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A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins using ICP-MS and MS/MS Data

W Andrew Lancaster, Jeremy L Praissman, Farris L Poole, Aleksandar Cvetkovic, Angeli Menon, Joseph W Scott, Francis E Jenney, Michael P Thorgersen, Ewa Kalisiak, Junefredo V Apon, Sunia A Trauger, Gary Siuzdak (+2 others)
2011 BMC Bioinformatics  
We recently developed a generally-applicable experimental technique for finding metalloproteins on a genome-wide scale.  ...  Applying this metal-directed protein purification approach (ICP-MS and MS/MS based) to the prototypical microbe Pyrococcus furiosus conclusively demonstrated the extent and diversity of the uncharacterized  ...  The GMPA analysis in particular was used to provide estimates of the numbers of metalloproteins that could be expected proteome-wide and a narrowed list of candidates (based on ICP-MS and MS/MS data) at  ... 
doi:10.1186/1471-2105-12-64 pmid:21356119 pmcid:PMC3058030 fatcat:bq5tmfealvd6lczh6n26ukvbxu

SPECIAL ISSUE ON BIOPHYSICS IN INDIA GUEST EDITORS

Md Hassan
unpublished
It has been argued and accepted that proteome analysis offers a new approach for identification of wide spectrum of genes that are expressed in living system.  ...  Here we present a method for correcting PacBio reads, which iteratively targets errors using short reads, and can be adapted to suit existing data and computational resources.  ...  Analysis of proteomic data of N. gonorrhoeae showed that ~43% of the proteome are listed as hypothetical protein (HP), for which functions are not known.  ... 
fatcat:7gngicns5nfltnba2jqucgci2y