex virus-infected cells.  ... 
doi:10.1096/fasebj.12.13.1255 pmid:9761770 fatcat:il7dbl7o6jelrglbmosajyxjki

Epstein-Barr virus and virus human protein interaction maps

M. A. Calderwood, K. Venkatesan, L. Xing, M. R. Chase, A. Vazquez, A. M. Holthaus, A. E. Ewence, N. Li, T. Hirozane-Kishikawa, D. E. Hill, M. Vidal, E. Kieff (+1 others)
2007 Proceedings of the National Academy of Sciences of the United States of America  
protein; TRAF, TNF receptor-associated factor.  ...  yeast two-hybrid; KSHV, Kaposi sarcoma-associated herpesvirus; DB, DNA binding; AD, activation domain; AP, affinity purification; EBNA, EBV nuclear antigen; Rta, R transactivator; ET-HP, EBV-targeted human  ...  A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and interactions of EBV proteins with human proteins should provide specific hypotheses and a broad perspective on EBV strategies  ... 
doi:10.1073/pnas.0702332104 pmid:17446270 pmcid:PMC1863443 fatcat:blfeuwy2bvgr5fwseijz43nnaa

Prediction and analysis of human-herpes simplex virus type 1 protein-protein interactions by integrating multiple methods

Xianyi Lian, Xiaodi Yang, Jiqi Shao, Fujun Hou, Shiping Yang, Dongli Pan, Ziding Zhang
2020 Quantitative Biology  
Results: As a result, a comprehensive high-confidence PPI network between human and HSV-1 was established, covering 10,432 interactions between 4,546 human proteins and 72 HSV-1 proteins.  ...  Herpes simplex virus type 1 (HSV-1) is a ubiquitous infectious pathogen that widely affects human health.  ...  INTRODUCTION Herpes simplex virus type 1 (HSV-1) is a neurotropic, enveloped, and double-stranded linear DNA virus [1] [2] [3] [4] .  ... 
doi:10.1007/s40484-020-0222-5 fatcat:xkbomzeyz5bynesz56f3rujmau

MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis

Miroslava Jankovic, Ninoslav Mitic
2012 International Journal of Molecular Sciences  
Specifically, a homology to conserved domains from the family of herpesvirus major outer envelope protein (BLLF1) was found.  ...  The results obtained pointed to the similarities within extracellular serine/threonine rich regions of MUC16 to sequences of proteins expressed in evolutionary distant taxa, all having in common an annotated  ...  Acknowledgment This work was supported by the Ministry for Education and Science of the Republic of Serbia, project code 173010.  ... 
doi:10.3390/ijms130810387 pmid:22949868 pmcid:PMC3431866 fatcat:ycz6tb6im5elpmtykt5gkq3wym

Protein-protein interactions of human viruses

Norman Goodacre, Prajwal Devkota, Eunhae Bae, Stefan Wuchty, Peter Uetz
2018 Seminars in Cell and Developmental Biology  
Viruses infect their human hosts by a series of interactions between viral and host proteins, indicating that detailed knowledge of such virus-host interaction interfaces are critical for our understanding  ...  Finally, we cover the current status of research that investigates the relationships of virus-targeted host proteins to other comorbidities as well as the influence of host-virus protein interactions on  ...  Among the first attempts to validate human virus-host interactions was our study of interactions between proteins of the human host and the Kaposi sarcoma herpes virus (KSHV) [34] .  ... 
doi:10.1016/j.semcdb.2018.07.018 pmid:30031213 pmcid:PMC7102568 fatcat:w7l24t6okrdifnwa45mgcg3spa

Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches [article]

Anna Onisiforou, George M Spyrou
2020 bioRxiv   pre-print
During the course of a viral infection, virus-host protein-protein interactions (PPIs) play a critical role in allowing viruses to evade host immune responses, replicate and hence survive within the host  ...  In this paper we initially review databases and tools that can be utilized to investigate viral-mediated perturbations in complex NDs using network-based analysis by examining the interaction between the  ...  Viral proteins have a preference to target human proteins that are hubs, have high betweenness (bottlenecks), are articulation points and belong to rich clubs [42] [43] [44] [45] .  ... 
doi:10.1101/2020.12.21.423742 fatcat:uo4xjtcohnbhvcd3y7g5mppcqa

Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge

Xuan Xu, Qing-Ye Zhang, Xin-Yi Chu, Yuan Quan, Bo-Min Lv, Hong-Yu Zhang
2021 Viruses  
Over the course of human history, billions of people worldwide have been infected by various viruses.  ...  In the past, antiviral drugs mainly targeted viral proteins when they were used as part of treatment strategies.  ...  This data can be found here: DrugBank (https://go.drugbank.com/, accessed on 20 October 2021) and the SCG-Drug database (Quan et al. 2019).  ... 
doi:10.3390/v13112117 pmid:34834924 pmcid:PMC8626054 fatcat:dywpho3lqbfnhk57kit2wb65pa

Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions

Nadia Martinez-Martin
2017 Journal of Immunology Research  
This review discusses available technologies for the high throughput study of extracellular protein interactions between pathogens and their hosts, with a focus on mammalian viruses and bacteria.  ...  strategies.  ...  Acknowledgments The author is grateful to Lino Gonzalez, Jennie Lill, Erik Verschueren, and Yvonne Franke for critical reading of the manuscript and insightful comments and suggestions.  ... 
doi:10.1155/2017/2197615 pmid:28321417 pmcid:PMC5340944 fatcat:y77otgrt5ffu7bwu4otm4vkx3u

When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases

Vincent Navratil, Benoit de Chassey, Chantal Combe, Vincent Lotteau
2011 BMC Systems Biology  
Results: Here, we describe the Human Infectome protein interaction Network, a novel systems virology model of a virtual virus-infected human cell concerning 110 viruses.  ...  Networking the Human Infectome and Diseasome unravels the connectivity of viruses to a wide range of diseases and profiled molecular basis of Hepatitis C Virus-induced diseases as well as 38 new candidate  ...  Acknowledgements The authors wish to thank the IMAP team for helpful discussions. V.N is supported by a grant from INRA. VN wish to thank Pr. Lyndon Emsley, Pr. Pierre Toulhoat, Dr.  ... 
doi:10.1186/1752-0509-5-13 pmid:21255393 pmcid:PMC3037315 fatcat:vnagxpsus5frxlox6l267ptvly

Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirus

U Utz, W Britt, L Vugler, M Mach
1989 Journal of Virology  
Both antibodies recognized sequences between amino acids 608 and 625 of the primary gp58 translation product.  ...  The antibodies almost completely inhibited one another in a competitive binding assay with intact virus as antigen.  ...  This role for gB of herpes simplex virus and gpII of varicella-zoster virus has been clearly shown (17, 22) , suggesting a similar function(s) for HCMV gp58.  ... 
pmid:2467992 pmcid:PMC250614 fatcat:bqkhgowgwveitopd3de6stslmm
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